{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T04:23:21Z","timestamp":1792383801237,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22591330 \/ 26461789"],"award-info":[{"award-number":["22591330 \/ 26461789"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["21103003"],"award-info":[{"award-number":["21103003"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.acra.2014.10.001","type":"journal-article","created":{"date-parts":[[2014,12,6]],"date-time":"2014-12-06T18:16:40Z","timestamp":1417889800000},"page":"303-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative Imaging"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-3789","authenticated-orcid":false,"given":"Masatoshi","family":"Hori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Higashiura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tonsok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Onishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetoshi","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Nagano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Umeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Wakasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acra.2014.10.001_bib1","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.tox.2008.06.013","article-title":"Hepatic fibrosis\u2014overview","volume":"254","author":"Friedman","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.acra.2014.10.001_bib2","doi-asserted-by":"crossref","first-page":"174","DOI":"10.7326\/0003-4819-131-3-199908030-00003","article-title":"Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT study group. Inhibition of hepatocarcinogenesis by interferon therapy","volume":"131","author":"Yoshida","year":"1999","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.acra.2014.10.001_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","article-title":"Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level","volume":"295","author":"Chen","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.acra.2014.10.001_bib4","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1002\/hep.21440","article-title":"Impact of disease severity on outcome of antiviral therapy for chronic hepatitis C: lessons from the HALT-C trial","volume":"44","author":"Everson","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/j.acra.2014.10.001_bib5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/gast.2003.50013","article-title":"Histological outcome during long-term lamivudine therapy","volume":"124","author":"Dienstag","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.acra.2014.10.001_bib6","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/hep.20073","article-title":"Effect of peginterferon alfa-2a on liver histology in chronic hepatitis C: a meta-analysis of individual patient data","volume":"39","author":"Camma","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.acra.2014.10.001_bib7","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/S0140-6736(12)61425-1","article-title":"Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study","volume":"381","author":"Marcellin","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.acra.2014.10.001_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.cca.2007.02.038","article-title":"Biomarkers of liver fibrosis: clinical translation of molecular pathogenesis or based on liver-dependent malfunction tests","volume":"381","author":"Gressner","year":"2007","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.acra.2014.10.001_bib9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1148\/radiology.135.2.7367613","article-title":"Diagnosis of cirrhosis based on regional changes in hepatic morphology: a radiological and pathological analysis","volume":"135","author":"Harbin","year":"1980","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2014.10.001_bib10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1148\/radiol.2243011495","article-title":"Cirrhosis: modified caudate-right lobe ratio","volume":"224","author":"Awaya","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2014.10.001_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1148\/radiol.2272020193","article-title":"Severe liver fibrosis or cirrhosis: accuracy of US for detection\u2014analysis of 300 cases","volume":"227","author":"Colli","year":"2003","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2014.10.001_bib12","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1148\/radiol.2402050606","article-title":"MR elastography of the liver: preliminary results","volume":"240","author":"Rouviere","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2014.10.001_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/hep.24677","article-title":"Staging hepatic fibrosis: computer-aided analysis of hepatic contours on gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid-enhanced hepatocyte-phase magnetic resonance imaging","volume":"55","author":"Goshima","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.acra.2014.10.001_bib14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/hepr.12025","article-title":"Magnetic resonance laparoscopy: a new non-invasive technique for the assessment of chronic viral liver disease","volume":"43","author":"Ogura","year":"2013","journal-title":"Hepatol Res"},{"key":"10.1016\/j.acra.2014.10.001_bib15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/MCG.0b013e3181e12c39","article-title":"Ultrasound-based hepatic elastography: origins, limitations, and applications","volume":"44","author":"Cohen","year":"2010","journal-title":"J Clin Gastroenterol"},{"key":"10.1016\/j.acra.2014.10.001_bib16","doi-asserted-by":"crossref","first-page":"4872","DOI":"10.1073\/pnas.0501117102","article-title":"Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors","volume":"102","author":"Styner","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.acra.2014.10.001_bib17","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1016\/j.neuroimage.2011.10.014","article-title":"Detecting global and local hippocampal shape changes in Alzheimer's disease using statistical shape models","volume":"59","author":"Shen","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.acra.2014.10.001_bib18","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.media.2009.05.004","article-title":"Statistical shape models for 3D medical image segmentation: a review","volume":"13","author":"Heimann","year":"2009","journal-title":"Med Image Anal"},{"key":"10.1016\/j.acra.2014.10.001_bib19","doi-asserted-by":"crossref","first-page":"264809","DOI":"10.1155\/2013\/264809","article-title":"Computer-aided