{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:34:07Z","timestamp":1790775247046,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.actatropica.2006.10.008","type":"journal-article","created":{"date-parts":[[2006,11,29]],"date-time":"2006-11-29T21:26:52Z","timestamp":1164835612000},"page":"185-191","source":"Crossref","is-referenced-by-count":42,"title":["Activity of azithromycin or erythromycin in combination with antimalarial drugs against multidrug-resistant Plasmodium falciparum in vitro"],"prefix":"10.1016","volume":"100","author":[{"given":"S.","family":"Nakornchai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Konthiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2006.10.008_bib1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.7326\/0003-4819-123-10-199511150-00005","article-title":"Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers","volume":"123","author":"Anderson","year":"1995","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.actatropica.2006.10.008_bib2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejphar.2003.11.035","article-title":"Azithromycin reverses anticancer drug resistance and modifies hepatobiliary excretion of doxorubicin in rats","volume":"484","author":"Asakura","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.actatropica.2006.10.008_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/infdis\/137.2.122","article-title":"A method for testing synergy with any number of agents","volume":"137","author":"Berenbaum","year":"1978","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2006.10.008_bib4","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1128\/AAC.37.8.1701","article-title":"Inhibition of Toxoplasma gondii protein synthesis by azithromycin","volume":"37","author":"Blais","year":"1993","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.actatropica.2006.10.008_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(97)00083-1","article-title":"A comparison of the phenomenology and genetics of multidrug resistance in Plasmodium falciparum","volume":"77","author":"Bray","year":"1998","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.actatropica.2006.10.008_bib6","first-page":"15","article-title":"Quinine-tetracycline for multidrug-resistant falciparum malaria","volume":"27","author":"Bunnag","year":"1996","journal-title":"Southeast Asian J. Trop. Med. Publ. Health"},{"key":"10.1016\/j.actatropica.2006.10.008_bib7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4269\/ajtmh.2006.74.407","article-title":"Lack of a pharmacokinetic interaction between azithromycin and chloroquine","volume":"74","author":"Cook","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib8","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1128\/AAC.16.6.710","article-title":"Quantitative assessment of antimalarial activity in vitro by semiautomated microdilution technique","volume":"16","author":"Desjardin","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2006.10.008_bib9","first-page":"407","article-title":"Short course of azithromycin\u2013artesunate against falciparum malaria: no full protection against recrudescence","volume":"4","author":"De Vries","year":"1999","journal-title":"Trop. Med. Intern. Health"},{"key":"10.1016\/j.actatropica.2006.10.008_bib10","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4269\/ajtmh.1996.54.197","article-title":"Randomized controlled trial of artesunate plus tetracycline versus standard treatment (quinine plus tetracycline) for uncomplicated Plasmodium falciparum malaria in Brazil","volume":"54","author":"Duarte","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib11","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2165\/00003495-199651030-00013","article-title":"Azithromycin: a review of its pharmacological properties and use as a 3-day therapy in respiratory tract infection","volume":"51","author":"Dunn","year":"1996","journal-title":"Drugs"},{"key":"10.1016\/j.actatropica.2006.10.008_bib12","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1086\/429343","article-title":"A multicenter study of azithromycin alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India","volume":"191","author":"Dunne","year":"2005","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2006.10.008_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00034983.1984.11811766","article-title":"Combination of antibiotics erythromycin and tetracycline with three standard antimalarials against Plasmodium falciparum in vitro","volume":"78","author":"Gershon","year":"1984","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.actatropica.2006.10.008_bib14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.4269\/ajtmh.1992.47.378","article-title":"Activity of azithromycin (CP-62,993) and erythromycin against chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum in vitro","volume":"47","author":"Gingras","year":"1992","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib15","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4269\/ajtmh.1993.49.101","article-title":"Antimalarial activity of azithromycin and erythromycin against Plasmodium berghei","volume":"49","author":"Gingras","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib16","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1128\/AAC.33.3.277","article-title":"In vitro and in vivo uptake of azithromycin (CP-62,993) by phagocytic cells: possible mechanism of delivery and release at sites of infection","volume":"33","author":"Gladue","year":"1989","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2006.10.008_bib17","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1128\/AAC.34.6.1056","article-title":"Intracellular accumulation of azithromycin by cultured human fibroblasts","volume":"34","author":"Gladue","year":"1990","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2006.10.008_bib18","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1067\/mob.2001.118158","article-title":"Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda","volume":"185","author":"Gray","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.actatropica.2006.10.008_bib19","doi-asserted-by":"crossref","first-page":"842","DOI":"10.4269\/ajtmh.2005.73.842","article-title":"Randomized controlled double-blind trial of daily oral azithromycin in adults for prophylaxis of Plasmodium vivax malaria in Western Thailand","volume":"73","author":"Heppner","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/infdis\/169.2.467","article-title":"Clindamycin in combination with chloroquine or quinine is an effective therapy for uncomplicated Plasmodium falciparum malaria in children from