{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:54:03Z","timestamp":1791305643462,"version":"4.3.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100011400","name":"Nanjing University State Key Laboratory of Analytical Chemistry for Life Science","doi-asserted-by":"publisher","award":["SKLACLS2521"],"award-info":[{"award-number":["SKLACLS2521"]}],"id":[{"id":"10.13039\/501100011400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22476043"],"award-info":[{"award-number":["22476043"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Province Natural Science Foundation","doi-asserted-by":"publisher","award":["2026AFB738"],"award-info":[{"award-number":["2026AFB738"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.aca.2026.346144","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:54:19Z","timestamp":1787064859000},"page":"346144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Metal organic frameworks derived Fe-N-C catalysts boosting dual-readout biosensing platform for vascular endothelial growth factor detection"],"prefix":"10.1016","volume":"1423","author":[{"given":"Qian","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengfu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.346144_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123352","article-title":"Vascular endothelial growth factor (VEGF) and endogenous calcium-capturing gelatin methacrylate hydrogels promote bone tissue regeneration","volume":"322","author":"Yuan","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.aca.2026.346144_bib2","doi-asserted-by":"crossref","first-page":"17835","DOI":"10.1021\/acs.analchem.2c03583","article-title":"Signal-on near-infrared photoelectrochemical aptasensors for sensing VEGF165 based on ionic liquid-functionalized Nd-MOF nanorods and in-site formation of gold nanoparticles","volume":"94","author":"Zhong","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12929-025-01128-8","article-title":"Beyond vessels: unraveling the impact of VEGFs on neuronal functions and structure","volume":"32","author":"Aksan","year":"2025","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.aca.2026.346144_bib4","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202501416","article-title":"Flow-induced vascular remodeling on-chip: implications for anti-VEGF therapy","volume":"35","author":"Mirzapour-Shafiyi","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib5","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1158\/1538-7445.AM2025-3693","article-title":"Modeling VEGF dynamics in cancer: an evolutionary game theoretic approach","volume":"85","author":"Bhattacharya","year":"2025","journal-title":"Cancer Res."},{"key":"10.1016\/j.aca.2026.346144_bib6","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202507170","article-title":"Supramolecular self-assembled multivalent anti-VEGF protein nanospheres for prolonged ocular retention","volume":"22","author":"Tian","year":"2026","journal-title":"Small"},{"key":"10.1016\/j.aca.2026.346144_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/s41392-024-01868-3","article-title":"Targeting cytokine and chemokine signaling pathways for cancer therapy","volume":"9","author":"Yi","year":"2024","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.aca.2026.346144_bib8","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.actbio.2021.11.040","article-title":"Vascular endothelial growth factor-capturing aligned electrospun polycaprolactone\/gelatin nanofibers promote patellar ligament regeneration","volume":"140","author":"Yuan","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.aca.2026.346144_bib9","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1021\/acssensors.1c02641","article-title":"Detection of VEGF165 in whole blood by differential pulse voltammetry based on a centrifugal microfluidic chip","volume":"7","author":"He","year":"2022","journal-title":"ACS Sens."},{"key":"10.1016\/j.aca.2026.346144_bib10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00604-024-06228-0","article-title":"A colorimetric immunoassay for the detection of human vascular endothelial growth factor 165 (VEGF165) based on anti-VEGF-iron oxide nanoparticle conjugation","volume":"191","author":"Ceylan","year":"2024","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.aca.2026.346144_bib11","doi-asserted-by":"crossref","first-page":"10451","DOI":"10.1021\/acs.analchem.2c01649","article-title":"Double signal amplification strategy for dual-analyte fluorescent aptasensors for visualizing cancer biomarker proteins","volume":"94","author":"Zhu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2021.130964","article-title":"A DNA-functionalized graphene field-effect transistor for quantitation of vascular endothelial growth factor, Sensor","volume":"351","author":"Chen","year":"2022","journal-title":"Actuators B: Chem"},{"key":"10.1016\/j.aca.2026.346144_bib13","doi-asserted-by":"crossref","first-page":"25138","DOI":"10.1021\/acs.analchem.5c04066","article-title":"Retractable DNA nanoprobes for ultrasensitive SERS detection and imaging of the VEGF","volume":"97","author":"Zhou","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib14","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1021\/acs.nanolett.4c05934","article-title":"Optical