{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:15:21Z","timestamp":1780503321057,"version":"3.54.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.acra.2026.03.002","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T11:41:36Z","timestamp":1776771696000},"page":"3061-3075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Disrupted Structural and Metabolic Brain Networks with Structural - Metabolic Decoupling in Parkinson's Disease: An Integrated PET\/MRI Study"],"prefix":"10.1016","volume":"33","author":[{"given":"Mengjiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-9150","authenticated-orcid":false,"given":"Peng","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehao","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yexin","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5996-7089","authenticated-orcid":false,"given":"Changjiu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib1","first-page":"434","article-title":"Premotor and nonmotor features of Parkinson's disease","volume":"27","author":"Goldman","year":"2014","journal-title":"Curr\u00a0Opin\u00a0Neurol"},{"issue":"10423","key":"10.1016\/j.acra.2026.03.002_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson's disease","volume":"403","author":"Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"issue":"s1","key":"10.1016\/j.acra.2026.03.002_bib3","first-page":"S51","article-title":"The synucleinopathies: twenty years on","volume":"7","author":"Goedert","year":"2017","journal-title":"J\u00a0Parkinsons Dis"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib4","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s40478-018-0587-0","article-title":"Rapid dissemination of alpha-synuclein seeds through neural circuits in an in-vivo prion-like seeding experiment","volume":"6","author":"Okuzumi","year":"2018","journal-title":"Acta Neuropathol Commun"},{"issue":"12","key":"10.1016\/j.acra.2026.03.002_bib5","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1002\/hbm.23324","article-title":"Characterizing structural neural networks in de novo Parkinson disease patients using diffusion tensor imaging","volume":"37","author":"Nigro","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.acra.2026.03.002_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118503","article-title":"Advances in resting state fMRI acquisitions for functional connectomics","volume":"243","author":"Raimondo","year":"2021","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib7","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1177\/0271678X16654497","article-title":"Metabolic connectomics targeting brain pathology in dementia with Lewy bodies","volume":"37","author":"Caminiti","year":"2017","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib8","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s11065-022-09559-y","article-title":"Global alterations of whole brain structural connectome in Parkinson's disease: a meta-analysis","volume":"33","author":"Zuo","year":"2023","journal-title":"Neuropsychol Rev"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib9","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.1038\/s41598-017-04102-z","article-title":"Altered brain metabolic connectivity at multiscale level in early Parkinson's disease","volume":"7","author":"Sala","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib10","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1038\/s41467-022-29770-y","article-title":"Local structure-function relationships in human brain networks across the lifespan","volume":"13","author":"Zamani Esfahlani","year":"2022","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib11","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s42003-020-01622-9","article-title":"Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson's disease","volume":"4","author":"Zarkali","year":"2021","journal-title":"Commun Biol"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib12","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12868-024-00918-4","article-title":"Structural-functional connectivity decoupling in multiscale brain networks in Parkinson's disease","volume":"25","author":"Zou","year":"2024","journal-title":"BMC Neurosci"},{"issue":"5","key":"10.1016\/j.acra.2026.03.002_bib13","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/brain.2012.0086","article-title":"Metabolic brain covariant networks as revealed by FDG-PET with reference to resting-state fMRI networks","volume":"2","author":"Di","year":"2012","journal-title":"Brain Connect"},{"issue":"6","key":"10.1016\/j.acra.2026.03.002_bib14","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/WCO.0000000000000494","article-title":"Metabolic connectivity: methods and applications","volume":"30","author":"Yakushev","year":"2017","journal-title":"Curr Opin Neurol"},{"issue":"2","key":"10.1016\/j.acra.2026.03.002_bib15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"E. Staging of brain pathology related to sporadic Parkinson's disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol Aging"},{"issue":"3","key":"10.1016\/j.acra.2026.03.002_bib16","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/j.neuroimage.2003.07.002","article-title":"C. Resting-state