{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:53:32Z","timestamp":1788800012758,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006484","name":"Vifor Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006484","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care & Pain Medicine"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.accpm.2022.101171","type":"journal-article","created":{"date-parts":[[2022,11,11]],"date-time":"2022-11-11T10:30:49Z","timestamp":1668162649000},"page":"101171","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effects of ferric carboxymaltose on hemoglobin level after cardiac surgery: A randomized controlled trial"],"prefix":"10.1016","volume":"42","author":[{"given":"Maha","family":"Houry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-0455","authenticated-orcid":false,"given":"Joanna","family":"Tohme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghassan","family":"Sleilaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalil","family":"Jabbour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wissam","family":"Bou Gebrael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Jebara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Madi-Jebara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2022.101171_bib0005","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jtcvs.2012.04.014","article-title":"Implications and management of anemia in cardiac surgery: current state of knowledge","volume":"144","author":"Loor","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0010","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1177\/1089253215613792","article-title":"Risks of anemia in cardiac surgery patients","volume":"19","author":"Lobel","year":"2015","journal-title":"Semin Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2022.101171_bib0015","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1161\/CIRCULATIONAHA.107.718353","article-title":"Reducing Bleeding in Cardiac Surgery (RBC) Investigators. Risk associated with preoperative anemia in cardiac surgery: a multicenter cohort study","volume":"117","author":"Karkouti","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.accpm.2022.101171_bib0020","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/j.athoracsur.2012.04.042","article-title":"Impact of preoperative anemia on outcome in adult cardiac surgery: a propensity-matched analysis","volume":"94","author":"Ranucci","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0025","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/S0022-5223(02)73291-1","article-title":"Adverse effects of low hematocrit during cardiopulmonary bypass in the adult: should current practice be changed?","volume":"125","author":"Habib","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0030","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.17843","article-title":"Prevalence of and recovery from anemia following hospitalization for critical illness among adults","volume":"3","author":"Warner","year":"2020","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.accpm.2022.101171_bib0035","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1378\/chest.119.5.1461","article-title":"Transfusion of blood components and postoperative infection in patients undergoing cardiac surgery","volume":"119","author":"Leal-Noval","year":"2001","journal-title":"Chest"},{"issue":"1 Suppl","key":"10.1016\/j.accpm.2022.101171_bib0040","first-page":"I43","article-title":"Intraoperative red blood cell transfusion during coronary artery bypass graft surgery increases the risk of postoperative low-output heart failure","volume":"114","author":"Surgenor","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.accpm.2022.101171_bib0045","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1097\/01.CCM.0000217920.48559.D8","article-title":"Morbidity and mortality risk associated with red blood cell and blood-component transfusion in isolated coronary artery bypass grafting","volume":"34","author":"Koch","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2022.101171_bib0050","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.athoracsur.2010.12.049","article-title":"Intraoperative hemoglobin levels and transfusion independently predict stroke after cardiac operations","volume":"91","author":"Bahrainwala","year":"2011","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0055","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1161\/CIRCULATIONAHA.107.698977","article-title":"Increased mortality, postoperative morbidity, and cost after red blood cell transfusion in patients having cardiac surgery","volume":"116","author":"Murphy","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.accpm.2022.101171_bib0060","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1510\/icvts.2009.203034","article-title":"Multi-modality blood conservation strategy in open-heart surgery: an audit","volume":"9","author":"Reddy","year":"2009","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0065","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0272-6386(96)90546-6","article-title":"Intravenous iron supplementation for the treatment of the anemia of moderate to severe chronic renal failure patients not receiving dialysis","volume":"27","author":"Silverberg","year":"1996","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"10.1016\/j.accpm.2022.101171_bib0070","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1089\/152581600419161","article-title":"Intravenous versus oral iron supplementation for preoperative stimulation of hemoglobin synthesis using recombinant human erythropoietin","volume":"9","author":"Rohling","year":"2000","journal-title":"J Hematother Stem Cell Res"},{"key":"10.1016\/j.accpm.2022.101171_bib0075","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.iac.2014.04.013","article-title":"Hypersensitivity from intravenous iron products","volume":"34","author":"Bircher","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1016\/j.accpm.2022.101171_bib0080","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2165\/00003495-200969060-00007","article-title":"Ferric carboxymaltose: a review of its use in iron-deficiency