{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:18:10Z","timestamp":1793650690120,"version":"4.5.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T00:00:00Z","timestamp":1759017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.accpm.2025.101620","type":"journal-article","created":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:50:53Z","timestamp":1759009853000},"page":"101620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Post-intensive care syndrome. What clinicians and researchers must know"],"prefix":"10.1016","volume":"45","author":[{"given":"Fanny","family":"Vardon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Fleischmann-Struzek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Latronico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Cinotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2025.101620_bib0005","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-017-1922-8","article-title":"Determinants of long-term outcome in ICU survivors: results from the FROG-ICU study","volume":"22","author":"Gayat","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2025.101620_bib0010","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/01.CCM.0000048622.01013.88","article-title":"Determinants of postintensive care unit mortality: a prospective multicenter study","volume":"31","author":"Azoulay","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0015","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1097\/CCM.0b013e318232da75","article-title":"Improving long-term outcomes after discharge from intensive care unit","volume":"40","author":"Needham","year":"2012","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0020","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S2213-2600(23)00239-4","article-title":"Post-acute sequelae of COVID-19: understanding and addressing the burden of multisystem manifestations","volume":"11","author":"Parotto","year":"2023","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0025","article-title":"Post-intensive cardiac care outpatient long-term outreach clinic (PICCOLO clinic): defining health care needs and outcomes among coronary care unit survivors","volume":"38","author":"Mason","year":"2024","journal-title":"Am Hear J Plus: Cardiol Res Pr"},{"key":"10.1016\/j.accpm.2025.101620_bib0030","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13054-023-04491-w","article-title":"Prevalence and risk factors of significant persistent pain symptoms after critical care illness: a prospective multicentric study","volume":"27","author":"Bourdiol","year":"2023","journal-title":"Critical Care Lond Engl"},{"key":"10.1016\/j.accpm.2025.101620_bib0035","article-title":"Anxiety and depression symptoms in relatives of moderate-to-severe traumatic brain injury survivors \u2014 A multicentre cohort","volume":"42","author":"Cinotti","year":"2023","journal-title":"Anaesth Crit Care Pa"},{"key":"10.1016\/j.accpm.2025.101620_bib0040","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/jama.2022.2017","article-title":"Association of COVID-19 acute respiratory distress syndrome with symptoms of posttraumatic stress disorder in family members after ICU discharge","volume":"327","author":"Azoulay","year":"2022","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101620_bib0045","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0140-6736(21)02176-0","article-title":"A three-step support strategy for relatives of patients dying in the intensive care unit: a cluster randomised trial","volume":"399","author":"Kentish-Barnes","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.accpm.2025.101620_bib0050","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1097\/CCM.0000000000003218","article-title":"Co-occurrence of post-intensive care syndrome problems among 406 survivors of critical illness","volume":"46","author":"Marra","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0055","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.bja.2023.11.052","article-title":"Persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a review of definitions, potential therapies, and research priorities","volume":"132","author":"Chadda","year":"2024","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.accpm.2025.101620_bib0060","first-page":"1133","article-title":"Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis","volume":"184","author":"Roquilly","year":"2020","journal-title":"Nat Immunol"},{"key":"10.1016\/j.accpm.2025.101620_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1177\/0885066612467162","article-title":"Subsequent infections in survivors of sepsis","volume":"29","author":"Wang","year":"2012","journal-title":"J Intensiv Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0070","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41590-024-01819-8","article-title":"Sepsis-trained macrophages promote antitumoral tissue-resident T cells","volume":"25","author":"Broquet","year":"2024","journal-title":"Nat Immunol"},{"key":"10.1016\/j.accpm.2025.101620_bib0075","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: a cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.accpm.2025.101620_bib0080","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1186\/s13054-016-1409-z","article-title":"Long-term outcome in ICU patients with acute kidney injury treated with renal replacement therapy: a prospective cohort study","volume":"20","author":"Corte","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2025.101620_bib0085","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1007\/s00134-020-05944-4","article-title":"ICU-acquired weakness","volume":"46","author":"Vanhorebeek","year":"2020","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0090","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1007\/s00134-020-05927-5","article-title":"Five-year impact of ICU-acquired neuromuscular complications: a prospective, observational study","volume":"46","author":"Aerde","year":"2020","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0095","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1097\/CCM.0000000000000882","article-title":"Posttraumatic stress disorder in critical illness survivors: a metaanalysis","volume":"43","author":"Parker","year":"2015","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0100","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1097\/CCM.0000000000001811","article-title":"Depressive symptoms after critical illness","volume":"44","author":"Rabiee","year":"2016","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0105","article-title":"Functional dependence following intensive care unit-treated Sepsis: three-year follow-up results from the prospective Mid-German Sepsis Cohort (MSC)","volume":"46","author":"Fleischmann-Struzek","year":"2024","journal-title":"Lancet Reg Heal - Eur"},{"key":"10.1016\/j.accpm.2025.101620_bib0110","first-page":"193","article-title":"Natural history of cognitive impairment in critical illness survivors: a systematic