{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:29:20Z","timestamp":1793914160766,"version":"4.8.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071953"],"award-info":[{"award-number":["82071953"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018608","name":"High-end Foreign Experts Recruitment Plan of China","doi-asserted-by":"publisher","award":["G2022154032L"],"award-info":[{"award-number":["G2022154032L"]}],"id":[{"id":"10.13039\/501100018608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.acra.2023.02.001","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T09:07:09Z","timestamp":1680167229000},"page":"2156-2168","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predicting Malignancy of Thyroid Micronodules: Radiomics Analysis Based on Two Types of Ultrasound Elastography Images"],"prefix":"10.1016","volume":"30","author":[{"given":"Xian-Ya","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Zhi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Sha","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Zhi","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph F.","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Yuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-6660","authenticated-orcid":false,"given":"Xin-Wu","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.acra.2023.02.001_bib0001","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1001\/jama.2018.0898","article-title":"The diagnosis and management of thyroid nodules a review","volume":"319","author":"Durante","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.acra.2023.02.001_bib0002","doi-asserted-by":"crossref","unstructured":"Sobin LH. Histological typing of thyroid tumours. Histopathology 1990; 16(5):513. doi:10.1111\/j.1365-2559.1990.tb01559.x.","DOI":"10.1111\/j.1365-2559.1990.tb01559.x"},{"issue":"11","key":"10.1016\/j.acra.2023.02.001_bib0003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/ijcp.14757","article-title":"A practical approach for the management of small thyroid nodules referred for biopsy","volume":"75","author":"G\u00fcnd\u00fcz","year":"2021","journal-title":"Int J Clin Pract"},{"issue":"4","key":"10.1016\/j.acra.2023.02.001_bib0004","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.beem.2012.07.001","article-title":"Thyroid microcarcinoma","volume":"26","author":"Pacini","year":"2012","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.acra.2023.02.001_bib0005","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.mnm.0000126625.17166.36","article-title":"Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience","volume":"25","author":"Pelizzo","year":"2004","journal-title":"Nucl Med Commun"},{"issue":"1111","key":"10.1016\/j.acra.2023.02.001_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1259\/bjr.20190923","article-title":"Qualitative analysis of contrast-enhanced ultrasound in the diagnosis of small, TR3-5 benign and malignant thyroid nodules measuring \u22641 cm","volume":"93","author":"Li","year":"2020","journal-title":"Br J Radiol"},{"issue":"11","key":"10.1016\/j.acra.2023.02.001_bib0007","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"issue":"6","key":"10.1016\/j.acra.2023.02.001_bib0009","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0002-9610(05)80728-7","article-title":"Role of ultrasound in the management of thyroid nodules and thyroid cancer","volume":"164","author":"Liu","year":"1992","journal-title":"Am J Surg"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0010","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1245\/s10434-011-1813-1","article-title":"The diagnostic values of ultrasound and ultrasound-guided fine needle aspiration in subcentimeter-sized thyroid nodules","volume":"19","author":"Moon","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"10.1016\/j.acra.2023.02.001_bib0011","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ejrad.2014.11.019","article-title":"Shear wave elastography of thyroid nodules for the prediction of malignancy in a large scale study","volume":"84","author":"Park","year":"2015","journal-title":"Eur J Radiol"},{"issue":"5","key":"10.1016\/j.acra.2023.02.001_bib0012","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.ultrasmedbio.2015.03.009","article-title":"WFUMB guidelines and recommendations for clinical use of ultrasound elastography: part 1: basic principles and terminology","volume":"41","author":"Shiina","year":"2015","journal-title":"Ultrasound Med Biol"},{"issue":"4","key":"10.1016\/j.acra.2023.02.001_bib0013","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1007\/s00261-014-0305-8","article-title":"Elastography: history, principles, and technique comparison","volume":"40","author":"Garra","year":"2015","journal-title":"Abdom Imaging"},{"issue":"10","key":"10.1016\/j.acra.2023.02.001_bib0014","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.acra.2020.12.013","article-title":"Shear wave elastography evaluation of meniscus degeneration with magnetic resonance imaging correlation","volume":"28","author":"Gurun","year":"2021","journal-title":"Acad Radiol"},{"issue":"9","key":"10.1016\/j.acra.2023.02.001_bib0015","doi-asserted-by":"crossref","first-page":"e278","DOI":"10.1016\/j.acra.2020.08.011","article-title":"Diagnosis of carpal tunnel syndrome using shear wave elastography and high-frequency