{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:03:01Z","timestamp":1791266581635,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015135","name":"Haemonetics Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015135","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009406","name":"Centre Hospitalier Universitaire de Nantes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009406","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014630","name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9","doi-asserted-by":"publisher","award":["PRME 2015_15-0214"],"award-info":[{"award-number":["PRME 2015_15-0214"]}],"id":[{"id":"10.13039\/501100014630","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care & Pain Medicine"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.accpm.2025.101704","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T02:57:10Z","timestamp":1763693830000},"page":"101704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context"],"prefix":"10.1016","volume":"45","author":[{"given":"Mickael","family":"Vourc\u2019h","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Boissier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Lakhal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Grosjean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Labaste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Robin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrien","family":"Bougle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Mattei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Wurtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul-Michel","family":"Mertes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane","family":"Zlotnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Lagier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Beurton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Rineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Olivier","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc-Antoine","family":"May","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"M\u00e9dard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Guimbretiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Durand-Zaleski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgane","family":"Pere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Rozec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Christophe","family":"Rigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2025.101704_bib0005","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/trf.13370","article-title":"Survival after ultramassive transfusion: a review of 1360 cases","volume":"56","author":"Dzik","year":"2016","journal-title":"Transfusion"},{"key":"10.1016\/j.accpm.2025.101704_bib0010","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1001\/jama.2010.1406","article-title":"Variation in use of blood transfusion in coronary artery bypass graft surgery","volume":"304","author":"Bennett-Guerrero","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101704_bib0015","unstructured":"National Institute for institute for Health and Care Excellence. Detecting, managing and monitoring haemostasis: viscoelastometric point-of-care testing. 2014, n.d."},{"key":"10.1016\/j.accpm.2025.101704_bib0020","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.athoracsur.2021.06.061","article-title":"Number and type of blood products are negatively associated with outcomes after cardiac surgery","volume":"113","author":"Ad","year":"2022","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.accpm.2025.101704_bib0025","article-title":"Effect of perioperative erythropoietin on postoperative morbidity and mortality after cardiac surgery: a meta-analysis of randomized controlled trials","volume":"43","author":"Abraham","year":"2024","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2025.101704_bib0030","article-title":"2024 EACTS\/EACTAIC Guidelines on patient blood management in adult cardiac surgery in collaboration with EBCP","volume":"67","author":"Casselman","year":"2024","journal-title":"Eur J Cardio-Thorac Surg"},{"key":"10.1016\/j.accpm.2025.101704_bib0035","article-title":"Perioperative Patient Blood Management (excluding obstetrics): guidelines from the French National Authority for Health","volume":"43","author":"Theissen","year":"2024","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2025.101704_bib0040","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.jtcvs.2011.03.015","article-title":"Bleeding and management of coagulopathy","volume":"142","author":"Sciecinski","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.accpm.2025.101704_bib0045","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/EJA.0000000000001803","article-title":"Management of severe peri-operative bleeding: Guidelines from the European Society of Anaesthesiology and Intensive Care","volume":"40","author":"Kietaibl","year":"2023","journal-title":"Eur J Anaesthesiol"},{"key":"10.1016\/j.accpm.2025.101704_bib0050","article-title":"Barriers to the implementation of enhanced recovery after cardiac surgery: a national