{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:20:09Z","timestamp":1790428809748,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.accpm.2019.01.009","type":"journal-article","created":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T13:48:25Z","timestamp":1550929705000},"page":"485-491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis: A prospective observational study"],"prefix":"10.1016","volume":"38","author":[{"given":"Nicolas","family":"Nesseler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Martin-Chouly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7430-2966","authenticated-orcid":false,"given":"Harmonie","family":"Perrichet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James T.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2466-4445","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Rousseau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Isslame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Masseret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Mall\u00e9dant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9105-8862","authenticated-orcid":false,"given":"Yoann","family":"Launey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Seguin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2019.01.009_bib0005","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.accpm.2019.01.009_bib0010","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.accpm.2019.01.009_bib0015","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1097\/TA.0b013e318256e000","article-title":"Persistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care","volume":"72","author":"Gentile","year":"2012","journal-title":"J Trauma Acute Care Surg"},{"key":"10.1016\/j.accpm.2019.01.009_bib0020","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1164\/rccm.200903-0363OC","article-title":"Granulocyte-Macrophage Colony-stimulating Factor to Reverse Sepsis-associated Immunosuppression","volume":"180","author":"Meisel","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0025","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00134-010-2088-x","article-title":"Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome","volume":"37","author":"Hall","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0030","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13054-016-1505-0","article-title":"Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study","volume":"20","author":"Drewry","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2019.01.009_bib0035","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00134-006-0204-8","article-title":"Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock","volume":"32","author":"Monneret","year":"2006","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0040","first-page":"2746","article-title":"Monocytic HLA-DR expression in intensive care patients: interest for prognosis and secondary infection prediction","volume":"37","author":"Lukaszewicz","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0045","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1007\/s00134-010-1962-x","article-title":"Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock","volume":"36","author":"Landelle","year":"2010","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0050","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1097\/CCM.0b013e318267633c","article-title":"Innate Immune Function and Mortality in Critically Ill Children With Influenza","volume":"41","author":"Hall","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0055","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/SHK.0000000000000217","article-title":"Innate immune function predicts the development of nosocomial infection in critically injured children","volume":"42","author":"Muszynski","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.accpm.2019.01.009_bib0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0182427","article-title":"Human leucocyte antigen (HLA-DR) gene expression is reduced in sepsis and correlates with impaired TNF\u03b1 response: A diagnostic tool for immunosuppression?","volume":"12","author":"Winkler","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.accpm.2019.01.009_bib0065","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.immuni.2014.03.002","article-title":"Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli","volume":"40","author":"Duffy","year":"2014","journal-title":"Immuni"},{"key":"10.1016\/j.accpm.2019.01.009_bib0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/109629603766956960","article-title":"Lower levels of whole blood LPS-stimulated cytokine release are associated with poorer clinical outcomes in surgical ICU patients","volume":"4","author":"Heagy","year":"2003","journal-title":"Surg Infect (Larchmt)"},{"key":"10.1016\/j.accpm.2019.01.009_bib0075","first-page":"129","article-title":"Lipopolysaccharide-induced tumor necrosis factor alpha production and not monocyte human leukocyte antigen-DR expression is correlated with survival in septic trauma patients","volume":"25","author":"Ploder","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.accpm.2019.01.009_bib0080","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1097\/01.CCM.0000240243.28129.36","article-title":"Interleukin-10 and its role in clinical immunoparalysis following pediatric cardiac surgery","volume":"34","author":"Allen","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0085","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/SHK.0000000000000391","article-title":"Reduced responsiveness of blood leukocytes to lipopolysaccharide does not predict nosocomial infections in critically Ill patients","volume":"44","author":"van Vught","year":"2015","journal-title":"Shock"},{"key":"10.1016\/j.accpm.2019.01.009_bib0090","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.201710-2006OC","article-title":"Early immune function and duration of organ dysfunction in critically Ill septic children","author":"Muszynski","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0095","article-title":"Innate immune function and organ failure recovery in adults with sepsis","volume":"11","author":"Maddux","year":"2017","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0100","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1007\/BF01540884","article-title":"Clinical and biological significance of interleukin-10 plasma levels in patients with septic shock","volume":"15","author":"Marchant","year":"1995","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.accpm.2019.01.009_bib0105","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00024382-200302000-00004","article-title":"Impaired production of interferon-gamma and tumor necrosis factor-alpha but not of interleukin 10 in whole blood of patients with sepsis","volume":"19","author":"Rigato","year":"2003","journal-title":"Shock"},{"key":"10.1016\/j.accpm.2019.01.009_bib0110","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1182\/blood.V85.5.1341.bloodjournal8551341","article-title":"Downregulation of proinflammatory cytokine release in whole blood from septic patients","volume":"85","author":"Ertel","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.accpm.2019.01.009_bib0115","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/08941939709099598","article-title":"Depression of tumor necrosis factor-a, interleukin-6, and interleukin-10 production: a reaction to the initial systemic hyperactivation in septic shock","volume":"10","author":"Haupt","year":"2009","journal-title":"J Invest