{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T04:52:40Z","timestamp":1785127960692,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T00:00:00Z","timestamp":1749081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care & Pain Medicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.accpm.2025.101561","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T19:41:52Z","timestamp":1748374912000},"page":"101561","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Optimization of antimicrobial therapy in critically ill patients, what clinicians and searchers must know"],"prefix":"10.1016","volume":"44","author":[{"given":"Claire","family":"Roger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despoina","family":"Koulenti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Novy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Dahyot-Fizelier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2025.101561_bib0005","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1001\/jama.2020.2717","article-title":"Prevalence and outcomes of infection among patients in intensive care units in 2017","volume":"323","author":"Vincent","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101561_bib0010","series-title":"Antimicrobial resistance surveillance in Europe 2023: 2021 data","year":"2023"},{"key":"10.1016\/j.accpm.2025.101561_bib0015","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13017-023-00518-3","article-title":"Ten golden rules for optimal antibiotic use in hospital settings: the WARNING call to action","volume":"18","year":"2023","journal-title":"World J Emerg Surg"},{"key":"10.1016\/j.accpm.2025.101561_bib0020","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1097\/CCM.0000000000000516","article-title":"Using the number needed to treat to assess appropriate antimicrobial therapy as a determinant of outcome in severe sepsis and septic shock","volume":"42","author":"Vazquez-Guillamet","year":"2014","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0025","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40262-023-01213-x","article-title":"Pharmacokinetic alterations associated with critical illness","volume":"62","author":"Morales Castro","year":"2023","journal-title":"Clin Pharmacokinet"},{"key":"10.1016\/j.accpm.2025.101561_bib0030","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.3390\/microorganisms9071505","article-title":"Beta-lactams toxicity in the intensive care unit: an underestimated collateral damage?","volume":"9","author":"Roger","year":"2021","journal-title":"Microorganisms"},{"key":"10.1016\/j.accpm.2025.101561_bib0035","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijantimicag.2017.11.013","article-title":"Association between augmented renal clearance, antibiotic exposure and clinical outcome in critically ill septic patients receiving high doses of \u03b2-lactams administered by continuous infusion: a prospective observational study","volume":"51","author":"Carri\u00e9","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.accpm.2025.101561_bib0040","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1002\/phar.2858","article-title":"Practical considerations for individualizing drug dosing in critically ill adults receiving renal replacement therapy","volume":"43","author":"Kanji","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.accpm.2025.101561_bib0045","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/CCM.0b013e3181961bff","article-title":"Pharmacokinetic issues for antibiotics in the critically ill patient","volume":"37","author":"Roberts","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0050","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3390\/antibiotics12040681","article-title":"The current status and future perspectives of beta-lactam therapeutic drug monitoring in critically ill patients","volume":"12","author":"Novy","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.accpm.2025.101561_bib0055","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01719-23","article-title":"Updated antimicrobial dosing recommendations for obese patients","volume":"68","author":"Castro-Balado","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.accpm.2025.101561_bib0060","first-page":"335","article-title":"Augmented renal clearance: a real phenomenon with an uncertain cause","volume":"38","author":"Baptista","year":"2019","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0065","first-page":"151","article-title":"Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies)","volume":"35","author":"Ichai","year":"2016","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0070","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/cid\/ciaa224","article-title":"The effect of renal replacement therapy and antibiotic dose on antibiotic concentrations in critically ill patients: data from the multinational sampling antibiotics in renal replacement therapy study","volume":"72","author":"Roberts","year":"2021","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.accpm.2025.101561_bib0075","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.1128\/AAC.00828-16","article-title":"Influence of renal replacement modalities on amikacin population pharmacokinetics in critically ill patients on continuous renal replacement therapy","volume":"60","author":"Roger","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.accpm.2025.101561_bib0080","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1164\/rccm.202207-1393OC","article-title":"Antimicrobial exposures in critically ill patients receiving extracorporeal membrane oxygenation","volume":"207","author":"Shekar","year":"2023","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1097\/ACO.0000000000000810","article-title":"Antibiotic dosing during extracorporeal membrane oxygenation: does the system matter?","volume":"33","author":"Abdul-Aziz","year":"2020","journal-title":"Curr Opin Anaesthesiol"},{"key":"10.1016\/j.accpm.2025.101561_bib0090","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1128\/AAC.04232-14","article-title":"Lung concentrations of ceftazidime administered by continuous versus intermittent infusion in patients with ventilator-associated pneumonia","volume":"59","author":"Cousson","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.accpm.2025.101561_bib0095","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/jac\/dkz407","article-title":"Serum and peritoneal exudate concentrations after high doses of \u03b2-lactams in critically ill patients with severe intra-abdominal infections: an observational prospective