{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:39:51Z","timestamp":1791470391729,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","academicradiology.org","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.acra.2024.10.002","type":"journal-article","created":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T06:18:17Z","timestamp":1730096297000},"page":"1431-1450","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["T2WI and ADC radiomics combined with a nomogram based on clinicopathologic features to quantitatively predict microsatellite instability in colorectal cancer"],"prefix":"10.1016","volume":"32","author":[{"given":"Leping","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuyan","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaokun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-3776","authenticated-orcid":false,"given":"Lili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.acra.2024.10.002_bib1","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3322\/caac.21834","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.acra.2024.10.002_bib2","doi-asserted-by":"crossref","DOI":"10.7189\/jogh.13.04096","article-title":"National and subnational incidence, mortality and associated factors of colorectal cancer in China: a systematic analysis and modelling study","volume":"13","author":"Xu","year":"2023","journal-title":"J Glob Health"},{"issue":"2","key":"10.1016\/j.acra.2024.10.002_bib3","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1053\/j.gastro.2019.08.059","article-title":"Pathways of colorectal carcinogenesis","volume":"158","author":"Nguyen","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.acra.2024.10.002_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.suronc.2020.03.009","article-title":"Microsatellite instability and response to neoadjuvant chemoradiotherapy in rectal cancer: a systematic review and meta-analysis","volume":"34","author":"O'Connell","year":"2020","journal-title":"Surg Oncol"},{"issue":"4","key":"10.1016\/j.acra.2024.10.002_bib5","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/SLA.0000000000003051","article-title":"Microsatellite instability (MSI) as an independent predictor of pathologic complete response (PCR) in locally advanced rectal cancer: a national cancer database (NCDB) analysis","volume":"271","author":"Hasan","year":"2020","journal-title":"Ann Surg"},{"issue":"3","key":"10.1016\/j.acra.2024.10.002_bib6","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/bjc.2015.213","article-title":"Microsatellite instable vs stable colon carcinomas: analysis of tumour heterogeneity, inflammation and angiogenesis","volume":"113","author":"De Smedt","year":"2015","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.acra.2024.10.002_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41575-019-0126-x","article-title":"Immunotherapy in colorectal cancer: rationale, challenges and potential","volume":"16","author":"Ganesh","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"18","key":"10.1016\/j.acra.2024.10.002_bib8","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1200\/JCO.19.03296","article-title":"Regorafenib plus nivolumab in patients with advanced gastric or colorectal cancer: an open-label, dose-escalation, and dose-expansion phase Ib trial (REGONIVO, EPOC1603)","volume":"38","author":"Fukuoka","year":"2020","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.acra.2024.10.002_bib9","doi-asserted-by":"crossref","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","article-title":"Colon cancer, version 2.2021, NCCN Clinical Practice Guidelines in Oncology","volume":"19","author":"Benson","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"key":"10.1016\/j.acra.2024.10.002_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ctrv.2016.10.005","article-title":"The evolving role of microsatellite instability in colorectal cancer: a review","volume":"51","author":"Gelsomino","year":"2016","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.acra.2024.10.002_bib11","article-title":"Landscape of microsatellite instability across 39 cancer types","volume":"2017","author":"Bonneville","year":"2017","journal-title":"JCO Precis Oncol"},{"issue":"6","key":"10.1016\/j.acra.2024.10.002_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061324","article-title":"Immune checkpoints as a target for colorectal cancer treatment","volume":"18","author":"Passardi","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.acra.2024.10.002_bib13","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1007\/s00330-021-08167-3","article-title":"Pre-treatment CT-based radiomics nomogram for predicting microsatellite instability status in colorectal cancer","volume":"32","author":"Pei","year":"2022","journal-title":"Eur Radiol"},{"key":"10.1016\/j.acra.2024.10.002_bib14","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.critrevonc.2019.03.015","article-title":"Radiomics: principles and radiotherapy applications","volume":"138","author":"Gardin","year":"2019","journal-title":"Crit Rev Oncol Hematol"},{"issue":"4","key":"10.1016\/j.acra.2024.10.002_bib15","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1007\/s00330-019-06572-3","article-title":"Development and validation of a MRI-based radiomics signature for prediction of KRAS mutation in rectal cancer","volume":"30","author":"Cui","year":"2020","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.acra.2024.10.002_bib16","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s00330-022-09160-0","article-title":"Development and external validation of a multiparametric MRI-based radiomics model for preoperative prediction of microsatellite instability status in rectal cancer: a retrospective multicenter study","volume":"33","author":"Li","year":"2023","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.acra.2024.10.002_bib17","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1186\/s12885-022-09584-3","article-title":"Development and validation of a radiomics-based nomogram for the preoperative prediction of microsatellite instability in colorectal cancer","volume":"22","author":"Ying","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.acra.2024.10.002_bib18","article-title":"Radiomics analysis of multi-sequence MR images for predicting microsatellite instability status preoperatively in rectal cancer","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.acra.2024.10.002_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s40644-023-00591-6","article-title":"Preoperative contrast-enhanced CT imaging and clinicopathological characteristics analysis of mismatch repair-deficient colorectal cancer","volume":"23","author":"Chen","year":"2023","journal-title":"Cancer Imaging"},{"issue":"2","key":"10.1016\/j.acra.2024.10.002_bib20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3322\/caac.21388","article-title":"The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population-based to a more \"personalized\" approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.acra.2024.10.002_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3781","article-title":"Radiomics in paediatric neuro-oncology: a multicentre study on MRI texture analysis","volume":"31","author":"Fetit","year":"2018","journal-title":"NMR Biomed"},{"issue":"9","key":"10.1016\/j.acra.2024.10.002_bib22","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1007\/s10350-004-6396-5","article-title":"Extent of nodal involvement in Stage III colorectal carcinoma: relationship to clinicopathologic variables and genetic alterations","volume":"45","author":"Elsaleh","year":"2002","journal-title":"Dis Colon rectum"},{"issue":"9","key":"10.1016\/j.acra.2024.10.002_bib23","article-title":"The significance of microsatellite instability in colorectal cancer after controlling for clinicopathological factors","volume":"97","author":"Kang","year":"2018","journal-title":"Medicine ((Baltimore))"},{"issue":"9","key":"10.1016\/j.acra.2024.10.002_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137365","article-title":"Importance of lymph node immune responses in MSI-H\/dMMR colorectal cancer","volume":"6","author":"Inamori","year":"2021","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/j.acra.2024.10.002_bib25","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s41591-020-0805-8","article-title":"Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers","volume":"26","author":"Chalabi","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.acra.2024.10.002_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.annonc.2020.08.602","article-title":"491P neoadjuvant nivolumab in early stage colorectal cancer","volume":"31","author":"Avallone","year":"2020","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.acra.2024.10.002_bib27","doi-asserted-by":"crossref","first-page":"134","DOI":"10.21037\/atm-20-7673","article-title":"Development and validation of magnetic resonance imaging-based radiomics models for preoperative prediction of microsatellite instability in rectal cancer","volume":"9","author":"Zhang","year":"2021","journal-title":"Ann Transl Med"},{"issue":"2","key":"10.1016\/j.acra.2024.10.002_bib28","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1053\/j.gastro.2021.04.042","article-title":"Genetic and epigenetic characteristics of inflammatory bowel disease-associated colorectal cancer","volume":"161","author":"Rajam\u00e4ki","year":"2021","journal-title":"Gastroenterology"},{"issue":"10","key":"10.1016\/j.acra.2024.10.002_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108655","article-title":"Alterations in p53, microsatellite stability and lack of MUC5AC expression as molecular features of colorectal carcinoma associated with inflammatory bowel disease","volume":"24","author":"Gen\u00e9","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.acra.2024.10.002_bib30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1097\/PAS.0000000000001409","article-title":"Assessment of tumor-infiltrating lymphocytes using International TILs Working Group (ITWG) system is a strong predictor of overall survival in colorectal carcinoma: a study of 1034 patients","volume":"44","author":"Fuchs","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"13","key":"10.1016\/j.acra.2024.10.002_bib31","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1158\/1078-0432.CCR-19-3728","article-title":"Mismatch repair-deficient rectal cancer and resistance to neoadjuvant chemotherapy","volume":"26","author":"Cercek","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1016\/j.acra.2024.10.002_bib32","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1007\/s00330-020-07403-6","article-title":"Multiparametric MRI-based radiomics signature for preoperative estimation of tumor-stroma ratio in rectal cancer","volume":"31","author":"Cai","year":"2021","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.acra.2024.10.002_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.7150\/jca.38354","article-title":"Value of intra-tumor heterogeneity evaluated by diffusion-weighted MRI for predicting pathological stages and therapeutic responses to chemoradiotherapy in lower rectal cancer","volume":"11","author":"Kudou","year":"2020","journal-title":"J Cancer"},{"key":"10.1016\/j.acra.2024.10.002_bib34","article-title":"Computed tomography-based radiomics model to preoperatively predict microsatellite instability status in colorectal cancer: a multicenter study","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.acra.2024.10.002_bib35","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12967-020-02215-0","article-title":"A clinical-radiomics nomogram for the preoperative prediction of lymph node metastasis in colorectal cancer","volume":"18","author":"Li","year":"2020","journal-title":"J Transl Med"},{"key":"10.1016\/j.acra.2024.10.002_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/s41568-023-00658-3","article-title":"Translating p53-based therapies for cancer into the clinic","author":"Peuget","year":"2024","journal-title":"Nat Rev Cancer"},{"issue":"6","key":"10.1016\/j.acra.2024.10.002_bib37","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s10147-012-0490-9","article-title":"Lymphatic invasion identified with D2-40 immunostaining as a risk factor of nodal metastasis in T1 colorectal cancer","volume":"18","author":"Wada","year":"2013","journal-title":"Int J Clin Oncol"},{"issue":"3","key":"10.1016\/j.acra.2024.10.002_bib38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.7150\/jca.65129","article-title":"Dynamic changes of platelets before and after surgery predict the prognosis of patients with operable non-small cell lung cancer","volume":"13","author":"Yang","year":"2022","journal-title":"J Cancer"},{"key":"10.1016\/j.acra.2024.10.002_bib39","article-title":"Emerging roles of platelets in cancer biology and their potential as therapeutic targets","volume":"12","author":"Wang","year":"2022","journal-title":"Front Oncol"},{"issue":"7-8","key":"10.1016\/j.acra.2024.10.002_bib40","doi-asserted-by":"crossref","first-page":"5461","DOI":"10.1002\/jcp.29494","article-title":"PD-1\/PD-L1-dependent immune response in colorectal cancer","volume":"235","author":"Payandeh","year":"2020","journal-title":"J Cell Physiol"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107663322400761X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S107663322400761X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T18:24:05Z","timestamp":1740680645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S107663322400761X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S107663322400761X"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2024.10.002","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T2WI and ADC radiomics combined with a nomogram based on clinicopathologic features to quantitatively predict microsatellite instability in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2024.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Association of Academic Radiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}