brain glucose utilization as measured by PET is directly","volume":"20","author":"Rocher","year":"2003","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib17","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1007\/s00259-021-05590-y","article-title":"Mapping covariance in brain FDG uptake to structural connectivity","volume":"49","author":"Yakushev","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"12","key":"10.1016\/j.acra.2026.03.002_bib18","first-page":"1591","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov\u00a0Disord"},{"issue":"3","key":"10.1016\/j.acra.2026.03.002_bib19","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1152\/jn.00338.2011","article-title":"The organization of the human cerebral cortex estimated by intrinsic functional connectivity","volume":"106","author":"Yeo","year":"2011","journal-title":"J Neurophysiol"},{"issue":"5","key":"10.1016\/j.acra.2026.03.002_bib20","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s12264-018-0240-8","article-title":"An automatic method for generating an unbiased intensity normalizing factor in positron emission tomography image analysis after stroke","volume":"34","author":"Nie","year":"2018","journal-title":"Neurosci Bull"},{"issue":"3","key":"10.1016\/j.acra.2026.03.002_bib21","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.neuroimage.2009.10.003","article-title":"Complex network measures of brain connectivity: uses and interpretations","volume":"52","author":"Rubinov","year":"2010","journal-title":"Neuroimage"},{"issue":"6684","key":"10.1016\/j.acra.2026.03.002_bib22","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/30918","article-title":"SS. Collective dynamics of \u201csmallworld\u201d networks","volume":"393","author":"Watts","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.acra.2026.03.002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116137","article-title":"MRtrix3: A fast, flexible and open software framework for medical image processing and visualisation","volume":"202","author":"Tournier","year":"2019","journal-title":"Neuroimage"},{"key":"10.1016\/j.acra.2026.03.002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110899","article-title":"Topological alteration of the brain structural network in Parkinson's disease with apathy","volume":"208","author":"Ge","year":"2024","journal-title":"Brain Res Bull"},{"issue":"7","key":"10.1016\/j.acra.2026.03.002_bib25","article-title":"A FDG-PET study of metabolic networks in apolipoprotein E \u03b54 allele carriers","volume":"10","author":"He","year":"2015","journal-title":"Plos One"},{"issue":"9","key":"10.1016\/j.acra.2026.03.002_bib26","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1093\/brain\/awad150","article-title":"Advances in understanding the function of alpha-synuclein: implications for Parkinson\u2019s disease","volume":"146","author":"Calabresi","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.acra.2026.03.002_bib27","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.nbd.2016.12.008","article-title":"Effects of alpha-synuclein on axonal transport","volume":"105","author":"Volpicelli-Daley","year":"2017","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.acra.2026.03.002_bib28","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.nicl.2016.12.019","article-title":"Changes in functional organization and white matter integrity in the connectome in Parkinson's disease","volume":"13","author":"Tinaz","year":"2016","journal-title":"Neuroimage Clin"},{"issue":"12","key":"10.1016\/j.acra.2026.03.002_bib29","first-page":"4121","article-title":"Network structure and function in Parkinson's Disease","volume":"28","author":"Ko","year":"2018","journal-title":"Cereb Cortex"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib30","first-page":"768","article-title":"Amygdala neurodegeneration: a key driver of visual dysfunction in Parkinson's disease","volume":"12","author":"Erramuzpe","year":"2025","journal-title":"Ann\u00a0Clin\u00a0Translat\u00a0Neurol"},{"issue":"8","key":"10.1016\/j.acra.2026.03.002_bib31","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1002\/hbm.25393","article-title":"The default mode network and cognition in Parkinson's disease: a multimodal resting-state network approach","volume":"42","author":"Ruppert","year":"2021","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.1016\/j.acra.2026.03.002_bib32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s11682-024-00862-1","article-title":"Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease","volume":"18","author":"Chen","year":"2024","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.acra.2026.03.002_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116241","article-title":"Comparison of resting-state functional connectivity in marmosets with tracer-based cellular connectivity","volume":"204","author":"Hori","year":"2020","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib34","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.1038\/s41467-024-51395-6","article-title":"Mapping the structure-function relationship along macroscale gradients in the human