ultrasound imaging","volume":"28","author":"Nam","year":"2021","journal-title":"Acad Radiol"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0016","first-page":"139","article-title":"Principles of ultrasound and elastography","volume":"176","author":"Ozturk","year":"2016","journal-title":"Physiol Behav"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0017","first-page":"63","article-title":"Differential of small single solid thyroid nodule with real-time ultrasound elastography","volume":"26","author":"Wang","year":"2010","journal-title":"Chin J Med Imaging Technol"},{"issue":"6","key":"10.1016\/j.acra.2023.02.001_bib0018","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1016\/j.ejrad.2013.01.009","article-title":"Efficacy of thyroid ultrasound elastography in differential diagnosis of small thyroid nodules","volume":"82","author":"Dighe","year":"2013","journal-title":"Eur J Radiol"},{"issue":"7","key":"10.1016\/j.acra.2023.02.001_bib0019","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.ultras.2014.04.027","article-title":"Diagnostic value of elastosonography for thyroid microcarcinoma","volume":"54","author":"Wang","year":"2014","journal-title":"Ultrasonics"},{"key":"10.1016\/j.acra.2023.02.001_bib0020","article-title":"Acoustic radiation force impulse imaging: a new tool for the diagnosis of papillary thyroid microcarcinoma","volume":"2014","author":"Zhang","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.acra.2023.02.001_bib0021","first-page":"1311","article-title":"Diagnostic value of two-dimensional shear wave elastography in papillary thyroid microcarcinoma","volume":"9","author":"Duan","year":"2016","journal-title":"Onco Targets Ther"},{"issue":"11","key":"10.1016\/j.acra.2023.02.001_bib0022","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1177\/0284185117692167","article-title":"Preoperative prediction of papillary thyroid microcarcinoma via multiparameter ultrasound","volume":"58","author":"Ma","year":"2017","journal-title":"Acta Radiol"},{"issue":"2","key":"10.1016\/j.acra.2023.02.001_bib0023","doi-asserted-by":"crossref","first-page":"257","DOI":"10.7863\/ultra.33.2.257","article-title":"Combined value of virtual touch tissue quantification and conventional sonographic features for differentiating benign and malignant thyroid nodules smaller than 10 mm","volume":"33","author":"Zhang","year":"2014","journal-title":"J Ultrasound Med"},{"key":"10.1016\/j.acra.2023.02.001_bib0024","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejrad.2018.10.024","article-title":"Combination of ultrasound elastography with TI-RADS in the diagnosis of small thyroid nodules (\u226410 mm): a new method to increase the diagnostic performance","volume":"109","author":"Du","year":"2018","journal-title":"Eur J Radiol"},{"issue":"2","key":"10.1016\/j.acra.2023.02.001_bib0025","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1148\/radiol.2015151169","article-title":"Radiomics: images are more than pictures, they are data","volume":"278","author":"Gillies","year":"2016","journal-title":"Radiology"},{"issue":"8","key":"10.1016\/j.acra.2023.02.001_bib0026","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1089\/thy.2017.0525","article-title":"Predicting malignancy in thyroid nodules: radiomics score versus 2017 American College of Radiology Thyroid Imaging, Reporting and Data System","volume":"28","author":"Liang","year":"2018","journal-title":"Thyroid"},{"key":"10.1016\/j.acra.2023.02.001_bib0027","first-page":"1","article-title":"Radiomics nomogram for identifying sub-1 cm benign and malignant thyroid lesions","volume":"11","author":"Wu","year":"2021","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.acra.2023.02.001_bib0028","doi-asserted-by":"crossref","first-page":"203","DOI":"10.20892\/j.issn.2095-3941.2017.0051","article-title":"2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma","volume":"14","author":"Gao","year":"2017","journal-title":"Cancer Biol Med"},{"issue":"6","key":"10.1016\/j.acra.2023.02.001_bib0029","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1530\/EJE-07-0896","article-title":"Thyroid papillary microcarcinoma: a descriptive and meta-analysis study","volume":"159","author":"Roti","year":"2008","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.acra.2023.02.001_bib0030","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12020-020-02441-y","article-title":"2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS","volume":"70","author":"Zhou","year":"2020","journal-title":"Endocrine"},{"issue":"21","key":"10.1016\/j.acra.2023.02.001_bib0031","doi-asserted-by":"crossref","first-page":"e104","DOI":"10.1158\/0008-5472.CAN-17-0339","article-title":"Computational radiomics system to decode the radiographic phenotype","volume":"77","author":"Van Griethuysen","year":"2017","journal-title":"Cancer Res"},{"issue":"30","key":"10.1016\/j.acra.2023.02.001_bib0032","doi-asserted-by":"crossref","first-page":"5512","DOI":"10.1002\/sim.3148","article-title":"Selection of important variables and determination of functional form for continuous predictors in multivariable model building","volume":"26","author":"Sauerbrei","year":"2007","journal-title":"Stat Med"},{"issue":"4","key":"10.1016\/j.acra.2023.02.001_bib0033","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00330-020-07365-9","article-title":"Combining