{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:09:51Z","timestamp":1789808991084,"version":"4.0.1"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005693","name":"Hainan University","doi-asserted-by":"publisher","award":["XJ2500008046"],"award-info":[{"award-number":["XJ2500008046"]}],"id":[{"id":"10.13039\/501100005693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22106113"],"award-info":[{"award-number":["22106113"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC1112"],"award-info":[{"award-number":["2023NSFSC1112"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.aca.2026.346103","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:18:25Z","timestamp":1786429105000},"page":"346103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Integrated dual-mode analytical device combining gas pressure and distance readout for rapid analysis of urea"],"prefix":"10.1016","volume":"1422","author":[{"given":"Linghuan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyue","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirong","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.346103_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.115805","article-title":"Electrochemical biosensors for urea detection: recent trends and future perspectives","volume":"219","author":"Thiyyadi","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2026.346103_bib2","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/bab.2168","article-title":"Urea biosensors: a comprehensive review","volume":"70","author":"Botewad","year":"2021","journal-title":"Biotechnol. Appl. Biochem."},{"key":"10.1016\/j.aca.2026.346103_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2024.101340","article-title":"Optical urea biosensor based on polyelectrolyte complex (PEC) pectin-chitosan membrane and anthocyanin from Catharanthus roseus L for a salivary simple urea detection","volume":"7","author":"Safitri","year":"2024","journal-title":"Results. Chem"},{"key":"10.1016\/j.aca.2026.346103_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1080\/87559129.2014.994818","article-title":"Milk preservatives and adulterants: processing, regulatory and safety issues","volume":"31","author":"Singh","year":"2015","journal-title":"Food Rev. Int."},{"key":"10.1016\/j.aca.2026.346103_bib5","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1016\/j.bios.2010.07.113","article-title":"Flow injection analysis biosensor for urea analysis in adulterated milk using enzyme thermistor","volume":"26","author":"Mishra","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.346103_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.sna.2024.115499","article-title":"Enzymatic electrochemical biosensors for urea detection: a review","volume":"374","author":"Mashhadban-K","year":"2024","journal-title":"Sensor. Actuat. A-Phys."},{"key":"10.1016\/j.aca.2026.346103_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341935","article-title":"A simple smartphone-assisted paper-based colorimetric biosensor for the detection of urea adulteration in milk based on an environment-friendly pH-sensitive nanocomposite","volume":"1284","author":"Shalileh","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.346103_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.114880","article-title":"Effect of applied potentials and electrolyte concentrations on porous nickel oxide growth by anodization methods for non-enzymatic urea detection","volume":"217","author":"Putri","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2026.346103_bib9","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.chroma.2007.05.085","article-title":"Determination of urea using high-performance liquid chromatography with fluorescence detection after automated derivatisation with xanthydrol","volume":"1161","author":"Clark","year":"2007","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.aca.2026.346103_bib10","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/chromsci\/bmac025","article-title":"Determination of urea in swimming pool water using high-performance liquid chromatography with online postcolumn derivatization by xanthydrol","volume":"61","author":"Zhou","year":"2023","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.aca.2026.346103_bib11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jcis.2024.01.068","article-title":"Self-adhesive, surface adaptive, regenerable SERS substrates for in-situ detection of urea on bio-surfaces","volume":"660","author":"Luo","year":"2024","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.aca.2026.346103_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.138392","article-title":"Wearable janus fabric SERS sensor for detection of urea, uric acid and pH in sweat","author":"Ye","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346103_bib13","doi-asserted-by":"crossref","first-page":"9527","DOI":"10.1038\/s41598-020-66422-x","article-title":"An AgNP-deposited commercial electrochemistry test strip as a platform for urea detection","volume":"10","author":"Liu","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aca.2026.346103_bib14","doi-asserted-by":"crossref","first-page":"13081","DOI":"10.1021\/acs.analchem.8b04223","article-title":"Flexible electrochemical urea sensor based on surface molecularly imprinted nanotubes for detection of human sweat","volume":"90","author":"Liu","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib15","doi-asserted-by":"crossref","first-page":"7752","DOI":"10.1039\/D4AY01593B","article-title":"Continuous flow microfluidic system with magnetic nanoparticles for the spectrophotometric quantification of urea in urine and plasma samples","volume":"16","author":"Ch\u00e1vez-Ramos","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.aca.2026.346103_bib16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.saa.2017.07.063","article-title":"Spectrophotometric methods for the determination of urea in real samples using silver nanoparticles by standard addition and 2nd order derivative methods","volume":"189","author":"Ali","year":"2018","journal-title":"Spectrochim. Acta A."