{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T13:44:11Z","timestamp":1769607851925,"version":"3.49.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,31]],"date-time":"2024-03-31T00:00:00Z","timestamp":1711843200000},"content-version":"am","delay-in-days":243,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care & Pain Medicine"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.accpm.2023.101219","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T13:36:07Z","timestamp":1678973767000},"page":"101219","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Toward individualized sedation in patients with acute brain damage"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8400-3839","authenticated-orcid":false,"given":"Jean-Fran\u00e7ois","family":"Payen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clotilde","family":"Schilte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barthelemy","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9484-4188","authenticated-orcid":false,"given":"Alexandre","family":"Behouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2023.101219_bib0005","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/CCM.0000000000003259","article-title":"Executive summary: clinical practice guidelines for the prevention and management of pain, Agitation\/Sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0010","first-page":"171","article-title":"Management of severe traumatic brain injury (first 24hours)","volume":"37","author":"Geeraerts","year":"2018","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0015","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1227\/NEU.0000000000001432","article-title":"Guidelines for the management of severe traumatic brain injury, fourth edition","volume":"80","author":"Carney","year":"2017","journal-title":"Neurosurgery"},{"key":"10.1016\/j.accpm.2023.101219_bib0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13054-016-1294-5","article-title":"Optimizing sedation in patients with acute brain injury","volume":"20","author":"Oddo","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0025","first-page":"97","article-title":"Sedatives in neurocritical care: an update on pharmacological agents and modes of sedation","volume":"25","author":"Opdenakker","year":"2019","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0030","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1097\/CCM.0b013e318228236f","article-title":"Sedation for critically ill adults with severe traumatic brain injury: a systematic review of randomized controlled trials","volume":"39","author":"Roberts","year":"2011","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0035","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMra1208708","article-title":"Traumatic intracranial hypertension","volume":"370","author":"Stocchetti","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0040","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1056\/NEJMoa1906759","article-title":"Nonsedation or light sedation in critically ill, mechanically ventilated patients","volume":"382","author":"Olsen","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0045","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1056\/NEJMoa1904710","article-title":"Early sedation with dexmedetomidine in critically ill patients","volume":"380","author":"Shehabi","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0050","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1056\/NEJMoa1901686","article-title":"Early neuromuscular blockade in the acute respiratory distress syndrome","volume":"380","author":"National Heart L","year":"2019","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0055","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1186\/s13054-015-1112-5","article-title":"Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports","volume":"19","author":"Krajcova","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0060","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1177\/10600280211069617","article-title":"Impact of ketamine on analgosedative consumption in critically ill patients: a systematic review and meta-analysis","volume":"56","author":"Chan","year":"2022","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.accpm.2023.101219_bib0065","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.annemergmed.2014.06.018","article-title":"The effect of ketamine on intracranial and cerebral perfusion pressure and health outcomes: a systematic review","volume":"65","author":"Cohen","year":"2015","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0070","first-page":"1","article-title":"Spreading depolarization in acute brain injury inhibited by ketamine: a prospective, randomized, multiple crossover trial","author":"Carlson","year":"2018","journal-title":"J Neurosurg"},{"key":"10.1016\/j.accpm.2023.101219_bib0075","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s13054-022-04019-8","article-title":"Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome","volume":"26","author":"Wendel-Garcia","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2020.110071","article-title":"Perioperative intravenous S-ketamine for acute postoperative pain in adults: a systematic review and meta-analysis","volume":"68","author":"Wang","year":"2021","journal-title":"J Clin Anesth"},{"key":"10.1016\/j.accpm.2023.101219_bib0085","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13054-019-2711-3","article-title":"Lasting s-ketamine block of spreading depolarizations in subarachnoid hemorrhage: a retrospective cohort study","volume":"23","author":"Santos","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0090","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/jcpt.13389","article-title":"Safety of dexmedetomidine for the control of agitation in critically ill traumatic brain injury patients: a descriptive study","volume":"46","author":"Bilodeau","year":"2021","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.accpm.2023.101219_bib0095","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1080\/02699052.2016.1187289","article-title":"ICU sedation with dexmedetomidine after severe traumatic brain injury","volume":"30","author":"Humble","year":"2016","journal-title":"Brain Inj"},{"key":"10.1016\/j.accpm.2023.101219_bib0100","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/0885066616689555","article-title":"Dexmedetomidine for refractory intracranial hypertension","volume":"34","author":"Schomer","year":"2019","journal-title":"J Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0105","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S2213-2600(21)00323-4","article-title":"Inhaled