radiomics with ultrasound-based risk stratification systems for thyroid nodules: an approach for improving performance","volume":"31","author":"Park","year":"2021","journal-title":"Eur Radiol"},{"issue":"7","key":"10.1016\/j.acra.2023.02.001_bib0034","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/j.ultrasmedbio.2016.01.013","article-title":"Feasibility study of texture analysis using ultrasound shear wave elastography to predict malignancy in thyroid nodules","volume":"42","author":"Bhatia","year":"2016","journal-title":"Ultrasound Med Biol"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1089\/105072504322783812","article-title":"Prevalence, clinical and ultrasonographic characteristics of thyroid incidentalomas","volume":"14","author":"Kang","year":"2004","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0036","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1046\/j.1365-2265.2003.01912.x","article-title":"Ultrasonography-guided fine-needle aspiration of thyroid incidentaloma: correlation with pathological findings","volume":"60","author":"Nam-Goong","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0037","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/RLU.0b013e318279bc65","article-title":"Aggressive papillary thyroid microcarcinoma: prognostic factors and therapeutic strategy","volume":"38","author":"Ardito","year":"2013","journal-title":"Clin Nucl Med"},{"issue":"10","key":"10.1016\/j.acra.2023.02.001_bib0038","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1089\/thy.2012.0563","article-title":"Aggressive variants of papillary thyroid microcarcinoma are associated with extrathyroidal spread and lymph-node metastases: a population-level analysis","volume":"23","author":"Kuo","year":"2013","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0039","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13244-022-01240-5","article-title":"Opinion: leading position of ultrasound in decision algorithm for small papillary thyroid carcinoma","volume":"13","author":"Marcy","year":"2022","journal-title":"Insights Imaging"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s41747-018-0068-z","article-title":"Radiomics: the facts and the challenges of image analysis","volume":"2","author":"Rizzo","year":"2018","journal-title":"Eur Radiol Exp"},{"key":"10.1016\/j.acra.2023.02.001_bib0041","doi-asserted-by":"crossref","DOI":"10.1177\/11795549221097675","article-title":"Radiomics features of different sizes of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC) tumors: a comparative study","volume":"16","author":"Zhao","year":"2022","journal-title":"Clin Med Insights Oncol"},{"issue":"10","key":"10.1016\/j.acra.2023.02.001_bib0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13102436","article-title":"Radiomics in differentiated thyroid cancer and nodules: explorations, application, and limitations","volume":"13","author":"Cao","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0043","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7863\/ultra.34.1.19","article-title":"A taller-than-wide shape is a good predictor of papillary thyroid carcinoma in small solid nodules","volume":"34","author":"Ren","year":"2015","journal-title":"J Ultrasound Med"},{"issue":"3","key":"10.1016\/j.acra.2023.02.001_bib0044","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1245\/s10434-012-2830-4","article-title":"Sonographic characteristics suggesting papillary thyroid carcinoma according to nodule size","volume":"20","author":"Kim","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.acra.2023.02.001_bib0045","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ultrasmedbio.2016.06.022","article-title":"WFUMB guidelines and recommendations on the clinical use of ultrasound elastography: part 4","volume":"43","author":"Cosgrove","year":"2017","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.acra.2023.02.001_bib0046","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.12659\/MSM.897011","article-title":"Diagnostic value of conventional ultrasonography combined with contrast-enhanced ultrasonography in thyroid imaging reporting and data system (TI-RADS) 3 and 4 thyroid micronodules","volume":"22","author":"Liu","year":"2016","journal-title":"Med Sci Monit"},{"issue":"3","key":"10.1016\/j.acra.2023.02.001_bib0047","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1148\/radiol.2473070944","article-title":"Benign and malignant thyroid nodules: US differentiation\u2014multicenter retrospective study","volume":"247","author":"Moon","year":"2008","journal-title":"Radiology"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633223000600?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633223000600?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T08:59:07Z","timestamp":1761037147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633223000600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":47,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S1076633223000600"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2023.02.001","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting Malignancy of Thyroid Micronodules: Radiomics Analysis Based on Two Types of Ultrasound Elastography Images","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2023.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}