study","volume":"75","author":"Leon","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.accpm.2025.101561_bib0100","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1007\/s00134-014-3403-8","article-title":"Risk factors for target non-attainment during empirical treatment with \u03b2-lactam antibiotics in critically ill patients","volume":"40","author":"De Waele","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0105","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/QCO.0000000000000681","article-title":"Prolonged infusion of beta-lactam antibiotics for Gram-negative infections: rationale and evidence base","volume":"33","author":"Abdul-Aziz","year":"2020","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.accpm.2025.101561_bib0110","first-page":"439","article-title":"Antibiotic dose optimisation in the critically ill: targets, evidence and future strategies","volume":"30","author":"Dyer","year":"2024","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.accpm.2025.101561_bib0115","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2024.9803","article-title":"Prolonged vs intermittent infusions of \u03b2-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis","author":"Abdul-Aziz","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101561_bib0120","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1007\/s00134-020-06050-1","article-title":"Antimicrobial therapeutic drug monitoring in critically ill adult patients: a position paper","volume":"46","author":"Abdul-Aziz","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0125","first-page":"446","article-title":"Optimal drug therapy for Staphylococcus aureus bacteraemia in adults","volume":"29","author":"Legg","year":"2023","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/j.accpm.2025.101561_bib0130","doi-asserted-by":"crossref","DOI":"10.1007\/s00134-025-07822-3","article-title":"Antibiotic dosing optimization in critically ill patients","author":"Koulenti","year":"2025","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2019.10.018","article-title":"Antimicrobial dosing in critical care: a pragmatic adult dosing nomogram","volume":"55","author":"Williams","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.accpm.2025.101561_bib0140","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.1128\/AAC.01291-12","article-title":"Dosing nomograms for attaining optimum concentrations of meropenem by continuous infusion in critically ill patients with severe gram-negative infections: a pharmacokinetics\/pharmacodynamics-based approach","volume":"56","author":"Pea","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.accpm.2025.101561_bib0145","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/phar.2844","volume":"43","author":"Hong","year":"2023","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.accpm.2025.101561_bib0150","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1001\/jama.2024.9779","article-title":"Continuous vs intermittent \u03b2-lactam antibiotic infusions in critically ill patients with sepsis: the BLING III randomized clinical trial","volume":"332","author":"Dulhunty","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101561_bib0155","article-title":"Intravenous administration of antibiotics by prolonged and continuous infusion","volume":"55","author":"Ourghanlian","year":"2025","journal-title":"Infectious Diseases Now"},{"key":"10.1016\/j.accpm.2025.101561_bib0160","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad305","article-title":"Optimizing the use of beta-lactam antibiotics in clinical practice: a test of time","volume":"10","author":"Tilanus","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"10.1016\/j.accpm.2025.101561_bib0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.jointm.2023.12.007","article-title":"Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy: a narrative review","volume":"4","author":"Roger","year":"2024","journal-title":"J Intensive Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0170","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1186\/s13054-023-04527-1","article-title":"International survey of antibiotic dosing and monitoring in adult intensive care units","volume":"27","author":"Williams","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2025.101561_bib0175","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/cid\/ciac506","article-title":"Beta-lactam antibiotic therapeutic drug monitoring in critically ill patients: a systematic review and meta-analysis","volume":"75","author":"Pai Mangalore","year":"2022","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.accpm.2025.101561_bib0180","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00134-021-06609-6","article-title":"Effect of therapeutic drug monitoring-based dose optimization of piperacillin\/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial","volume":"48","author":"Hagel","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0185","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00134-023-07060-5","article-title":"What\u2019s new in therapeutic drug monitoring of antimicrobials?","volume":"49","author":"Sj\u00f6vall","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0190","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1007\/s00134-022-06847-2","article-title":"Machines that help machines to help patients: optimising antimicrobial dosing in patients receiving extracorporeal membrane oxygenation and renal replacement therapy using dosing software","volume":"48","author":"Roberts","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2025.101561_bib0195","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1007\/s00134-022-06921-9","article-title":"Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial","volume":"48","author":"Ewoldt","year":"2022","journal-title":"Intensive Care Med"}],"container-title":["Anaesthesia Critical Care & Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556825000931?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556825000931?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:57:13Z","timestamp":1760551033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556825000931"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2352556825000931"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101561","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optimization of antimicrobial therapy in critically ill patients, what clinicians and searchers must know","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101561","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation (SFAR).","name":"copyright","label":"Copyright"}],"article-number":"101561"}}