{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T10:28:58Z","timestamp":1772188138592,"version":"3.50.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003981","name":"Agenzia Spaziale Italiana","doi-asserted-by":"crossref","award":["DC-DTE-2011-033"],"award-info":[{"award-number":["DC-DTE-2011-033"]}],"id":[{"id":"10.13039\/501100003981","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.acra.2015.11.009","type":"journal-article","created":{"date-parts":[[2016,1,7]],"date-time":"2016-01-07T15:05:03Z","timestamp":1452179103000},"page":"273-283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study"],"prefix":"10.1016","volume":"23","author":[{"given":"Giulia","family":"Di Pietro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Capuani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guglielmo","family":"Manenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Vinicola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Fusco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Scimeca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Hagberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Bozzali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"Tarantino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acra.2015.11.009_bib0010","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fendo.2015.00040","article-title":"Marrow fat and bone: review of clinical findings","volume":"6","author":"Schwartz","year":"2015","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.acra.2015.11.009_bib0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ncprheum0070","article-title":"Mechanisms of disease: is osteoporosis the obesity of bone?","volume":"2","author":"Rosen","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"key":"10.1016\/j.acra.2015.11.009_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s11914-014-0199-y","article-title":"Fat and bone interactions","volume":"12","author":"Bermeo","year":"2014","journal-title":"Curr Osteop Report"},{"key":"10.1016\/j.acra.2015.11.009_bib0025","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00256-010-0936-y","article-title":"Perspective: the bone-fat connection","volume":"39","author":"Bredella","year":"2010","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.acra.2015.11.009_bib0030","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1023\/A:1011513223894","article-title":"Adipocyte tissue volume in bone marrow is increased with aging and in patients with osteoporosis","volume":"2","author":"Justesen","year":"2001","journal-title":"Biogerontology"},{"key":"10.1016\/j.acra.2015.11.009_bib0035","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1002\/jbmr.2013","article-title":"Bone marrow composition, diabetes, and fracture risk: more bad news for saturated fat","volume":"28","author":"Devlin","year":"2013","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0040","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s11095-006-0025-z","article-title":"Metabonomics techniques and applications to pharmaceutical research & development","volume":"23","author":"Lindon","year":"2006","journal-title":"Pharm Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0045","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1007\/BF02636990","article-title":"Gas liquid chromatography analysis of the fatty acid composition of fats and oils: a total system for high accuracy","volume":"64","author":"Craske","year":"1987","journal-title":"J Am Oil Chem Soc"},{"key":"10.1016\/j.acra.2015.11.009_bib0050","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/term.120","article-title":"HRMAS 1H-NMR measured changes of the metabolite profile as mesenchymal stem cells differentiate to targeted fat cells in vitro: implications for non-invasive monitoring of stem cell differentiation in vivo","volume":"2","author":"Shi","year":"2008","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.acra.2015.11.009_bib0055","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1093\/jnci\/94.16.1197","article-title":"Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions","volume":"94","author":"Katz-Brull","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.acra.2015.11.009_bib0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.crad.2008.07.002","article-title":"Magnetic resonance spectroscopy of the brain: review of metabolites and clinical applications","volume":"64","author":"Soares","year":"2009","journal-title":"Clin Radiol"},{"key":"10.1016\/j.acra.2015.11.009_bib0065","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.3748\/wjg.14.3476","article-title":"Non-invasive means of measuring hepatic fat content","volume":"14","author":"Mehta","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.acra.2015.11.009_bib0070","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/(SICI)1097-0045(19990215)38:3<237::AID-PROS8>3.0.CO;2-O","article-title":"Citrate in the diagnosis of prostate cancer","volume":"38","author":"Costello","year":"1999","journal-title":"Prostate"},{"key":"10.1016\/j.acra.2015.11.009_bib0075","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0079-6565(96)01030-8","article-title":"Bone marrow NMR in vivo","volume":"29","author":"Schick","year":"1996","journal-title":"Prog Nucl Mag Res Spec"},{"key":"10.1016\/j.acra.2015.11.009_bib0080","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1007\/s11746-998-0295-1","article-title":"Determination of unsaturated fatty acid composition by high-resolution nuclear magnetic resonance spectroscopy","volume":"75","author":"Miyake","year":"1998","journal-title":"J Am Oil