{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:09:34Z","timestamp":1778591374678,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"am","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1-TR-000040"],"award-info":[{"award-number":["UL1-TR-000040"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["RD831697"],"award-info":[{"award-number":["RD831697"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["RD-83830001"],"award-info":[{"award-number":["RD-83830001"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000139","name":"U.S. Environmental Protection Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000139","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-001420"],"award-info":[{"award-number":["UL1-TR-001420"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1-TR-001079"],"award-info":[{"award-number":["UL1-TR-001079"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.acra.2025.06.002","type":"journal-article","created":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T23:18:53Z","timestamp":1754435933000},"page":"5724-5732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Non-cardiovascular Calcification Measures and Warranty Period of a Zero CAC in Young Adults: the Multi-ethnic Study of Atherosclerosis"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-2335","authenticated-orcid":false,"given":"Elena","family":"Ghotbi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khurram","family":"Nasir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Bancks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil","family":"Subhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sepehr","family":"Akhtarkhavari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsima","family":"Shabani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roham","family":"Hadidchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Bluemke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy S.","family":"Post","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Budoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Graham Barr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o A.C.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadpour","family":"Demehri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.acra.2025.06.002_bib1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.jcmg.2015.01.025","article-title":"A 15-Year warranty period for asymptomatic individuals without coronary artery calcium: a prospective follow-up of 9,715 individuals","volume":"8","author":"Valenti","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jacc.2019.05.032","article-title":"Coronary artery calcium scores of zero and establishing the concept of negative risk factors","volume":"74","author":"Blaha","year":"2019","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.acra.2025.06.002_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1161\/CIRCULATIONAHA.115.018524","article-title":"Role of coronary artery calcium score of zero and other negative risk markers for cardiovascular disease: the multi-ethnic study of atherosclerosis (MESA)","volume":"133","author":"Blaha","year":"2016","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.acra.2025.06.002_bib4","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.jcmg.2020.06.048","article-title":"Warranty period of a calcium score of zero: comprehensive analysis from multi-ethnic study of atherosclerosis","volume":"14","author":"Dzaye","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"issue":"13","key":"10.1016\/j.acra.2025.06.002_bib5","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1016\/j.jacc.2020.01.047","article-title":"Incidence of new coronary calcification: time to conversion from CAC = 0","volume":"75","author":"Dzaye","year":"2020","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"10.1016\/j.acra.2025.06.002_bib6","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.123.016465","article-title":"Impact of nonalcoholic hepatic steatosis on the warranty period of a coronary artery calcium score of 0: results from the multi-ethnic study of atherosclerosis","volume":"17","author":"Ichikawa","year":"2024","journal-title":"Circ Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12902-023-01301-w","article-title":"Cross-sectional analysis of potential risk factors of the pineal gland calcification","volume":"23","author":"Jalali","year":"2023","journal-title":"BMC Endocr Disord"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13643-023-02205-5","article-title":"Prevalence of pineal gland calcification: systematic review and meta-analysis","volume":"12","author":"Belay","year":"2023","journal-title":"Syst Rev"},{"key":"10.1016\/j.acra.2025.06.002_bib9","unstructured":"S.R. Vaidya, S.N.S. Yarrarapu, N.R. Aeddula. Nephrocalcinosis. Radiology\u00a0Illustrated: Uroradiology (Second Edition) 9783642053221: 2023; 527\u2013549. doi:\u00a010.1007\/978-3-642-05322-1_23."},{"issue":"3","key":"10.1016\/j.acra.2025.06.002_bib10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1148\/radiographics.17.3.9153697","article-title":"The costal cartilages in health and disease","volume":"17","author":"Ontell","year":"1997","journal-title":"Radiographics"},{"issue":"5","key":"10.1016\/j.acra.2025.06.002_bib11","first-page":"1416","article-title":"Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia","volume":"24","author":"Graciolli","year":"2009","journal-title":"Nephrol\u00a0Dial\u00a0Transplant"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5414\/CN109505","article-title":"The relationship between serum osteopontin and FGF 23 levels with valvular calcification in hemodialysis patients","volume":"91","author":"Ganidagli","year":"2019","journal-title":"Clin Nephrol"},{"issue":"4","key":"10.1016\/j.acra.2025.06.002_bib13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3390\/nu10040415","article-title":"Is matrix gla protein associated with vascular calcification? A systematic review","volume":"10","author":"Barrett","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.acra.2025.06.002_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.785957","article-title":"Association of quantified costal cartilage calcification and long-term cumulative blood glucose exposure: the multi-ethnic study of