{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:58:47Z","timestamp":1766145527534,"version":"3.48.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82327803"],"award-info":[{"award-number":["82327803"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.acra.2025.08.031","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T20:05:15Z","timestamp":1756843515000},"page":"7486-7495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative Analysis of MRI Features and Overall Survival: IDH-Wildtype Diffuse Lower-grade Glioma and Glioblastoma in Adults"],"prefix":"10.1016","volume":"32","author":[{"given":"Xiaojun","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujue","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoli","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fucai","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2980-5171","authenticated-orcid":false,"given":"Xin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.acra.2025.08.031_bib1","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"1","key":"10.1016\/j.acra.2025.08.031_bib2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/neuonc\/nox132","article-title":"Prognostic relevance of genetic alterations in diffuse lower-grade gliomas","volume":"20","author":"Aoki","year":"2018","journal-title":"Neuro Oncol"},{"issue":"5","key":"10.1016\/j.acra.2025.08.031_bib3","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00401-018-1905-0","article-title":"Distribution of EGFR amplification, combined chromosome 7 gain and chromosome 10 loss, and TERT promoter mutation in brain tumors and their potential for the reclassification of IDHwt astrocytoma to glioblastoma","volume":"136","author":"Stichel","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"10","key":"10.1016\/j.acra.2025.08.031_bib4","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/neuonc\/nox078","article-title":"Adult IDH wild-type lower-grade gliomas should be further stratified","volume":"19","author":"Aibaidula","year":"2017","journal-title":"Neuro Oncol"},{"issue":"5","key":"10.1016\/j.acra.2025.08.031_bib5","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1007\/s00401-018-1913-0","article-title":"cIMPACT-NOW update 3: recommended diagnostic criteria for \"Diffuse astrocytic glioma, IDH-wildtype, with molecular features of glioblastoma, WHO grade IV\"","volume":"136","author":"Brat","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"6","key":"10.1016\/j.acra.2025.08.031_bib6","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/neuonc\/noaa258","article-title":"IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification","volume":"23","author":"Berzero","year":"2021","journal-title":"Neuro Oncol"},{"issue":"4","key":"10.1016\/j.acra.2025.08.031_bib7","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/neuonc\/noz200","article-title":"Survival of diffuse astrocytic glioma, IDH1\/2 wildtype, with molecular features of glioblastoma, WHO grade IV: a confirmation of the cIMPACT-NOW criteria","volume":"22","author":"Tesileanu","year":"2020","journal-title":"Neuro Oncol"},{"issue":"10","key":"10.1016\/j.acra.2025.08.031_bib8","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1093\/neuonc\/noac089","article-title":"Prospective genomically guided identification of \"early\/evolving\" and \"undersampled\" IDH-wildtype glioblastoma leads to improved clinical outcomes","volume":"24","author":"Zhang","year":"2022","journal-title":"Neuro Oncol"},{"issue":"8","key":"10.1016\/j.acra.2025.08.031_bib9","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/noab106","article-title":"The 2021 WHO Classification of Tumors of the Central Nervous System: a summary","volume":"23","author":"Louis","year":"2021","journal-title":"Neuro Oncol"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib10","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1002\/jmri.28743","article-title":"The 2021 WHO Classification for Gliomas and Implications on Imaging Diagnosis: Part 1-Key Points of the Fifth Edition and Summary of Imaging Findings on Adult-Type Diffuse Gliomas","volume":"58","author":"Park","year":"2023","journal-title":"J Magn Reson Imaging"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.rxeng.2024.03.002","article-title":"Presurgical diagnosis of diffuse gliomas in adults: Post-WHO 2021 practical perspectives from radiologists in neuro-oncology units","volume":"66","author":"Pons-Escoda","year":"2024","journal-title":"Radiologia (Engl Ed"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11060-022-03995-9","article-title":"Gyriform infiltration as imaging biomarker for molecular glioblastomas","volume":"157","author":"Mesny","year":"2022","journal-title":"J Neurooncol"},{"issue":"33","key":"10.1016\/j.acra.2025.08.031_bib13","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1200\/JCO.23.01059","article-title":"RANO 2.0: Update to the Response Assessment in Neuro-Oncology Criteria for High- and Low-Grade Gliomas in Adults","volume":"41","author":"Wen","year":"2023","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.acra.2025.08.031_bib14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1148\/radiol.2020191832","article-title":"World Health Organization Grade II\/III Glioma Molecular Status: Prediction by MRI Morphologic Features and Apparent Diffusion Coefficient","volume":"296","author":"Maynard","year":"2020","journal-title":"Radiology"},{"issue":"9","key":"10.1016\/j.acra.2025.08.031_bib15","doi-asserted-by":"crossref","first-page":"3801","DOI":"10.1007\/s00330-018-5359-5","article-title":"Differentiation between primary CNS lymphoma and glioblastoma: qualitative and quantitative analysis using arterial spin labeling MR imaging","volume":"28","author":"You","year":"2018","journal-title":"Eur