{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T01:32:11Z","timestamp":1794360731317,"version":"4.9.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.actatropica.2008.05.004","type":"journal-article","created":{"date-parts":[[2008,5,19]],"date-time":"2008-05-19T08:05:00Z","timestamp":1211184300000},"page":"124-130","source":"Crossref","is-referenced-by-count":15,"title":["Aging and immune response in chronic human schistosomiasis"],"prefix":"10.1016","volume":"108","author":[{"given":"F.","family":"Comin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Speziali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Correa-Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.M.C.","family":"Faria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2008.05.004_bib1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.coi.2005.07.019","article-title":"Memory T cell homeostasis and senescence during aging","volume":"17","author":"Akbar","year":"2005","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1074\/jbc.M411223200","article-title":"Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells","volume":"280","author":"Aksoy","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2008.05.004_bib3","doi-asserted-by":"crossref","first-page":"336","DOI":"10.4269\/ajtmh.2002.67.336","article-title":"Additive host genetic factors influence fecal egg excretion rates during Schistosoma mansoni infection in a rural area in Brazil","volume":"67","author":"Bethony","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2008.05.004_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1749-6632.1986.tb18507.x","article-title":"Immunoregulation of granuloma formation in murine schistosomiasis mansoni","volume":"465","author":"Boros","year":"1986","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.actatropica.2008.05.004_bib5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-3083.2000.00710.x","article-title":"CD4+ T cells of schistosomiasis naturally resistant individuals living in an endemic area produce interferon-gamma and tumour necrosis factor-alpha in response to the recombinant 14KDA Schistosoma mansoni fatty acid-binding protein","volume":"51","author":"Brito","year":"2000","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S0031182000053956","article-title":"Immunity in human schistosomiasis mansoni: prevention by blocking antibodies of the expression of immunity in young children","volume":"94","author":"Butterworth","year":"1987","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2008.05.004_bib7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1365-2249.2007.03403.x","article-title":"Ageing and Toll-like receptor expression by innate immune cells in chronic human schistosomiasis","volume":"149","author":"Comin","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/(SICI)1097-0320(19970401)27:4<297::AID-CYTO1>3.0.CO;2-A","article-title":"Cytometric analysis of immunosenescence","volume":"27","author":"Cossarizza","year":"1997","journal-title":"Cytometry"},{"key":"10.1016\/j.actatropica.2008.05.004_bib9","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.4049\/jimmunol.150.12.5219","article-title":"Altered regulation of IL-6 production with normal aging. Possible linkage to the age-associated decline in dehydroepiandrosterone and its sulfated derivative","volume":"150","author":"Daynes","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1093\/intimm\/12.5.623","article-title":"Antigen-specific cellular hyporesponsiveness in a chronic human helminth infection is mediated by T(h)3\/T(r)1-type cytokines IL-10 and transforming growth factor-beta but not by a T(h)1 to T(h)2 shift","volume":"12","author":"Doetze","year":"2000","journal-title":"Int. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib11","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1046\/j.1365-3024.1998.00166.x","article-title":"Human schistosomiasis mansoni: IL-10 modulates the in vitro granuloma formation","volume":"20","author":"Falcao","year":"1998","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib12","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0065-2776(08)60787-7","article-title":"Oral tolerance: mechanisms and therapeutic applications","volume":"73","author":"Faria","year":"1999","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib13","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.0105-2896.2005.00280.x","article-title":"Oral tolerance","volume":"206","author":"Faria","year":"2005","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.actatropica.2008.05.004_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/7403","article-title":"Dendritic cells directly trigger NK cell functions: cross-talk relevant in innate anti-tumor immune responses in vivo","volume":"5","author":"Fernandez","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.actatropica.2008.05.004_bib15","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.4049\/jimmunol.156.9.3315","article-title":"Recombinant IL-10 and IL-10\/Fc treatment down-regulate egg antigen-specific delayed hypersensitivity reactions and egg granuloma formation in schistosomiasis","volume":"156","author":"Flores-Villanueva","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib16","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0264-410X(99)00513-7","article-title":"Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space","volume":"18","author":"Franceschi","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.actatropica.2008.05.004_bib17","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0531-5565(00)00172-8","article-title":"The network and the remodeling theories of aging: historical background and new perspectives","volume":"35","author":"Franceschi","year":"2000","journal-title":"Exp. Gerontol."