survey","volume":"44","author":"Gac","year":"2025","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2025.101704_bib0055","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1161\/CIRCULATIONAHA.116.023956","article-title":"Point-of-care hemostatic testing in cardiac surgery","volume":"134","author":"Karkouti","year":"2016","journal-title":"Circulation"},{"key":"10.1016\/j.accpm.2025.101704_bib0060","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-029751","volume":"9","author":"Rigal","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.accpm.2025.101704_bib0065","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1053\/j.jvca.2011.09.021","article-title":"Increased chest tube drainage is independently associated with adverse outcome after cardiac surgery","volume":"26","author":"Christensen","year":"2012","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0070","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1053\/j.jvca.2013.05.014","article-title":"Management of hemorrhage in cardiothoracic surgery","volume":"27","author":"G\u00f6rlinger","year":"2013","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0075","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1111\/j.1524-4733.2009.00515.x","article-title":"QALYs: the basics","volume":"12","author":"Weinstein","year":"2009","journal-title":"Value Heal"},{"key":"10.1016\/j.accpm.2025.101704_bib0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10198-011-0351-x","article-title":"Valuing EQ-5D using time trade-off in France","volume":"14","author":"Chevalier","year":"2013","journal-title":"Eur J Heal Econ"},{"key":"10.1016\/j.accpm.2025.101704_bib0085","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically ill patients","volume":"286","author":"Ferreira","year":"2001","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2025.101704_bib0090","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1056\/NEJMoa070403","article-title":"Duration of Red-Cell Storage and Complications after Cardiac Surgery","volume":"358","author":"Koch","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1016\/j.accpm.2025.101704_bib0095","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/11585070-000000000-00000","article-title":"Sample size and power for cost-effectiveness analysis (Part 1)","volume":"29","author":"Glick","year":"2011","journal-title":"PharmacoEconomics"},{"key":"10.1016\/j.accpm.2025.101704_bib0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/hec.3831","article-title":"A cost\u2010effectiveness threshold based on the marginal returns of cardiovascular hospital spending","volume":"28","author":"Baal","year":"2019","journal-title":"Heal Econ"},{"key":"10.1016\/j.accpm.2025.101704_bib0105","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1472-6963-14-84","article-title":"Intraclass correlation coefficients for cluster randomized trials in care pathways and usual care: hospital treatment for heart failure","volume":"14","author":"Kul","year":"2014","journal-title":"BMC Heal Serv Res"},{"key":"10.1016\/j.accpm.2025.101704_bib0110","first-page":"713","article-title":"Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement","volume":"16","author":"Husereau","year":"2013","journal-title":"J M\u00e9d Econ"},{"key":"10.1016\/j.accpm.2025.101704_bib0115","unstructured":"Haute Autorit\u00e9 de Sant\u00e9. Choices in methods for economic evaluation, 2012 n.d. https:\/\/www.has-sante.fr\/ (accessed November 26, 2024)."},{"key":"10.1016\/j.accpm.2025.101704_bib0120","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13063-017-1833-7","article-title":"Analysis of cluster randomised stepped wedge trials with repeated cross-sectional samples","volume":"18","author":"Hemming","year":"2017","journal-title":"Trials"},{"key":"10.1016\/j.accpm.2025.101704_bib0125","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1093\/ejcts\/ezs043","article-title":"EuroSCORE II","volume":"41","author":"Nashef","year":"2012","journal-title":"Eur J Cardio Thorac Surg"},{"key":"10.1016\/j.accpm.2025.101704_bib0130","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.jtcvs.2013.10.070","article-title":"Universal definition of perioperative bleeding in adult cardiac surgery","volume":"147","author":"Dyke","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.accpm.2025.101704_bib0135","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12871-019-0875-7","article-title":"Thrombelastometry guided blood-component therapy after cardiac surgery: a randomized study","volume":"19","author":"Haensig","year":"2019","journal-title":"BMC Anesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0140","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/ALN.0b013e318264c644","article-title":"Point-of-care testing","volume":"117","author":"Weber","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.accpm.2025.101704_bib0145","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1053\/j.jvca.2019.06.030","article-title":"Viscoelastic blood tests use in adult cardiac surgery: meta-analysis, meta-regression, and trial sequential analysis","volume":"34","author":"Meco","year":"2020","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0150","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1007\/s12630-018-1217-9","article-title":"Point-of-care