Gabon","volume":"169","author":"Kremsner","year":"1994","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2006.10.008_bib21","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.3317830","article-title":"Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance","volume":"238","author":"Krogstad","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.actatropica.2006.10.008_bib22","first-page":"525","article-title":"A comparative clinical trial of combination of dihydroartemisinin plus azithromycin and dihydroartemisinin plus mefloquine for treatment of multidrug-resistant falciparum malaria","volume":"33","author":"Krudsood","year":"2002","journal-title":"Southeast Asian J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0001-706X(94)90092-2","article-title":"Randomised trial of mefloquine\u2013tetracycline and quinine\u2013tetracycline for acute uncomplicated falciparum malaria","volume":"57","author":"Looareesuwan","year":"1994","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2006.10.008_bib24","doi-asserted-by":"crossref","first-page":"784","DOI":"10.4269\/ajtmh.1994.50.784","article-title":"Randomized trial of mefloquine\u2013doxycycline and artesunate\u2013doxycycline for the treatment of acute uncomplicated falciparum malaria","volume":"50","author":"Looareesuwan","year":"1994","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib25","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1128\/AAC.40.11.2577","article-title":"Safety, toleration, and pharmacokinetics of intravenous azithromycin","volume":"40","author":"Luke","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2006.10.008_bib26","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0035-9203(01)90106-3","article-title":"Randomized comparison of quinine\u2013clindamycin versus artesunate in the treatment of falciparum malaria in pregnancy","volume":"95","author":"Mc Gready","year":"2001","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib27","series-title":"Program and Abstracts of the American Society of Tropical Medicine and Hygeine, Denver, CO, Abstract 567","article-title":"Azithromycin\u2013quinine combination therapy for the treatment of uncomplicated falciparum malaria in Thailand","author":"Miller","year":"2002"},{"key":"10.1016\/j.actatropica.2006.10.008_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.4269\/ajtmh.2006.74.401","article-title":"Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin\u2013quinine combinations: a randomized dose-ranging study","volume":"74","author":"Miller","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib29","first-page":"522","article-title":"Activity of artemether\u2013azithromycin versus artemether\u2013doxycycline in the treatment of multiple drug resistant falciparum malaria","volume":"27","author":"Na-Bangchang","year":"1996","journal-title":"Southeast Asian J. Trop. Med. Publ. Health"},{"key":"10.1016\/j.actatropica.2006.10.008_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0001-706X(01)00141-3","article-title":"Antimalarial activity of azithromycin, artemisinin and dihydroartemisinin in fresh isolates of Plasmodium falciparum in Thailand","volume":"80","author":"Noedl","year":"2001","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2006.10.008_bib31","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1128\/AAC.46.8.2518-2524.2002","article-title":"Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro","volume":"46","author":"Ohrt","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2006.10.008_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0140-6736(84)90357-X","article-title":"Failure of chloroquine\u2013erythromycin and chloroquine\u2013tetracycline combination in treatment of chloqroquine-resistant falciparum malaria in Eastern Thailand","volume":"323","author":"Phillips","year":"1984","journal-title":"Lancet"},{"key":"10.1016\/j.actatropica.2006.10.008_bib33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1006\/expr.1999.4465","article-title":"Azithromycin: antimalarial profile against blood and sporozoite-induced infections in mice and monkey","volume":"94","author":"Puri","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2006.10.008_bib34","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0140-6736(95)92712-3","article-title":"Effects of azithromycin on malariometric indices in the Gambia","volume":"346","author":"Sadiq","year":"1995","journal-title":"Lancet"},{"issue":"Suppl. 2","key":"10.1016\/j.actatropica.2006.10.008_bib35","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1007\/BF01640864","article-title":"The pharmacokinetics of 1000mg erythromycin lactobionate i.v. in patients with respiratory tract infections","volume":"10","author":"Sietzen","year":"1982","journal-title":"Infection"},{"key":"10.1016\/j.actatropica.2006.10.008_bib36","doi-asserted-by":"crossref","first-page":"223","DOI":"10.4269\/ajtmh.2001.64.223","article-title":"Chloroquine\/doxycycline combination versus chloroquine alone, and doxycycline alone for treatment of Plasmodium falciparum and Plasmodium vivax malaria in northeastern Irian Jaya, Indonesia","volume":"64","author":"Taylor","year":"2001","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib37","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.actatropica.2006.10.008_bib38","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/00034983.1976.11687121","article-title":"The chemotherapy of rodent malaria XXIV. The blood schizontocidal action of erythromycin upon Plasmodium berghei","volume":"70","author":"Warhurst","year":"1976","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.actatropica.2006.10.008_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.4269\/ajtmh.1992.47.108","article-title":"Quinine with tetracycline for the treatment of drug-resistant falciparum malaria in Thailand","volume":"47","author":"Watt","year":"1992","journal-title":"Am. J Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2006.10.008_bib40","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S0140-6736(98)06439-3","article-title":"Control of sexually transmitted diseases of AIDS prevention in Uganda: a randomised community trial","volume":"353","author":"Wawer","year":"1999","journal-title":"Lancet"}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X06002087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X06002087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T16:35:36Z","timestamp":1555950936000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X06002087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0001706X06002087"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2006.10.008","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}