{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T05:14:31Z","timestamp":1788671671591,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011351","name":"State Key Laboratory of Information Photonics and Optical Communications","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011351","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.aca.2026.346009","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T23:00:20Z","timestamp":1784934020000},"page":"346009","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Temperature-compensated multiparameter SPR fiber-optic sensor for EGFR biomarker detection based on multi-mechanism signal amplification"],"prefix":"10.1016","volume":"1421","author":[{"given":"Pengxiao","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianshe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanglei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.346009_bib1","doi-asserted-by":"crossref","DOI":"10.21037\/tlcr-23-291","article-title":"Biomarkers of lung cancer for screening and in never-smokers-a narrative review","volume":"12","author":"Stephens","year":"2023","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.aca.2026.346009_bib2","doi-asserted-by":"crossref","DOI":"10.1186\/s40364-023-00486-5","article-title":"Accurate detection of early-stage lung cancer using a panel of circulating cell-free DNA methylation biomarkers","volume":"11","author":"Hu","year":"2023","journal-title":"Biomarker Res."},{"key":"10.1016\/j.aca.2026.346009_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/s12964-023-01082-8","article-title":"Toward the next generation EGFR inhibitors: an overview of osimertinib resistance mediated by EGFR mutations in non-small cell lung cancer","volume":"21","author":"Li","year":"2023","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.aca.2026.346009_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13194926","article-title":"Molecular mechanism of EGFR-TKI resistance in EGFR-mutated non-small cell lung cancer: application to biological diagnostic and monitoring","volume":"13","author":"Reita","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.aca.2026.346009_bib5","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.21037\/tcr.2018.10.06","article-title":"EGFR first- and second-generation TKIs-there is still place for them in EGFR-Mutant NSCLC patients","volume":"8","author":"Karachaliou","year":"2019","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.aca.2026.346009_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.pathol.2024.02.012","article-title":"Detection of EGFR exon 20 insertion mutations in non-small cell lung cancer: implications for consistent nomenclature in precision medicine","volume":"56","author":"Park","year":"2024","journal-title":"Pathology"},{"key":"10.1016\/j.aca.2026.346009_bib7","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1111\/cas.15722","article-title":"Metabolic adaptations of cancer in extreme tumor microenvironments","volume":"114","author":"Nakahara","year":"2023","journal-title":"Cancer Sci."},{"key":"10.1016\/j.aca.2026.346009_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121898","article-title":"Commercialized diagnostic technologies to combat SARS-CoV2: advantages and disadvantages","volume":"225","author":"P\u00e9rez-L\u00f3pez","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346009_bib9","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1007\/s00330-024-11036-4","article-title":"Diagnostic accuracy of CT and PET\/CT radiomics in predicting lymph node metastasis in non-small cell lung cancer","volume":"35","author":"Li","year":"2025","journal-title":"Eur. Radiol."},{"key":"10.1016\/j.aca.2026.346009_bib10","first-page":"382","article-title":"Imaging methods to evaluate tumor microenvironment factors affecting nanoparticle drug delivery and antitumor response","volume":"4","author":"Moody","year":"2021","journal-title":"Cancer drug resistance (Alhambra, Calif.)"},{"key":"10.1016\/j.aca.2026.346009_bib11","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.3892\/or.2016.4608","article-title":"Real-time RT-PCR systems for CTC detection from blood samples of breast cancer and gynaecological tumour patients","volume":"35","author":"Andergassen","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.aca.2026.346009_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.aca.2018.02.076","article-title":"Electrochemical detection of sequence-specific DNA based on formation of G-quadruplex-hemin through continuous hybridization chain reaction","volume":"1021","author":"Sun","year":"2018","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.346009_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.measurement.2025.117331","article-title":"Study on SPR sensors modulated by ZnO films of different thicknesses for dual-parameter measurement of ocean salinity and temperature","volume":"251","author":"Guo","year":"2025","journal-title":"Measurement"},{"key":"10.1016\/j.aca.2026.346009_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.optlastec.2021.106981","article-title":"Optical fiber sensors for glucose concentration measurement: a review","volume":"139","author":"Gong","year":"2021","journal-title":"Opt. Laser Technol."