{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:54:05Z","timestamp":1791305645609,"version":"4.3.1"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2024GXNSFAA010175"],"award-info":[{"award-number":["2024GXNSFAA010175"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22267002"],"award-info":[{"award-number":["22267002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Analytica Chimica Acta"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.aca.2026.346147","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:12:09Z","timestamp":1787181129000},"page":"346147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A near-infrared fluorescent probe for monitoring hepatic cysteine dynamics in drug-induced liver injury guided by cholic acid group"],"prefix":"10.1016","volume":"1423","author":[{"given":"Guiting","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3917-8327","authenticated-orcid":false,"given":"Jianyi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aca.2026.346147_bib1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fct.2013.07.008","article-title":"Glutathione defense mechanism in liver injury: insights from animal models","volume":"60","author":"Chen","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.aca.2026.346147_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mam.2008.08.006","article-title":"Glutathione: overview of its protective roles, measurement, and biosynthesis","volume":"30","author":"Forman","year":"2009","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.aca.2026.346147_bib3","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mam.2008.07.001","article-title":"Environmental toxicity, redox signaling and lung inflammation: the role of glutathione","volume":"30","author":"Biswas","year":"2009","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.aca.2026.346147_bib4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.20517\/mtod.2022.20","article-title":"Concise review: gamma-glutamyl transferase - evolution from an indiscriminate liver test to a biomarker of cardiometabolic risk","volume":"2","author":"Lonardo","year":"2022","journal-title":"Metabol. Target Organ Damage"},{"key":"10.1016\/j.aca.2026.346147_bib5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1089\/ars.2016.6633","article-title":"Clinically evaluated cancer drugs inhibiting redox signaling","volume":"26","author":"Kirkpatrick","year":"2017","journal-title":"Antioxid. Redox Signaling"},{"key":"10.1016\/j.aca.2026.346147_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3390\/antiox10030390","article-title":"Oxidative stress in drug-induced liver injury (DILI): from mechanisms to biomarkers for use in clinical practice","volume":"10","author":"Villanueva-Paz","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.aca.2026.346147_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/3320325","article-title":"Drug\u2010induced liver injury: clinical evidence of N\u2010acetyl cysteine protective effects","volume":"2021","author":"Ntamo","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.aca.2026.346147_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127459","article-title":"Imaging alkaline phosphatase activity in alcoholic liver disease via a rational-designed NIR fluorogenic probe","volume":"350","author":"Ding","year":"2026","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.346147_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127676","article-title":"Illuminating epilepsy: a deep NIR-I fluorogenic sensor reports peroxynitrite dynamics in vivo","volume":"355","author":"Han","year":"2026","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.346147_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122685","article-title":"Development of a NIR fluorescent probe for highly selective and sensitive detection of cysteine in living cells and in vivo","volume":"234","author":"Qi","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346147_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123345","article-title":"A new lysosome-targeted Cys probe and its application in biology and food samples","volume":"304","author":"Zhang","year":"2024","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.346147_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136565","article-title":"A novel golgi-targetable isocyano-based cysteine-specific fluorescent probe for the visualization of cysteine during drug-induced oxidative stress","volume":"422","author":"Liu","year":"2025","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346147_bib13","doi-asserted-by":"crossref","first-page":"12478","DOI":"10.1021\/acs.analchem.3c02134","article-title":"Tumor-targeting probe for dual-modal imaging of cysteine in vivo","volume":"95","author":"Gu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124974","article-title":"Cysteine triggered cascade reaction forming coumarin: visualization of cysteine fluctuation in alcoholic liver disease by a NIR fluorescent probe","volume":"324","author":"Shen","year":"2025","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.346147_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2025.143106","article-title":"Smartphone-aided fluorescent probe combining lateral flow assay for Cys testing in food and organism","volume":"473","author":"Xu","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2026.346147_bib16","doi-asserted-by":"crossref","first-page":"6030","DOI":"10.1021\/acs.analchem.4c00467","article-title":"Near-infrared fluorescence probe with a new recognition moiety for the specific detection of cysteine to study the corresponding physiological processes in cells, zebrafish, and arabidopsis thaliana","volume":"96","author":"Jia","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125354","article-title":"A D-\u03c0-A-based near-infrared fluorescent probe with large Stokes shift for the detection of cysteine in vivo","volume":"268","author":"Fang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346147_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134616","article-title":"Lysosome-targeted fluorescence probe for discriminating cysteine from homocysteine\/glutathione and assessing autophagy in drug-induced liver injury","volume":"396","author":"Zeng","year":"2023","journal-title":"Sensor. Actuator. B Chem."