Surg"},{"key":"10.1016\/j.accpm.2019.01.009_bib0120","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM Consensus Conference Committee. American College of Chest Physicians\/Society of Critical Care Medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.accpm.2019.01.009_bib0125","doi-asserted-by":"crossref","first-page":"22655","DOI":"10.1371\/journal.pone.0022655","article-title":"Anti-inflammatory effect of fluvastatin on IL-8 production induced by pseudomonas aeruginosa and aspergillus fumigatus antigens in cystic fibrosis","volume":"6","author":"Jouneau","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.accpm.2019.01.009_bib0130","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archinte.1962.03620240029006","article-title":"Gram-Negative Bacteremia","volume":"110","author":"McCabe","year":"1962","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0135","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/cc5055","article-title":"Bench-to-bedside review: endotoxin tolerance as a model of leukocyte reprogramming in sepsis","volume":"10","author":"Cavaillon","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2019.01.009_bib0140","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1097\/CCM.0b013e3182190d5d","article-title":"Differential ex vivo and in vivo endotoxin tolerance kinetics following human endotoxemia*","volume":"39","author":"Kox","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0145","doi-asserted-by":"crossref","first-page":"2377","DOI":"10.1097\/01.CCM.0000233875.93866.88","article-title":"Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients*","volume":"34","author":"Adib-Conquy","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0150","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00134-005-2575-7","article-title":"High interleukin 12 and low interleukin 10 production after in vitro stimulation detected in sepsis survivors","volume":"31","author":"Stanilova","year":"2005","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.imlet.2004.07.009","article-title":"The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration","volume":"95","author":"Monneret","year":"2004","journal-title":"Immunol Lett"},{"key":"10.1016\/j.accpm.2019.01.009_bib0160","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","article-title":"Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the genetic and inflammatory markers of sepsis (GenIMS) study","volume":"167","author":"Kellum","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0165","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/CCM.0000000000002206","article-title":"Relationship between alternative resuscitation strategies, host response and injury biomarkers, and outcome in septic shock","volume":"45","author":"Kellum","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0170","doi-asserted-by":"crossref","first-page":"e493","DOI":"10.1097\/CCM.0000000000002292","article-title":"An unbalanced inflammatory cytokine response is not associated with mortality following sepsis","volume":"45","author":"Frencken","year":"2017","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0175","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1097\/CCM.0000000000000100","article-title":"Immunological characterization of compensatory anti-inflammatory response syndrome in patients with severe sepsis","volume":"42","author":"Gomez","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0180","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jim.2010.03.006","article-title":"Comparative in vitro stimulation with lipopolysaccharide to study TNF\u03b1 gene expression in fresh whole blood, fresh and frozen peripheral blood mononuclear cells","volume":"357","author":"Chen","year":"2010","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.accpm.2019.01.009_bib0185","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im0718bs66","article-title":"Measurement of cytokine production using whole blood","author":"Thurm","year":"2005","journal-title":"Curr Protoc Immunol"},{"key":"10.1016\/j.accpm.2019.01.009_bib0190","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1097\/SHK.0000000000000557","article-title":"Stimulated Whole Blood Cytokine Release as a Biomarker of Immunosuppression in the Critically Ill","volume":"45","author":"Segre","year":"2016","journal-title":"Shock"},{"key":"10.1016\/j.accpm.2019.01.009_bib0195","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.pupt.2004.09.031","article-title":"The novel phosphodiesterase 4 inhibitor, CI-1044, inhibits LPS-induced TNF-alpha production in whole blood from COPD patients","volume":"18","author":"Ouagued","year":"2005","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.accpm.2019.01.009_bib0200","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1046\/j.1365-2249.1999.01045.x","article-title":"Impaired production of proinflammatory cytokines in response to lipopolysaccharide (LPS) stimulation in elderly humans","volume":"118","author":"Bruunsgaard","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.accpm.2019.01.009_bib0205","first-page":"126","article-title":"Sepsis in old age: review of human and animal studies","volume":"5","author":"Starr","year":"2014","journal-title":"Aging Dis"},{"key":"10.1016\/j.accpm.2019.01.009_bib0210","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1001\/jama.2014.2637","article-title":"Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012","volume":"311","author":"Kaukonen","year":"2014","journal-title":"Jama"},{"key":"10.1016\/j.accpm.2019.01.009_bib0215","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S2213-2600(14)70061-X","article-title":"Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit","volume":"2","author":"Vincent","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2019.01.009_bib0220","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1001\/jama.2017.13836","article-title":"Incidence and trends of sepsis in US hospitals using clinical vs claims data, 2009-2014","volume":"318","author":"Rhee","year":"2017","journal-title":"Jama"},{"key":"10.1016\/j.accpm.2019.01.009_bib0225","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1001\/jama.2016.2691","article-title":"Incidence, risk factors, and attributable mortality of secondary infections in the intensive care unit after admission for sepsis","volume":"315","author":"van Vught","year":"2016","journal-title":"Jama"},{"key":"10.1016\/j.accpm.2019.01.009_bib0230","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13054-016-1505-0","article-title":"Comparison of monocyte human leukocyte antigen-DR expression and stimulated tumor necrosis factor alpha production as outcome predictors in severe sepsis: a prospective observational study","volume":"20","author":"Drewry","year":"2016","journal-title":"Critical Care"}],"container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556818303047?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556818303047?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:45:14Z","timestamp":1762479914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556818303047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S2352556818303047"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2019.01.009","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis: A prospective observational study","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2019.01.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Soci\u00e9t\u00e9 fran\u00e7aise d'anesth\u00e9sie et de r\u00e9animation (Sfar). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}