{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:08:56Z","timestamp":1789808936133,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ2400810"],"award-info":[{"award-number":["GJJ2400810"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360619"],"award-info":[{"award-number":["32360619"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20224ACB203016"],"award-info":[{"award-number":["20224ACB203016"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.aca.2026.346076","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:34:43Z","timestamp":1785911683000},"page":"346076","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Mesoporous medium-entropy nanozyme with enhanced peroxidase-like activity: design, mechanism, and application as a sensor for ultrasensitive detection of trace thiophanate methyl"],"prefix":"10.1016","volume":"1422","author":[{"given":"Yuhao","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailong","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.346076_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.170863","article-title":"Ultra-small medium-entropy nanozymes for targeting catalysis therapy of tumor","volume":"526","author":"He","year":"2025","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2026.346076_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138711","article-title":"Valence electron modulation strategy in high\u2013entropy alloy nanozyme with cold-adapted properties integrated with mobile APP for detecting antioxidants in cold-chain transportation of beverages","volume":"446","author":"Li","year":"2026","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346076_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116379","article-title":"Realizing selective detection with nanozymes: strategies and trends","volume":"143","author":"Li","year":"2021","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"10","key":"10.1016\/j.aca.2026.346076_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202211210","article-title":"Multienzyme\u2010like nanozymes: regulation, rational design, and application","volume":"36","author":"Sheng","year":"2023","journal-title":"Adv. Mater."},{"issue":"26","key":"10.1016\/j.aca.2026.346076_bib5","doi-asserted-by":"crossref","first-page":"24013","DOI":"10.1021\/acsnano.5c06349","article-title":"Modulating p-d orbital hybridization in mesoporous medium-entropy alloy nanozymes with enhanced peroxidase-like activity","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"issue":"11","key":"10.1016\/j.aca.2026.346076_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/adem.202000466","article-title":"Phase selection, lattice distortions, and mechanical properties in high\u2010entropy alloys","volume":"22","author":"Nutor","year":"2020","journal-title":"Adv. Eng. Mater."},{"key":"10.1016\/j.aca.2026.346076_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmatsci.2020.100754","article-title":"Multicomponent high-entropy cantor alloys","volume":"120","author":"Cantor","year":"2021","journal-title":"Prog. Mater. Sci."},{"key":"10.1016\/j.aca.2026.346076_bib8","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1126\/science.abo4940","article-title":"Machine learning\u2013enabled high-entropy alloy discovery","volume":"378","author":"Rao","year":"2022","journal-title":"Science"},{"issue":"38","key":"10.1016\/j.aca.2026.346076_bib9","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202406149","article-title":"PdMoPtCoNi high entropy nanoalloy with d electron self-complementation-induced multisite synergistic effect for efficient nanozyme catalysis","volume":"11","author":"Yang","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/j.aca.2026.346076_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz0510","article-title":"Computationally aided, entropy-driven synthesis of highly efficient and durable multi-elemental alloy catalysts","volume":"6","author":"Yao","year":"2020","journal-title":"Sci. Adv."},{"issue":"6417","key":"10.1016\/j.aca.2026.346076_bib11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1126\/science.aas8815","article-title":"Multicomponent intermetallic nanoparticles and superb mechanical behaviors of complex alloys","volume":"362","author":"Yang","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.aca.2026.346076_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intermet.2024.108182","article-title":"An investigation on microstructure and mechanical properties of strong yet ductile nanoparticle-strengthened, partially recrystallized, medium-entropy alloy","volume":"166","author":"Peng","year":"2024","journal-title":"Intermetallics"},{"issue":"6531","key":"10.1016\/j.aca.2026.346076_bib13","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1126\/science.abe1292","article-title":"High-entropy-stabilized chalcogenides with high thermoelectric performance","volume":"371","author":"Jiang","year":"2021","journal-title":"Science"},{"issue":"7808","key":"10.1016\/j.aca.2026.346076_bib14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-020-2275-z","article-title":"Short-range order and its impact on the CrCoNi medium-entropy