{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T03:47:18Z","timestamp":1778212038827,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.acra.2004.04.018","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T13:22:03Z","timestamp":1094822523000},"page":"996-1004","source":"Crossref","is-referenced-by-count":207,"title":["Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery1"],"prefix":"10.1016","volume":"11","author":[{"given":"Hoon","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seok Rye","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hank F.","family":"Kung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acra.2004.04.018_BIB1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0169-409X(99)00060-5","article-title":"Recent advances in cellular, sub-cellular and molecular targeting","volume":"41","author":"Moghimi","year":"2000","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.acra.2004.04.018_BIB2","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1126\/science.1070200","article-title":"Tumor regression by targeted gene delivery to the neovasculature","volume":"296","author":"Hood","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.acra.2004.04.018_BIB3","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/35051599","article-title":"Identification of the platelet ADP receptor targeted by antithrombotic drugs","volume":"409","author":"Hollopeter","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.acra.2004.04.018_BIB4","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.nu.16.070196.002441","article-title":"Folate receptors","volume":"16","author":"Antony","year":"1996","journal-title":"Ann Rev Nutr"},{"key":"10.1016\/j.acra.2004.04.018_BIB5","first-page":"557","article-title":"Trophoblast and ovarian cancer antigen LK26. Sensitivity and specificity in immunopathology and molecular identification as a folate-binding protein","volume":"142","author":"Garin-Chesa","year":"1993","journal-title":"Am J Pathol"},{"key":"10.1016\/j.acra.2004.04.018_BIB6","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1002\/1097-0142(19940501)73:9<2432::AID-CNCR2820730929>3.0.CO;2-S","article-title":"Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications","volume":"73","author":"Ross","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.acra.2004.04.018_BIB7","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0169-409X(02)00042-X","article-title":"Folate-mediated delivery of macromolecular anticancer therapeutic agents","volume":"54","author":"Lu","year":"2002","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.acra.2004.04.018_BIB8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0169-409X(99)00062-9","article-title":"Targeted drug delivery via the folate receptor","volume":"41","author":"Sudimack","year":"2000","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.acra.2004.04.018_BIB9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0168-3659(01)00324-8","article-title":"Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo\/radiotherapy","volume":"74","author":"Xu","year":"2001","journal-title":"J Control Release"},{"key":"10.1016\/j.acra.2004.04.018_BIB10","doi-asserted-by":"crossref","first-page":"11086","DOI":"10.1074\/jbc.274.16.11086","article-title":"Complete mapping of divergent amino acids responsible for differential ligand binding of folate receptors \u03b1 and \u03b2","volume":"274","author":"Maziarz","year":"1999","journal-title":"J Biolog Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB11","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/bi00171a021","article-title":"Identification of a novel folate receptor, a truncated receptor, and receptor type \u03b2 in hematopoietic cells","volume":"33","author":"Shen","year":"1994","journal-title":"Biochem"},{"key":"10.1016\/j.acra.2004.04.018_BIB12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1021\/bc9701297","article-title":"Design and synthesis of [111In]DTPA-folate for use as a tumor-targeted radiopharmaceutical","volume":"8","author":"Wang","year":"1997","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB13","first-page":"1003","article-title":"Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake","volume":"37","author":"Mathias","year":"1996","journal-title":"J Nucl Med"},{"key":"10.1016\/j.acra.2004.04.018_BIB14","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1021\/bc025586o","article-title":"Synthesis and biological evaluation of folate receptor-targeted boronated PAMAM dendrimers as potential agents for neutron capture therapy","volume":"14","author":"Shukla","year":"2003","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB15","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1021\/bc025642l","article-title":"Folate-targeted PEG as a potential carrier for carboplatin analogs. Synthesis and in vitro studies","volume":"14","author":"Aronov","year":"2003","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB16","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1021\/bc0340114","article-title":"Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate","volume":"14","author":"Moon","year":"2003","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/73219","article-title":"In vivo magnetic resonance imaging of transgene expression","volume":"6","author":"Weissleder","year":"2000","journal-title":"Nat Med"},{"key":"10.1016\/j.acra.2004.04.018_BIB18","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/nbt1201-1141","article-title":"Magnetodendrimers allow andosomal magnetic labeling and in vivo tracking of stem cells","volume":"19","author":"Bulte","year":"2001","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.acra.2004.04.018_BIB19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0168-3659(00)00302-3","article-title":"Dextrans for targeted and sustained delivery of therapeutic and imaging agents","volume":"69","author":"Mehvar","year":"2000","journal-title":"J Control Release"},{"key":"10.1016\/j.acra.2004.04.018_BIB20","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1021\/bc970153k","article-title":"Fluorescently detectable magnetic resonance imaging agents","volume":"9","author":"H\u00fcber","year":"1998","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB21","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0022-1759(82)90007-2","article-title":"Immunospecific ferromagnetic iron dextran reagents for the labeling and magnetic separation of cells","volume":"52","author":"Molday","year":"1982","journal-title":"Immunol Methods"},{"key":"10.1016\/j.acra.2004.04.018_BIB22","first-page":"1563","article-title":"99mTc-HYNIC-folate","volume":"40","author":"Guo","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1016\/j.acra.2004.04.018_BIB23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1021\/bc010084g","article-title":"Preparation and tumor cell uptake of poly(N-isopropylacrylamide) folate conjugates","volume":"13","author":"Dube","year":"2002","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB24","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/mrm.10423","article-title":"Assessment of global and regional myocardial function in the mouse using cine and tagged MRI","volume":"49","author":"Zhou","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.acra.2004.04.018_BIB25","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0168-3659(02)00361-9","article-title":"Preparation and characterization of folate-targeted PEG-coated pDMAEMA-based polyplexes","volume":"87","author":"Steenis","year":"2003","journal-title":"J Control Release"},{"key":"10.1016\/j.acra.2004.04.018_BIB26","doi-asserted-by":"crossref","first-page":"3198","DOI":"10.1016\/S0021-9258(17)41848-5","article-title":"Delivery of Liposomes into cultured KB cells via folate receptor-mediated endocytosis","volume":"269","author":"Lee","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.acra.2004.04.018_BIB27","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/S0142-9612(01)00267-8","article-title":"Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake","volume":"23","author":"Zhang","year":"2002","journal-title":"Biomaterials"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633204002867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633204002867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T16:13:08Z","timestamp":1624637588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633204002867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S1076633204002867"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2004.04.018","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}