{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:51:05Z","timestamp":1789696265216,"version":"4.0.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.actatropica.2004.10.007","type":"journal-article","created":{"date-parts":[[2004,12,24]],"date-time":"2004-12-24T15:45:12Z","timestamp":1103903112000},"page":"161-167","source":"Crossref","is-referenced-by-count":33,"title":["Activity of a paromomycin hydrophilic formulation for topical treatment of infections by Leishmania (Leishmania) amazonensis and Leishmania (Viannia) braziliensis"],"prefix":"10.1016","volume":"93","author":[{"given":"Gisele Santos","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Celi Carvalho","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarbas Eust\u00e1quio","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"de Oliveira-Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Cristina","family":"Maciel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Rabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Ant\u00f4nio Miranda","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2004.10.007_bib1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4269\/ajtmh.2001.65.466","article-title":"Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in Guatemala","volume":"65","author":"Arana","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2004.10.007_bib2","first-page":"104","article-title":"Human cutaneous leishmaniasis: recent advances in physiopathology and treatment","volume":"5","author":"Barral-Netto","year":"1995","journal-title":"Eur. J. Dermatol."},{"key":"10.1016\/j.actatropica.2004.10.007_bib3","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/clind\/24.4.684","article-title":"Human leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years","volume":"24","author":"Berman","year":"1997","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2004.10.007_bib4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1097\/00001432-200310000-00005","article-title":"Current treatment approaches to leishmaniasis","volume":"16","author":"Berman","year":"2003","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2004.10.007_bib5","first-page":"203","article-title":"In vitro skin permeation of paromomycin from topical formulations across normal and stripped hairless mouse skin","volume":"13","author":"Castro","year":"2003","journal-title":"S. T. P. Pharma. Sci."},{"key":"10.1016\/j.actatropica.2004.10.007_bib6","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.pt.2003.09.008","article-title":"Leishmaniasis-current chemotherapy and recent advances in the search for novel drugs","volume":"19","author":"Croft","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.actatropica.2004.10.007_bib7","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1128\/AAC.26.5.745","article-title":"Development of topical treatment for cutaneous leishmaniasis caused by Leishmania major in experimental animals","volume":"26","author":"El-On","year":"1984","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2004.10.007_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0169-4758(88)90200-1","article-title":"Topical chemotherapy of cutaneous leishmaniasis","volume":"4","author":"El-On","year":"1988","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.actatropica.2004.10.007_bib9","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1086\/320699","article-title":"Combined interleukin-12 and topical chemotherapy for established Leishmaniasis drastically reduces tissue parasitism and relapses in susceptible mice","volume":"183","author":"Fernandes","year":"2001","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2004.10.007_bib10","first-page":"S113","article-title":"Desenvolvimento de formula\u00e7\u00f5es hidrof\u00edlicas para tratamento t\u00f3pico da leishmaniose cut\u00e2nea","volume":"35","author":"Ferreira","year":"2002","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.actatropica.2004.10.007_bib11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0190-9622(96)80121-6","article-title":"Leishmaniasis","volume":"34","author":"Grevelink","year":"1996","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.actatropica.2004.10.007_bib12","doi-asserted-by":"crossref","first-page":"354","DOI":"10.2307\/3285646","article-title":"Successful topical treatment of murine cutaneous leishmaniasis with a combination of paromomycin (aminosidine) and gentamycin","volume":"85","author":"Grogl","year":"1999","journal-title":"J. Parasitol."},{"key":"10.1016\/j.actatropica.2004.10.007_bib13","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1128\/IAI.65.8.3225-3230.1997","article-title":"Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production","volume":"65","author":"Li","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.actatropica.2004.10.007_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/S0037-86821985000300011","article-title":"Pentavalent antimonials old drugs for new diseases","volume":"18","author":"Marsden","year":"1985","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.actatropica.2004.10.007_bib15","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1007\/s004360050476","article-title":"Effect of glucantime on field and patient isolates of New World Leishmania: use of growth parameters of promastigotes to assess antimony susceptibility","volume":"84","author":"Moreira","year":"1998","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2004.10.007_bib16","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1086\/315890","article-title":"Interleukin-12 regulates the response to chemotherapy in experimental visceral leishmaniasis","volume":"182","author":"Murray","year":"2000","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2004.10.007_bib17","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4269\/ajtmh.1995.53.55","article-title":"Activity of pentostam (sodium stibogluconate) against cutaneous leishmaniasis in mice treated with neutralizing anti-interferon-gamma antibody","volume":"53","author":"Nabors","year":"1995","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2004.10.007_bib18","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/jac\/35.5.577","article-title":"The sensitivity of Leishmania species to aminosidine","volume":"35","author":"Neal","year":"1995","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2004.10.007_bib19","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4269\/ajtmh.2001.65.456","article-title":"Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: therapeutic response to meglumine antimoniate","volume":"65","author":"Romero","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2004.10.007_bib20","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1086\/319990","article-title":"Comparison of cutaneous leishmaniasis due to Leishmania (Viannia) braziliensis and L. (V.) guyanensis in Brazil: clinical findings and diagnostic approach","volume":"32","author":"Romero","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2004.10.007_bib21","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1590\/S0037-86821996000600005","article-title":"Estudo terap\u00eautico aberto com sulfato de aminosidine da leishmaniose mucosa causada por Leishmania (Viannia) braziliensis","volume":"29","author":"Romero","year":"1996","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.actatropica.2004.10.007_bib22","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4269\/ajtmh.2002.66.147","article-title":"Treatment of cutaneous leishmaniasis with a topical antileishmanial drug (WR279396): phase 2 pilot study","volume":"66","author":"Soto","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2004.10.007_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1086\/516267","article-title":"Topical paromomycin\/methylbenzethonium chloride plus parenteral meglumine antimonate as treatment for American cutaneous leishmaniasis: controlled study","volume":"26","author":"Soto","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2004.10.007_bib24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1046\/j.1365-3156.2001.00778.x","article-title":"Drug resistance in Indian visceral leishmaniasis","volume":"6","author":"Sundar","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.actatropica.2004.10.007_bib25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0924-8579(99)00133-8","article-title":"A comparison of the activities of three amphotericin B lipid formulations against experimental visceral and cutaneous leishmaniasis","volume":"13","author":"Yardley","year":"2000","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.actatropica.2004.10.007_bib26","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1086\/341406","article-title":"A randomized, double-blind study of the efficacy of a 10- or 20-day course of sodium stibogluconate for treatment of cutaneous leishmaniasis in United States military personnel","volume":"35","author":"Wortmann","year":"2002","journal-title":"Clin. Infect. Dis."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X04002384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X04002384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T23:06:16Z","timestamp":1586041576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X04002384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0001706X04002384"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2004.10.007","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]}}}