nanopore blockade sensors for multiplexed detection of proteins","volume":"25","author":"Doan","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.aca.2026.346144_bib15","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1021\/acs.analchem.0c05257","article-title":"Two-dimensional MnO2 nanozyme-mediated homogeneous electrochemical detection of organophosphate pesticides without the interference of H2O2 and color","volume":"93","author":"Wu","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib16","doi-asserted-by":"crossref","first-page":"3669","DOI":"10.1021\/acs.analchem.1c05300","article-title":"Two-dimensional cobalt-doped Ti3C2 MXene nanozyme-mediated homogeneous electrochemical strategy for pesticides assay based on in situ generation of electroactive substances","volume":"94","author":"Yu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib17","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1021\/acs.analchem.1c04135","article-title":"Photo-assisted robust anti-interference self-powered biosensing of microRNA based on Pt-S bonds and the inorganic-organic hybridization strategy","volume":"94","author":"Song","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202423106","article-title":"Laser-induced nanozyme biofuel cell-based self-powered patch for accelerating diabetic wound healing with real-time monitoring","volume":"35","author":"Gu","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.152952","article-title":"Structural regulation of covalent organic framework boost high-performance self-powered electrochemical sensor based on zinc-air battery","volume":"494","author":"Cui","year":"2024","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2026.346144_bib20","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202503027","article-title":"Enhanced electrochemical and photochemical sensors for in vivo biological monitoring based on carbon nanomaterials","volume":"35","author":"Huang","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2020.213618","article-title":"Metal-organic framework-derived nanomaterials in environment related fields: fundamentals, properties and applications","volume":"429","author":"He","year":"2021","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2026.346144_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137883","article-title":"MOF-in-cavity structure with co-location effect of hotspots and molecules suitable for both ex-situ and in-situ SERS detections, Sensor","volume":"440","author":"Wang","year":"2025","journal-title":"Actuators B: Chem"},{"key":"10.1016\/j.aca.2026.346144_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2026.139943","article-title":"MOF-on-MOF cascade nanozymes for dual-mode colorimetric\/fluorescent sensing of exhaled hydrogen sulfide","volume":"460","author":"Liang","year":"2026","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346144_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202414724","article-title":"Adsorption and separation by flexible MOFs","volume":"37","author":"Senkovska","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2021.214264","article-title":"Bimetallic metal-organic frameworks and MOF-derived composites: recent progress on electro- and photoelectrocatalytic applications","volume":"451","author":"Zhou","year":"2022","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2026.346144_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.215926","article-title":"Brain-specific targeted delivery of therapeutic agents using metal-organic framework-based nanomedicine","volume":"514","author":"Han","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2026.346144_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2025.118345","article-title":"Emerging metal-organic framework (MOF)-based biosensors with high potential for point-of-care determination of biomarkers: mechanisms and applications","volume":"191","author":"Farzin","year":"2025","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib28","article-title":"Flexible-robust MOFs\/HOFs for challenging gas separations","volume":"505","author":"Amooghin","year":"2024","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2026.346144_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117425","article-title":"Metal organic framework-derived carbon nanomaterials and MOF hybrids for chemical sensing","volume":"170","author":"Hammad","year":"2024","journal-title":"TrAC, Trends Anal. Chem."},{"key":"10.1016\/j.aca.2026.346144_bib30","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202415399","article-title":"State\u2010of\u2010the\u2010art, insights, and perspectives for MOFs\u2010nanocomposites and MOF\u2010derived (nano)materials","volume":"37","author":"Mourdikoudis","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2025.217083","article-title":"MOF-derived nanomaterials: transformative innovations for renewable energy and environmental sustainability","volume":"546","author":"Mohtaram","year":"2026","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.aca.2026.346144_bib32","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mattod.2023.08.007","article-title":"Catalysts by pyrolysis: transforming metal-organic frameworks (MOFs) precursors into metal-nitrogen-carbon (MNC) materials","volume":"69","author":"Huang","year":"2023","journal-title":"Mater. Today"},{"key":"10.1016\/j.aca.2026.346144_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132409","article-title":"MOF-derived N-doped porous carbon with active magnesium sites as an efficient oxidase mimic for biosensing, Sensor","volume":"370","author":"Hou","year":"2022","journal-title":"Actuators B: Chem"},{"key":"10.1016\/j.aca.2026.346144_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202413658","article-title":"MOF-derived carbon-based materials for energy-related applications","volume":"37","author":"Chai","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib35","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s40820-024-01332-5","article-title":"Laser-induced and MOF-derived metal oxide\/carbon composite for synergistically improved ethanol sensing at room temperature","volume":"16","author":"Lim","year":"2024","journal-title":"Nano-Micro Lett."},{"key":"10.1016\/j.aca.2026.346144_bib36","article-title":"Highly sensitive NO2 gas sensor based on polyoxometalate electron acceptor decorated MOFs-derived Co3O4 p-n heterojunctions, Sensor","volume":"469","author":"Guo","year":"2026","journal-title":"Actuators B: Chem"},{"key":"10.1016\/j.aca.2026.346144_bib37","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1021\/acscatal.9b03175","article-title":"Porosity-induced high selectivity for CO2 electroreduction to CO on Fe-doped ZIF-derived carbon catalysts","volume":"9","author":"Hu","year":"2019","journal-title":"ACS Catal."},{"key":"10.1016\/j.aca.2026.346144_bib38","article-title":"Networking pyrolyzed zeolitic imidazolate frameworks by carbon nanotubes improves conductivity and enhances oxygen-reduction performance in polymer-electrolyte-membrane fuel cells","volume":"29","author":"Zhang","year":"2017","journal-title":"Adv. Mater."},{"key":"10.1016\/j.aca.2026.346144_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.135723","article-title":"Highly efficient adsorption and catalytic degradation of aflatoxin B1 by a novel porous carbon material derived from Fe-doped ZIF-8","volume":"440","author":"Zhang","year":"2022","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2026.346144_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jssc.2020.121492","article-title":"KOH activated ZIF-L derived N-doped porous carbon with enhanced adsorption performance towards antibiotics removal from aqueous solution","volume":"289","author":"Sun","year":"2020","journal-title":"J. Solid State Chem."},{"key":"10.1016\/j.aca.2026.346144_bib41","doi-asserted-by":"crossref","first-page":"9886","DOI":"10.1039\/D2TA00884J","article-title":"Vicinal Co atom-coordinated Fe-N-C catalysts to boost the oxygen reduction reaction","volume":"10","author":"Chen","year":"2022","journal-title":"J. Mater. Chem. A"},{"key":"10.1016\/j.aca.2026.346144_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117258","article-title":"Magnetically controlled all-in-one sensing platform for triple-mode detection of organophosphorus pesticides using DNA tetrahedrons-polydopamine reporters","volume":"276","author":"Xiao","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.346144_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.141499","article-title":"Peptide-nucleic acid aptamer pair biosensor for disease biomarker detection in clinical samples","volume":"458","author":"Gao","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.aca.2026.346144_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114424","article-title":"A novel \u201csignal on-off-super on\u201d sandwich-type aptamer sensor of CRISPR-Cas12a coupled voltage enrichment assay for VEGF detection","volume":"221","author":"Yuan","year":"2023","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.aca.2026.346144_bib45","doi-asserted-by":"crossref","first-page":"24976","DOI":"10.1021\/jacs.5c07699","article-title":"Intrareticular energy transfer in dual-photosensitized metal-organic frameworks to enhance photoelectrochemical performance","volume":"147","author":"Kong","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.aca.2026.346144_bib46","article-title":"Microneedles with interdigitated electrodes for in situ impedimetric VEGF sensing","volume":"12","author":"Das","year":"2025","journal-title":"Adv. Mater. Interfac."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010949?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010949?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:11:22Z","timestamp":1791303082000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026010949"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":46,"alternative-id":["S0003267026010949"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.346144","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metal organic frameworks derived Fe-N-C catalysts boosting dual-readout biosensing platform for vascular endothelial growth factor detection","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.346144","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"346144"}}