},{"key":"10.1016\/j.aca.2026.346103_bib17","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.microc.2019.03.063","article-title":"Rapid and quantitative determination of urea in milk by reaction headspace gas chromatography","volume":"147","author":"Xie","year":"2019","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2026.346103_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.108990","article-title":"Sensing approaches toward detection of urea adulteration in milk","volume":"193","author":"Shalileh","year":"2023","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2026.346103_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.122002","article-title":"Point-of-care cancer diagnostic devices: from academic research to clinical translation","volume":"225","author":"Syedmoradi","year":"2021","journal-title":"Talanta"},{"issue":"8","key":"10.1016\/j.aca.2026.346103_bib20","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.tibtech.2017.03.013","article-title":"Multiplexed point-of-care testing - xPOCT","volume":"35","author":"Dincer","year":"2017","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.aca.2026.346103_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.339882","article-title":"Sweat urea bioassay based on degradation of Prussian Blue as the sensing architecture","volume":"1210","author":"Salatiello","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.346103_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclepro.2021.128149","article-title":"Enzyme-functionalized structural color hydrogel particles for urea detection and elimination","volume":"315","author":"Wang","year":"2021","journal-title":"J. Clean. Prod."},{"key":"10.1016\/j.aca.2026.346103_bib23","article-title":"Cascading chemiresistive paper-based enzymatic biosensor for urea detection","volume":"9","author":"Rath","year":"2025","journal-title":"Sens. Acutators Rep."},{"issue":"1","key":"10.1016\/j.aca.2026.346103_bib24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/s41378-025-00931-5","article-title":"pH-inhibited fenton etching of gold nanobipyramids: a multicolor approach for enhanced urea detection","volume":"11","author":"Elbalaawy","year":"2025","journal-title":"Microsyst. Nanoeng."},{"key":"10.1016\/j.aca.2026.346103_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2024.117897","article-title":"Advances in gas pressure-based portable biosensing","volume":"180","author":"Shi","year":"2024","journal-title":"TrAC-Trends. Anal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib26","doi-asserted-by":"crossref","first-page":"10448","DOI":"10.1002\/anie.201503963","article-title":"Translating molecular recognition into a pressure signal to enable rapid, sensitive, and portable biomedical analysis","volume":"54","author":"Zhu","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2026.346103_bib27","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.1021\/acs.analchem.2c05677","article-title":"Logic-gates of gas pressure for portable, intelligent and multiple analysis of metal ions","volume":"95","author":"Shi","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.113116","article-title":"Detection of Ca2+ in water samples and calcium gluconate oral liquids using gas pressure meter as portable detector","volume":"211","author":"Zhuo","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.aca.2026.346103_bib29","doi-asserted-by":"crossref","first-page":"9442","DOI":"10.1021\/acsami.1c22764","article-title":"Achieving ultrasensitive point-of-care assay for mercury ions with a triple-mode strategy based on the mercury-triggered dual-enzyme mimetic activities of Au\/WO3 hierarchical hollow nanoflowers","volume":"14","author":"Zhi","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2026.346103_bib30","doi-asserted-by":"crossref","first-page":"6743","DOI":"10.1007\/s00216-025-06170-x","article-title":"A portable gas pressure meter-based analytical kit for rapid analysis of S2- in water samples and food additives","volume":"417","author":"Zeng","year":"2025","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib31","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1021\/acssensors.2c01186","article-title":"Shape-encoded functional hydrogel pellets for multiplexed detection of pathogenic bacteria using a gas pressure sensor","volume":"7","author":"Li","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.aca.2026.346103_bib32","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1021\/acs.analchem.8b04584","article-title":"Point-of-care testing of pathogenic bacteria at the single-colony level via gas pressure readout using aptamer-coated magnetic CuFe2O4 and vancomycin-capped platinum