Chem Soc"},{"key":"10.1016\/j.acra.2015.11.009_bib0085","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.chemphyslip.2007.10.006","article-title":"Analysis of bone marrow fatty acid composition using high-resolution proton NMR spectroscopy","volume":"151","author":"Yeung","year":"2008","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.acra.2015.11.009_bib0090","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1194\/jlr.D800010-JLR200","article-title":"Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 tesla","volume":"49","author":"Ren","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0095","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1148\/radiol.2363041425","article-title":"Vertebral bone mineral density marrow perfusion and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy","volume":"236","author":"Griffith","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2015.11.009_bib0100","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/jmri.20367","article-title":"Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study","volume":"22","author":"Yeung","year":"2005","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.acra.2015.11.009_bib0105","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1148\/radiol.2413051858","article-title":"Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation","volume":"241","author":"Griffith","year":"2006","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2015.11.009_bib0110","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/jmri.22489","article-title":"Quantification of vertebral bone marrow fat content using 3 tesla MR spectroscopy: reproducibility, vertebral variation, and applications in osteoporosis","volume":"33","author":"Li","year":"2011","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.acra.2015.11.009_bib0115","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/S0140-6736(02)08657-9","article-title":"Osteoporosis I: epidemiology and outcomes of osteoporotic fractures","volume":"359","author":"Cummings","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.acra.2015.11.009_bib0120","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1359\/jbmr.2002.17.12.2265","article-title":"Quantitative magnetic resonance imaging in the calcaneus and femur of women with varying degrees of osteopenia and vertebral deformity status","volume":"17","author":"Wehrli","year":"2002","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0125","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.rli.0000129154.50654.4e","article-title":"Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best?","volume":"39","author":"Link","year":"2004","journal-title":"Invest Radiol"},{"key":"10.1016\/j.acra.2015.11.009_bib0130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00223-007-9058-5","article-title":"Fuzzy logic structure analysis of trabecular bone of the calcaneus to estimate proximal femur fracture load and discriminate subjects with and without vertebral fractures using high-resolution magnetic resonance imaging at 1.5T and 3T","volume":"81","author":"Patel","year":"2007","journal-title":"Calcified Tissue Intl"},{"key":"10.1016\/j.acra.2015.11.009_bib0135","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bone.2008.11.003","article-title":"Effect of increasing vertebral marrow fat content on BMD measurement, T-Score status and fracture risk prediction by DXA","volume":"44","author":"Blake","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.acra.2015.11.009_bib0140","article-title":"Prevention and management of osteoporosis","year":"2000"},{"key":"10.1016\/j.acra.2015.11.009_bib0145","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jocd.2007.12.010","article-title":"Clinical use of quantitative computed tomography and peripheral quantitative computed tomography in the management of osteoporosis in adults: the 2007 ISCD official positions","volume":"11","author":"Engelke","year":"2008","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.acra.2015.11.009_bib0150","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1749-6632.1987.tb32915.x","article-title":"Spatial localization in NMR spectroscopy in vivo","volume":"508","author":"Bottomley","year":"1987","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.acra.2015.11.009_bib0155","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/nbm.698","article-title":"Automatic quantitation of localized in vivo 1H spectra with LCModel","volume":"14","author":"Provencher","year":"2001","journal-title":"NMR Biomed"},{"key":"10.1016\/j.acra.2015.11.009_bib0160","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/jmri.21072","article-title":"Age, gender, and skeletal variation in bone marrow composition: a preliminary study at 3.0 tesla","volume":"26","author":"Liney","year":"2007","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.acra.2015.11.009_bib0165","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1359\/jbmr.080233","article-title":"Compromised bone marrow perfusion in osteoporosis","volume":"23","author":"Griffith","year":"2008","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0170","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1148\/radiology.217.2.r00nv20527","article-title":"Cross-sectional study of osteopenia with quantitative MRI imaging and bone densitometry","volume":"217","author":"Wehrli","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2015.11.009_bib0175","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1088\/0031-9155\/55\/19\/010","article-title":"In vitro and in vivo MR evaluation of internal gradient