},{"key":"10.1016\/j.aca.2026.346009_bib15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1364\/BOE.10.000215","article-title":"Side-polished flexible SPR sensor modified by graphene with in situ temperature self-compensation","volume":"10","author":"Zhang","year":"2019","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.aca.2026.346009_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.130942","article-title":"In-situ DNA detection with an interferometric-type optical sensor based on tapered exposed core microstructured optical fiber","volume":"351","author":"Li","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346009_bib17","doi-asserted-by":"crossref","first-page":"10561","DOI":"10.1021\/acs.analchem.1c01660","article-title":"In situ temperature-compensated DNA hybridization detection using a dual-channel optical fiber sensor","volume":"93","author":"Gong","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346009_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2024.117076","article-title":"ZnO-Nafion assisted optical fiber dual-SPR biosensor for simultaneous detection of urea and uric acid concentrations","volume":"271","author":"Cheng","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.346009_bib19","volume":"271","author":"Cheng","year":"2025"},{"key":"10.1016\/j.aca.2026.346009_bib20","doi-asserted-by":"crossref","first-page":"6931","DOI":"10.1109\/JSEN.2023.3247599","article-title":"Miniature optical fiber DNA hybridization sensor with temperature compensation using a gold nanofilm-coated optical fiber","volume":"23","author":"Zhou","year":"2023","journal-title":"IEEE Sens. J."},{"key":"10.1016\/j.aca.2026.346009_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/mi14051086","article-title":"A novel NanoMIP\u2013SPR sensor for the Point-of-Care diagnosis of breast cancer","volume":"14","author":"Erol","year":"2023","journal-title":"Micromachines"},{"key":"10.1016\/j.aca.2026.346009_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2026.139730","article-title":"Ultra-trace detection of antidepressants in hospital wastewater using nanoMIP-based surface plasmon resonance sensors","volume":"457","author":"Erol","year":"2026","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346009_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134957","article-title":"Lab on a single fiber: a three-parameter sensor based on triple-SPR for one-to-one detection of DNA, pH and temperature","volume":"401","author":"Gong","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346009_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131596","article-title":"Plug-in optical fiber SPR biosensor for lung cancer gene detection with temperature and pH compensation","volume":"359","author":"Li","year":"2022","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346009_bib25","doi-asserted-by":"crossref","first-page":"7191","DOI":"10.1109\/TIM.2020.2976405","article-title":"Two-channel surface plasmon resonance sensor for simultaneous measurement of seawater salinity and temperature","volume":"69","author":"Siyu","year":"2020","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"10.1016\/j.aca.2026.346009_bib26","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1364\/OL.30.002988","article-title":"Investigation of dual-channel fiber-optic surface plasmon resonance sensing for biological applications","volume":"30","author":"Peng","year":"2005","journal-title":"Opt Lett."},{"key":"10.1016\/j.aca.2026.346009_bib27","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1364\/OL.40.004452","article-title":"Distributed fiber surface plasmon resonance sensor based on the incident angle adjusting method","volume":"40","author":"Liu","year":"2015","journal-title":"Opt Lett."},{"key":"10.1016\/j.aca.2026.346009_bib28","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1039\/c3cs60479a","article-title":"Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications","volume":"43","author":"Zeng","year":"2014","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2026.346009_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adom.201801433","article-title":"Optical refractive index sensors with plasmonic and photonic structures: promising and inconvenient truth","volume":"7","author":"Xu","year":"2019","journal-title":"Adv. Opt. Mater."},{"key":"10.1016\/j.aca.2026.346009_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.optlastec.2024.110579","article-title":"Cascaded dual-channel broadband SPR fiber optic sensor based on Ag\/ZnO and Ag\/TiO2\/PDMS films structure","volume":"174","author":"Yin","year":"2024","journal-title":"Opt Laser. Technol."},{"key":"10.1016\/j.aca.2026.346009_bib31","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bios.2018.04.027","article-title":"An enzyme-free and label-free surface plasmon resonance biosensor for ultrasensitive detection of fusion gene based on DNA self-assembly hydrogel with streptavidin encapsulation","volume":"112","author":"Guo","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.346009_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2022.214461","article-title":"Surface-functionalized gold and silver nanoparticles for colorimetric and fluorescent sensing of metal ions and biomolecules","volume":"459","author":"Chatterjee","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2026.346009_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/electronics10121419","article-title":"Metal-insulator-metal waveguide-based racetrack integrated circular cavity for refractive index sensing application","volume":"10","author":"Butt","year":"2021","journal-title":"Electronics"},{"key":"10.1016\/j.aca.2026.346009_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymer.2023.125915","article-title":"Surface