nanoparticles","volume":"91","author":"Li","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib33","doi-asserted-by":"crossref","first-page":"12526","DOI":"10.1021\/acsami.8b02551","article-title":"Ultrasensitive and facile detection of microRNA via a portable pressure meter","volume":"10","author":"Shi","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2026.346103_bib34","doi-asserted-by":"crossref","first-page":"6090","DOI":"10.1021\/acs.analchem.3c00259","article-title":"Dual-mode logic gate for intelligent and portable detection of microRNA based on gas pressure and lateral flow assay","volume":"95","author":"Shi","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib35","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1039\/D3AY02100A","article-title":"Enhanced portable detection for Sars-CoV-2 utilizing DNA tetrahedron-tethered aptamers and a pressure meter","volume":"16","author":"Yu","year":"2024","journal-title":"Anal. Methods"},{"key":"10.1016\/j.aca.2026.346103_bib36","doi-asserted-by":"crossref","first-page":"14307","DOI":"10.1021\/acs.analchem.1c03486","article-title":"NIR II light-response Au nanoframes: amplification of a pressure and temperature-sensing strategy for portable detection and photothermal therapy of cancer cells","volume":"93","author":"Liu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346103_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2024.122758","article-title":"Heating and ultraviolet irradiation: gas pressure meter-based analytical system for on-site and rapid monitoring of permanganate index (CODMn)","volume":"268","author":"Tang","year":"2025","journal-title":"Water Res."},{"key":"10.1016\/j.aca.2026.346103_bib38","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1049\/iet-smt.2016.0215","article-title":"Silver nanoparticles for melamine detection in milk based on transmitted light intensity","volume":"11","author":"Ramalingam","year":"2017","journal-title":"IET Sci. Meas. Technol."},{"key":"10.1016\/j.aca.2026.346103_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2022.152917","article-title":"Preparation of urea-modified graphene oxide-gold composite detection of nitrite","author":"Xian","year":"2022","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.aca.2026.346103_bib40","doi-asserted-by":"crossref","first-page":"16287","DOI":"10.1109\/JSEN.2023.3282810","article-title":"Portable and low-cost colorimetric sensor for detection of urea in milk samples","volume":"23","author":"Nandeshwar","year":"2023","journal-title":"IEEE Sens. J."},{"issue":"11","key":"10.1016\/j.aca.2026.346103_bib41","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00604-024-06734-1","article-title":"Detection of urea in milk by urease-inorganic hybrid nanoflowers combined with portable colorimetric microliter tube","volume":"191","author":"Wan","year":"2024","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.aca.2026.346103_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.343731","article-title":"Visual and label-free detection of urea based on amorphous photonic films with non-iridescent structural colors","volume":"1345","author":"Han","year":"2025","journal-title":"Anal. Chim. Acta"},{"issue":"33","key":"10.1016\/j.aca.2026.346103_bib43","doi-asserted-by":"crossref","first-page":"10421","DOI":"10.1364\/AO.437787","article-title":"Urea detection in milk by urease-assisted pH-sensitive carbon dots","volume":"60","author":"Yin","year":"2021","journal-title":"Appl. Opt."},{"key":"10.1016\/j.aca.2026.346103_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340733","article-title":"Construction of a ratiometric fluorescent probe for visual detection of urea in human urine based on carbon dots prepared from Toona sinensis leaves and 5-carboxyfluorescein","volume":"1240","author":"Bei","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.346103_bib45","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1039\/D0QM00772B","article-title":"Urease-free Ni microwires-intercalated Co-ZIF electrocatalyst for rapid detection of urea in human fluid and milk samples in diverse electrolytes","volume":"5","author":"Arul","year":"2021","journal-title":"Mater. Chem. Front."},{"key":"10.1016\/j.aca.2026.346103_bib46","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.jfda.2016.05.009","article-title":"Determination of urea in milk based on N -bromosuccinimide-dichlorofluorescein postchemiluminescence method","volume":"25","author":"Nie","year":"2017","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.aca.2026.346103_bib47","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1039\/D3LC00730H","article-title":"Designing and prototyping a novel biosensor based on a volumetric bar-chart chip for urea detection","volume":"24","author":"Samadi Khezri","year":"2024","journal-title":"Lab Chip"}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010536?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010536?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:22:01Z","timestamp":1789806121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026010536"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":47,"alternative-id":["S0003267026010536"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.346103","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrated dual-mode analytical device combining gas pressure and distance readout for rapid analysis of urea","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.346103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"346103"}}