{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:11:02Z","timestamp":1792595462124,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"am","delay-in-days":372,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.acra.2025.01.012","type":"journal-article","created":{"date-parts":[[2025,1,26]],"date-time":"2025-01-26T06:59:07Z","timestamp":1737874747000},"page":"1895-1905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prediction of Radiation Therapy Induced Cardiovascular Toxicity from Pretreatment CT Images in Patients with Thoracic Malignancy via an Optimal Biomarker Approach"],"prefix":"10.1016","volume":"32","author":[{"given":"Mujun","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2155-3451","authenticated-orcid":false,"given":"Mostafa","family":"Alnoury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaram K.","family":"Udupa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Poole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sutirth","family":"Mannikeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Ky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Feigenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer W.","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew A.","family":"Torigian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.acra.2025.01.012_bib1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11936-018-0627-x","article-title":"Radiation-induced cardiovascular toxicity: mechanisms, prevention, and treatment","volume":"20","author":"Spetz","year":"2018","journal-title":"Curr Treat Options Cardiovasc Med"},{"issue":"5","key":"10.1016\/j.acra.2025.01.012_bib2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11883-017-0658-x","article-title":"Radiation-induced cardiovascular disease","volume":"19","author":"Raghunathan","year":"2017","journal-title":"Curr Atheroscler Rep"},{"key":"10.1016\/j.acra.2025.01.012_bib3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fonc.2015.00039","article-title":"Radiation-induced heart disease: pathologic abnormalities and putative mechanisms","volume":"5","author":"Taunk","year":"2015","journal-title":"Front Oncol"},{"issue":"11","key":"10.1016\/j.acra.2025.01.012_bib4","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa1209825","article-title":"Risk of ischemic heart disease in women after radiotherapy for breast cancer","volume":"368","author":"Darby","year":"2013","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.acra.2025.01.012_bib5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1182\/blood-2010-06-291328","article-title":"Clinically significant cardiac disease in patients with Hodgkin lymphoma treated with mediastinal irradiation","volume":"117","author":"Galper","year":"2011","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.acra.2025.01.012_bib6","doi-asserted-by":"crossref","first-page":"7118","DOI":"10.1002\/mp.15854","article-title":"Combining natural and artificial intelligence for robust automatic anatomy segmentation: application in neck and thorax auto-contouring","volume":"49","author":"Udupa","year":"2022","journal-title":"Med Phys"},{"issue":"9","key":"10.1016\/j.acra.2025.01.012_bib7","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1136\/thoraxjnl-2019-214461","article-title":"Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study","volume":"75","author":"Anderson","year":"2020","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.acra.2025.01.012_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282573","article-title":"Prediction of lymphoma response to CAR T cells by deep learning-based image analysis","volume":"18","author":"Tong","year":"2023","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.acra.2025.01.012_bib9","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/SLA.0000000000005583","article-title":"Preoperative computed tomography morphological features indicative of incisional hernia formation after abdominal surgery","volume":"276","author":"McAuliffe","year":"2022","journal-title":"Ann Surg"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/s10278-007-9060-5","article-title":"CAVASS: a computer-assisted visualization and analysis software system","volume":"20 1","author":"Grevera","year":"2007","journal-title":"J Digit Imaging"},{"issue":"3","key":"10.1016\/j.acra.2025.01.012_bib11","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.adro.2018.04.011","article-title":"Radiomics-guided therapy for bladder cancer: Using an optimal biomarker approach to determine extent of bladder cancer invasion from t2-weighted magnetic resonance images","volume":"3","author":"Tong","year":"2018","journal-title":"Adv Radiat Oncol"},{"issue":"8","key":"10.1016\/j.acra.2025.01.012_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159327","article-title":"MR image analytics to characterize the upper airway structure in obese children with obstructive sleep apnea syndrome","volume":"11","author":"Tong","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.acra.2025.01.012_bib13","doi-asserted-by":"crossref","first-page":"b4606","DOI":"10.1136\/bmj.b4606","article-title":"Cardiac outcomes in a cohort of adult survivors of childhood and adolescent cancer: retrospective analysis of the Childhood Cancer Survivor Study cohort","volume":"339","author":"Mulrooney","year":"2009","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.acra.2025.01.012_bib14","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1200\/JCO.2015.64.0409","article-title":"Cardiovascular disease among survivors of adult-onset cancer: a community-based retrospective cohort study","volume":"34","author":"Armenian","year":"2016","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.acra.2025.01.012_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009584","article-title":"Declining death rates reflect progress against cancer","volume":"5","author":"Jemal","year":"2010","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.acra.2025.01.012_bib16","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/jnci\/djq366","article-title":"Improved estimates of cancer-specific survival rates from population-based data","volume":"102","author":"Howlader","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"48","key":"10.1016\/j.acra.2025.01.012_bib17","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1093\/eurheartj\/ehz781","article-title":"From trends to transformation: where cardio-oncology is to make a difference","volume":"40","author":"Herrmann","year":"2019","journal-title":"Eur Heart J"},{"issue":"30","key":"10.1016\/j.acra.2025.01.012_bib18","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1200\/JCO.2012.45.2938","article-title":"Late cardiac effects of cancer treatment [published correction appears in J Clin Oncol. 