diagnosis and quantification of cirrhotic livers based on morphological analysis and machine learning","volume":"2013","author":"Chen","year":"2013","journal-title":"Comput Math Methods Med"},{"key":"10.1016\/j.acra.2014.10.001_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1109\/42.921475","article-title":"An adaptive-focus statistical shape model for segmentation and shape modeling of 3-D brain structures","volume":"20","author":"Shen","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.acra.2014.10.001_bib21","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.acra.2008.07.008","article-title":"Automated segmentation of the liver from 3D CT images using probabilistic atlas and multilevel statistical shape model","volume":"15","author":"Okada","year":"2008","journal-title":"Acad Radiol"},{"key":"10.1016\/j.acra.2014.10.001_bib22","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s11517-013-1082-1","article-title":"Automatic segmentation of the fetal cerebellum on ultrasound volumes, using a 3D statistical shape model","volume":"51","author":"Gutierrez-Becker","year":"2013","journal-title":"Med Biol Eng Comput"},{"key":"10.1016\/j.acra.2014.10.001_bib23","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.media.2013.10.003","article-title":"A conditional statistical shape model with integrated error estimation of the conditions; application to liver segmentation in non-contrast CT images","volume":"18","author":"Tomoshige","year":"2014","journal-title":"Med Image Anal"},{"key":"10.1016\/j.acra.2014.10.001_bib24","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S0928-4346(96)00325-8","article-title":"New Inuyama classification; new criteria for histological assessment of chronic hepatitis","volume":"6","author":"Ichida","year":"1996","journal-title":"Int Hepatol Commun"},{"key":"10.1016\/j.acra.2014.10.001_bib25","first-page":"155","article-title":"Support vector regression machines","volume":"9","author":"Drucker","year":"1996","journal-title":"Adv Neural Inf Process Syst"},{"key":"10.1016\/j.acra.2014.10.001_bib26","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1023\/B:STCO.0000035301.49549.88","article-title":"A tutorial on support vector regression","volume":"14","author":"Smola","year":"2004","journal-title":"Statistics and Computing"},{"key":"10.1016\/j.acra.2014.10.001_bib27","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1109\/42.974920","article-title":"A statistical 3-D pattern processing method for computer-aided detection of polyps in CT colonography","volume":"20","author":"Gokturk","year":"2001","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.acra.2014.10.001_bib28","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1053-8119(03)00049-1","article-title":"Functional magnetic resonance imaging (fMRI) \u201cbrain reading\u201d: detecting and classifying distributed patterns of fMRI activity in human visual cortex","volume":"19","author":"Cox","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.acra.2014.10.001_bib29","first-page":"647","article-title":"Nonlinear estimation and modeling of fMRI data using spatio-temporal support vector regression","volume":"18","author":"Wang","year":"2003","journal-title":"Inf Process Med Imaging"},{"key":"10.1016\/j.acra.2014.10.001_bib30","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1118\/1.3562898","article-title":"Massive-training support vector regression and Gaussian process for false-positive reduction in computer-aided detection of polyps in CT colonography","volume":"38","author":"Xu","year":"2011","journal-title":"Med Phys"},{"issue":"27","key":"10.1016\/j.acra.2014.10.001_bib31","first-page":"21","article-title":"LIBSVM: a library for support vector machines","volume":"2","author":"Chang","year":"2011","journal-title":"ACM TIST"},{"key":"10.1016\/j.acra.2014.10.001_bib32","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1148\/radiol.2403050850","article-title":"Automated hepatic volumetry for living related liver transplantation at multisection CT","volume":"240","author":"Nakayama","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2014.10.001_bib33","doi-asserted-by":"crossref","first-page":"W706","DOI":"10.2214\/AJR.10.5958","article-title":"Quantitative radiology: automated CT liver volumetry compared with interactive volumetry and manual volumetry","volume":"197","author":"Suzuki","year":"2011","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.acra.2014.10.001_bib34","doi-asserted-by":"crossref","first-page":"091917","DOI":"10.1118\/1.4819824","article-title":"Adaptive fast marching method for automatic liver segmentation from CT images","volume":"40","author":"Song","year":"2013","journal-title":"Med Phys"},{"key":"10.1016\/j.acra.2014.10.001_bib35","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2214\/AJR.13.10812","article-title":"Computerized liver volumetry on MRI by using 3D geodesic active contour segmentation","volume":"202","author":"Huynh","year":"2014","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.acra.2014.10.001_bib36","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/hep.21972","article-title":"Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications","volume":"47","author":"Talwalkar","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/j.acra.2014.10.001_bib37","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cgh.2007.06.012","article-title":"Assessment of hepatic fibrosis with magnetic resonance elastography","volume":"5","author":"Yin","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.acra.2014.10.001_bib38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s00330-013-2978-8","article-title":"Magnetic resonance elastography for the detection and staging of liver fibrosis in chronic hepatitis B","volume":"24","author":"Venkatesh","year":"2014","journal-title":"Eur Radiol"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633214003845?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633214003845?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:44:27Z","timestamp":1761036267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633214003845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S1076633214003845"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2014.10.001","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Imaging","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2014.10.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 AUR. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}