isoflurane via the anaesthetic conserving device versus propofol for sedation of invasively ventilated patients in intensive care units in Germany and Slovenia: an open-label, phase 3, randomised controlled, non-inferiority trial","volume":"9","author":"Meiser","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0110","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1097\/CCM.0b013e31825b8bc6","article-title":"Inhalation versus endovenous sedation in subarachnoid hemorrhage patients: effects on regional cerebral blood flow","volume":"40","author":"Villa","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0115","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1007\/s00134-012-2708-8","article-title":"Volatile isoflurane sedation in cerebrovascular intensive care patients using AnaConDa((R)): effects on cerebral oxygenation, circulation, and pressure","volume":"38","author":"Bosel","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0120","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bja.2022.02.031","article-title":"Avoiding kidney damage in ICU sedation with sevoflurane: use isoflurane instead","volume":"129","author":"Sneyd","year":"2022","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.accpm.2023.101219_bib0125","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/EJA.0000000000000836","article-title":"Renal dysfunction during sevoflurane sedation in the ICU: a case report","volume":"36","author":"Maussion","year":"2019","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.accpm.2023.101219_bib0130","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1213\/ane.0b013e318184e9ab","article-title":"The use of bispectral index to monitor barbiturate coma in severely brain-injured patients with refractory intracranial hypertension","volume":"107","author":"Cottenceau","year":"2008","journal-title":"Anesth Analg"},{"key":"10.1016\/j.accpm.2023.101219_bib0135","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1227\/01.NEU.0000327882.10629.06","article-title":"Barbiturate infusion for intractable intracranial hypertension and its effect on brain oxygenation","volume":"63","author":"Chen","year":"2008","journal-title":"Neurosurgery"},{"key":"10.1016\/j.accpm.2023.101219_bib0140","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1605215","article-title":"Trial of decompressive craniectomy for traumatic intracranial hypertension","volume":"375","author":"Hutchinson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0145","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S2213-2600(20)30552-X","article-title":"Prevalence and risk factors for delirium in critically ill patients with COVID-19 (COVID-D): a multicentre cohort study","volume":"9","author":"Pun","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0150","doi-asserted-by":"crossref","first-page":"540","DOI":"10.3389\/fneur.2017.00540","article-title":"The neurological wake-up test-a role in neurocritical care monitoring of traumatic brain injury patients?","volume":"8","author":"Marklund","year":"2017","journal-title":"Front Neurol"},{"key":"10.1016\/j.accpm.2023.101219_bib0155","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/00003246-199407000-00011","article-title":"Energy expenditure and withdrawal of sedation in severe head-injured patients","volume":"22","author":"Bruder","year":"1994","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s12028-009-9255-3","article-title":"Effects of the neurological wake-up test on intracranial pressure and cerebral perfusion pressure in brain-injured patients","volume":"11","author":"Skoglund","year":"2009","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0165","doi-asserted-by":"crossref","first-page":"R226","DOI":"10.1186\/cc11880","article-title":"Effects of the neurological wake-up test on clinical examination, intracranial pressure, brain metabolism and brain tissue oxygenation in severely brain-injured patients","volume":"16","author":"Helbok","year":"2012","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0170","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00134-022-06702-4","article-title":"Management of moderate to severe traumatic brain injury: an update for the intensivist","volume":"48","author":"Meyfroidt","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0175","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00134-007-0948-9","article-title":"Refractory intracranial hypertension and \"second-tier\" therapies in traumatic brain injury","volume":"34","author":"Stocchetti","year":"2008","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0180","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s00134-007-0558-6","article-title":"Transcranial Doppler ultrasound goal-directed therapy for the early management of severe traumatic brain injury","volume":"33","author":"Ract","year":"2007","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0185","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1213\/ANE.0000000000004173","article-title":"Using pupillary pain index to assess nociception in sedated critically ill patients","volume":"129","author":"Vinclair","year":"2019","journal-title":"Anesth Analg"},{"key":"10.1016\/j.accpm.2023.101219_bib0190","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s00701-016-2932-z","article-title":"The best marker for guiding the clinical management of patients with raised intracranial pressure-the RAP index or the mean pulse amplitude?","volume":"158","author":"Hall","year":"2016","journal-title":"Acta Neurochir (Wien)"},{"key":"10.1016\/j.accpm.2023.101219_bib0195","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11910-018-0912-9","article-title":"A precision medicine approach to cerebral edema and intracranial hypertension after severe traumatic brain injury: quo vadis?","volume":"18","author":"Jha","year":"2018","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.accpm.2023.101219_bib0200","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00134-012-2572-6","article-title":"Brain compliance: the old story with a new\u2019 et cetera\u2019","volume":"38","author":"Czosnyka","year":"2012","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.107079","article-title":"Establishment and validation of a prediction model for intraparenchymal hematoma expansion in patients with cerebral contusion: a reliable nomogram","volume":"212","author":"Zhu","year":"2022","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.accpm.2023.101219_bib0210","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s10143-019-01098-0","article-title":"Demographics, presentation, and clinical outcomes after traumatic bifrontal