},{"issue":"1","key":"10.1016\/j.actatropica.2008.05.004_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0169-4758(97)01168-X","article-title":"Puberty and age-related changes in susceptibility to schistosome infection","volume":"14","author":"Fulford","year":"1998","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.actatropica.2008.05.004_bib19","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1084\/jem.20020190","article-title":"Interleukin 2 signaling is required for CD4(+) regulatory T cell function","volume":"196","author":"Furtado","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.actatropica.2008.05.004_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1046\/j.1365-3156.2001.00684.x","article-title":"Exposure to Schistosoma mansoni infection in a rural area of Brazil. I. Water contact","volume":"6","author":"Gazzinelli","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.actatropica.2008.05.004_bib21","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1084\/jem.20010938","article-title":"Reciprocal activating interaction between natural killer cells and dendritic cells","volume":"195","author":"Gerosa","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.actatropica.2008.05.004_bib22","doi-asserted-by":"crossref","first-page":"5627","DOI":"10.4049\/jimmunol.158.12.5627","article-title":"Induction of human T helper cell type 1 differentiation results in loss of IFN-gamma receptor beta-chain expression","volume":"158","author":"Groux","year":"1997","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib23","first-page":"209","article-title":"Epidemiology, immunology and chemotherapy of Schistosoma mansoni infections in a recently exposed community in Senegal","volume":"46","author":"Gryseels","year":"1994","journal-title":"Trop. Geogr. Med."},{"key":"10.1016\/j.actatropica.2008.05.004_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.182.1.1","article-title":"Molecular alterations in the aging immune system","volume":"182","author":"Hodes","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.actatropica.2008.05.004_bib25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0065-308X(02)52014-5","article-title":"Cytokine-mediated host responses during schistosome infections; walking the fine line between immunological control and immunopathology","volume":"52","author":"Hoffmann","year":"2002","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib26","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.actatropica.2008.05.004_bib27","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.4049\/jimmunol.162.9.5317","article-title":"Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance","volume":"162","author":"Itoh","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib28","doi-asserted-by":"crossref","first-page":"R879","DOI":"10.1016\/S0960-9822(00)80073-1","article-title":"Lipoproteins take their toll on the host","volume":"9","author":"Janeway","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib29","first-page":"397","article-title":"A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni","volume":"14","author":"Katz","year":"1972","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.actatropica.2008.05.004_bib30","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1006\/clim.1999.4816","article-title":"The origin and functions of natural killer cells","volume":"95","author":"Lanier","year":"2000","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib31","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0047-6374(84)90152-0","article-title":"Admission criteria for immunogerontological studies in man: the SENIEUR protocol","volume":"28","author":"Ligthart","year":"1984","journal-title":"Mech. Age. Dev."},{"key":"10.1016\/j.actatropica.2008.05.004_bib32","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/bcmd.2001.0443","article-title":"Immunophenotypic characterization of normal blood CD56+lo versus CD56+hi NK-cell subsets and its impact on the understanding of their tissue distribution and functional properties","volume":"27","author":"Lima","year":"2001","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.actatropica.2008.05.004_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4943(00)00086-8","article-title":"Immunosenescence: a review","volume":"32","author":"Malaguarnera","year":"2001","journal-title":"Arch. Gerontol. Geriatr."},{"key":"10.1016\/j.actatropica.2008.05.004_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1046\/j.1365-3083.1997.d01-136.x","article-title":"Cytokine regulation of human immune response to Schistosoma mansoni: analysis of the role of IL-4, IL-5 and IL-10 on peripheral blood mononuclear cell responses","volume":"46","author":"Malaquias","year":"1997","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib35","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1365-3083.1997.d01-119.x","article-title":"Flow cytometric study of blood leucocytes in clinical forms of human schistosomiasis","volume":"46","author":"Martins-Filho","year":"1997","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib36","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1067\/mai.2002.129339","article-title":"The role of suppressor T cells in regulation of immune responses","volume":"110","author":"McHugh","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib37","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/35100529","article-title":"Toll-like receptors and innate immunity","volume":"1","author":"Medzhitov","year":"2001","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib38","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.273.5271.70","article-title":"The aging immune system: primer and prospectus","volume":"273","author":"Miller","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.actatropica.2008.05.004_bib39","doi-asserted-by":"crossref","first-page":"834","DOI":"10.4049\/jimmunol.172.2.834","article-title":"TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice","volume":"172","author":"Nakamura","year":"2004","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.actatropica.2008.05.004_bib40","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1128\/IAI.67.7.3444-3451.1999","article-title":"Development of antibody isotype responses to Schistosoma mansoni in an immunologically naive immigrant population: influence of infection duration, infection intensity, and host age","volume":"67","author":"Naus","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.actatropica.2008.05.004_bib41","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/1521-4141(200109)31:9<2633::AID-IMMU2633>3.0.CO;2-2","article-title":"Human monocyte-derived and CD83(+) blood dendritic cells enhance NK cell-mediated cytotoxicity","volume":"31","author":"Nishioka","year":"2001","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib42","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.4049\/jimmunol.170.5.2516","article-title":"CD4+CD25\u2212 T cells that express latency-associated peptide on the surface suppress CD4+CD45RBhigh-induced colitis by