{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:47:07Z","timestamp":1791751627489,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-KJFZMSX0098"],"award-info":[{"award-number":["CSTB2024NSCQ-KJFZMSX0098"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["CSTB2025NSCQ-GPX0699"],"award-info":[{"award-number":["CSTB2025NSCQ-GPX0699"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032579","name":"Beijing Medical Award Foundation","doi-asserted-by":"publisher","award":["YXJL-2025-0483-0259"],"award-info":[{"award-number":["YXJL-2025-0483-0259"]}],"id":[{"id":"10.13039\/100032579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["academicradiology.org","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Academic Radiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.acra.2026.08.063","type":"journal-article","created":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T11:25:49Z","timestamp":1789212349000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between CT-Based Body Composition and Cardiotoxicity and Overall Survival in Patients with Prostate Cancer"],"prefix":"10.1016","author":[{"given":"Xun","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0239-6988","authenticated-orcid":false,"given":"Jiuquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.acra.2026.08.063_bib1","article-title":"Correlation between second and first primary cancer: systematic review and meta-analysis of 9 million cancer patients","volume":"111","author":"Wang","year":"2023","journal-title":"Br J Surg"},{"key":"10.1016\/j.acra.2026.08.063_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.6004\/jnccn.2022.7083","article-title":"Androgen deprivation therapy and risk of cardiovascular disease in patients with prostate cancer based on existence of cardiovascular risk","volume":"21","author":"Alice","year":"2023","journal-title":"J Natl Compr Cancer Netw"},{"key":"10.1016\/j.acra.2026.08.063_bib3","first-page":"825","article-title":"Adverse effects of androgen deprivation therapy and strategies to mitigate them","volume":"67","author":"Paul","year":"2014","journal-title":"Eur Urol"},{"key":"10.1016\/j.acra.2026.08.063_bib4","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Hyuna","year":"2021","journal-title":"CA Cancer J\u00a0Clin"},{"key":"10.1016\/j.acra.2026.08.063_bib5","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030447","article-title":"Cancer therapy-related cardiac dysfunction in patients with prostate cancer undergoing androgen deprivation therapy","volume":"12","author":"Chen","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.acra.2026.08.063_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jare.2025.09.028","article-title":"Cancer stem cell plasticity in shaping drug resistance landscapes in prostate cancer","volume":"84","author":"Zhang","year":"2026","journal-title":"J Adv Res"},{"key":"10.1016\/j.acra.2026.08.063_bib7","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1097\/JS9.0000000000001479","article-title":"Comparative investigation of neoadjuvant immunotherapy versus adjuvant immunotherapy in perioperative patients with cancer: a global-scale, cross-sectional, and large-sample informatics study","volume":"11","author":"Guo","year":"2024","journal-title":"Int J Surg"},{"key":"10.1016\/j.acra.2026.08.063_bib8","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1200\/JCO-25-00007","article-title":"Systemic therapy in patients with metastatic castration-resistant prostate cancer: ASCO guideline update","volume":"43","author":"Garje","year":"2025","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.acra.2026.08.063_bib9","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1038\/onc.2013.206","article-title":"Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches","volume":"32","author":"T","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.acra.2026.08.063_bib10","article-title":"Efficacy of testosterone replacement therapy in correcting anemia in men with hypogonadism: a randomized clinical trial","volume":"6","author":"Karol","year":"2023","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.acra.2026.08.063_bib11","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.3390\/cancers14071803","article-title":"Androgen deprivation therapy in high-risk localized and locally advanced prostate cancer","volume":"14","author":"Iwamoto","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.acra.2026.08.063_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.urology.2024.06.037","article-title":"Balancing efficacy and cardiotoxicity in prostate cancer therapy: a call for precision in treatment strategies","volume":"87","author":"Omar","year":"2024","journal-title":"Eur Urol"},{"key":"10.1016\/j.acra.2026.08.063_bib13","first-page":"e333","article-title":"2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS)","volume":"24","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acra.2026.08.063_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.101830","article-title":"Risk profiles and incidence of cardiovascular events across different cancer types","volume":"8","author":"Mitchell","year":"2023","journal-title":"ESMO Open"},{"key":"10.1016\/j.acra.2026.08.063_bib15","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jaccao.2024.05.015","article-title":"Predictive