{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:44:17Z","timestamp":1782312257059,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care & Pain Medicine"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.accpm.2025.101550","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T11:14:24Z","timestamp":1747480464000},"page":"101550","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating early mobilisation in critically ill COVID-19 patients: Secondary analysis from the ESICM UNITE-COVID-II multicentre observational study"],"prefix":"10.1016","volume":"44","author":[{"given":"Maximilian","family":"Markus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Lindholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Daum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Pohrt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Azoulay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Cecconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Citerio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"De Corte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frantisek","family":"Duska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Galarza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armand R.J.","family":"Girbes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozef","family":"Kesecioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Mellinghoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlies","family":"Ostermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Teboul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan J.","family":"De Waele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan J.","family":"Schaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.accpm.2025.101550_bib0005","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1007\/s00134-021-06388-0","article-title":"Evolving changes in mortality of 13,301 critically ill adult patients with COVID-19 over 8 months","volume":"47","author":"Kurtz","year":"2021","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.accpm.2025.101550_bib0010","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00134-022-06705-1","article-title":"Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study","volume":"48","author":"Greco","year":"2022","journal-title":"Intensive Care Med"},{"issue":"2","key":"10.1016\/j.accpm.2025.101550_bib0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/CCM.0000000000002058","article-title":"Point prevalence study of mobilization practices for acute respiratory failure patients in the United States","volume":"45","author":"Jolley","year":"2017","journal-title":"Crit Care Med"},{"issue":"11","key":"10.1016\/j.accpm.2025.101550_bib0020","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1007\/s00134-020-06244-7","article-title":"Intensive care unit acquired muscle weakness in COVID-19 patients","volume":"46","author":"Van Aerde","year":"2020","journal-title":"Intensive Care Med"},{"issue":"10","key":"10.1016\/j.accpm.2025.101550_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223185","article-title":"Early mobilization of critically ill patients in the intensive care unit: a systematic review and meta-analysis","volume":"14","author":"Zhang","year":"2019","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.accpm.2025.101550_bib0030","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1177\/08850666221097644","article-title":"Mobilization and rehabilitation practice in ICUs during the COVID-19 pandemic","volume":"37","author":"Liu","year":"2022","journal-title":"J Intensive Care Med"},{"issue":"8","key":"10.1016\/j.accpm.2025.101550_bib0035","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s00134-024-07532-2","article-title":"Guideline on positioning and early mobilisation in the critically ill by an expert panel","volume":"50","author":"Schaller","year":"2024","journal-title":"Intensive Care Med"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0040","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13613-023-01201-1","article-title":"Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study","volume":"13","author":"Kloss","year":"2023","journal-title":"Ann Intensive Care"},{"issue":"11","key":"10.1016\/j.accpm.2025.101550_bib0045","doi-asserted-by":"crossref","DOI":"10.2196\/33509","article-title":"Central COVID-19 coordination centers in Germany: description, economic evaluation, and systematic review","volume":"7","author":"Schopow","year":"2021","journal-title":"JMIR Public Health Surveill"},{"issue":"2","key":"10.1016\/j.accpm.2025.101550_bib0050","doi-asserted-by":"crossref","DOI":"10.2196\/18810","article-title":"Global telemedicine implementation and integration within health systems to fight the COVID-19 pandemic: a call to action","volume":"6","author":"Ohannessian","year":"2020","journal-title":"JMIR Public Health Surveill"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0055","doi-asserted-by":"crossref","DOI":"10.1136\/bmjhci-2022-100675","article-title":"Telemedicine in emergency responses: reflections from a critical care telemedicine programme between Uzbekistani and German clinicians during COVID-19","volume":"30","author":"Boklage","year":"2023","journal-title":"BMJ Health Care Inform"},{"issue":"22","key":"10.1016\/j.accpm.2025.101550_bib0060","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1001\/jama.2020.6825","article-title":"Management of COVID-19 respiratory distress","volume":"323","author":"Marini","year":"2020","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.accpm.2025.101550_bib0065","doi-asserted-by":"crossref","DOI":"10.3390\/socsci10050178","article-title":"Protective factors against emergency stress and burnout in healthcare and emergency workers during second wave of COVID-19","volume":"10","author":"Vagni","year":"2021","journal-title":"Soc Sci"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0070","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s13054-022-04108-8","article-title":"Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set","volume":"26","author":"Conway Morris","year":"2022","journal-title":"Crit Care"},{"issue":"43","key":"10.1016\/j.accpm.2025.101550_bib0075","doi-asserted-by":"crossref","DOI":"10.21105\/joss.01686","article-title":"Welcome to the Tidyverse","volume":"4","author":"Wickham","year":"2019","journal-title":"J Open Source Softw"},{"key":"10.1016\/j.accpm.2025.101550_bib0080","series-title":"ggplot2: elegant graphics for data analysis","author":"Wickham","year":"2016"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0085","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models Usinglme4","volume":"67","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"10.1016\/j.accpm.2025.101550_bib0090","unstructured":"Yoshida K. Create 'Table 1' to Describe Baseline Characteristics with or without propensity Score Weights. 