{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:31:24Z","timestamp":1777887084683,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2017_Kolleg.07"],"award-info":[{"award-number":["2017_Kolleg.07"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.acra.2023.05.007","type":"journal-article","created":{"date-parts":[[2023,6,16]],"date-time":"2023-06-16T15:53:14Z","timestamp":1686930794000},"page":"S257-S267","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"S1","title":["Subcutaneous Fat Abundance and Density Are Associated with an Enhanced Response to Immunotherapy in Metastatic Melanoma: A Retrospective Cohort Study"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1651-7114","authenticated-orcid":false,"given":"Miriam","family":"Mengoni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas Dominik","family":"Braun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattes Simon","family":"Hinnerichs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"T\u00fcting","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexey","family":"Surov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.acra.2023.05.007_bib1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jid.2020.03.943","article-title":"Treatment of advanced melanoma in 2020 and beyond","volume":"141","author":"Jenkins","year":"2021","journal-title":"J Investig Dermatol"},{"key":"10.1016\/j.acra.2023.05.007_bib2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S1470-2045(18)30078-0","article-title":"Association of body-mass index and outcomes in patients with metastatic melanoma treated with targeted therapy, immunotherapy, or chemotherapy: a retrospective, multicohort analysis","volume":"19","author":"McQuade","year":"2018","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.acra.2023.05.007_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s40425-019-0512-5","article-title":"Complex inter-relationship of body mass index, gender and serum creatinine on survival: exploring the obesity paradox in melanoma patients treated with checkpoint inhibition","volume":"7","author":"Naik","year":"2019","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.acra.2023.05.007_bib4","doi-asserted-by":"crossref","first-page":"3579","DOI":"10.1245\/s10434-011-1976-9","article-title":"Sarcopenia as a prognostic factor among patients with stage III melanoma","volume":"18","author":"Sabel","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.acra.2023.05.007_bib5","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1038\/bjc.2016.431","article-title":"The impact of body composition parameters on ipilimumab toxicity and survival in patients with metastatic melanoma","volume":"116","author":"Daly","year":"2017","journal-title":"Br J Cancer"},{"key":"10.1016\/j.acra.2023.05.007_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005226","article-title":"Visceral adiposity and systemic inflammation in the obesity paradox in patients with unresectable or metastatic melanoma undergoing immune checkpoint inhibitor therapy: a retrospective cohort study","volume":"10","author":"Lee","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.acra.2023.05.007_bib7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.ejca.2008.10.026","article-title":"New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1)","volume":"45","author":"Eisenhauer","year":"2009","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.acra.2023.05.007_bib8","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1007\/s00330-019-06573-2","article-title":"Imaging of sarcopenia: old evidence and new insights","volume":"30","author":"Albano","year":"2020","journal-title":"Eur Radiol"},{"key":"10.1016\/j.acra.2023.05.007_bib9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/jcm9010199","article-title":"The predictive value of low muscle mass as measured on CT scans for postoperative complications and mortality in gastric cancer patients: a systematic review and meta-analysis","volume":"9","author":"Borggreve","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.acra.2023.05.007_bib10","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1470-2045(08)70153-0","article-title":"Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study","volume":"9","author":"Prado","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.acra.2023.05.007_bib11","first-page":"472","article-title":"Melanoma staging: evidence-based changes in the American Joint Committee on Cancer eighth edition cancer staging manual","volume":"67","author":"Gershenwald","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.acra.2023.05.007_bib12","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.acra.2023.05.007_bib13","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.acra.2020.07.010","article-title":"Deep learning-based quantification of abdominal subcutaneous and visceral fat volume on CT images","volume":"28","author":"Grainger","year":"2021","journal-title":"Acad Radiol"},{"key":"10.1016\/j.acra.2023.05.007_bib14","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.3390\/diagnostics11122314","article-title":"Deep learning-based body composition analysis predicts outcome in melanoma patients treated with immune checkpoint inhibitors","volume":"11","author":"Faron","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.acra.2023.05.007_bib15","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1159\/000525928","article-title":"Role of sarcopenia in advanced malignant cutaneous melanoma treated with immunotherapy: a meta-analysis","volume":"100","author":"Surov","year":"2022","journal-title":"Oncology"},{"key":"10.1016\/j.acra.2023.05.007_bib16","article-title":"Sarcopenia is an independent prognostic factor in patients with pancreatic cancer - a meta-analysis","author":"Thormann","year":"2022","journal-title":"Acad Radiol"},{"key":"10.1016\/j.acra.2023.05.007_bib17","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1007\/s10637-017-0464-x","article-title":"Sarcopenic overweight is associated with early acute limiting toxicity of anti-PD1 checkpoint inhibitors in melanoma patients","volume":"35","author":"Heidelberger","year":"2017","journal-title":"Investig New Drugs"},{"key":"10.1016\/j.acra.2023.05.007_bib18","first-page":"141","article-title":"Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade","volume":"1","author":"Wang","year":"2018","journal-title":"Nat Med"},{"key":"10.1016\/j.acra.2023.05.007_bib19","doi-asserted-by":"crossref","DOI":"10.1084\/jem.2021004202072022c","article-title":"Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function","volume":"219","author":"Dyck","year":"2022","journal-title":"J Exp Med"},{"key":"10.1016\/j.acra.2023.05.007_bib20","first-page":"1","article-title":"Obesity is associated with altered tumor metabolism in metastatic melanoma","volume":"29","author":"Hahn","year":"2022","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.acra.2023.05.007_bib21","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.it.2014.12.005","article-title":"Fatty acid metabolism in the regulation of T cell function","volume":"36","author":"Lochner","year":"2015","journal-title":"Trends Immunol"},{"key":"10.1016\/j.acra.2023.05.007_bib22","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.immuni.2013.09.015","article-title":"T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming","volume":"39","author":"Yang","year":"2013","journal-title":"Immunity"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633223002477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633223002477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:00:33Z","timestamp":1777608033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633223002477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":22,"alternative-id":["S1076633223002477"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2023.05.007","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Subcutaneous Fat Abundance and Density Are Associated with an Enhanced Response to Immunotherapy in Metastatic Melanoma: A Retrospective Cohort Study","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2023.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}