to assess trabecular bone density","volume":"55","author":"De Santis","year":"2010","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.acra.2015.11.009_bib0180","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bone.2013.03.004","article-title":"Diffusion tensor imaging and magnetic resonance spectroscopy assessment of cancellous bone quality in femoral neck of healthy, osteopenic and osteoporotic subjects at 3T: preliminary experience","volume":"55","author":"Manenti","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.acra.2015.11.009_bib0185","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.micromeso.2013.05.016","article-title":"Diffusion in cancellous bone","volume":"178","author":"Capuani","year":"2013","journal-title":"Microp Mesop Mater"},{"key":"10.1016\/j.acra.2015.11.009_bib0190","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bone.2013.07.027","article-title":"Potential diagnostic role of the MRI-derived internal magnetic field gradient in calcaneus cancellous bone for evaluating postmenopausal osteoporosis at 3T","volume":"57","author":"Rebuzzi","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.acra.2015.11.009_bib0195","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1002\/jmri.23783","article-title":"Reproducibility of 1H MR spectroscopy of hip bone marrow at 3 tesla","volume":"36","author":"Pansini","year":"2012","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.acra.2015.11.009_bib0200","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/jmri.21765","article-title":"Reproducibility of MR perfusion and H spectroscopy of bone marrow","volume":"29","author":"Griffith","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.acra.2015.11.009_bib0205","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/jbmr.1950","article-title":"Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures","volume":"28","author":"Patsch","year":"2013","journal-title":"J Bone Mineral Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jmri.21809","article-title":"The effect of PRESS and STEAM sequences on magnetic resonance spectroscopic liver fat quantification","volume":"30","author":"Hamilton","year":"2009","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.acra.2015.11.009_bib0215","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/mrm.24775","article-title":"Bone marrow fat quantification in the presence of trabecular bone: initial comparison between water-fat imaging and single-voxel MRS","volume":"71","author":"Karampinos","year":"2013","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.acra.2015.11.009_bib0220","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1148\/radiology.179.3.2027962","article-title":"Trabecular structure: preliminary application of MR interferometry","volume":"179","author":"Wehrli","year":"1991","journal-title":"Radiology"},{"key":"10.1016\/j.acra.2015.11.009_bib0225","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s12013-013-9725-2","article-title":"Asiatic acid inhibits adipogenic differentiation of bone marrow stromal cells","volume":"68","author":"Li","year":"2014","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.acra.2015.11.009_bib0230","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12020-010-9353-1","article-title":"Genetic variant in the aquaporin 9 gene is associated with bone mineral density in postmenopausal women","volume":"38","author":"Chanprasertyothin","year":"2010","journal-title":"Endocrine"},{"key":"10.1016\/j.acra.2015.11.009_bib0235","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1002\/ana.410070509","article-title":"Glycerol kinase deficiency with neuromuscular, skeletal, and adrenal abnormalities","volume":"7","author":"Guggenheim","year":"1980","journal-title":"Ann Neurol"},{"key":"10.1016\/j.acra.2015.11.009_bib0240","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.plipres.2009.05.001","article-title":"Lipolysis and lipid mobilization in human adipose tissue","volume":"48","author":"Lafontan","year":"2009","journal-title":"Prog Lipid Res"},{"key":"10.1016\/j.acra.2015.11.009_bib0245","doi-asserted-by":"crossref","first-page":"820615","DOI":"10.1155\/2014\/820615","article-title":"Osteoporosis, fractures, and diabetes","volume":"2014","author":"Jackuliak","year":"2014","journal-title":"Int J Endocrinol"},{"key":"10.1016\/j.acra.2015.11.009_bib0250","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3945\/ajcn.2010.29955","article-title":"Fatty acid consumption and risk of fracture in the women's health initiative","volume":"92","author":"Orchard","year":"2010","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.acra.2015.11.009_bib0255","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.bone.2014.06.014","article-title":"Marrow fat composition in anorexia nervosa","volume":"66","author":"Bredella","year":"2014","journal-title":"Bone"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633215005218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633215005218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,3]],"date-time":"2019-09-03T07:40:25Z","timestamp":1567496425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633215005218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1076633215005218"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2015.11.009","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bone Marrow Lipid Profiles from Peripheral Skeleton as Potential Biomarkers for Osteoporosis: A 1H-MR Spectroscopy Study","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2015.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}