alloy","volume":"581","author":"Zhang","year":"2020","journal-title":"Nature"},{"issue":"7866","key":"10.1016\/j.aca.2026.346076_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41586-021-03607-y","article-title":"Bifunctional nanoprecipitates strengthen and ductilize a medium-entropy alloy","volume":"595","author":"Yang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.aca.2026.346076_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijhydene.2025.153081","article-title":"A multisite HEA catalyst with etching-induced active surface for synergistic alkaline hydrogen evolution","volume":"203","author":"Liu","year":"2026","journal-title":"Int. J. Hydrogen Energy"},{"issue":"1","key":"10.1016\/j.aca.2026.346076_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1021\/acscatal.0c03496","article-title":"Atomic Fe dispersed hierarchical mesoporous fe\u2013n\u2013c nanostructures for an efficient oxygen reduction reaction","volume":"11","author":"Zhou","year":"2020","journal-title":"ACS Catal."},{"issue":"22","key":"10.1016\/j.aca.2026.346076_bib18","doi-asserted-by":"crossref","first-page":"18651","DOI":"10.1021\/jacs.5c01260","article-title":"Mesoporous single-crystal high-entropy alloy","volume":"147","author":"Nandan","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2026.346076_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.micromeso.2019.04.016","article-title":"Cr doped mesoporous silica spheres for propane dehydrogenation in the presence of CO2: effect of Cr adding time in sol-gel process","volume":"284","author":"Wang","year":"2019","journal-title":"Microporous Mesoporous Mater."},{"key":"10.1016\/j.aca.2026.346076_bib20","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.saa.2013.05.083","article-title":"Synthesis of Cu\/CuO nanoparticles in mesoporous material by solid state reaction","volume":"114","author":"Sohrabnezhad","year":"2013","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"5","key":"10.1016\/j.aca.2026.346076_bib21","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1021\/acs.energyfuels.1c04435","article-title":"Review on template removal techniques for synthesis of mesoporous silica materials","volume":"36","author":"Ghaedi","year":"2022","journal-title":"Energy Fuel."},{"issue":"9","key":"10.1016\/j.aca.2026.346076_bib22","doi-asserted-by":"crossref","first-page":"5310","DOI":"10.1021\/jacs.2c12977","article-title":"Tunable hierarchically structured meso-macroporous carbon spheres from a solvent-mediated polymerization-induced self-assembly","volume":"145","author":"Liu","year":"2023","journal-title":"J. Am. Chem. Soc."},{"issue":"9","key":"10.1016\/j.aca.2026.346076_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/bmc.4851","article-title":"Residue analysis and kinetics modeling of thiophanate\u2010methyl, carbendazim, tebuconazole and pyraclostrobin in apple tree bark using QuEChERS\/HPLC\u2013VWD","volume":"34","author":"Li","year":"2020","journal-title":"Biomed. Chromatogr."},{"issue":"1","key":"10.1016\/j.aca.2026.346076_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ijleo.2013.06.012","article-title":"Determination of thiophanate-methyl using UV absorption spectra based on multiple linear regression","volume":"125","author":"Jiao","year":"2014","journal-title":"Optik"},{"key":"10.1016\/j.aca.2026.346076_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2019.109420","article-title":"Immunomodulatory effect of mancozeb, chlorothalonil, and thiophanate methyl pesticides on macrophage cells","volume":"182","author":"Weis","year":"2019","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aca.2026.346076_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2020.128923","article-title":"A novel thioctic acid-carbon dots fluorescence sensor for the detection of Hg2+ and thiophanate methyl via S-Hg affinity","volume":"346","author":"Wang","year":"2021","journal-title":"Food Chem."},{"issue":"28","key":"10.1016\/j.aca.2026.346076_bib27","doi-asserted-by":"crossref","first-page":"7298","DOI":"10.1021\/acs.jafc.0c01962","article-title":"An overview on the mechanisms and applications of enzyme inhibition-based methods for determination of organophosphate and carbamate pesticides","volume":"68","author":"Cao","year":"2020","journal-title":"J. Agric. Food Chem."},{"issue":"28","key":"10.1016\/j.aca.2026.346076_bib28","doi-asserted-by":"crossref","first-page":"23287","DOI":"10.1021\/acsami.7b03937","article-title":"Recent progress in nanomaterial-based optical aptamer assay for the detection of food chemical contaminants","volume":"9","author":"Lan","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"2","key":"10.1016\/j.aca.2026.346076_bib29","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1021\/acs.jafc.1c06808","article-title":"Recent progress on single-molecule detection technologies for food safety","volume":"70","author":"Su","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.aca.2026.346076_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2023.115554","article-title":"Specific detection of fungicide thiophanate-methyl: a smartphone colorimetric sensor based on target-regulated oxidase-like activity of copper-doped carbon nanozyme","volume":"237","author":"Zhang","year":"2023","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.aca.2026.346076_bib31","doi-asserted-by":"crossref","DOI":"10.1007\/s00604-024-06907-y","article-title":"Sensitive