},{"key":"10.1016\/j.aca.2026.346147_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.140064","article-title":"A novel LD-targeting cysteine-activated fluorescent probe for diagnosis of APAP-induced liver injury and its application in food analysis","volume":"456","author":"Yang","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2026.346147_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2022.340713","article-title":"Photoacoustic\/fluorescence dual-modality cyanine-based probe for real-time imaging of endogenous cysteine and in situ diagnosis of cervical cancer in vivo","volume":"1239","author":"Zou","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.aca.2026.346147_bib21","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1021\/ac5045498","article-title":"Hemicyanine-based high resolution ratiometric near-infrared fluorescent probe for monitoring pH changes in vivo","volume":"87","author":"Li","year":"2015","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2020.108954","article-title":"A self-immolative near-infrared probe based on hemi-benzothiazolecyanine for visualizing hydrogen peroxide in living cells and mice","volume":"186","author":"Gong","year":"2021","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2026.346147_bib23","doi-asserted-by":"crossref","first-page":"7750","DOI":"10.3390\/molecules27227750","article-title":"Activity-based fluorescent probes based on hemicyanine for biomedical sensing","volume":"27","author":"Luo","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.aca.2026.346147_bib24","doi-asserted-by":"crossref","first-page":"27968","DOI":"10.1021\/acsami.5b10607","article-title":"Mitochondria-targeted near-infrared fluorescent off\u2013on probe for selective detection of cysteine in living cells and in vivo","volume":"7","author":"Han","year":"2015","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.aca.2026.346147_bib25","doi-asserted-by":"crossref","first-page":"6189","DOI":"10.3390\/molecules28176189","article-title":"A new lysosome-targeted NIR fluorescent probe for specific detection of cysteine over homocysteine and glutathione","volume":"28","author":"Liu","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.aca.2026.346147_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107260","article-title":"D-A-D type based NIR fluorescence probe for monitoring the cysteine levels in pancreatic cancer cell during ferroptosis","volume":"146","author":"Qin","year":"2024","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/17425247.2021.1874916","article-title":"Factors affecting the dynamics and heterogeneity of the EPR effect: pathophysiological and pathoanatomic features, drug formulations and physicochemical factors","volume":"19","author":"Islam","year":"2021","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.aca.2026.346147_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3390\/jpm11030229","article-title":"The 35th anniversary of the discovery of EPR effect: a new wave of nanomedicines for tumor-targeted drug delivery\u2014personal remarks and future prospects","volume":"11","author":"Maeda","year":"2021","journal-title":"J. Personalized Med."},{"key":"10.1016\/j.aca.2026.346147_bib29","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.3390\/ijms26104590","article-title":"A high-throughput cell-based luciferase reporter assay for identifying inhibitors of ASGR1","volume":"26","author":"Gan","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aca.2026.346147_bib30","article-title":"Deficiency of ASGR1 promotes liver injury by increasing GP73-mediated hepatic endoplasmic reticulum stress","volume":"15","author":"Zhang","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.aca.2026.346147_bib31","article-title":"A novel carboxylesterase 2-targeted fluorescent probe with cholic acid as a recognition group for early diagnosis of drug- and environment-related liver diseases","volume":"480","author":"Li","year":"2024","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.aca.2026.346147_bib32","doi-asserted-by":"crossref","first-page":"14855","DOI":"10.1039\/D1SC04825B","article-title":"Enzyme-activated near-infrared fluorogenic probe with high-efficiency intrahepatic targeting ability for visualization of drug-induced liver injury","volume":"12","author":"Zhang","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2026.346147_bib33","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1021\/acs.analchem.2c05476","article-title":"Liver-targeted near-infrared fluorescence\/photoacoustic dual-modal probe for real-time imaging of in situ hepatic inflammation","volume":"95","author":"Zhang","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib34","doi-asserted-by":"crossref","first-page":"10690","DOI":"10.1002\/anie.201103759","article-title":"Conjugate addition\/cyclization sequence enables selective and simultaneous fluorescence detection of cysteine and homocysteine","volume":"50","author":"Yang","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.aca.2026.346147_bib35","doi-asserted-by":"crossref","first-page":"6143","DOI":"10.1039\/C5CS00152H","article-title":"Design strategies of fluorescent probes for selective