{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T10:11:08Z","timestamp":1789726268536,"version":"4.0.1"},"reference-count":14,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T00:00:00Z","timestamp":1684454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma GmbH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.accpm.2023.101249","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T02:03:52Z","timestamp":1684548232000},"page":"101249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A prospective phase IIA multicenter double-blinded randomized placebo-controlled clinical trial evaluating the efficacy and safety of inhaled Tobramycin in patients with ventilator-associated pneumonia (iToVAP)"],"prefix":"10.1016","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5440-6968","authenticated-orcid":false,"given":"Stefan","family":"Angermair","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Deja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Thronicke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Grehn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3481-4956","authenticated-orcid":false,"given":"Nilufar","family":"Akbari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Uhrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Golschan","family":"Asgarpur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Spies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0549-7680","authenticated-orcid":false,"given":"Sascha","family":"Treskatsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2023.101249_bib0005","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1093\/cid\/ciw353","article-title":"Management of adults with hospital-acquired and ventilator-associated pneumonia: 2016 clinical practice guidelines by the Infectious Diseases Society of America and the American Thoracic Society","volume":"63","author":"Kalil","year":"2016","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.accpm.2023.101249_bib0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1378\/chest.122.1.219","article-title":"Pharmacokinetics and bioavailability of aerosolized tobramycin in cystic fibrosis","volume":"122","author":"Geller","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.accpm.2023.101249_bib0015","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1055\/s-0032-1325924","volume":"66","author":"Dalhoff","year":"2012","journal-title":"Pneumologie"},{"key":"10.1016\/j.accpm.2023.101249_bib0020","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1002\/sim.3531","article-title":"Recommended tests for association in 2\u00d72 tables","volume":"28","author":"Lydersen","year":"2009","journal-title":"Stat Med"},{"key":"10.1016\/j.accpm.2023.101249_bib0025","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/sim.1047","article-title":"A solution to the problem of separation in logistic regression","volume":"21","author":"Heinze","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.accpm.2023.101249_bib0030","first-page":"281","article-title":"[The composition and antimicrobial resistance of isolates from lower respiratory tract and blood in hospitalized patients in respiratory ward: a multicenter national study in China]. Article in Chinese","volume":"41","author":"Tang","year":"2018","journal-title":"Chin J Tuberc Respir Dis"},{"key":"10.1016\/j.accpm.2023.101249_bib0035","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1473-3099(19)30574-2","article-title":"Inhaled amikacin adjunctive to intravenous standard-of-care antibiotics in mechanically ventilated patients with Gram-negative pneumonia (INHALE): a double-blind, randomised, placebo-controlled, phase 3, superiority trial","volume":"20","author":"Niederman","year":"2020","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.accpm.2023.101249_bib0040","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/j.1469-0691.2009.03040.x","article-title":"Inhaled colistin as adjunctive therapy to intravenous colistin for the treatment of microbiologically documented ventilator-associated pneumonia: a comparative cohort study","volume":"16","author":"Korbila","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.accpm.2023.101249_bib0045","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1378\/chest.13-1018","article-title":"Effect of aerosolized colistin as adjunctive treatment on the outcomes of microbiologically documented ventilator-associated pneumonia caused by colistin-only susceptible gram-negative bacteria","volume":"144","author":"Tumbarello","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.accpm.2023.101249_bib0050","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1164\/rccm.201011-1894OC","article-title":"Nebulized cefazidime and amikacin in ventilator-associated pneumonia caused by Pseudomonas aeruginosa","volume":"184","author":"Lu","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101249_bib0055","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1164\/rccm.200204-363OC","article-title":"Lung deposition and efficiency of nebulized amikacin during Escherichia coli pneumonia in ventilated piglets","volume":"166","author":"Goldstein","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2023.101249_bib0060","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.4103\/0366-6999.205846","article-title":"Aerosolized amikacin as adjunctive therapy of ventilator-associated pneumonia caused by multidrug-resistant Gram-negative bacteria: a single-center randomized controlled trial","volume":"130","author":"Liu","year":"2017","journal-title":"Chin Med J"},{"key":"10.1016\/j.accpm.2023.101249_bib0065","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jcrc.2021.06.004","article-title":"Effectiveness and safety of adjunctive inhaled antibiotics for ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials","volume":"65","author":"Tang","year":"2021","journal-title":"J Crit Care"},{"key":"10.1016\/j.accpm.2023.101249_bib0070","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1038\/s41598-021-86342-8","article-title":"Amikacin nebulization for the adjunctive therapy of Gram-negative pneumonia in mechanically ventilated patients: a systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"Qin","year":"2021","journal-title":"Sci Rep"}],"container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556823000577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556823000577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T01:50:44Z","timestamp":1762480244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556823000577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S2352556823000577"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2023.101249","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A prospective phase IIA multicenter double-blinded randomized placebo-controlled clinical trial evaluating the efficacy and safety of inhaled Tobramycin in patients with ventilator-associated pneumonia (iToVAP)","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2023.101249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 fran\u00e7aise d'anesth\u00e9sie et de r\u00e9animation (Sfar).","name":"copyright","label":"Copyright"}],"article-number":"101249"}}