{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T01:44:05Z","timestamp":1783993445301,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.acra.2025.07.064","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T23:12:56Z","timestamp":1756422776000},"page":"6884-6893","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Whole-Brain Analysis of Increased Brain Iron in Patients with \u03b2-Thalassemia"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9359-927X","authenticated-orcid":false,"given":"Mingrui","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxia","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiatong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaotian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-1352","authenticated-orcid":false,"given":"Peng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.acra.2025.07.064_bib1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/gim.2016.173","article-title":"beta-Thalassemia","volume":"19","author":"Origa","year":"2017","journal-title":"Genet Med"},{"issue":"10343","key":"10.1016\/j.acra.2025.07.064_bib2","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1016\/S0140-6736(22)00536-0","article-title":"Thalassaemia","volume":"399","author":"Kattamis","year":"2022","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.acra.2025.07.064_bib3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1182\/asheducation-2017.1.265","article-title":"Iron overload in thalassemia: different organs at different rates","volume":"2017","author":"Taher","year":"2017","journal-title":"Hematol Am Soc Hematol Educ Program"},{"issue":"7","key":"10.1016\/j.acra.2025.07.064_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23073612","article-title":"Iron metabolism in aging and age-related diseases","volume":"23","author":"Tian","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.acra.2025.07.064_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.102077","article-title":"Ferroptosis in Parkinson's disease: molecular mechanisms and therapeutic potential","volume":"91","author":"Ding","year":"2023","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.acra.2025.07.064_bib6","article-title":"Brain glucose hypometabolism and iron accumulation in different brain regions in Alzheimer's and Parkinson's Diseases","volume":"15","author":"Rao","year":"2022","journal-title":"Pharmaceuticals ((Basel))"},{"issue":"4","key":"10.1016\/j.acra.2025.07.064_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103741","article-title":"Cerebral iron accumulation in multiple sclerosis: pathophysiology and therapeutic implications","volume":"24","author":"Bjorklund","year":"2025","journal-title":"Autoimmun Rev"},{"issue":"23","key":"10.1016\/j.acra.2025.07.064_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/ijms252312987","article-title":"The underestimated role of iron in frontotemporal dementia: a narrative review","volume":"25","author":"Ferretti","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.acra.2025.07.064_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110210","article-title":"Ferroptosis and cognitive impairment: unraveling the link and potential therapeutic targets","volume":"263","author":"Naderi","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.acra.2025.07.064_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.618435","article-title":"Systematic review: quantitative susceptibility mapping (QSM) of brain iron profile in neurodegenerative diseases","volume":"15","author":"Ravanfar","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1016\/j.acra.2025.07.064_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119683","article-title":"Altered brain iron depositions from aging to Parkinson's disease and Alzheimer's disease: a quantitative susceptibility mapping study","volume":"264","author":"Guan","year":"2022","journal-title":"Neuroimage"},{"key":"10.1016\/j.acra.2025.07.064_bib12","doi-asserted-by":"crossref","DOI":"10.1177\/20406207231167050","article-title":"Brain iron content and cognitive function in patients with beta-thalassemia","volume":"14","author":"Bu","year":"2023","journal-title":"Ther Adv Hematol"},{"issue":"5","key":"10.1016\/j.acra.2025.07.064_bib13","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.ajodo.2023.08.003","article-title":"Support vector machines","volume":"164","author":"Valkenborg","year":"2023","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"9","key":"10.1016\/j.acra.2025.07.064_bib14","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1002\/hbm.25369","article-title":"Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and mild cognitive impairment: A systematic review","volume":"42","author":"Ibrahim","year":"2021","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.acra.2025.07.064_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.587250","article-title":"MRI-based radiomics of basal nuclei in differentiating idiopathic Parkinson's disease from Parkinsonian variants of multiple system atrophy: a susceptibility-weighted imaging study","volume":"12","author":"Pang","year":"2020","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.acra.2025.07.064_bib16","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.comppsych.2018.12.014","article-title":"Reliability and validity of a self-report scale for daily assessments of the severity of anxiety symptoms","volume":"90","author":"Zimmerman","year":"2019","journal-title":"Compr Psychiatry"},{"issue":"12","key":"10.1016\/j.acra.2025.07.064_bib17","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1111\/jgs.14530","article-title":"Validation of the Chinese Version of montreal cognitive assessment basic for screening mild cognitive impairment","volume":"64","author":"Chen","year":"2016","journal-title":"J Am Geriatr Soc"},{"issue":"4","key":"10.1016\/j.acra.2025.07.064_bib18","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1002\/mrm.29265","article-title":"Deep learning-based quantitative susceptibility mapping (QSM) in the presence of fat using synthetically generated multi-echo phase training data","volume":"88","author":"Hanspach","year":"2022","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.acra.2025.07.064_bib19","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1002\/mrm.27492","article-title":"Background field removal for susceptibility mapping of human brain with large susceptibility variations","volume":"81","author":"Fang","year":"2019","journal-title":"Magn Reson Med"},{"issue":"3","key":"10.1016\/j.acra.2025.07.064_bib20","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"issue":"12","key":"10.1016\/j.acra.2025.07.064_bib21","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s11920-022-01399-0","article-title":"Machine learning and non-affective psychosis: identification, differential diagnosis, and treatment","volume":"24","author":"Ferrara","year":"2022","journal-title":"Curr