{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T05:18:23Z","timestamp":1773983903921,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.accpm.2018.08.005","type":"journal-article","created":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T20:26:03Z","timestamp":1539807963000},"page":"243-249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Levosimendan in patients with low cardiac output syndrome undergoing cardiac surgery: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"38","author":[{"given":"Junchen","family":"Zhu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lvlin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Qing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.accpm.2018.08.005_bib0005","first-page":"e38","article-title":"Heart disease and stroke statistics\u2009\u2013\u20092016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0010","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1053\/j.jvca.2016.05.029","article-title":"Low-cardiac-output syndrome after cardiac surgery","volume":"31","author":"Lomivorotov","year":"2017","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0015","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0022-5223(96)70176-9","article-title":"Predictors of low cardiac output syndrome after coronary artery bypass","volume":"112","author":"Rao","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.accpm.2018.08.005_bib0020","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jtcvs.2009.11.022","article-title":"Predictors of low cardiac output syndrome after isolated mitral valve surgery","volume":"140","author":"Maganti","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"9 Suppl","key":"10.1016\/j.accpm.2018.08.005_bib0025","first-page":"I448","article-title":"Predictors of low cardiac output syndrome after isolated aortic valve surgery","volume":"112","author":"Maganti","year":"2005","journal-title":"Circulation"},{"issue":"11","key":"10.1016\/j.accpm.2018.08.005_bib0030","first-page":"559","article-title":"Acute renal failure after isolated CABG surgery: six years of experience","volume":"73","author":"Landoni","year":"2007","journal-title":"Minerva anestesiol"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0035","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jtcvs.2014.05.014","article-title":"2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"148","author":"Nishimura","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"10.1016\/j.accpm.2018.08.005_bib0040","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/cc3024","article-title":"Bench-to-bedside review: inotropic drug therapy after adult cardiac surgery\u2009\u2212\u2009a systematic literature review","volume":"9","author":"Gillies","year":"2005","journal-title":"Crit Care"},{"issue":"2","key":"10.1016\/j.accpm.2018.08.005_bib0045","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijcard.2011.07.022","article-title":"Levosimendan: molecular mechanisms and clinical implications: consensus of experts on the mechanisms of action of levosimendan","volume":"159","author":"Papp","year":"2012","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.accpm.2018.08.005_bib0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ijcard.2016.07.202","article-title":"Levosimendan beyond inotropy and acute heart failure: evidence of pleiotropic effects on the heart and other organs: an expert panel position paper","volume":"222","author":"Farmakis","year":"2016","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.accpm.2018.08.005_bib0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ijcard.2015.02.022","article-title":"Preoperative and perioperative use of levosimendan in cardiac surgery: European expert opinion","volume":"184","author":"Toller","year":"2015","journal-title":"Int J Cardiol"},{"issue":"3","key":"10.1016\/j.accpm.2018.08.005_bib0060","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1093\/bja\/aeq402","article-title":"Preoperative levosimendan infusion in combined aortic valve and coronary bypass surgery","volume":"106","author":"Leppikangas","year":"2011","journal-title":"Br J Anaesth"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.jvca.2009.05.031","article-title":"Reducing mortality in cardiac surgery with levosimendan: a meta-analysis of randomized controlled trials","volume":"24","author":"Landoni","year":"2010","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"21","key":"10.1016\/j.accpm.2018.08.005_bib0070","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1056\/NEJMoa1616218","article-title":"Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery","volume":"376","author":"Mehta","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1016\/j.accpm.2018.08.005_bib0075","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1093\/bja\/aeu446","article-title":"A Bayesian network meta-analysis on the effect of inodilatory agents on mortality","volume":"114","author":"Greco","year":"2015","journal-title":"Br J Anaesth"},{"issue":"7","key":"10.1016\/j.accpm.2018.08.005_bib0080","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/jocs.12562","article-title":"Levosimendan reduces mortality in adults with left ventricular dysfunction undergoing cardiac surgery: a systematic review and meta-analysis","volume":"30","author":"Lim","year":"2015","journal-title":"J Card Surg"},{"issue":"6","key":"10.1016\/j.accpm.2018.08.005_bib0085","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1053\/j.jvca.2013.03.027","article-title":"Effect of levosimendan on survival and adverse events after cardiac surgery: a meta-analysis","volume":"27","author":"Harrison","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2018.08.005_bib0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijcard.2017.10.077","article-title":"Perioperative levosimendan in cardiac surgery: a systematic review with meta-analysis and trial sequential analysis","volume":"251","author":"Putzu","year":"2018","journal-title":"Int J Cardiol"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0095","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s13054-017-1849-0","article-title":"Levosimendan for patients with severely reduced left ventricular systolic function and\/or