contusions: a systematic review","volume":"43","author":"Van de Zande","year":"2020","journal-title":"Neurosurg Rev"},{"key":"10.1016\/j.accpm.2023.101219_bib0215","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1007\/s00134-020-06283-0","article-title":"Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus","volume":"46","author":"Robba","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0220","doi-asserted-by":"crossref","first-page":"R32","DOI":"10.1186\/cc3010","article-title":"Differentiating midazolam over-sedation from neurological damage in the intensive care unit","volume":"9","author":"McKenzie","year":"2005","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2023.101219_bib0225","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.3109\/02699052.2012.667587","article-title":"The prevalence, treatment and outcomes of agitation among patients with brain injury admitted to acute care units","volume":"26","author":"McNett","year":"2012","journal-title":"Brain Inj"},{"key":"10.1016\/j.accpm.2023.101219_bib0230","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/WNF.0000000000000242","article-title":"Effect of amantadine on agitation in critically ill patients with traumatic brain injury","volume":"40","author":"Gramish","year":"2017","journal-title":"Clin Neuropharmacol"},{"key":"10.1016\/j.accpm.2023.101219_bib0235","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13643-016-0374-6","article-title":"Pharmacological interventions for agitation in patients with traumatic brain injury: protocol for a systematic review and meta-analysis","volume":"5","author":"Williamson","year":"2016","journal-title":"Syst Rev"},{"key":"10.1016\/j.accpm.2023.101219_bib0240","first-page":"639","article-title":"Therapeutic options for agitation in the intensive care unit","volume":"39","author":"Aubanel","year":"2020","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0245","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/CCM.0b013e3182783b72","article-title":"Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit","volume":"41","author":"Barr","year":"2013","journal-title":"Crit Care Med"},{"issue":"9 Suppl 1","key":"10.1016\/j.accpm.2023.101219_bib0250","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1097\/CCM.0b013e3182a16919","article-title":"Regroupement de Soins Critiques RdSRQ. Alcohol, nicotine, and iatrogenic withdrawals in the ICU","volume":"41","author":"Awissi","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0255","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00134-008-1251-0","article-title":"Respiratory, metabolic and hemodynamic effects of clonidine in ventilated patients presenting with withdrawal syndrome","volume":"35","author":"Liatsi","year":"2009","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0260","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.annfar.2011.10.018","article-title":"Evaluation d\u2019un protocole d\u2019arr\u00eat de la s\u00e9dation chez le patient c\u00e9r\u00e9brol\u00e9s\u00e9","volume":"31","author":"Reynaud-Davin","year":"2012","journal-title":"Ann Fr Anesth Reanim"},{"key":"10.1016\/j.accpm.2023.101219_bib0265","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.2174\/1570159X19666210119153839","article-title":"Challenges of delirium management in patients with traumatic brain injury: from pathophysiology to clinical practice","volume":"19","author":"Roberson","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.accpm.2023.101219_bib0270","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S2213-2600(18)30062-6","article-title":"Clinical phenotypes of delirium during critical illness and severity of subsequent long-term cognitive impairment: a prospective cohort study","volume":"6","author":"Girard","year":"2018","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0275","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1097\/CCM.0000000000003349","article-title":"Delirium monitoring in neurocritically ill patients: a systematic review","volume":"46","author":"Patel","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0280","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/aas.13270","article-title":"Delirium assessment in neuro-critically ill patients: a validation study","volume":"63","author":"Larsen","year":"2019","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.accpm.2023.101219_bib0285","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1111\/jocn.14334","article-title":"Influence of physical restraint on delirium of adult patients in ICU: a nested case-control study","volume":"27","author":"Pan","year":"2018","journal-title":"J Clin Nurs"},{"key":"10.1016\/j.accpm.2023.101219_bib0290","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S2213-2600(13)70166-8","article-title":"Effect of intravenous haloperidol on the duration of delirium and coma in critically ill patients (Hope-ICU): a randomised, double-blind, placebo-controlled trial","volume":"1","author":"Page","year":"2013","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2023.101219_bib0295","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1097\/ALN.0000000000002812","article-title":"Prophylactic haloperidol effects on Long-term quality of life in critically ill patients at High risk for delirium: results of the REDUCE study","volume":"131","author":"Rood","year":"2019","journal-title":"Anesthesiology"},{"key":"10.1016\/j.accpm.2023.101219_bib0300","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s12028-009-9315-8","article-title":"Dexmedetomidine controls agitation and facilitates reliable, serial neurological examinations in a non-intubated patient with traumatic brain injury","volume":"15","author":"Tang","year":"2011","journal-title":"Neurocrit Care"}],"container-title":["Anaesthesia Critical Care & Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556823000279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556823000279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:51:26Z","timestamp":1762480286000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556823000279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":60,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S2352556823000279"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2023.101219","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toward individualized sedation in patients with acute brain damage","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2023.101219","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Soci\u00e9t\u00e9 fran\u00e7aise d'anesth\u00e9sie et de r\u00e9animation (Sfar). Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"101219"}}