{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:22:27Z","timestamp":1790194947152,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010819","name":"Bureau of Education of Guangzhou Municipality","doi-asserted-by":"publisher","award":["2024312233"],"award-info":[{"award-number":["2024312233"]}],"id":[{"id":"10.13039\/501100010819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515012265"],"award-info":[{"award-number":["2023A1515012265"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.aca.2026.345861","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T23:32:59Z","timestamp":1781739179000},"page":"345861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nanozyme-loaded colorimetric gelatin methacryloyl microneedles for glucose detection in interstitial fluid"],"prefix":"10.1016","volume":"1418","author":[{"given":"Shixian","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqing","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijie","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupeng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7898-7672","authenticated-orcid":false,"given":"Jixiang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.345861_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176275","article-title":"Pathophysiology of type 2 diabetes mellitus","volume":"21","author":"Galicia-Garcia","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aca.2026.345861_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26031094","article-title":"Type 2 diabetes mellitus: new pathogenetic mechanisms, treatment and the most important complications","volume":"26","author":"M\u0142ynarska","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aca.2026.345861_bib3","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1177\/1932296820974748","article-title":"Continuous glucose monitoring for the detection of hypoglycemia in patients with diabetes of the exocrine pancreas","volume":"15","author":"Shivaprasad","year":"2021","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.aca.2026.345861_bib4","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1210\/clinem\/dgac601","article-title":"A systematic review supporting the endocrine society guidelines: management of diabetes and high risk of hypoglycemia","volume":"108","author":"Torres Roldan","year":"2023","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.aca.2026.345861_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2021.339226","article-title":"Glucose detection through surface-enhanced raman spectroscopy: a review","volume":"1206","author":"Sun","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.345861_bib6","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1177\/00037028221092474","article-title":"In vivo near-infrared noninvasive glucose measurement and detection in humans","volume":"76","author":"Han","year":"2022","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.aca.2026.345861_bib7","article-title":"Progress and perspectives of mid-infrared photoacoustic spectroscopy for non-invasive glucose detection","volume":"13","author":"Kaysir","year":"2023","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.aca.2026.345861_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-99367-0","article-title":"A low-power approach to optical glucose sensing via polarisation switching","volume":"15","author":"Hassanpour","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2026.345861_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117823","article-title":"Hydrogel microneedle based transdermal fluorescent patch for the on-site and non-invasive diagnosis of alzheimer's disease","volume":"288","author":"Zuo","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.345861_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaw0285","article-title":"Sampling interstitial fluid from human skin using a microneedle patch","volume":"12","author":"Samant","year":"2020","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.aca.2026.345861_bib11","article-title":"Gelatin methacryloyl microneedle patches for minimally invasive extraction of skin interstitial fluid","volume":"16","author":"Zhu","year":"2020","journal-title":"Small"},{"key":"10.1016\/j.aca.2026.345861_bib12","doi-asserted-by":"crossref","first-page":"5134","DOI":"10.1039\/D4BM00794H","article-title":"Advances in microneedle technology for biomedical detection","volume":"12","author":"Zhang","year":"2024","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.aca.2026.345861_bib13","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1007\/s00604-024-06458-2","article-title":"Advances in microneedles for transdermal diagnostics and sensing applications","volume":"191","author":"Wang","year":"2024","journal-title":"Mikrochim. Acta"},{"key":"10.1016\/j.aca.2026.345861_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26195912","article-title":"Advances of microneedles in biomedical applications","volume":"26","author":"Xu","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.aca.2026.345861_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201901683","article-title":"Osmosis-powered hydrogel microneedles for microliters of skin interstitial fluid extraction within minutes","volume":"9","author":"Zheng","year":"2020","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.aca.2026.345861_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202401782","article-title":"Hydrogel-forming microneedles and applications in interstitial fluid diagnostic devices","volume":"14","author":"Aroche","year":"2025","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.aca.2026.345861_bib17","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1039\/D1BM01834E","article-title":"A theranostic microneedle array patch for integrated glycemia sensing and self-regulated release of insulin","volume":"10","author":"Sun","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.aca.2026.345861_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.134408","article-title":"Glucose detection: In-situ colorimetric analysis with double-layer hydrogel microneedle patch based on polyvinyl alcohol and carboxymethyl chitosan","volume":"277","author":"Yin","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.aca.2026.345861_bib19","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/bios13050537","article-title":"Porous colorimetric microneedles for minimally invasive rapid glucose sampling and sensing in skin interstitial fluid","volume":"13","author":"Zeng","year":"2023","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.aca.2026.345861_bib20","article-title":"Microenvironment-optimized GelMA microneedles for interstitial fluid extraction and real-time glucose detection","volume":"45","author":"Lin","year":"2024","journal-title":"Surf. Interfaces"},{"key":"10.1016\/j.aca.2026.345861_bib21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s13346-014-0211-1","article-title":"Considerations in the sterile manufacture of polymeric microneedle arrays","volume":"5","author":"McCrudden","year":"2015","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.aca.2026.345861_bib22","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.talanta.2012.06.061","article-title":"Enhanced chemiluminescence of the luminol-hydrogen peroxide system by colloidal cupric oxide nanoparticles as peroxidase mimic","volume":"99","author":"Chen","year":"2012","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.345861_bib23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/adfm.201001302","article-title":"V2O5 nanowires with an intrinsic peroxidase-like activity","volume":"21","author":"Andre","year":"2011","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.aca.2026.345861_bib24","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1039\/c2cc17013b","article-title":"Intrinsic peroxidase-like activity and catalase-like activity of Co3O4 nanoparticles","volume":"48","author":"Mu","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.aca.2026.345861_bib25","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-012-1053-8","article-title":"Solution-processable carboxylate-capped CuO nanoparticles obtained by a simple solventless method","volume":"14","author":"Estruga","year":"2012","journal-title":"J. Nanopart. Res."},{"key":"10.1016\/j.aca.2026.345861_bib26","doi-asserted-by":"crossref","first-page":"21224","DOI":"10.1021\/jp3065568","article-title":"A vapor-phase corrosion strategy to hierarchically mesoporous nanosheet-assembled gearlike pillar arrays for super-performance lithium storage","volume":"116","author":"Chen","year":"2012","journal-title":"J. Phys. Chem. C"},{"key":"10.1016\/j.aca.2026.345861_bib27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1166\/jnn.2016.10681","article-title":"Controlled synthesis of nanostructured copper oxides through an elaborate solution route","volume":"16","author":"Hu","year":"2016","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.aca.2026.345861_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpowsour.2020.228058","article-title":"Halides-assisted electrochemical synthesis of cu\/Cu2O\/CuO core-shell electrocatalyst for oxygen evolution reaction","volume":"457","author":"Li","year":"2020","journal-title":"J. Power Sources"},{"key":"10.1016\/j.aca.2026.345861_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2020.105020","article-title":"Two ultrasonic applications for the synthesis of nanostructured copper oxide (II)","volume":"64","author":"Hajnorouzi","year":"2020","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.aca.2026.345861_bib30","doi-asserted-by":"crossref","DOI":"10.1088\/2053-1591\/aab7b7","article-title":"Coordination-induced formation of nanometer-scale infinite coordination polymer at room temperature and conversion to CuO nanoparticles","volume":"5","author":"Mohammadikish","year":"2018","journal-title":"Mater. Res. Express"},{"key":"10.1016\/j.aca.2026.345861_bib31","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.apsusc.2014.07.113","article-title":"Large-scale and green synthesis of octahedral flower-like cupric oxide nanocrystals with enhanced photochemical properties","volume":"315","author":"Li","year":"2014","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.aca.2026.345861_bib32","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1039\/c2an35072f","article-title":"Peroxidase-like activity of water-soluble cupric oxide nanoparticles and its analytical application for detection of hydrogen peroxide and glucose","volume":"137","author":"Chen","year":"2012","journal-title":"Analyst"},{"key":"10.1016\/j.aca.2026.345861_bib33","article-title":"Peroxidases and peroxidase\u2010mimicking capacities of copper nanozymes: catalytic mechanism, applications, and properties\u2010a review","author":"Bahramnejad","year":"2025","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.aca.2026.345861_bib34","article-title":"Overcoming water diffusion limitations in hydrogels via microtubular graphene networks for soft actuators","volume":"35","author":"Hauck","year":"2023","journal-title":"Adv. Mater."},{"key":"10.1016\/j.aca.2026.345861_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117278","article-title":"Effect of diffusional limitations on the kinetics of deacetylation of chitin\/chitosan","volume":"254","author":"De Souza","year":"2021","journal-title":"Carbohydr. Polym."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026008111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026008111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T08:11:43Z","timestamp":1786954303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026008111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":35,"alternative-id":["S0003267026008111"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.345861","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanozyme-loaded colorimetric gelatin methacryloyl microneedles for glucose detection in interstitial fluid","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.345861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"345861"}}