performance of cardiovascular risk scores in cancer survivors from the UK Biobank","volume":"6","author":"Celeste","year":"2024","journal-title":"JACC Cardio\u00a0Oncol"},{"key":"10.1016\/j.acra.2026.08.063_bib16","article-title":"Cancer therapy-related cardiac dysfunction in patients with prostate cancer undergoing androgen deprivation therapy","volume":"12","author":"Dong-Yi","year":"2023","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.acra.2026.08.063_bib17","article-title":"Develop prediction model to help forecast advanced prostate cancer patients' prognosis after surgery using neural network","volume":"15","author":"Shanshan","year":"2024","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.acra.2026.08.063_bib18","first-page":"776","article-title":"Major adverse cardiovascular events of enzalutamide versus abiraterone in prostate cancer: a retrospective cohort study","volume":"27","author":"Yan Hiu Athena","year":"2023","journal-title":"Prostate Cancer Prostatic Dis"},{"key":"10.1016\/j.acra.2026.08.063_bib19","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1210\/endrev\/bnaa016","article-title":"Muscle-organ crosstalk: the emerging roles of myokines","volume":"41","author":"Severinsen","year":"2020","journal-title":"Endocr Rev"},{"key":"10.1016\/j.acra.2026.08.063_bib20","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1056\/NEJMcibr1203160","article-title":"Targeting the skeletal muscle-metabolism axis in prostate-cancer therapy","volume":"367","author":"Shehzad","year":"2012","journal-title":"New Engl J Med"},{"key":"10.1016\/j.acra.2026.08.063_bib21","first-page":"229","article-title":"Low-density lipoprotein cholesterol and prostate cancer: a retrospective study","volume":"77","author":"Pengcheng","year":"2024","journal-title":"Arch Esp\u00a0Urol"},{"key":"10.1016\/j.acra.2026.08.063_bib22","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jaccao.2024.08.004","article-title":"Body composition during androgen deprivation therapy in prostate cancer: a target to reduce cardiovascular risk","volume":"6","author":"Lee","year":"2024","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.acra.2026.08.063_bib23","first-page":"253","article-title":"The cardiovascular effects of gonadotropin-releasing hormone antagonists in men with prostate cancer","volume":"8","author":"Filipe","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acra.2026.08.063_bib24","first-page":"1036","article-title":"The clinical relevance of adiposity when assessing muscle health in men treated with androgen deprivation for prostate cancer","volume":"10","author":"Patrick","year":"2019","journal-title":"J Cachexia\u00a0Sarcopenia Muscle"},{"key":"10.1016\/j.acra.2026.08.063_bib25","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1093\/jnci\/djae107","article-title":"Long-term cardiovascular disease risk after anthracycline and trastuzumab treatments in US breast cancer survivors","volume":"116","author":"Jacqueline","year":"2024","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.acra.2026.08.063_bib26","article-title":"Association between increased C-reactive protein and cardiovascular disease among patients with rectal cancer","volume":"13","author":"Hui","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.acra.2026.08.063_bib27","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10549-016-3923-8","article-title":"Impact of body mass index (BMI) on the prognosis of high-risk early breast cancer (EBC) patients treated with adjuvant chemotherapy","volume":"159","author":"Alessandra","year":"2016","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.acra.2026.08.063_bib28","first-page":"264","article-title":"Body composition, adherence to anthracycline and taxane-based chemotherapy, and survival after nonmetastatic breast cancer","volume":"6","author":"Elizabeth","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.acra.2026.08.063_bib29","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.jaccao.2024.07.011","article-title":"Adiposity and muscle strength in men with prostate cancer and cardiovascular outcomes","volume":"6","author":"Darryl","year":"2024","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.acra.2026.08.063_bib30","article-title":"Androgen deprivation therapy-induced muscle loss and fat gain predict cardiovascular events in prostate cancer patients","volume":"16","author":"Jie","year":"2025","journal-title":"J Cachexia\u00a0Sarcopenia Muscle"},{"key":"10.1016\/j.acra.2026.08.063_bib31","first-page":"1408","article-title":"Computed tomography-defined low skeletal muscle index and density in cancer patients: observations from a systematic review","volume":"12","author":"Josh","year":"2021","journal-title":"J Cachexia\u00a0Sarcopenia Muscle"},{"key":"10.1016\/j.acra.2026.08.063_bib32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1139\/H08-075","article-title":"A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care","volume":"33","author":"Marina","year":"2008","journal-title":"Appl Physiol Nutr Metab"},{"key":"10.1016\/j.acra.2026.08.063_bib33","first-page":"2114","article-title":"Association of malignant ascites with systemic inflammation and muscle loss after treatment in advanced-stage ovarian