low cardiac output syndrome undergoing cardiac surgery: a systematic review and meta-analysis","volume":"21","author":"Sanfilippo","year":"2017","journal-title":"Crit Care"},{"issue":"12","key":"10.1016\/j.accpm.2018.08.005_bib0100","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00134-017-4927-5","article-title":"Effects of levosimendan for perioperative cardiovascular dysfunction in patients receiving cardiac surgery: a meta-analysis with trial sequential analysis","volume":"43","author":"Lee","year":"2017","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.accpm.2018.08.005_bib0105","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s00134-014-3604-1","article-title":"Effects of levosimendan for low cardiac output syndrome in critically ill patients: systematic review with meta-analysis and trial sequential analysis","volume":"41","author":"Koster","year":"2015","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.accpm.2018.08.005_bib0110","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/CCM.0b013e318232962a","article-title":"Effects of levosimendan on mortality and hospitalization. A meta-analysis of randomized controlled studies","volume":"40","author":"Landoni","year":"2012","journal-title":"Crit Care Med"},{"issue":"7","key":"10.1016\/j.accpm.2018.08.005_bib0115","first-page":"389","article-title":"[Hemodynamic effects of levosimendan following cardiac surgery]","volume":"52","author":"Alvarez","year":"2005","journal-title":"Rev Esp Anestesiol Reanim"},{"issue":"21","key":"10.1016\/j.accpm.2018.08.005_bib0120","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1056\/NEJMoa1616325","article-title":"Levosimendan for hemodynamic support after cardiac surgery","volume":"376","author":"Landoni","year":"2017","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.accpm.2018.08.005_bib0125","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1001\/jama.2017.9973","article-title":"Effect of levosimendan on low cardiac output syndrome in patients with low ejection fraction undergoing coronary artery bypass grafting with cardiopulmonary bypass: the licorn randomized clinical trial","volume":"318","author":"Cholley","year":"2017","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.accpm.2018.08.005_bib0130","doi-asserted-by":"crossref","first-page":"W65","DOI":"10.7326\/0003-4819-151-4-200908180-00136","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"151","author":"Liberati","year":"2009","journal-title":"Ann Intern Med"},{"issue":"7650","key":"10.1016\/j.accpm.2018.08.005_bib0135","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ijnurstu.2014.09.006","article-title":"Basic statistical reporting for articles published in biomedical journals: the \u201cStatistical Analyses and Methods in the Published Literature\u201d or the SAMPL guidelines","volume":"52","author":"Lang","year":"2015","journal-title":"Int J Nurs Stud"},{"issue":"11","key":"10.1016\/j.accpm.2018.08.005_bib0145","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"issue":"3","key":"10.1016\/j.accpm.2018.08.005_bib0150","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1177\/0300060513516293","article-title":"Influence of levosimendan on organ dysfunction in patients with severely reduced left ventricular function undergoing cardiac surgery","volume":"42","author":"Erb","year":"2014","journal-title":"J Int Med Res"},{"issue":"3","key":"10.1016\/j.accpm.2018.08.005_bib0155","first-page":"125","article-title":"Preoperative levosimendan decreases mortality and the development of low cardiac output in high-risk patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting with cardiopulmonary bypass","volume":"17","author":"Levin","year":"2012","journal-title":"Exp Clin Cardiol"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0160","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/0253-7613.125161","article-title":"Study of levosimendan during off-pump coronary artery bypass grafting in patients with LV dysfunction: a double-blind randomized study","volume":"46","author":"Shah","year":"2014","journal-title":"Indian J Pharmacol"},{"issue":"1","key":"10.1016\/j.accpm.2018.08.005_bib0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s13054-017-1848-1","article-title":"Effect of levosimendan on prognosis in adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials","volume":"21","author":"Chen","year":"2017","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.accpm.2018.08.005_bib0170","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1053\/j.ajkd.2015.09.015","article-title":"Levosimendan for prevention of acute kidney injury after cardiac surgery: a meta-analysis of randomized controlled trials","volume":"67","author":"Zhou","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.accpm.2018.08.005_bib0175","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1631\/jzus.B1200290","article-title":"Levosimendan versus dobutamine in critically ill patients: a meta-analysis of randomized controlled trials","volume":"14","author":"Huang","year":"2013","journal-title":"J Zhejiang Univ Sci B"},{"issue":"5","key":"10.1016\/j.accpm.2018.08.005_bib0180","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1157\/13119990","article-title":"[The calcium sensitizer levosimendan gives superior results to dobutamine in postoperative low cardiac output syndrome]","volume":"61","author":"Levin","year":"2008","journal-title":"Rev Esp Cardiol"}],"container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556818301711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556818301711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T02:30:51Z","timestamp":1557369051000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556818301711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S2352556818301711"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2018.08.005","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Levosimendan in patients with low cardiac output syndrome undergoing cardiac surgery: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2018.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 fran\u00e7aise d'anesth\u00e9sie et de r\u00e9animation (Sfar).","name":"copyright","label":"Copyright"}]}}