Radiol"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib16","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s11060-024-04737-9","article-title":"Comparative analysis of molecular and histological glioblastomas: insights into prognostic variance","volume":"169","author":"Lee","year":"2024","journal-title":"J Neurooncol"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib17","doi-asserted-by":"crossref","first-page":"E448","DOI":"10.1093\/neuros\/nyy513","article-title":"Radiological characteristics and natural history of adult IDH-wildtype astrocytomas with TERT promoter mutations","volume":"85","author":"Izquierdo","year":"2019","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.acra.2025.08.031_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s11060-020-03677-4","article-title":"Diffuse astrocytic glioma, IDH-Wildtype, with molecular features of glioblastoma, WHO grade IV: A single-institution case series and review","volume":"152","author":"Lee","year":"2021","journal-title":"J Neurooncol"},{"issue":"2","key":"10.1016\/j.acra.2025.08.031_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/neuros\/nyab136","article-title":"Magnetic resonance imaging parameters for noninvasive prediction of epidermal growth factor receptor amplification in isocitrate dehydrogenase-wild-type lower-grade gliomas: a multicenter study","volume":"89","author":"Park","year":"2021","journal-title":"Neurosurgery"},{"issue":"12","key":"10.1016\/j.acra.2025.08.031_bib20","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1007\/s00330-020-07090-3","article-title":"Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-wildtype lower-grade gliomas","volume":"30","author":"Park","year":"2020","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.acra.2025.08.031_bib21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12868-022-00750-8","article-title":"Feasibility of evaluating the histologic and genetic subtypes of WHO grade II-IV gliomas by diffusion-weighted imaging","volume":"23","author":"Liu","year":"2022","journal-title":"BMC Neurosci"},{"issue":"9","key":"10.1016\/j.acra.2025.08.031_bib22","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1093\/neuonc\/nov010","article-title":"Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis","volume":"17","author":"Spiegl-Kreinecker","year":"2015","journal-title":"Neuro Oncol"},{"issue":"9","key":"10.1016\/j.acra.2025.08.031_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41582-022-00679-w","article-title":"Clinical implications of the 2021 edition of the WHO classification of central nervous system tumours","volume":"18","author":"Horbinski","year":"2022","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"10.1016\/j.acra.2025.08.031_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18061295","article-title":"EGFR and EGFRvIII promote angiogenesis and cell invasion in glioblastoma: combination therapies for an effective treatment","volume":"18","author":"Keller","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib25","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s11060-022-04040-5","article-title":"The early infiltrative phase of GBM hypothesis: are molecular glioblastomas histological glioblastomas in the making? a preliminary multicenter study","volume":"158","author":"Ramos-Fresnedo","year":"2022","journal-title":"J Neurooncol"},{"issue":"1","key":"10.1016\/j.acra.2025.08.031_bib26","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s11060-022-03960-6","article-title":"The survival outcomes of molecular glioblastoma IDH-wildtype: a multicenter study","volume":"157","author":"Ramos-Fresnedo","year":"2022","journal-title":"J Neurooncol"},{"issue":"3","key":"10.1016\/j.acra.2025.08.031_bib27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10014-023-00463-8","article-title":"IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis","volume":"40","author":"Nakasu","year":"2023","journal-title":"Brain Tumor Pathol"},{"issue":"2","key":"10.1016\/j.acra.2025.08.031_bib28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11060-024-04656-9","article-title":"Revisiting prognostic factors of gliomatosis cerebri in adult-type diffuse gliomas","volume":"168","author":"Shin","year":"2024","journal-title":"J Neurooncol"},{"issue":"5","key":"10.1016\/j.acra.2025.08.031_bib29","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1093\/jnen\/nlab023","article-title":"Molecular characterization of \"True\" low-grade IDH-wildtype astrocytomas","volume":"80","author":"Richardson","year":"2021","journal-title":"J Neuropathol Exp Neurol"},{"issue":"5","key":"10.1016\/j.acra.2025.08.031_bib30","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13234","article-title":"Diagnostic utility of genetic alterations in distinguishing IDH-wildtype glioblastoma from lower-grade gliomas: Insight from next-generation sequencing analysis of 479 cases","volume":"34","author":"Lee","year":"2024","journal-title":"Brain Pathol"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225008013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225008013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T11:55:38Z","timestamp":1766145338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633225008013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S1076633225008013"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2025.08.031","relation":{},"ISSN":["1076-6332"],"issn-type":[{"type":"print","value":"1076-6332"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative Analysis of MRI Features and Overall Survival: IDH-Wildtype Diffuse Lower-grade Glioma and Glioblastoma in Adults","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2025.08.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Association of Academic Radiology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}