brain","volume":"15","author":"Collins","year":"2024","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib35","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.tics.2020.01.008","article-title":"Linking structure and function in macroscale brain networks","volume":"24","author":"Suarez","year":"2020","journal-title":"Trends Cogn Sci"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/WCO.0000000000000109","article-title":"FDG-PET and amyloid-PET imaging: the diverging paths","volume":"27","author":"Perani","year":"2014","journal-title":"Curr Opin Neurol"},{"issue":"1","key":"10.1016\/j.acra.2026.03.002_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2967\/jnumed.116.183152","article-title":"Metabolic imaging in Parkinson Disease","volume":"58","author":"Meles","year":"2017","journal-title":"J Nucl Med"},{"issue":"2","key":"10.1016\/j.acra.2026.03.002_bib38","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1177\/0271678X231204769","article-title":"Similarity between structural and proxy estimates of brain connectivity","volume":"44","author":"Lizarraga","year":"2024","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib39","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209678","article-title":"Pathologic substrates of structural brain network resilience and topology in Parkinson disease decedents","volume":"103","author":"Frigerio","year":"2024","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.acra.2026.03.002_bib40","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1093\/cercor\/bhaa335","article-title":"Sex differences in anatomical rich-club and structural-functional coupling in the human brain network","volume":"31","author":"Zhao","year":"2021","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.acra.2026.03.002_bib41","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neuroimage.2015.09.009","article-title":"The contribution of geometry to the human connectome","volume":"124","author":"Roberts","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.acra.2026.03.002_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.neuroimage.2016.12.061","article-title":"The dynamic functional connectome: state-of-the-art and perspectives","volume":"160","author":"Preti","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.acra.2026.03.002_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106323","article-title":"Neurovascular coupling dysfunction of visual network organization in Parkinson's disease","volume":"188","author":"Li","year":"2023","journal-title":"Neurobiol Dis"},{"issue":"2","key":"10.1016\/j.acra.2026.03.002_bib44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s11682-017-9764-1","article-title":"Imaging behavioural complications of Parkinson's disease","volume":"13","author":"Valli","year":"2019","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.acra.2026.03.002_bib45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejrad.2017.05.018","article-title":"Functional and structural changes in gray matter of parkinson's disease patients with mild cognitive impairment","volume":"93","author":"Chen","year":"2017","journal-title":"Eur J Radiol"},{"issue":"7","key":"10.1016\/j.acra.2026.03.002_bib46","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/hbm.22006","article-title":"Prefrontal dopaminergic receptor abnormalities and executive functions in Parkinson's disease","volume":"34","author":"Ko","year":"2013","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.1016\/j.acra.2026.03.002_bib47","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/brain\/awaa019","article-title":"Network degeneration in Parkinson's disease: multimodal imaging of nigro-striato-cortical dysfunction","volume":"143","author":"Ruppert","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.acra.2026.03.002_bib48","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fnins.2019.00080","article-title":"Abnormal dynamic functional connectivity associated with subcortical networks in Parkinson's disease: a temporal variability perspective","volume":"13","author":"Zhu","year":"2019","journal-title":"Front Neurosci"},{"issue":"9","key":"10.1016\/j.acra.2026.03.002_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12091248","article-title":"Imaging the limbic system in Parkinson's disease-a review of limbic pathology and clinical symptoms","volume":"12","author":"Banwinkler","year":"2022","journal-title":"Brain Sci"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633226001698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633226001698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:38:58Z","timestamp":1780501138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633226001698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S1076633226001698"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2026.03.002","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted Structural and Metabolic Brain Networks with Structural - Metabolic Decoupling in Parkinson's Disease: An Integrated PET\/MRI Study","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2026.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Association of Academic Radiology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}