0.13.2 ed.; 2022:Creates 'Table 1', i.e., description of baseline patient characteristics, which is essential in every medical research. Supports both continuous and categorical variables, as well as p-values and standardized mean differences. Weighted data are supported via the 'survey' package."},{"issue":"4","key":"10.1016\/j.accpm.2025.101550_bib0095","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1080\/09593985.2022.2160680","article-title":"Timing to out-of-bed mobilization and mobility levels of COVID-19 patients admitted to the ICU: experiences in Brazilian clinical practice","volume":"40","author":"Uhlig","year":"2024","journal-title":"Physiother Theory Pract"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0100","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1513\/AnnalsATS.202005-560OC","article-title":"Rehabilitation levels in patients with COVID-19 admitted to intensive care requiring invasive ventilation. An Observational Study","volume":"18","author":"McWilliams","year":"2021","journal-title":"Ann Am Thorac Soc"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40560-023-00697-w","article-title":"Japanese clinical practice guidelines for rehabilitation in critically ill patients 2023 (J-ReCIP 2023)","volume":"11","author":"Unoki","year":"2023","journal-title":"J Intensive Care"},{"issue":"11","key":"10.1016\/j.accpm.2025.101550_bib0110","doi-asserted-by":"crossref","first-page":"e1121","DOI":"10.1097\/CCM.0000000000004574","article-title":"Clinical practice guidelines for early mobilization in the ICU: a systematic review","volume":"48","author":"Lang","year":"2020","journal-title":"Crit Care Med"},{"issue":"10","key":"10.1016\/j.accpm.2025.101550_bib0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0223151","article-title":"What is the optimum time for initiation of early mobilization in mechanically ventilated patients? A network meta-analysis","volume":"14","author":"Ding","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.accpm.2025.101550_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.iccn.2023.103573","article-title":"Early mobilisation within 72 hours after admission of critically ill patients in the intensive care unit: a systematic review with network meta-analysis","volume":"80","author":"Daum","year":"2024","journal-title":"Intensive Crit Care Nurs"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0125","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jphys.2021.12.012","article-title":"Physiotherapy management for COVID-19 in the acute hospital setting and beyond: an update to clinical practice recommendations","volume":"68","author":"Thomas","year":"2022","journal-title":"J Physiother"},{"issue":"2","key":"10.1016\/j.accpm.2025.101550_bib0130","doi-asserted-by":"crossref","first-page":"104","DOI":"10.5606\/tftrd.2020.6444","article-title":"Pulmonary rehabilitation principles in SARS-COV-2 infection (COVID-19): a guideline for the acute and subacute rehabilitation","volume":"66","author":"Kurtais Aytur","year":"2020","journal-title":"Turk J Phys Med Rehabil"},{"key":"10.1016\/j.accpm.2025.101550_bib0135","series-title":"Clinical management of COVID-19: living guideline","article-title":"Clinical management of COVID-19: living guideline","year":"2023"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0140","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13613-022-00985-y","article-title":"Practices in sedation, analgesia, mobilization, delirium, and sleep deprivation in adult intensive care units (SAMDS-ICU): an international survey before and during the COVID-19 pandemic","volume":"12","author":"Luz","year":"2022","journal-title":"Ann Intensive Care"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0145","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s40560-023-00703-1","article-title":"The optimal dose of mobilisation therapy in the ICU: a prospective cohort study","volume":"11","author":"Lorenz","year":"2023","journal-title":"J Intensive Care"},{"key":"10.1016\/j.accpm.2025.101550_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijnurstu.2020.103708","article-title":"Effects of early mobilization on the prognosis of critically ill patients: a systematic review and meta-analysis","volume":"110","author":"Wang","year":"2020","journal-title":"Int J Nurs Stud"},{"issue":"7","key":"10.1016\/j.accpm.2025.101550_bib0155","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1097\/CCM.0000000000004382","article-title":"Effects of rehabilitation interventions on clinical outcomes in critically ill patients: systematic review and meta-analysis of randomized controlled trials","volume":"48","author":"Waldauf","year":"2020","journal-title":"Crit Care Med"},{"issue":"6","key":"10.1016\/j.accpm.2025.101550_bib0160","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/nicc.12455","article-title":"The effect of early mobilization in critically ill patients: a meta-analysis","volume":"25","author":"Zang","year":"2020","journal-title":"Nurs Crit Care"},{"issue":"1","key":"10.1016\/j.accpm.2025.101550_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-022-04291-8","article-title":"Clustering of critically ill patients using an individualized learning approach enables dose optimization of mobilization in the ICU","volume":"27","author":"Fuest","year":"2023","journal-title":"Crit Care"}],"container-title":["Anaesthesia Critical Care & Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556825000827?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556825000827?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:40:54Z","timestamp":1770914454000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556825000827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2352556825000827"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101550","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating early mobilisation in critically ill COVID-19 patients: Secondary analysis from the ESICM UNITE-COVID-II multicentre observational study","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101550","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101553","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation (SFAR).","name":"copyright","label":"Copyright"}],"article-number":"101550"}}