properties of \u03bcm and sub-\u03bcm polydimethylsiloxane thin films after oxygen plasma treatment","volume":"275","author":"Xiang","year":"2023","journal-title":"Polymer"},{"key":"10.1016\/j.aca.2026.346009_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11468-022-01774-w","article-title":"Highly efficient D-type photonic crystal fiber surface plasmon resonance sensor for same space\u2013time temperature and refractive index detection","volume":"18","author":"Zhang","year":"2023","journal-title":"Plasmonics"},{"key":"10.1016\/j.aca.2026.346009_bib36","doi-asserted-by":"crossref","first-page":"12930","DOI":"10.1364\/OE.423307","article-title":"No-core optical fiber sensor based on surface plasmon resonance for glucose solution concentration and temperature measurement","volume":"29","author":"Li","year":"2021","journal-title":"Opt. Express"},{"key":"10.1016\/j.aca.2026.346009_bib37","doi-asserted-by":"crossref","DOI":"10.1109\/TIM.2025.3609324","article-title":"TiO2-Modified SPR fiber-optic sensor for high-sensitivity salinity and temperature detection in low-temperature environments","volume":"74","author":"Guo","year":"2025","journal-title":"IEEE Trans. Instrum. Meas."},{"key":"10.1016\/j.aca.2026.346009_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341286","article-title":"In-situ detection scheme for EGFR gene with temperature and pH compensation using a triple-channel optical fiber biosensor","volume":"1263","author":"Li","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.346009_bib39","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.105.136805","article-title":"Atomically thin MoS2: a new direct-gap semiconductor","volume":"105","author":"Mak","year":"2010","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.aca.2026.346009_bib40","doi-asserted-by":"crossref","DOI":"10.1007\/s10854-024-14061-7","article-title":"Optical bandgap tuning in SnO2-MoS2 nanocomposites: manipulating the mass of SnO2 and MoS2 using sonochemical solution mixing","volume":"36","author":"Ong","year":"2025","journal-title":"J. Mater. Sci. Mater. Electron."},{"key":"10.1016\/j.aca.2026.346009_bib41","doi-asserted-by":"crossref","first-page":"29812","DOI":"10.1039\/D4RA05458J","article-title":"Yttrium-induced tunable bandgap for optical data storage applications","volume":"14","author":"Agarwal","year":"2024","journal-title":"RSC Adv."},{"key":"10.1016\/j.aca.2026.346009_bib42","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1364\/JOSAB.416741","article-title":"Ab initio theory of the drude plasma frequency","volume":"38","author":"Mendoza","year":"2021","journal-title":"J. Opt. Soc. Am. B Opt. Phys."},{"key":"10.1016\/j.aca.2026.346009_bib43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/nmat3004","article-title":"Localized surface plasmon resonances arising from free carriers in doped quantum dots","volume":"10","author":"Luther","year":"2011","journal-title":"Nat. Mater."},{"key":"10.1016\/j.aca.2026.346009_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.optcom.2023.130236","article-title":"High Q all-dielectric metasurface sensor for seawater salinity and temperature simultaneous measurements","volume":"555","author":"Su","year":"2024","journal-title":"Opt. Commun."},{"key":"10.1016\/j.aca.2026.346009_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.optlastec.2023.109978","article-title":"Probe type optical fiber DNA hybridization biosensor based on polyethylenimine and Poly-L-Lysine surface functionalization method","volume":"168","author":"Gong","year":"2024","journal-title":"Opt Laser. Technol."},{"key":"10.1016\/j.aca.2026.346009_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2019.111621","article-title":"A disposable fiber optic SPR probe for immunoassay","volume":"144","author":"Mai","year":"2019","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.346009_bib47","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1021\/acssensors.9b01328","article-title":"Single plasmon-active optical fiber probe for instantaneous chiral detection","volume":"5","author":"Miliutina","year":"2020","journal-title":"ACS Sens."},{"key":"10.1016\/j.aca.2026.346009_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133727","article-title":"Lab-in-fibers: single optical fiber with three channels for simultaneous detection of pH value, refractive index and temperature","volume":"385","author":"Kong","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346009_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.optlastec.2025.114645","article-title":"Spectrally-selective SPR fiber-optic sensor for simultaneous monitoring of glucose, pH, and temperature in biopharmaceutical processes","volume":"196","author":"Guo","year":"2026","journal-title":"Opt Laser. Technol."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026009591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026009591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:29:59Z","timestamp":1788668999000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026009591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"alternative-id":["S0003267026009591"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.346009","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temperature-compensated multiparameter SPR fiber-optic sensor for EGFR biomarker detection based on multi-mechanism signal amplification","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.346009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"346009"}}