cancer","volume":"14","author":"Chia-Sui","year":"2023","journal-title":"J Cachexia\u00a0Sarcopenia Muscle"},{"key":"10.1016\/j.acra.2026.08.063_bib34","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3803\/EnM.2021.1041","article-title":"Reference values for skeletal muscle mass at the third lumbar vertebral level measured by computed tomography in a healthy Korean population","volume":"36","author":"Ja Kyung","year":"2021","journal-title":"Endocrinol Metab"},{"key":"10.1016\/j.acra.2026.08.063_bib35","article-title":"Development of formulas for calculating L3 Skeletal Muscle Mass Index and visceral fat area based on anthropometric parameters","volume":"9","author":"Wei","year":"2022","journal-title":"Front Nutr"},{"key":"10.1016\/j.acra.2026.08.063_bib36","first-page":"1063","article-title":"Expert consensus for multimodality imaging evaluation of adult patients during and after cancer therapy: a report from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"15","author":"Juan Carlos","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acra.2026.08.063_bib37","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehad655.2677","article-title":"Androgen deprivation therapy for prostate cancer, measures of adiposity and strength, and adverse cardiovascular outcomes: observations from 3000 men in 5 countries in the RADICAL PC study","volume":"44","author":"Leong","year":"2023","journal-title":"Eur Heart J"},{"key":"10.1016\/j.acra.2026.08.063_bib38","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.2147\/CMAR.S160901","article-title":"Association of low skeletal muscle index with increased systematic inflammatory responses and interferon \u03b3-induced protein 10 levels in patients with colon cancer","volume":"10","author":"Wen","year":"2018","journal-title":"Cancer Manag Res"},{"key":"10.1016\/j.acra.2026.08.063_bib39","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1056\/NEJMcibr1203160","article-title":"Targeting the skeletal muscle-metabolism axis in prostate-cancer therapy","volume":"367","author":"Basaria","year":"2012","journal-title":"New Engl J Med"},{"key":"10.1016\/j.acra.2026.08.063_bib40","article-title":"Underestimation of cardiovascular risk by QRISK3 and RA-adapted SCORE2 in a Chinese rheumatoid arthritis population","volume":"13","author":"Li","year":"2026","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.acra.2026.08.063_bib41","article-title":"Cardiovascular disease risk prediction in multi-ethnic Asian populations: evidence from two population-based cohorts in Singapore","volume":"66","author":"Lim","year":"2026","journal-title":"Lancet Reg Health\u00a0West Pac"},{"key":"10.1016\/j.acra.2026.08.063_bib42","first-page":"1811","article-title":"Physical exercise for bone health in men with prostate cancer receiving androgen deprivation therapy: a systematic review","volume":"29","author":"Barbara","year":"2020","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.acra.2026.08.063_bib43","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10522-021-09932-z","article-title":"Sarcopenia versus cancer cachexia: the muscle wasting continuum in healthy and diseased aging","volume":"22","author":"Alexandra","year":"2021","journal-title":"Biogerontology"},{"key":"10.1016\/j.acra.2026.08.063_bib44","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1001\/jamaoncol.2019.0695","article-title":"Body composition and cardiovascular events in patients with colorectal cancer: a population-based retrospective cohort study","volume":"5","author":"Justin","year":"2019","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.acra.2026.08.063_bib45","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1001\/jamacardio.2025.5586","article-title":"Coronary plaque progression after androgen deprivation therapy in men with prostate cancer: a randomized clinical trial","volume":"11","author":"Patel","year":"2026","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.acra.2026.08.063_bib46","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/pros.24096","article-title":"Risk of major adverse cardiovascular events among second-line hormonal therapy for metastatic castration-resistant prostate cancer: a real-world evidence study","volume":"81","author":"Liu","year":"2021","journal-title":"Prostate"}],"container-title":["Academic Radiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633226006768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1076633226006768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T20:37:14Z","timestamp":1791751034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1076633226006768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":46,"alternative-id":["S1076633226006768"],"URL":"https:\/\/doi.org\/10.1016\/j.acra.2026.08.063","relation":{},"ISSN":["1076-6332"],"issn-type":[{"value":"1076-6332","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between CT-Based Body Composition and Cardiotoxicity and Overall Survival in Patients with Prostate Cancer","name":"articletitle","label":"Article Title"},{"value":"Academic Radiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.acra.2026.08.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Association of Academic Radiology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}