{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:09:08Z","timestamp":1789808948010,"version":"4.0.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22574027"],"award-info":[{"award-number":["22574027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["Project 22274027"],"award-info":[{"award-number":["Project 22274027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.aca.2026.346083","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:03:55Z","timestamp":1785942235000},"page":"346083","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Smart dual-ligand-functionalized magnetic nanocomposites for rapid disruption of EpCAM-positive extracellular vesicles"],"prefix":"10.1016","volume":"1422","author":[{"given":"Ning","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangmin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6478","key":"10.1016\/j.aca.2026.346083_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13578-019-0282-2","article-title":"Exosomes: biogenesis, biologic function and clinical potential","volume":"9","author":"Zhang","year":"2019","journal-title":"Cell Biosci."},{"issue":"3","key":"10.1016\/j.aca.2026.346083_bib3","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/s41556-026-01878-z","article-title":"Defining the reference proteomes for small extracellular vesicles and non-vesicular components","volume":"28","author":"Morales-Sanfrutos","year":"2026","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.aca.2026.346083_bib4","series-title":"A Deep, Quantitative Lipid Atlas of Extracellular Vesicles Across Multiple Cell Lines","author":"Acari","year":"2025"},{"issue":"6","key":"10.1016\/j.aca.2026.346083_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.aca.2026.346083_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2021.05.032","article-title":"Extracellular vesicles in the tumor immune microenvironment","volume":"516","author":"Hou","year":"2021","journal-title":"Cancer Lett."},{"key":"10.1016\/j.aca.2026.346083_bib7","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v3.24641","article-title":"Routes and mechanisms of extracellular vesicle uptake","volume":"3","author":"Mulcahy","year":"2014","journal-title":"J. Extracell. Vesicles"},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib8","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1182\/blood-2005-01-0220","article-title":"ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-Cell priming","volume":"106","author":"Segura","year":"2005","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.aca.2026.346083_bib9","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/85438","article-title":"Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming","volume":"7","author":"Wolfers","year":"2001","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.immuni.2014.05.019","article-title":"MicroRNA-Containing T-Regulatory-Cell-Derived exosomes suppress pathogenic T helper 1 cells","volume":"41","author":"Okoye","year":"2014","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.aca.2026.346083_bib11","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1111\/jcmm.16192","article-title":"Exosomes from microRNA-126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2-Mediated PI3K\/Akt signalling pathway","volume":"25","author":"Zhang","year":"2021","journal-title":"J. Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.aca.2026.346083_bib12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.ccr.2014.03.007","article-title":"Cancer-secreted miR-105 destroys vascular endothelial barriers to promote metastasis","volume":"25","author":"Zhou","year":"2014","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.aca.2026.346083_bib13","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nrc3125","article-title":"Unravelling the complexity of metastasis \u2014 molecular understanding and targeted therapies","volume":"11","author":"Sethi","year":"2011","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.aca.2026.346083_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117495","article-title":"Exosomes released from breast cancer carcinomas stimulate cell movement","volume":"10","author":"Harris","year":"2015","journal-title":"PLoS One"},{"issue":"18","key":"10.1016\/j.aca.2026.346083_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13184537","article-title":"Tumor-derived exosomes: hidden players in PD-1\/PD-L1 resistance","volume":"13","author":"Vautrot","year":"2021","journal-title":"Cancers"},{"issue":"23","key":"10.1016\/j.aca.2026.346083_bib16","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1158\/0008-5472.CAN-16-0868","article-title":"The biodistribution and immune suppressive effects of breast cancer\u2013derived exosomes","volume":"76","author":"Wen","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.aca.2026.346083_bib17","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3389\/fimmu.2018.00871","article-title":"Breast cancer-derived exosomes alter macrophage polarization via Gp130\/STAT3 signaling","volume":"9","author":"Ham","year":"2018","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.aca.2026.346083_bib18","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1038\/s41563-024-01961-6","article-title":"Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery","volume":"23","author":"Gong","year":"2024","journal-title":"Nat. Mater."