{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T20:23:09Z","timestamp":1787516589450,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J011618"],"award-info":[{"award-number":["2024J011618"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013095","name":"Science and Technology Project of Longyan City","doi-asserted-by":"publisher","award":["2024LYF17027"],"award-info":[{"award-number":["2024LYF17027"]}],"id":[{"id":"10.13039\/501100013095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.acra.2026.06.006","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:23:08Z","timestamp":1782588188000},"page":"3758-3767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual-layer Spectral Detector CT Quantitative Parameters for Predicting Tumor Budding Grade and Prognosis in Stage \u2161 Colorectal Cancer"],"prefix":"10.1016","volume":"33","author":[{"given":"Pingtai","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Langlang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junli","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huipeng","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2978-4358","authenticated-orcid":false,"given":"Jinkai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.acra.2026.06.006_bib1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"issue":"8","key":"10.1016\/j.acra.2026.06.006_bib2","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1200\/JCO.21.02538","article-title":"Adjuvant Therapy for Stage II Colon Cancer: ASCO Guideline Update","volume":"40","author":"Baxter","year":"2022","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.acra.2026.06.006_bib3","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.annonc.2025.05.537","article-title":"Enhanced risk stratification for stage II colorectal cancer using deep learning-based CT classifier and pathological markers to optimize adjuvant therapy decision","volume":"36","author":"Huang","year":"2025","journal-title":"Ann Oncol"},{"key":"10.1016\/j.acra.2026.06.006_bib4","article-title":"Adjuvant chemotherapy benefit in Elderly Stage II\/III colon cancer patients","volume":"12","author":"Chen","year":"2022","journal-title":"Front Oncol"},{"issue":"4","key":"10.1016\/j.acra.2026.06.006_bib5","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/jso.26970","article-title":"Adjuvant chemotherapy is associated with improved overall survival in select patients with Stage II colon cancer: A National Cancer Database analysis","volume":"126","author":"Grant","year":"2022","journal-title":"J Surg Oncol"},{"issue":"1","key":"10.1016\/j.acra.2026.06.006_bib6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1001\/jamaoncol.2023.5098","article-title":"Incidence of recurrence and time to recurrence in stage I to III colorectal cancer: a Nationwide Danish Cohort Study","volume":"10","author":"Nors","year":"2024","journal-title":"JAMA Oncol"},{"issue":"10","key":"10.1016\/j.acra.2026.06.006_bib7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.6004\/jnccn.2022.0051","article-title":"Rectal cancer, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Benson","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"issue":"3","key":"10.1016\/j.acra.2026.06.006_bib8","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/cjp2.73","article-title":"Cytokeratin-based assessment of tumour budding in colorectal cancer: analysis in stage II patients and prospective diagnostic experience","volume":"3","author":"Koelzer","year":"2017","journal-title":"J Pathol Clin Res"},{"issue":"2","key":"10.1016\/j.acra.2026.06.006_bib9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/10668969241265017","article-title":"Tumour budding is a useful predictor to identify high-risk Stage II colon cancer patients after curative surgery","volume":"33","author":"Zengin","year":"2025","journal-title":"Int J Surg Pathol"},{"issue":"10","key":"10.1016\/j.acra.2026.06.006_bib10","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.1007\/s00330-025-11612-2","article-title":"Intravoxel incoherent motion-derived histogram analysis for quantitative evaluation of tumor budding and prognostic stratification in rectal cancer","volume":"35","author":"Yang","year":"2025","journal-title":"Eur Radiol"},{"issue":"12","key":"10.1016\/j.acra.2026.06.006_bib11","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1245\/s10434-012-2426-z","article-title":"Tumor budding is an independent predictor of outcome in AJCC\/UICC stage II colorectal cancer","volume":"19","author":"Betge","year":"2012","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"10.1016\/j.acra.2026.06.006_bib12","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.21873\/invivo.12898","article-title":"Tumor budding as a predictive marker of relapse and survival in patients with stage II colon cancer","volume":"36","author":"Saito","year":"2022","journal-title":"Vivo"},{"issue":"2","key":"10.1016\/j.acra.2026.06.006_bib13","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1007\/s00261-025-05112-6","article-title":"Multi-DECT image-based radiomics with interpretable machine learning for preoperative prediction of tumor budding grade and prognosis in colorectal cancer: a dual-center study","volume":"51","author":"Lin","year":"2026","journal-title":"Abdom Radiol"},{"issue":"7","key":"10.1016\/j.acra.2026.06.006_bib14","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1016\/j.acra.2025.02.028","article-title":"A Preoperative CT-based multiparameter deep learning and radiomic model with extracellular volume parameter images can predict the tumor budding grade in rectal cancer patients","volume":"32","author":"Tang","year":"2025","journal-title":"Acad Radiol"},{"issue":"6","key":"10.1016\/j.acra.2026.06.006_bib15","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1016\/j.acra.2023.11.023","article-title":"Preoperative noninvasive evaluation of tumor budding in rectal cancer using multiparameter mri radiomics","volume":"31","author":"Peng","year":"2024","journal-title":"Acad Radiol"},{"issue":"8","key":"10.1016\/j.acra.2026.06.006_bib16","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1016\/j.acra.2025.03.046","article-title":"Prediction of tumor budding grading in rectal cancer using a multiparametric MRI radiomics combined with a 3D vision transformer deep learning approach","volume":"32","author":"Liu","year":"2025","journal-title":"Acad Radiol"},{"issue":"5","key":"10.1016\/j.acra.2026.06.006_bib17","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00330-020-07413-4","article-title":"Imaging alternatives to colonoscopy: CT