a TGF-beta-dependent mechanism","volume":"170","author":"Oida","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib43","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1440-1711.2006.01444.x","article-title":"Immunobiology of Toll-like receptors: emerging trends","volume":"84","author":"Pandey","year":"2006","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib44","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.4049\/jimmunol.140.7.2401","article-title":"Immune responses during human schistosomiasis mansoni. XV. Anti-idiotypic T cells can recognize and respond to anti-SEA idiotypes directly","volume":"140","author":"Parra","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib45","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/jlb.64.6.703","article-title":"Impact of aging on innate immunity","volume":"64","author":"Pawelec","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib46","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S1471-4906(01)01956-1","article-title":"Immunoageing\u2014the cause or effect of morbidity","volume":"22","author":"Pawelec","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib47","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1189\/jlb.1103592","article-title":"Aging and innate immune cells","volume":"76","author":"Plackett","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib48","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.smim.2003.10.004","article-title":"Toll-like receptors and dendritic cells: for whom the bug tolls","volume":"16","author":"Reis e Sousa","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib49","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.169.9.4697","article-title":"Cutting edge: impaired Toll-like receptor expression and function in aging","volume":"169","author":"Renshaw","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib50","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib51","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1146\/annurev.immunol.21.120601.141122","article-title":"Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses","volume":"22","author":"Sakaguchi","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib52","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.1182\/blood.V82.9.2767.2767","article-title":"Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians","volume":"82","author":"Sansoni","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.actatropica.2008.05.004_bib53","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/S0531-5565(99)00008-X","article-title":"Natural killer cells in healthy aging","volume":"34","author":"Solana","year":"1999","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib54","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/S0264-410X(99)00495-8","article-title":"NK and NK\/T cells in human senescence","volume":"18","author":"Solana","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/j.actatropica.2008.05.004_bib55","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2006.05.003","article-title":"Aging and innate immunity","volume":"24","author":"Solana","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.actatropica.2008.05.004_bib56","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1080\/09629350400008802","article-title":"Production of interferon-gamma by natural killer cells and aging in chronic human schistosomiasis","volume":"13","author":"Speziali","year":"2004","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.actatropica.2008.05.004_bib57","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1286-4579(99)80089-6","article-title":"The development of granulomas in schistosomiasis: genetic backgrounds, regulatory pathways, and specific egg antigen responses that influence the magnitude of disease","volume":"1","author":"Stadecker","year":"1999","journal-title":"Microb. Infect."},{"key":"10.1016\/j.actatropica.2008.05.004_bib58","doi-asserted-by":"crossref","first-page":"267","DOI":"10.4049\/jimmunol.173.1.267","article-title":"Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells","volume":"173","author":"Stassen","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1462-5822.2003.00264.x","article-title":"Toll receptors and pathogen resistance","volume":"5","author":"Takeda","year":"2003","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib60","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib61","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/0035-9203(94)90436-7","article-title":"Interferon-gamma production by peripheral blood mononuclear cells from residents of an area endemic for Schistosoma mansoni","volume":"88","author":"Viana","year":"1994","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2008.05.004_bib62","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.4049\/jimmunol.177.8.5490","article-title":"Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens","volume":"177","author":"Walter","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2008.05.004_bib63","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4269\/ajtmh.1997.57.487","article-title":"Factors affecting high and low human IgE responses to schistosome worm antigens in an area of Brazil endemic for Schistosoma mansoni and hookworm","volume":"57","author":"Webster","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2008.05.004_bib64","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.immuni.2006.05.001","article-title":"Aging of the immune system: how much can the adaptive immune system adapt?","volume":"24","author":"Weng","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.actatropica.2008.05.004_bib65","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.4049\/jimmunol.166.3.1590","article-title":"Enhancement of human cord blood CD34+ cell-derived NK cell cytotoxicity by dendritic cells","volume":"166","author":"Yu","year":"2001","journal-title":"J. Immunol."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X08001393?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X08001393?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:02:00Z","timestamp":1684411320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X08001393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":65,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0001706X08001393"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2008.05.004","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}