},{"issue":"9","key":"10.1016\/j.aca.2026.346083_bib19","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/s12276-022-00856-3","article-title":"Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer","volume":"54","author":"Li","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"5867","key":"10.1016\/j.aca.2026.346083_bib20","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1126\/science.1153124","article-title":"Ceramide triggers budding of exosome vesicles into multivesicular endosomes","volume":"319","author":"Trajkovic","year":"2008","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib21","doi-asserted-by":"crossref","first-page":"8161","DOI":"10.1038\/s41598-018-26411-7","article-title":"High-throughput screening identified selective inhibitors of exosome biogenesis and secretion: a drug repurposing strategy for advanced cancer","volume":"8","author":"Datta","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib22","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1080\/14756366.2020.1754814","article-title":"Advances in the discovery of exosome inhibitors in cancer","volume":"35","author":"Zhang","year":"2020","journal-title":"J. Enzym. Inhib. Med. Chem."},{"issue":"5","key":"10.1016\/j.aca.2026.346083_bib23","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/s41563-023-01515-2","article-title":"Curvature-sensing peptide inhibits tumour-derived exosomes for enhanced cancer immunotherapy","volume":"22","author":"Shin","year":"2023","journal-title":"Nat. Mater."},{"issue":"11","key":"10.1016\/j.aca.2026.346083_bib24","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/s41563-018-0194-2","article-title":"Therapeutic treatment of zika virus infection using a brain-penetrating antiviral peptide","volume":"17","author":"Jackman","year":"2018","journal-title":"Nat. Mater."},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib25","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.28533","article-title":"Single exosome study reveals subpopulations distributed among cell lines with variability related to membrane content","volume":"4","author":"Smith","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"3","key":"10.1016\/j.aca.2026.346083_bib26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41551-018-0343-6","article-title":"Low-cost thermophoretic profiling of extracellular-vesicle surface proteins for the early detection and classification of cancers","volume":"3","author":"Liu","year":"2019","journal-title":"Nat. Biomed. Eng."},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ctrv.2011.04.002","article-title":"Epithelial cell adhesion molecule expression (CD326) in cancer: a short review","volume":"38","author":"Patriarca","year":"2012","journal-title":"Cancer Treat Rev."},{"issue":"12","key":"10.1016\/j.aca.2026.346083_bib28","doi-asserted-by":"crossref","first-page":"10737","DOI":"10.1021\/jacs.5c01973","article-title":"Profiling nascent tumor extracellular vesicles via metabolic timestamping and aptamer-driven specific click chemistry","volume":"147","author":"Wu","year":"2025","journal-title":"J. Am. Chem. Soc."},{"issue":"20","key":"10.1016\/j.aca.2026.346083_bib29","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.201800484","article-title":"Recent progress in isolation and detection of extracellular vesicles for cancer diagnostics","volume":"7","author":"Wang","year":"2018","journal-title":"Adv. Healthc. Mater."},{"issue":"6","key":"10.1016\/j.aca.2026.346083_bib30","doi-asserted-by":"crossref","first-page":"3827","DOI":"10.1021\/acs.analchem.8b03619","article-title":"Avoiding pre-isolation step in exosome analysis: direct isolation and sensitive detection of exosomes using gold-loaded nanoporous ferric oxide nanozymes","volume":"91","author":"Boriachek","year":"2019","journal-title":"Anal. Chem."},{"issue":"8","key":"10.1016\/j.aca.2026.346083_bib31","doi-asserted-by":"crossref","first-page":"4141","DOI":"10.1021\/ac400366b","article-title":"Selection of DNA aptamers against epithelial cell adhesion molecule for cancer cell imaging and circulating tumor cell capture","volume":"85","author":"Song","year":"2013","journal-title":"Anal. Chem."