detection among biothiols","volume":"44","author":"Niu","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.aca.2026.346147_bib36","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1039\/D0SC04960C","article-title":"The chronological evolution of small organic molecular fluorescent probes for thiols","volume":"12","author":"Yue","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.aca.2026.346147_bib37","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3390\/chemosensors13120413","article-title":"Hemicyanine-based fluorescent probes for cysteine detection in cellular imaging and food samples","volume":"13","author":"Jiang","year":"2025","journal-title":"Chemosensors"},{"key":"10.1016\/j.aca.2026.346147_bib38","doi-asserted-by":"crossref","first-page":"5702","DOI":"10.3390\/molecules28155702","article-title":"Bioimaging and sensing thiols in vivo and in tumor tissues based on a near-infrared fluorescent probe with large stokes shift","volume":"28","author":"Ma","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.aca.2026.346147_bib39","doi-asserted-by":"crossref","first-page":"eadx6659","DOI":"10.1126\/sciadv.adx6659","article-title":"A fluorescent probe for concurrent detection of cysteine, homocysteine, and superoxide anion","volume":"11","author":"Li","year":"2025","journal-title":"Sci. Adv."},{"key":"10.1016\/j.aca.2026.346147_bib40","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s13238-020-00789-5","article-title":"Cystine transporter SLC7A11\/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy","volume":"12","author":"Koppula","year":"2020","journal-title":"Protein Cell"},{"key":"10.1016\/j.aca.2026.346147_bib41","doi-asserted-by":"crossref","DOI":"10.1186\/s40170-024-00352-4","article-title":"Epigenetic repression of de novo cysteine synthetases induces intra-cellular accumulation of cysteine in hepatocarcinoma by up-regulating the cystine uptake transporter xCT","volume":"12","author":"Yamauchi","year":"2024","journal-title":"Cancer Metabol."},{"key":"10.1016\/j.aca.2026.346147_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.135730","article-title":"BODIPY-based fluorescent probe for cysteine detection and its applications in food analysis, test strips and biological imaging","volume":"416","author":"Yang","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.aca.2026.346147_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128581","article-title":"A novel cysteine-specific fluorescent probe and its applications in biological imaging and food detection","volume":"297","author":"Qu","year":"2026","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346147_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.tet.2023.133492","article-title":"An AIE-active fluorescent probe with near-infrared (NIR) emission for selectively monitoring and bioimaging Cys in living cells","volume":"140","author":"Zhang","year":"2023","journal-title":"Tetrahedron"},{"key":"10.1016\/j.aca.2026.346147_bib45","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.saa.2017.04.051","article-title":"Fluorescent coumarin-based probe for cysteine and homocysteine with live cell application","volume":"183","author":"Wei","year":"2017","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.aca.2026.346147_bib46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jphotochem.2017.06.001","article-title":"A novel near-infrared fluorescent probe for cysteine in living cells based on a push-pull dicyanoisophorone system","volume":"346","author":"Yu","year":"2017","journal-title":"J. Photochem. Photobiol. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2022.110994","article-title":"Chalcone dye-based fluorescent probe for selective and specific detection of cysteine in lysosomes of living cells","volume":"210","author":"Dong","year":"2023","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.aca.2026.346147_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.124153","article-title":"A single-wavelength excited NIR fluorescence probe for distinguishing GSH\/H2S and Cys\/Hcy in living cells and zebrafish through separated dual-channels","volume":"254","author":"Liu","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.aca.2026.346147_bib49","doi-asserted-by":"crossref","first-page":"17559","DOI":"10.1021\/acs.analchem.3c02872","article-title":"Long-term imaging of Cys in cells and tumor mice by a solid-state fluorescence probe","volume":"95","author":"Fu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.aca.2026.346147_bib50","doi-asserted-by":"crossref","first-page":"12576","DOI":"10.1039\/D2CC05038B","article-title":"Optimizing phenyl selenide-based BODIPYs as fluorescent probes for diagnosing cancer and drug-induced liver injury via cysteine","volume":"58","author":"Lu","year":"2022","journal-title":"Chem. Commun."}],"container-title":["Analytica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010974?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0003267026010974?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:12:18Z","timestamp":1791303138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0003267026010974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":50,"alternative-id":["S0003267026010974"],"URL":"https:\/\/doi.org\/10.1016\/j.aca.2026.346147","relation":{},"ISSN":["0003-2670"],"issn-type":[{"value":"0003-2670","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A near-infrared fluorescent probe for monitoring hepatic cysteine dynamics in drug-induced liver injury guided by cholic acid group","name":"articletitle","label":"Article Title"},{"value":"Analytica Chimica Acta","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aca.2026.346147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"346147"}}