colonography and colon capsule. European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastrointestinal and Abdominal Radiology (ESGAR) Guideline - update 2020","volume":"31","author":"Spada","year":"2021","journal-title":"Eur Radiol"},{"key":"10.1016\/j.acra.2026.06.006_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejrad.2024.111594","article-title":"Quantitative parameters of dual-layer spectral detector computed tomography for evaluating differentiation grade and lymphovascular and perineural invasion in colorectal adenocarcinoma","volume":"178","author":"Chen","year":"2024","journal-title":"Eur J Radiol"},{"issue":"5","key":"10.1016\/j.acra.2026.06.006_bib19","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1097\/JCMA.0000000000000706","article-title":"Application of dual-layer spectral detector computed tomography to evaluate the expression of Ki-67 in colorectal cancer","volume":"85","author":"Wang","year":"2022","journal-title":"J Chin Med Assoc"},{"issue":"9","key":"10.1016\/j.acra.2026.06.006_bib20","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/modpathol.2017.46","article-title":"Recommendations for reporting tumor budding in colorectal cancer based on the International Tumor Budding Consensus Conference (ITBCC) 2016","volume":"30","author":"Lugli","year":"2017","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.acra.2026.06.006_bib21","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00384-019-03478-w","article-title":"High-grade intratumoral tumor budding is a predictor for lymphovascular invasion and adverse outcome in stage II colorectal cancer","volume":"35","author":"Marx","year":"2020","journal-title":"Int J Colorectal Dis"},{"issue":"1","key":"10.1016\/j.acra.2026.06.006_bib22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00423-023-02864-x","article-title":"Is there no need to discuss adjuvant chemotherapy in stage II colon cancer patients with high tumor budding and lymphovascular invasion?","volume":"408","author":"Zenger","year":"2023","journal-title":"Langenbecks Arch Surg"},{"issue":"7","key":"10.1016\/j.acra.2026.06.006_bib23","doi-asserted-by":"crossref","first-page":"651","DOI":"10.18632\/oncotarget.199","article-title":"Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: tumor budding as oncotarget","volume":"1","author":"Zlobec","year":"2010","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.acra.2026.06.006_bib24","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1016\/j.humpath.2011.02.010","article-title":"Intratumoral budding as a potential parameter of tumor progression in mismatch repair-proficient and mismatch repair-deficient colorectal cancer patients","volume":"42","author":"Lugli","year":"2011","journal-title":"Hum Pathol"},{"issue":"5","key":"10.1016\/j.acra.2026.06.006_bib25","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.21037\/jgo-2025-112","article-title":"Preoperative prediction of tumor budding in colorectal cancer based on quantitative parameters of dual-layer detector spectral computed tomography: a preliminary study","volume":"16","author":"Li","year":"2025","journal-title":"J Gastrointest Oncol"},{"issue":"8","key":"10.1016\/j.acra.2026.06.006_bib26","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1007\/s00261-025-04803-4","article-title":"Preoperative prediction of tumor budding and lymphovascular invasion in colon cancer using dual-energy CT: a prospective study with internal model validation","volume":"50","author":"Shao","year":"2025","journal-title":"Abdom Radiol"},{"issue":"1","key":"10.1016\/j.acra.2026.06.006_bib27","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-022-02300-w","article-title":"Tumor bud-derived CCL5 recruits fibroblasts and promotes colorectal cancer progression via CCR5-SLC25A24 signaling","volume":"41","author":"Ling-Fang","year":"2022","journal-title":"J Exp Clin Canc Res"},{"issue":"3","key":"10.1016\/j.acra.2026.06.006_bib28","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.3892\/ol.2020.11811","article-title":"Tumor budding index and microvessel density assessment in patients with endometrial cancer: a pilot study","volume":"20","author":"Tomasz","year":"2020","journal-title":"Oncol Lett"},{"issue":"11","key":"10.1016\/j.acra.2026.06.006_bib29","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.3390\/biomedicines11112906","article-title":"Prognostic value of tumor budding for early breast cancer","volume":"11","author":"Silva","year":"2023","journal-title":"Biomedicines"},{"issue":"5","key":"10.1016\/j.acra.2026.06.006_bib30","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1097\/RCT.0000000000000441","article-title":"Lesion size and iodine quantification to distinguish low-grade from high-grade clear cell renal cell carcinoma using dual-energy spectral computed tomography","volume":"40","author":"Jinkun","year":"2016","journal-title":"J Comput Assist Tomogr"},{"issue":"07","key":"10.1016\/j.acra.2026.06.006_bib31","first-page":"1270","article-title":"Quantitative parameters of dual-energy CT for predicting high-grade tumor budding of colon cancer","volume":"44","author":"Dong","year":"2025","journal-title":"J Clin Radiol"},{"issue":"1","key":"10.1016\/j.acra.2026.06.006_bib32","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.humpath.2015.08.007","article-title":"Tumor budding in colorectal cancer-ready for diagnostic practice?","volume":"47","author":"Koelzer","year":"2016","journal-title":"Hum Pathol"},{"issue":"5","key":"10.1016\/j.acra.2026.06.006_bib33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00428-015-1740-9","article-title":"Tumor budding in colorectal cancer revisited: results of a multicenter interobserver study","volume":"466","author":"Koelzer","year":"2015","journal-title":"Virchows Arch"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633226004204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633226004204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T20:11:16Z","timestamp":1787515876000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633226004204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S1076633226004204"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2026.06.006","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-layer Spectral Detector CT Quantitative Parameters for Predicting Tumor Budding Grade and Prognosis in Stage \u2161 Colorectal Cancer","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2026.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Association of Academic Radiology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}