2012 Dec 20;30(36):4590]","volume":"30","author":"Lenihan","year":"2012","journal-title":"J Clin Oncol"},{"issue":"48","key":"10.1016\/j.acra.2025.01.012_bib19","doi-asserted-by":"crossref","first-page":"3889","DOI":"10.1093\/eurheartj\/ehz766","article-title":"A population-based study of cardiovascular disease mortality risk in US cancer patients","volume":"40","author":"Sturgeon","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acra.2025.01.012_bib20","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s40471-017-0117-9","article-title":"Prevention of cardiovascular disease among cancer survivors: the role of pre-existing risk factors and cancer treatments","volume":"4","author":"Rothe","year":"2017","journal-title":"Curr Epidemiol Rep"},{"issue":"12","key":"10.1016\/j.acra.2025.01.012_bib21","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.jacc.2009.11.053","article-title":"Understanding radiation-induced vascular disease","volume":"55","author":"Weintraub","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.acra.2025.01.012_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11864-021-00868-7","article-title":"Cardiotoxicity of radiation therapy: mechanisms, management, and mitigation","volume":"22","author":"Ell","year":"2021","journal-title":"Curr Treat Options Oncol"},{"issue":"8","key":"10.1016\/j.acra.2025.01.012_bib23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41569-020-0348-1","article-title":"Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia","volume":"17","author":"Herrmann","year":"2020","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"10.1016\/j.acra.2025.01.012_bib24","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.3390\/cancers13071712","article-title":"Breast radiotherapy-related cardiotoxicity. when, how, why. risk prevention and control strategies","volume":"13","author":"D\u00edaz-Gavela","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1016\/j.acra.2025.01.012_bib25","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1102\/1470-7330.2004.0003","article-title":"Intensity-modulated radiotherapy--what is it?","volume":"4","author":"Taylor","year":"2004","journal-title":"Cancer Imaging"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib26","doi-asserted-by":"crossref","DOI":"10.2349\/biij.2.1.e19","article-title":"Intensity modulated radiotherapy: advantages, limitations and future developments","volume":"2","author":"Cheung","year":"2006","journal-title":"Biomed Imaging Interv J"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10549-014-3149-6","article-title":"Whole breast proton irradiation for maximal reduction of heart dose in breast cancer patients","volume":"148","author":"Mast","year":"2014","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.1016\/j.acra.2025.01.012_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2967\/jnumed.118.220137","article-title":"Precision cardio-oncology","volume":"60","author":"Dreyfuss","year":"2019","journal-title":"J Nucl Med"},{"issue":"7","key":"10.1016\/j.acra.2025.01.012_bib29","first-page":"842","article-title":"Cancer therapy-related cardiac dysfunction: unresolved issues","volume":"32","author":"Marwick","year":"2016","journal-title":"Can J Cardiol"},{"issue":"3","key":"10.1016\/j.acra.2025.01.012_bib30","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11897-022-00544-3","article-title":"LVEF by multigated acquisition scan compared to other imaging modalities in cardio-oncology: a systematic review","volume":"19","author":"Printezi","year":"2022","journal-title":"Curr Heart Fail Rep"},{"issue":"9","key":"10.1016\/j.acra.2025.01.012_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11886-016-0768-z","article-title":"The role of imaging with cardiac computed tomography in cardio-oncology patients","volume":"18","author":"Pitekova","year":"2016","journal-title":"Curr Cardiol Rep"},{"issue":"8","key":"10.1016\/j.acra.2025.01.012_bib32","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jcmg.2018.06.004","article-title":"Cardiovascular magnetic resonance in the oncology patient","volume":"11","author":"Jordan","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib33","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13014-019-1234-z","article-title":"Is mean heart dose a relevant surrogate parameter of left ventricle and coronary arteries exposure during breast cancer radiotherapy: a dosimetric evaluation based on individually-determined radiation dose (BACCARAT study)","volume":"14","author":"Jacob","year":"2019","journal-title":"Radiat Oncol"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00066-018-1378-z","article-title":"Heart toxicity from breast cancer radiotherapy: current findings, assessment, and prevention. Kardiale Toxizit\u00e4t durch Strahlentherapie bei Brustkrebs: Aktuelle Ergebnisse, Bewertung und Pr\u00e4vention","volume":"195","author":"Piroth","year":"2019","journal-title":"Strahlenther Onkol"},{"issue":"2","key":"10.1016\/j.acra.2025.01.012_bib35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jacc.2018.10.057","article-title":"Cardiovascular