and selective colorimetric detection of thiophanate-methyl based on a novel Ru-Fe3O4 nanozyme with enhanced peroxidase-like activity","volume":"192","author":"Gu","year":"2025","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.aca.2026.346076_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.127417","article-title":"Copper-based fluorescent nanozyme used to construct a ratiometric sensor for visual detection of thiophanate methyl","volume":"285","author":"Liu","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346076_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139258","article-title":"Sensitive colorimetric and fluorescence dual-mode detection of thiophanate-methyl based on spherical Fe3O4\/GONRs composite nanozyme","volume":"450","author":"Tai","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2026.346076_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.135041","article-title":"Self-supported PtPdMnCoFe high-entropy alloy with nanochain-like internetworks for ultrasensitive electrochemical immunoassay of biomarker","volume":"401","author":"Lv","year":"2024","journal-title":"Sensor. Actuator. B Chem."},{"issue":"13","key":"10.1016\/j.aca.2026.346076_bib35","doi-asserted-by":"crossref","first-page":"6073","DOI":"10.1021\/acs.nanolett.3c01454","article-title":"Atomically site synergistic effects of dual-atom nanozyme enhances peroxidase-like properties","volume":"23","author":"Zeng","year":"2023","journal-title":"Nano Lett."},{"key":"10.1016\/j.aca.2026.346076_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.seppur.2026.136842","article-title":"Trimetallic PCN-250 MOFs for synergistic radical-mediated photocatalytic degradation of microplastics","volume":"389","author":"Khan","year":"2026","journal-title":"Sep. Purif. Technol."},{"key":"10.1016\/j.aca.2026.346076_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136878","article-title":"Single-enzymatic (AChE\/ChOx) colorimetric detection of organophosphorus pesticides based on controllable nanoparticles supported by FeCoCu flower-like structure with peroxidase-like activity","volume":"424","author":"Yan","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346076_bib38","article-title":"DFT-guided design of a multi-enzyme mimetic high-entropy nanozyme for cascaded glutathione detection and point-of-care testing","author":"Lin","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.aca.2026.346076_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ces.2025.122808","article-title":"Colorimetric-ratiometric fluorescence dual-mode visual detection of perfluorodecanoic acid in cosmetics based on ligand-regulated metal-optimized framework composite nanozyme","volume":"321","author":"Nie","year":"2026","journal-title":"Chem. Eng. Sci."},{"key":"10.1016\/j.aca.2026.346076_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.114852","article-title":"Oxygen-coordinated bimetallic FeCu in nitrogen-doped carbon nanorod with dual-enzymatic activities for colorimetric detection of norfloxacin and ascorbic acid in food samples","volume":"217","author":"Chen","year":"2025","journal-title":"Microchem. J."},{"issue":"9","key":"10.1016\/j.aca.2026.346076_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nnano.2007.260","article-title":"Intrinsic peroxidase-like activity of ferromagnetic nanoparticles","volume":"2","author":"Gao","year":"2007","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.aca.2026.346076_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.144597","article-title":"Au-decorated \u03b1-Fe2O3-based electrochemical sensor for the detection of propyl gallate for monitoring preservative levels in packaged foods","volume":"486","author":"Jana","year":"2025","journal-title":"Food Chem."},{"issue":"8","key":"10.1016\/j.aca.2026.346076_bib43","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1021\/acs.analchem.1c05300","article-title":"Two-dimensional cobalt-doped Ti3C2 MXene nanozyme-mediated homogeneous electrochemical strategy for pesticides assay based on in situ generation of electroactive substances","volume":"94","author":"Yu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346076_bib44","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.foodchem.2018.03.062","article-title":"Residue dissipation and risk assessment of tebuconazole, thiophanate-methyl and its metabolite in table grape by liquid chromatography-tandem mass spectrometry","volume":"260","author":"Dong","year":"2018","journal-title":"Food Chem."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:19:54Z","timestamp":1789805994000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026010263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0003267026010263"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.346076","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesoporous medium-entropy nanozyme with enhanced peroxidase-like activity: design, mechanism, and application as a sensor for ultrasensitive detection of trace thiophanate methyl","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.346076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"346076"}}