atherosclerosis","volume":"12","author":"Shabani","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.acra.2025.06.002_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/523405","article-title":"Premature calcifications of costal cartilages: a new perspective","volume":"2014","author":"Rhomberg","year":"2014","journal-title":"Radiol Res Pract"},{"issue":"4","key":"10.1016\/j.acra.2025.06.002_bib16","first-page":"230","article-title":"Epidemiology of cardiovascular disease in young individuals","volume":"15","author":"Andersson","year":"2017","journal-title":"Nat\u00a0Rev\u00a0Cardiol"},{"issue":"10","key":"10.1016\/j.acra.2025.06.002_bib17","doi-asserted-by":"crossref","DOI":"10.1161\/CIR.0000000000000485","article-title":"Heart disease and stroke statistics\u20142017 update: a report from the American Heart Association","volume":"135","author":"Benjamin","year":"2017","journal-title":"Circulation"},{"issue":"19","key":"10.1016\/j.acra.2025.06.002_bib18","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.034456","article-title":"Characteristics of young women presenting with acute myocardial infarction: the prospective, multicenter, observational young women presenting acute myocardial infarction in France Study","volume":"13","author":"Manzo-Silberman","year":"2024","journal-title":"J Am Heart Assoc"},{"issue":"13","key":"10.1016\/j.acra.2025.06.002_bib19","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1056\/NEJMoa072100","article-title":"Coronary calcium as a predictor of coronary events in four racial or ethnic groups","volume":"358","author":"Detrano","year":"2008","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.acra.2025.06.002_bib20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1093\/aje\/kwf113","article-title":"Multi-ethnic study of atherosclerosis: objectives and design","volume":"156","author":"Bild","year":"2002","journal-title":"Am J Epidemiol"},{"issue":"10","key":"10.1016\/j.acra.2025.06.002_bib21","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1161\/01.CIR.0000157730.94423.4B","article-title":"Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"111","author":"Bild","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib22","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1148\/radiol.2341040439","article-title":"Calcified coronary artery plaque measurement with cardiac CT in population-based studies: standardized protocol of Multi-Ethnic Study of Atherosclerosis (MESA) and Coronary Artery Risk Development in Young Adults (CARDIA) study","volume":"234","author":"Carr","year":"2005","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.acra.2025.06.002_bib23","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10554-015-0799-3","article-title":"Coronary calcium scans and radiation exposure in the multi-ethnic study of atherosclerosis","volume":"32","author":"Messenger","year":"2015","journal-title":"Int J Cardiovasc Imaging"},{"issue":"12","key":"10.1016\/j.acra.2025.06.002_bib24","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jcmg.2016.03.001","article-title":"Improving the CAC score by addition of regional measures of calcium distribution: multi-ethnic study of atherosclerosis","volume":"9","author":"Blaha","year":"2016","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.acra.2025.06.002_bib25","unstructured":"MESA Overview and Protocol. Available at: \u3008https:\/\/www.mesa-nhlbi.org\/aboutMESAOverviewProtocol.aspx\u3009. Accessed August 31, 2024."},{"key":"10.1016\/j.acra.2025.06.002_bib26","doi-asserted-by":"crossref","unstructured":"G. Schwarz. Estimating the dimension of a model. The Annals of Statistics.\u00a06(2); 2007. doi:\u00a010.1214\/AOS\/1176344136.","DOI":"10.1214\/aos\/1176344136"},{"key":"10.1016\/j.acra.2025.06.002_bib27","first-page":"267","article-title":"Proceedings of the second international symposium on information theory","author":"Akaike","year":"1973","journal-title":"Akademiai Kaido"},{"key":"10.1016\/j.acra.2025.06.002_bib28","unstructured":"D. Cox D., Hinkley N., Reid\u00a0et al. An introduction to the bootstrap. An Introduction to the Bootstrap. 21(2); 1994: 32. doi:\u00a010.1201\/9780429246593."},{"issue":"4","key":"10.1016\/j.acra.2025.06.002_bib29","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1093\/aje\/kwm324","article-title":"Immortal time bias in pharmaco-epidemiology","volume":"167","author":"Suissa","year":"2008","journal-title":"Am J Epidemiol"},{"issue":"3","key":"10.1016\/j.acra.2025.06.002_bib30","first-page":"1191","article-title":"Low-dose coronary artery calcium scoring compared to the standard protocol","volume":"30","author":"Allio","year":"2022","journal-title":"J\u00a0Nucl\u00a0Cardiol"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib31","doi-asserted-by":"crossref","DOI":"10.1148\/ryct.2021200484","article-title":"An update on coronary artery calcium interpretation at chest and cardiac CT","volume":"3","author":"Obisesan","year":"2021","journal-title":"Radiol Cardiothorac Imaging"},{"issue":"12","key":"10.1016\/j.acra.2025.06.002_bib32","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1093\/ehjci\/jey019","article-title":"Ultra-low-dose coronary artery calcium scoring using novel scoring thresholds for low tube voltage protocols-a pilot study","volume":"19","author":"Gr\u00e4ni","year":"2018","journal-title":"Eur Heart J Cardiovasc Imaging"},{"issue":"1","key":"10.1016\/j.acra.2025.06.002_bib33","first-page":"98","article-title":"Major global coronary artery calcium guidelines","volume":"16","author":"Golub","year":"2023","journal-title":"Cardiovascular Imaging"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225005501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225005501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T12:14:58Z","timestamp":1778588098000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633225005501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1076633225005501"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2025.06.002","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-cardiovascular Calcification Measures and Warranty Period of a Zero CAC in Young Adults: the Multi-ethnic Study of Atherosclerosis","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2025.06.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Association of Academic Radiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}