{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:50:03Z","timestamp":1793022603989,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,3,1]],"date-time":"2027-03-01T00:00:00Z","timestamp":1803859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"published-print":{"date-parts":[[2027,3]]},"DOI":"10.1016\/j.accpm.2026.101929","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T15:55:18Z","timestamp":1791215718000},"page":"101929","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of beta-lactam Therapeutic Drug Monitoring in clinical practice: A prospective, comparative, interventional study in intensive care unit patients"],"prefix":"10.1016","volume":"46","author":[{"given":"Romain","family":"Guilhaumou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Foinet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Duclos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wael","family":"Alkassab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthea","family":"Deschamps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Jouve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Lipman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Velly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Leone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.accpm.2026.101929_bib0005","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s00134-017-4683-6","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016","volume":"43","author":"Rhodes","year":"2017","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0010","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1007\/s00134-016-4504-3","article-title":"Incidence of severe sepsis and septic shock in German intensive care units: the prospective, multicentre INSEP study","volume":"42","year":"2016","journal-title":"Intensive Care Med"},{"issue":"6","key":"10.1016\/j.accpm.2026.101929_bib0015","doi-asserted-by":"crossref","first-page":"561.e7","DOI":"10.1016\/j.cmi.2016.01.026","article-title":"Systematic review of antibiotic consumption in acute care hospitals","volume":"22","author":"Bitterman","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.accpm.2026.101929_bib0020","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.CCM.0000194725.48928.3A","article-title":"Sepsis in European intensive care units: results of the SOAP study","volume":"34","author":"Vincent","year":"2006","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/516284","article-title":"Pharmacokinetic\/pharmacodynamic parameters: rationale for antibacterial dosing of mice and men","volume":"26","author":"Craig","year":"1998","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.accpm.2026.101929_bib0030","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1055\/s-0034-1398490","article-title":"Applying pharmacokinetic\/pharmacodynamic principles in critically ill patients: optimizing efficacy and reducing resistance development","volume":"36","author":"Abdul-Aziz","year":"2015","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ijantimicag.2007.12.009","article-title":"Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T&MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections","volume":"31","author":"McKinnon","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.accpm.2026.101929_bib0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13054-019-2378-9","article-title":"Optimization of the treatment with beta-lactam antibiotics in critically ill patients\u2014guidelines from the SFPT and SFAR","volume":"23","author":"Guilhaumou","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2026.101929_bib0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2014.07.006","article-title":"The effect of pathophysiology on pharmacokinetics in the critically ill patient: concepts appraised by the example of antimicrobial agents","volume":"77","author":"Blot","year":"2014","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.accpm.2026.101929_bib0050","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1186\/cc10257","article-title":"Recommended \u03b2-lactam regimens are inadequate in septic patients treated with continuous renal replacement therapy","volume":"15","author":"Seyler","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2026.101929_bib0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijantimicag.2014.12.017","article-title":"Augmented renal clearance, low \u03b2-lactam concentrations and clinical outcomes in the critically ill: an observational prospective cohort study","volume":"45","author":"Huttner","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.accpm.2026.101929_bib0060","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.cmi.2019.06.028","article-title":"Cefepime neurotoxicity: thresholds and risk factors","volume":"26","author":"Boschung-Pasquier","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.accpm.2026.101929_bib0065","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2125.2011.03991.x","article-title":"Neurotoxic effects associated with antibiotic use: management considerations","volume":"72","author":"Grill","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.accpm.2026.101929_bib0070","doi-asserted-by":"crossref","first-page":"e00654","DOI":"10.1128\/AAC.00654-17","article-title":"Neurotoxic concentration of piperacillin during continuous infusion in critically ill patients","volume":"61","author":"Quinton","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.accpm.2026.101929_bib0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1007\/s00134-013-3187-2","article-title":"Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial","volume":"40","author":"De Waele","year":"2014","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0080","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.burns.2015.01.001","article-title":"Impact of the introduction of real-time therapeutic drug monitoring on empirical doses of carbapenems in critically ill burn patients","volume":"41","author":"Fournier","year":"2015","journal-title":"Burns J Int Soc Burn Inj"},{"key":"10.1016\/j.accpm.2026.101929_bib0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00134-021-06609-6","article-title":"Effect of therapeutic drug monitoring-based dose optimization of piperacillin\/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized controlled trial","volume":"48","author":"Hagel","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0090","article-title":"Optimization