{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:47:34Z","timestamp":1776077254529,"version":"3.50.1"},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.acra.2025.12.034","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T20:23:37Z","timestamp":1768076617000},"page":"1556-1564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hemodynamic Patterns on Contrast-Enhanced Ultrasound Predict Semen Improvement After Varicocelectomy: A Novel Nomogram"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8231-1392","authenticated-orcid":false,"given":"Penglin","family":"Zou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiusheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianlin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.acra.2025.12.034_bib1","doi-asserted-by":"crossref","first-page":"748","DOI":"10.5534\/wjmh.240290","article-title":"Recent guidelines and perspectives for varicocele: a clinical consensus and recommendations from the Korean Society for sexual medicine and andrology","volume":"43","author":"Kim","year":"2025","journal-title":"World J Mens Health"},{"issue":"6","key":"10.1016\/j.acra.2025.12.034_bib2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1097\/JU.0000000000004180","article-title":"Updates to male infertility: AUA\/ASRM Guideline (2024)","volume":"212","author":"Brannigan","year":"2024","journal-title":"J Urol"},{"issue":"5","key":"10.1016\/j.acra.2025.12.034_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4103\/aja202420","article-title":"Predictive parameters of the efficacy of varicocele repair: a review","volume":"26","author":"Crafa","year":"2024","journal-title":"Asian J Androl"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4103\/aja2021125","article-title":"Predictors of microsurgical varicocelectomy efficacy in male infertility treatment: critical assessment and systematization","volume":"25","author":"Shomarufov","year":"2023","journal-title":"Asian J Androl"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12610-024-00249-8","article-title":"A new approach for hemodynamics of varicoceles: blood flow patterns based on contrast-enhanced ultrasound","volume":"35","author":"Zou","year":"2025","journal-title":"Basic Clin Androl"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.4103\/aja202248","article-title":"Intense venous reflux, quantified by a new software to analyze presurgical ultrasound, is associated with unfavorable outcomes of microsurgical varicocelectomy","volume":"25","author":"You","year":"2023","journal-title":"Asian J Androl"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/andr.12556","article-title":"The clinical usefulness of a novel grading system for varicocoeles using duplex Doppler ultrasound examination based on postsurgical modifications of seminal parameters","volume":"7","author":"Cavallini","year":"2019","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib8","doi-asserted-by":"crossref","first-page":"6517","DOI":"10.1038\/s41598-018-24890-2","article-title":"A novel method for investigating the role of reflux pattern in color doppler ultrasound for grading of varicocele","volume":"8","author":"Bagheri","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib9","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.mcna.2024.07.009","article-title":"Principles of doppler ultrasonography and basic applications for the clinician","volume":"109","author":"Goffi","year":"2025","journal-title":"Med Clin North Am"},{"issue":"8","key":"10.1016\/j.acra.2025.12.034_bib10","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s11547-025-02035-6","article-title":"Update on newer ultrasound systems to study the microvasculature","volume":"130","author":"Catalano","year":"2025","journal-title":"Radiol Med"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib11","first-page":"22","article-title":"General principles and overview of vascular contrast-enhanced ultrasonography","volume":"39","author":"Rafailidis","year":"2020","journal-title":"Ultrason Seoul Korea"},{"issue":"2","key":"10.1016\/j.acra.2025.12.034_bib12","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s00330-024-10964-5","article-title":"The role of the radiologist in the evaluation of male infertility: recommendations of the European Society of Urogenital Radiology-Scrotal and Penile Imaging Working Group (ESUR-SPIWG) for scrotal imaging","volume":"35","author":"Lotti","year":"2025","journal-title":"Eur Radiol"},{"key":"10.1016\/j.acra.2025.12.034_bib13","series-title":"In: World Health Organization. WHO laboratory manual for the examination and processing of human semen","first-page":"7","article-title":"Semen analysis","year":"2010"},{"issue":"8","key":"10.1016\/j.acra.2025.12.034_bib14","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1111\/andr.13281","article-title":"Prediction of semen analysis parameter improvement after varicocoelectomy using 1H NMR-based metabonomics assays","volume":"10","author":"Neto","year":"2022","journal-title":"Andrology"},{"key":"10.1016\/j.acra.2025.12.034_bib15","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.euros.2023.11.008","article-title":"Nomograms for predicting postoperative sperm improvements in varicocele patients","volume":"59","author":"Maimaitiming","year":"2024","journal-title":"Eur Urol Open Sci"},{"issue":"5","key":"10.1016\/j.acra.2025.12.034_bib16","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1590\/s1677-5538.ibju.2024.9917","article-title":"From pathophysiology to practice: addressing oxidative stress and sperm DNA fragmentation in Varicocele-affected subfertile men","volume":"50","author":"Lira","year":"2024","journal-title":"Int Braz J Urol Off J Braz Soc Urol"},{"issue":"2","key":"10.1016\/j.acra.2025.12.034_bib17","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3390\/biology13020080","article-title":"The evolving landscape of male varicocele pathophysiology in the era of multi-omics: a narrative review of the current literature","volume":"13","author":"Munoz-Lopez","year":"2024","journal-title":"Biology"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib18","doi-asserted-by":"crossref","first-page":"87","DOI":"10.5534\/wjmh.210153","article-title":"Oxidative stress: a comprehensive review of biochemical, molecular, and genetic aspects in the pathogenesis and management of varicocele","volume":"40","author":"Finelli","year":"2022","journal-title":"World J Mens Health"},{"issue":"6","key":"10.1016\/j.acra.2025.12.034_bib19","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/humrep\/deab065","article-title":"Reduced FSH and LH action: implications for medically assisted reproduction","volume":"36","author":"Bosch","year":"2021","journal-title":"Hum Reprod Oxf Engl"},{"issue":"11","key":"10.1016\/j.acra.2025.12.034_bib20","doi-asserted-by":"crossref","first-page":"5805","DOI":"10.3390\/ijms25115805","article-title":"Hormone regulation in testicular development and function","volume":"25","author":"Li","year":"2024","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.acra.2025.12.034_bib21","first-page":"E27","article-title":"Preoperative follicle-stimulating hormone: a\u00a0factor associated with semen parameter improvement after microscopic subinguinal varicocelectomy","volume":"14","author":"Madhusoodanan","year":"2020","journal-title":"Can Urol Assoc J"},{"issue":"11","key":"10.1016\/j.acra.2025.12.034_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/and.13887","article-title":"Can preoperative gonadotropin and testosterone levels predict the success of varicocelectomy?","volume":"52","author":"Ok","year":"2020","journal-title":"Andrologia"},{"key":"10.1016\/j.acra.2025.12.034_bib23","doi-asserted-by":"crossref","unstructured":"Tay JK, Narasimhan B, Hastie T. Elastic net regularization paths for all generalized linear models. J Stat Softw 2023; 106(1):1\u201331. https:\/\/doi.org\/10.18637\/jss.v106.i01, https:\/\/www.jstatsoft.org\/article\/view\/v106i01.","DOI":"10.18637\/jss.v106.i01"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225011699?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633225011699?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:55:06Z","timestamp":1776074106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633225011699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1076633225011699"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2025.12.034","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hemodynamic Patterns on Contrast-Enhanced Ultrasound Predict Semen Improvement After Varicocelectomy: A Novel Nomogram","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2025.12.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Association of Academic Radiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}