Psychiatry Rep"},{"issue":"Pt B","key":"10.1016\/j.acra.2025.07.064_bib22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbr.2016.06.043","article-title":"Classification of patients with MCI and AD from healthy controls using directed graph measures of resting-state fMRI","volume":"322","author":"Khazaee","year":"2017","journal-title":"Behav Brain Res"},{"issue":"8","key":"10.1016\/j.acra.2025.07.064_bib23","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1109\/TPAMI.2010.95","article-title":"Maximum likelihood model selection for 1-norm soft margin SVMs with multiple parameters","volume":"32","author":"Glasmachers","year":"2010","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1016\/j.acra.2025.07.064_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fnsys.2021.642225","article-title":"Functional connectivity of the cognitive cerebellum","volume":"15","author":"Habas","year":"2021","journal-title":"Front Syst Neurosci"},{"issue":"1","key":"10.1016\/j.acra.2025.07.064_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12993-022-00193-5","article-title":"The shifting role of the cerebellum in executive, emotional and social processing across the lifespan","volume":"18","author":"Beuriat","year":"2022","journal-title":"Behav Brain Funct"},{"issue":"1","key":"10.1016\/j.acra.2025.07.064_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1093\/brain\/awac339","article-title":"Temporopolar regions of the human brain","volume":"146","author":"Mesulam","year":"2023","journal-title":"Brain"},{"issue":"15","key":"10.1016\/j.acra.2025.07.064_bib27","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1002\/hbm.25976","article-title":"The role of the ventrolateral anterior temporal lobes in social cognition","volume":"43","author":"Balgova","year":"2022","journal-title":"Hum Brain Mapp"},{"issue":"5","key":"10.1016\/j.acra.2025.07.064_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/biom12050714","article-title":"Cerebral iron deposition in neurodegeneration","volume":"12","author":"Dusek","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.acra.2025.07.064_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2023.120068","article-title":"Multimodal comparisons of QSM and PET in neurodegeneration and aging","volume":"273","author":"Cogswell","year":"2023","journal-title":"Neuroimage"},{"issue":"19","key":"10.1016\/j.acra.2025.07.064_bib30","doi-asserted-by":"crossref","first-page":"e2081","DOI":"10.1212\/WNL.0000000000201106","article-title":"Spatial navigation and its association with biomarkers and future dementia in memory clinic patients without dementia","volume":"99","author":"Tangen","year":"2022","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.acra.2025.07.064_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24119637","article-title":"Iron and ferroptosis more than a suspect: beyond the most common mechanisms of neurodegeneration for new therapeutic approaches to cognitive decline and dementia","volume":"24","author":"Cerasuolo","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.acra.2025.07.064_bib32","article-title":"Brain iron metabolism, redox balance and neurological diseases","volume":"12","author":"Gao","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"16","key":"10.1016\/j.acra.2025.07.064_bib33","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1016\/j.neuron.2023.04.023","article-title":"20 years of the default mode network: a review and synthesis","volume":"111","author":"Menon","year":"2023","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.acra.2025.07.064_bib34","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3758\/s13415-021-00933-6","article-title":"Frontoparietal and default mode network contributions to self-referential processing in social anxiety disorder","volume":"22","author":"Dixon","year":"2022","journal-title":"Cogn Affect Behav Neurosci"},{"issue":"1","key":"10.1016\/j.acra.2025.07.064_bib35","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3233\/JAD-180847","article-title":"Resting state abnormalities of the default mode network in mild cognitive impairment: a systematic review and meta-analysis","volume":"70","author":"Eyler","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"10.1016\/j.acra.2025.07.064_bib36","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12916","article-title":"A neural mechanism of the relationship between impulsivity and emotion dysregulation in patients with Internet gaming disorder","volume":"26","author":"Shin","year":"2021","journal-title":"Addict Biol"},{"key":"10.1016\/j.acra.2025.07.064_bib37","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnsys.2017.00025","article-title":"Cortico-striatal-thalamic loop circuits of the orbitofrontal cortex: promising therapeutic targets in psychiatric illness","volume":"11","author":"Fettes","year":"2017","journal-title":"Front Syst Neurosci"},{"issue":"5","key":"10.1016\/j.acra.2025.07.064_bib38","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41583-021-00446-8","article-title":"The self in context: brain systems linking mental and physical health","volume":"22","author":"Koban","year":"2021","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.acra.2025.07.064_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.803145","article-title":"Case report: atonic PNES Capture in fMRI","volume":"13","author":"Hologne","year":"2022","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.acra.2025.07.064_bib40","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s11682-019-00121-8","article-title":"Neuroimaging gender dysphoria: a novel psychobiological model","volume":"14","author":"Altinay","year":"2020","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.acra.2025.07.064_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.216967","article-title":"Personalized prediction of postoperative complication and survival among colorectal liver metastases patients receiving simultaneous resection using machine learning approaches: a multi-center study","volume":"593","author":"Chen","year":"2024","journal-title":"Cancer Lett"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225007342?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225007342?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T21:04:12Z","timestamp":1763327052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633225007342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1076633225007342"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2025.07.064","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-Brain Analysis of Increased Brain Iron in Patients with \u03b2-Thalassemia","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2025.07.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Association of Academic Radiology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}