viscoelastic hemostatic testing in cardiac surgery patients: a systematic review and meta-analysis","volume":"65","author":"Lodewyks","year":"2018","journal-title":"Can J Anesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0155","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/EJA.0b013e32835f4d5b","article-title":"Management of severe perioperative bleeding","volume":"30","author":"Kozek-Langenecker","year":"2013","journal-title":"Eur J Anaesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0160","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.athoracsur.2021.04.011","article-title":"Trends and outcomes of surgical reexploration after cardiac operations in the United States","volume":"113","author":"Tran","year":"2022","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.accpm.2025.101704_bib0165","first-page":"627","article-title":"Transfusion-related renal dysfunction after cardiac surgery the role of myeloid-related Protein_14 in neutrophil-mediated tubular damage","volume":"7","author":"Vourc\u2019h","year":"2022","journal-title":"JACC: Basic Transl Sci"},{"key":"10.1016\/j.accpm.2025.101704_bib0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2021.100891","article-title":"The recipe for TACO: a narrative review on the pathophysiology and potential mitigation strategies of transfusion-associated circulatory overload","volume":"52","author":"Bulle","year":"2022","journal-title":"Blood Rev"},{"key":"10.1016\/j.accpm.2025.101704_bib0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12871-019-0717-7","article-title":"Assessment of agreement and interchangeability between the TEG5000 and TEG6S thromboelastography haemostasis analysers: a prospective validation study","volume":"19","author":"Lloyd-Donald","year":"2019","journal-title":"BMC Anesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0180","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.bja.2024.09.028","article-title":"Comparison of ROTEM\u00ae Delta and ROTEM\u00ae Sigma transfusion algorithm performance in thoracic aortic surgery: a single-centre prospective observational cohort study","volume":"134","author":"van Haeren","year":"2025","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.accpm.2025.101704_bib0185","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1160\/TH16-02-0117","article-title":"Effect of high or low protamine dosing on postoperative bleeding following heparin anticoagulation in cardiac surgery","volume":"116","author":"Meesters","year":"2016","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.accpm.2025.101704_bib0190","article-title":"Comparing the effects of 5% albumin and 6% hydroxyethyl starch 130\/0.4 (Voluven) on renal function as priming solutions for cardiopulmonary bypass: a randomized double blind clinical trial","volume":"6","author":"Maleki","year":"2016","journal-title":"Anesth Pain Med"},{"key":"10.1016\/j.accpm.2025.101704_bib0195","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s13063-015-0840-9","article-title":"Sample size calculation for a stepped wedge trial","volume":"16","author":"Baio","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.accpm.2025.101704_bib0200","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/0272989X11418372","article-title":"Developing appropriate methods for cost-effectiveness analysis of cluster randomized trials","volume":"32","author":"Gomes","year":"2011","journal-title":"M\u00e9d Decis Mak"},{"key":"10.1016\/j.accpm.2025.101704_bib0205","doi-asserted-by":"crossref","first-page":"S154","DOI":"10.1016\/j.jval.2021.04.768","article-title":"PMU56 health economic evaluation alongside stepped wedge trials: a methodological systematic review and recommendations of appropriate modelling approaches","volume":"24","author":"Di","year":"2021","journal-title":"Value Heal"},{"key":"10.1016\/j.accpm.2025.101704_bib0210","doi-asserted-by":"crossref","first-page":"c179","DOI":"10.1159\/000339789","article-title":"KDIGO Clinical Practice Guidelines for Acute Kidney Injury","volume":"120","author":"Khwaja","year":"2012","journal-title":"Nephron Clin Pr"}],"container-title":["Anaesthesia Critical Care & Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235255682500236X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S235255682500236X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T11:24:49Z","timestamp":1777980289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S235255682500236X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S235255682500236X"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101704","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cost-utility of point-of-care viscoelastic hemostatic assays in the management of bleeding during cardiac surgery: A single-blinded prospective multicenter stepped wedge cluster randomized trial in French context","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2025.101704","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Masson SAS on behalf of Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation (SFAR).","name":"copyright","label":"Copyright"}],"article-number":"101704"}}