anaemia","volume":"69","author":"Lyseng-Williamson","year":"2009","journal-title":"Drugs"},{"key":"10.1016\/j.accpm.2022.101171_bib0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.jvca.2003.10.012","article-title":"Postoperative intravenous iron used alone or in combination with low-dose erythropoietin is not effective for correction of anemia after cardiac surgery","volume":"18","author":"Madi-Jebara","year":"2004","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2022.101171_bib0090","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1053\/j.jvca.2019.01.063","article-title":"Intravenous iron versus placebo in the management of postoperative functional iron deficiency anemia in patients undergoing cardiac valvular surgery: a prospective, single-blinded, randomized controlled trial","volume":"33","author":"Xu","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2022.101171_bib0095","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.accpm.2022.101171_bib0100","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1177\/1060028016647977","article-title":"Strategies for the management of postoperative anemia in elective orthopedic surgery","volume":"50","author":"Steuber","year":"2016","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.accpm.2022.101171_bib0105","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1016\/S2352-3026(16)30078-3","article-title":"Intravenous ferric carboxymaltose versus standard care in the management of postoperative anaemia: a prospective, open-label, randomised controlled trial","volume":"3","author":"Khalafallah","year":"2016","journal-title":"Lancet Haematol"},{"key":"10.1016\/j.accpm.2022.101171_bib0110","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/anae.13773","article-title":"International consensus statement on the peri-operative management of anaemia and iron deficiency","volume":"72","author":"Mu\u00f1oz","year":"2017","journal-title":"Anaesthesia"},{"key":"10.1016\/j.accpm.2022.101171_bib0115","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.amjcard.2012.05.036","article-title":"Effects of preoperative intravenous erythropoietin plus iron on outcome in anemic patients after cardiac valve replacement","volume":"110","author":"Cladellas","year":"2012","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.accpm.2022.101171_bib0120","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/icvts\/ivs344","article-title":"The effect of intravenous and oral iron administration on perioperative anaemia and transfusion requirements in patients undergoing elective cardiac surgery: a randomized clinical trial","volume":"15","author":"Garrido-Mart\u00edn","year":"2012","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0125","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/vox.12278","volume":"109","author":"Johansson","year":"2015","journal-title":"Vox Sang"},{"key":"10.1016\/j.accpm.2022.101171_bib0130","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1093\/ejcts\/ezu200","article-title":"The impact of anaemia and intravenous iron replacement therapy on outcomes in cardiac surgery","volume":"47","author":"Hogan","year":"2015","journal-title":"Eur J Cardio-Thorac Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.14740\/jh696","article-title":"The impact of preoperative intravenous iron therapy on perioperative outcomes in cardiac surgery: a systematic review","volume":"9","author":"Tankard","year":"2020","journal-title":"J Hematol"},{"key":"10.1016\/j.accpm.2022.101171_bib0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13643-021-01579-8","article-title":"Role of preoperative intravenous iron therapy to correct anemia before major surgery: a systematic review and meta-analysis","volume":"10","author":"Elhenawy","year":"2021","journal-title":"Syst Rev"},{"key":"10.1016\/j.accpm.2022.101171_bib0145","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/S0140-6736(18)32555-8","article-title":"Effect of ultra-short-term treatment of patients with iron deficiency or anaemia undergoing cardiac surgery: a prospective randomised trial","volume":"393","author":"Spahn","year":"2019","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.accpm.2022.101171_bib0150","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.bja.2022.01.034","article-title":"Randomised open-label trial comparing intravenous iron and an erythropoiesis-stimulating agent versus oral iron to treat preoperative anaemia in cardiac surgery (INITIATE trial)","volume":"128","author":"Kong","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.accpm.2022.101171_bib0155","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.athoracsur.2012.03.038","article-title":"Hemoglobin drift after cardiac surgery","volume":"94","author":"George","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.accpm.2022.101171_bib0160","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1186\/s13063-018-2545-3","article-title":"The effect of perioperative intravenously administered iron isomaltoside 1000 (Monofer\u00ae) on transfusion requirements for patients undergoing complex valvular heart surgery: study protocol for a randomized controlled trial","volume":"19","author":"Lee","year":"2018","journal-title":"Trials"},{"key":"10.1016\/j.accpm.2022.101171_bib0165","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/sur.2006.7.361","article-title":"Intravenous iron following cardiac surgery does not increase the infection rate","volume":"7","author":"Torres","year":"2006","journal-title":"Surg Infect"}],"container-title":["Anaesthesia Critical Care & Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556822001527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556822001527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:50:05Z","timestamp":1762480205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556822001527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2352556822001527"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2022.101171","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of ferric carboxymaltose on hemoglobin level after cardiac surgery: A randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2022.101171","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Soci\u00e9t\u00e9 fran\u00e7aise d'anesth\u00e9sie et de r\u00e9animation (Sfar). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101171"}}