function phenotypes in response to cardiotoxic breast cancer therapy","volume":"73","author":"Demissei","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.acra.2025.01.012_bib36","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1159\/000505429","article-title":"The emerging role of radiomics in COPD and lung cancer","volume":"99","author":"Refaee","year":"2020","journal-title":"Respiration"},{"issue":"3","key":"10.1016\/j.acra.2025.01.012_bib37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.radonc.2015.02.015","article-title":"CT-based radiomic signature predicts distant metastasis in lung adenocarcinoma","volume":"114","author":"Coroller","year":"2015","journal-title":"Radiother Oncol"},{"issue":"9","key":"10.1016\/j.acra.2025.01.012_bib38","doi-asserted-by":"crossref","first-page":"e189","DOI":"10.1016\/j.acra.2021.10.014","article-title":"Radiomic analysis of contrast-enhanced MRI predicts DNA copy-number subtype and outcome in lower-grade gliomas","volume":"29","author":"Wan","year":"2022","journal-title":"Acad Radiol"},{"issue":"9","key":"10.1016\/j.acra.2025.01.012_bib39","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.acra.2021.12.016","article-title":"Preoperative prediction of BRAF mutation status in colorectal cancer using a clinical-radiomics model","volume":"29","author":"Xue","year":"2022","journal-title":"Acad Radiol"},{"key":"10.1016\/j.acra.2025.01.012_bib40","article-title":"Comparison of feature selection methods and machine learning classifiers for predicting chronic obstructive pulmonary disease using texture-based CT lung radiomic features [published online ahead of print, 2022 Aug 11]","author":"Makimoto","year":"2022","journal-title":"Acad Radiol"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib41","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.radonc.2017.10.009","article-title":"Is the coronary artery calcium score associated with acute coronary events in breast cancer patients treated with radiotherapy?","volume":"126","author":"Roos","year":"2018","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib42","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000527683","article-title":"Prediction of cardiac toxicity by measurement of coronary artery calcium scoring method using chest computed tomography in early breast cancer patients treated with Trastuzumab","volume":"18","author":"Yoon","year":"2023","journal-title":"Breast Care (Basel)"},{"key":"10.1016\/j.acra.2025.01.012_bib43","article-title":"\u201cNovel risk score for predicting acute cardiovascular and cerebrovascular events after chest radiotherapy in patients with breast or lung cancer.\u201d","volume":"25","author":"Abu Rmilah","year":"2024","journal-title":"Eur J Prevent Cardiol"},{"issue":"4","key":"10.1016\/j.acra.2025.01.012_bib44","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jaccao.2024.05.009","article-title":"\u201cBaseline cardiac parameters as biomarkers of radiation cardiotoxicity in lung cancer: an NI-HEART analysis.\u201d","volume":"6","author":"Walls","year":"2024","journal-title":"JACC. CardioOncology"},{"issue":"6","key":"10.1016\/j.acra.2025.01.012_bib45","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.echo.2016.02.018","article-title":"Myocardial strain is associated with adverse clinical cardiac events in patients treated with anthracyclines","volume":"29","author":"Ali","year":"2016","journal-title":"J Am Soc Echocardiogr"},{"issue":"2","key":"10.1016\/j.acra.2025.01.012_bib46","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s12350-020-02277-z","article-title":"Radionuclide ventriculography phase analysis for risk stratification of patients undergoing cardiotoxic cancer therapy","volume":"29","author":"Jones","year":"2022","journal-title":"J Nucl Cardiol"},{"issue":"8","key":"10.1016\/j.acra.2025.01.012_bib47","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1200\/JCO.2015.65.7916","volume":"35","author":"Zardavas","year":"2017","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1016\/j.acra.2025.01.012_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165262","article-title":"Body surface area and baseline blood pressure predict subclinical anthracycline cardiotoxicity in women treated for early breast cancer","volume":"11","author":"Kotwinski","year":"2016","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.acra.2025.01.012_bib49","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1007\/s00204-022-03341-y","article-title":"An artificial intelligence approach for predicting cardiotoxicity in breast cancer patients receiving anthracycline","volume":"96","author":"Chang","year":"2022","journal-title":"Arch Toxicol"},{"issue":"1","key":"10.1016\/j.acra.2025.01.012_bib50","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1038\/s41467-024-45733-x","article-title":"Artificial intelligence-enabled prediction of chemotherapy-induced cardiotoxicity from baseline electrocardiograms","volume":"15","author":"Yagi","year":"2024","journal-title":"Nat Commun"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225000121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225000121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T17:30:56Z","timestamp":1762363856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633225000121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S1076633225000121"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2025.01.012","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prediction of Radiation Therapy Induced Cardiovascular Toxicity from Pretreatment CT Images in Patients with Thoracic Malignancy via an Optimal Biomarker Approach","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2025.01.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Association of Academic Radiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}