review","volume":"0","author":"Honarmand","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0115","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1001\/jama.2010.1553","article-title":"Long-term cognitive impairment and functional disability among survivors of severe sepsis","volume":"304","author":"Iwashyna","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101620_bib0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.rehab.2022.101715","article-title":"Relationship between health-related quality-of-life and functional outcome 6 months after moderate to severe TBI","volume":"66","author":"Cinotti","year":"2023","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0125","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1164\/rccm.200604-493OC","article-title":"Informal caregiver burden among survivors of prolonged mechanical ventilation","volume":"175","author":"Pelt","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0130","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1089\/jpm.2019.0369","article-title":"The patient and family member experience of financial stress related to critical illness","volume":"23","author":"Khandelwal","year":"2020","journal-title":"J Palliat Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0899-5885(18)30605-1","article-title":"Needs of children during the critical illness of a parent or sibling","volume":"4","author":"Lewandowski","year":"1992","journal-title":"Crit Care Nurs Clin North Am"},{"key":"10.1016\/j.accpm.2025.101620_bib0140","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.aucc.2024.02.004","article-title":"Experiences of parents visiting an adult family member in the intensive care unit accompanied by their underaged children: a qualitative study","volume":"37","author":"Belser","year":"2024","journal-title":"Aust Crit Care"},{"key":"10.1016\/j.accpm.2025.101620_bib0145","series-title":"Diagnostic et prise en charge despatients adultes avec un syndrome post-r\u00e9animation (PICS) et de leur entourage","author":"Sant\u00e9","year":"2023"},{"key":"10.1016\/j.accpm.2025.101620_bib0150","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1097\/CCM.0000000000004586","article-title":"Society of critical care medicine\u2019s international consensus conference on prediction and identification of long-term impairments after critical illness","volume":"48","author":"Mikkelsen","year":"2020","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0155","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s00134-024-07359-x","article-title":"A randomized clinical trial to evaluate the effect of post-intensive care multidisciplinary consultations on mortality and the quality of life at 1 year","volume":"50","author":"Sharshar","year":"2024","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0160","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13613-024-01341-y","article-title":"Post-intensive care syndrome screening: a French multicentre survey","volume":"14","author":"Agbakou","year":"2024","journal-title":"Ann Intensiv Care"},{"key":"10.1016\/j.accpm.2025.101620_bib0165","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/s13054-024-05089-6","article-title":"Exploring the effectiveness of eHealth interventions in treating Post Intensive Care Syndrome (PICS) outcomes: a systematic review","volume":"28","author":"Lai","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2025.101620_bib0170","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s00134-024-07414-7","article-title":"Navigating complex interventions in post-ICU care: insights from a randomized clinical trial of post-intensive care multidisciplinary consultations","volume":"50","author":"Rosa","year":"2024","journal-title":"Intensiv Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0175","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1056\/NEJMoa2100433","article-title":"Interleukin-6 receptor antagonists in critically ill patients with Covid-19","volume":"384","author":"Investigators","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0180","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1016\/j.cell.2023.09.013","article-title":"Serotonin reduction in post-acute sequelae of viral infection","volume":"186","author":"Wong","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.accpm.2025.101620_bib0185","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1164\/rccm.201702-0372OC","article-title":"Core outcome measures for clinical research in acute respiratory failure survivors. An international modified Delphi consensus study","volume":"196","author":"Needham","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0190","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S2213-2600(23)00370-3","article-title":"Core outcome measurement instruments for use in clinical and research settings for adults with post-COVID-19 condition: an international Delphi consensus study","volume":"11","author":"Gorst","year":"2023","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.accpm.2025.101620_bib0195","doi-asserted-by":"crossref","DOI":"10.2196\/54525","article-title":"Standardized outcomes for randomized controlled trials targeting early interventions in patients with moderate-to-severe traumatic brain injury: protocol for the development of a core outcome set","volume":"14","author":"Cinotti","year":"2025","journal-title":"JMIR Res Protoc"},{"key":"10.1016\/j.accpm.2025.101620_bib0200","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1007\/s11136-023-03403-3","article-title":"Psychometric properties of the reintegration to normal living index for sepsis survivors","volume":"32","author":"Streich","year":"2023","journal-title":"Qual Life Res"},{"key":"10.1016\/j.accpm.2025.101620_bib0205","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13054-024-04810-9","article-title":"Improving management of ARDS: uniting acute management and long-term recovery","volume":"28","author":"Latronico","year":"2024","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2025.101620_bib0210","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1056\/NEJMoa1212722","article-title":"A randomized trial of glutamine and antioxidants in critically ill patients","volume":"368","author":"Heyland","year":"2013","journal-title":"N Engl J Med"}],"container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556825001523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556825001523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T12:38:49Z","timestamp":1774701529000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556825001523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2352556825001523"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101620","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Post-intensive care syndrome. What clinicians and researchers must know","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation (SFAR).","name":"copyright","label":"Copyright"}],"article-number":"101620"}}