of antimicrobial therapy in critically ill patients, what clinicians and searchers must know","volume":"44","author":"Roger","year":"2025","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0095","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1093\/jac\/dkac291","article-title":"Assessment of current practice for beta-lactam therapeutic drug monitoring in French ICUs in 2021: a nationwide cross-sectional survey","volume":"77","author":"Tritscher","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.accpm.2026.101929_bib0100","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1473-3099(14)70036-2","article-title":"Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions","volume":"14","author":"Roberts","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.accpm.2026.101929_bib0105","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cmi.2021.11.025","article-title":"European Society of Clinical Microbiology and Infectious Diseases (ESCMID) guidelines for the treatment of infections caused by multidrug-resistant Gram-negative bacilli","volume":"28","author":"Paul","year":"2022","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.accpm.2026.101929_bib0110","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1097\/CCM.0000000000005337","article-title":"Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021","volume":"49","author":"Evans","year":"2021","journal-title":"Crit Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0115","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3390\/antibiotics12081289","article-title":"\u03b2-Lactam pharmacokinetic\/pharmacodynamic target attainment in intensive care unit patients: a prospective observational cohort study","volume":"12","author":"Guilhaumou","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.accpm.2026.101929_bib0120","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.cmi.2017.01.005","article-title":"Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study","volume":"23","author":"Huwyler","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.accpm.2026.101929_bib0125","first-page":"3045","article-title":"Sample size for F-tests on the equality of coefficients of variation","volume":"24","author":"Jung","year":"2005","journal-title":"Stat Med"},{"issue":"8","key":"10.1016\/j.accpm.2026.101929_bib0130","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1001\/jama.2024.9803","article-title":"Prolonged vs intermittent infusions of \u03b2-lactam antibiotics in adults with sepsis or septic shock: a systematic review and meta-analysis","volume":"332","author":"Abdul-Aziz","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.accpm.2026.101929_bib0135","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40265-018-0880-z","article-title":"Therapeutic drug monitoring of \u03b2-lactams and other antibiotics in the intensive care unit","volume":"78","author":"Muller","year":"2018","journal-title":"Drugs"},{"key":"10.1016\/j.accpm.2026.101929_bib0140","article-title":"Efficiency of dosing software using Bayesian forecasting in achieving target antibiotic exposures in critically ill patients, a prospective cohort study","volume":"42","author":"Chai","year":"2023","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0145","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/cid\/ciu027","article-title":"DALI: defining antibiotic levels in intensive care unit patients","volume":"58","author":"Roberts","year":"2014","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.accpm.2026.101929_bib0150","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1186\/s13054-020-03272-z","article-title":"Failure of target attainment of beta-lactam antibiotics in critically ill patients","volume":"24","author":"Abdulla","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.accpm.2026.101929_bib0155","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/cpt.2202","article-title":"From therapeutic drug monitoring to model-informed precision dosing for antibiotics","volume":"109","author":"Wicha","year":"2021","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.accpm.2026.101929_bib0160","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1007\/s00134-022-06921-9","article-title":"Model-informed precision dosing of beta-lactam antibiotics in critically ill patients","volume":"48","author":"Ewoldt","year":"2022","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.accpm.2026.101929_bib0165","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/cid\/ciac506","article-title":"Beta-lactam antibiotic therapeutic drug monitoring in critically ill patients: a systematic review and meta-analysis","volume":"75","author":"Pai","year":"2022","journal-title":"Clin Infect Dis"},{"issue":"10","key":"10.1016\/j.accpm.2026.101929_bib0170","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.cmi.2026.04.010","article-title":"Pharmacokinetics, target attainment, and outcomes of piperacillin\/tazobactam in critically ill patients receiving continuous infusion with therapeutic drug monitoring: a retrospective analysis","volume":"32","author":"Chiriac","year":"2026","journal-title":"Clin Microbiol Infect"}],"container-title":["Anaesthesia Critical Care &amp; Pain Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556826001876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2352556826001876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:22:55Z","timestamp":1793020975000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2352556826001876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2027,3]]}},"alternative-id":["S2352556826001876"],"URL":"https:\/\/doi.org\/10.1016\/j.accpm.2026.101929","relation":{},"ISSN":["2352-5568"],"issn-type":[{"value":"2352-5568","type":"print"}],"subject":[],"published":{"date-parts":[[2027,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implementation of beta-lactam Therapeutic Drug Monitoring in clinical practice: A prospective, comparative, interventional study in intensive care unit patients","name":"articletitle","label":"Article Title"},{"value":"Anaesthesia Critical Care & Pain Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.accpm.2026.101929","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Soci\u00e9t\u00e9 Fran\u00e7aise d'Anesth\u00e9sie et de R\u00e9animation (SFAR). Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"101929"}}