},{"issue":"44","key":"10.1016\/j.aca.2026.346083_bib32","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2213236119","article-title":"Fluid nanoporous microinterface enables multiscale-enhanced affinity interaction for tumor-derived extracellular vesicle detection","volume":"119","author":"Niu","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"14","key":"10.1016\/j.aca.2026.346083_bib33","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1002\/anie.202015628","article-title":"Tracing tumor-derived exosomal PD-L1 by dual-aptamer activated proximity-induced droplet digital PCR","volume":"60","author":"Lin","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2026.346083_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126956","article-title":"Specific isolation and quantification of PD-L1 positive tumor derived exosomes for accurate breast cancer discrimination via aptamer-functionalized magnetic composites and SERS immunoassay","volume":"281","author":"Su","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346083_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342109","article-title":"Immunomagnetic capture and traceless release of native tumor-derived exosomes from human plasma for exploring interaction with recipient cells by aptamer-functionalized nanoflowers","volume":"1287","author":"Zheng","year":"2024","journal-title":"Anal. Chim. Acta"},{"issue":"6","key":"10.1016\/j.aca.2026.346083_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw9562","article-title":"Trimethylamine N-Oxide\u2013Derived zwitterionic polymers: a new class of ultralow fouling bioinspired materials","volume":"5","author":"Li","year":"2019","journal-title":"Sci. Adv."},{"issue":"7","key":"10.1016\/j.aca.2026.346083_bib37","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1021\/bm300545b","article-title":"Effect of size, surface charge, and hydrophobicity of Poly(Amidoamine) dendrimers on their skin penetration","volume":"13","author":"Yang","year":"2012","journal-title":"Biomacromolecules"},{"issue":"12","key":"10.1016\/j.aca.2026.346083_bib38","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1021\/cb900149b","article-title":"Mechanism of an amphipathic \u03b1-Helical peptide's antiviral activity involves size-dependent virus particle lysis","volume":"4","author":"Cho","year":"2009","journal-title":"ACS Chem. Biol."},{"issue":"6","key":"10.1016\/j.aca.2026.346083_bib39","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1021\/acs.jproteome.9b00693","article-title":"Characterization of urinary exosomes purified with size exclusion chromatography and ultracentrifugation","volume":"19","author":"Guan","year":"2020","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.aca.2026.346083_bib40","doi-asserted-by":"crossref","first-page":"2484","DOI":"10.1038\/s41467-019-10127-x","article-title":"PRL3-Zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein","volume":"10","author":"Thura","year":"2019","journal-title":"Nat. Commun."},{"issue":"21","key":"10.1016\/j.aca.2026.346083_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252111433","article-title":"Colon cancer-derived exosomal LncRNA-XIST promotes M2-like macrophage polarization by regulating PDGFRA","volume":"25","author":"Gao","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.aca.2026.346083_bib42","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.cmet.2021.09.002","article-title":"Tumor-derived exosomes drive immunosuppressive macrophages in a pre-metastatic niche through glycolytic dominant metabolic reprogramming","volume":"33","author":"Morrissey","year":"2021","journal-title":"Cell Metab."},{"issue":"11","key":"10.1016\/j.aca.2026.346083_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206759","article-title":"Tumor-promoting effects of pancreatic cancer cell exosomes on THP-1-Derived macrophages","volume":"13","author":"Linton","year":"2018","journal-title":"PLoS One"},{"issue":"36","key":"10.1016\/j.aca.2026.346083_bib44","doi-asserted-by":"crossref","first-page":"14621","DOI":"10.1021\/acs.analchem.4c03260","article-title":"Single-cell time-resolved metabolomics and lipidomics reveal apoptotic and ferroptotic heterogeneity during foam cell formation","volume":"96","author":"Wang","year":"2024","journal-title":"Anal. Chem."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:21:02Z","timestamp":1789806062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026010330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":44,"alternative-id":["S0003267026010330"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.346083","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Smart dual-ligand-functionalized magnetic nanocomposites for rapid disruption of EpCAM-positive extracellular vesicles","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.346083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"346083"}}