{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T07:26:28Z","timestamp":1790234788119,"version":"4.1.0"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2013,8,1]],"date-time":"2013-08-01T00:00:00Z","timestamp":1375315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1016\/j.actatropica.2013.04.003","type":"journal-article","created":{"date-parts":[[2013,4,16]],"date-time":"2013-04-16T16:32:00Z","timestamp":1366129920000},"page":"101-104","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment"],"prefix":"10.1016","volume":"127","author":[{"given":"Jos\u00e9 A.","family":"P\u00e9rez-Molina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Sojo-Dorado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Norman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Monge-Maillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"D\u00edaz-Men\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Albajar-Vi\u00f1as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"L\u00f3pez-V\u00e9lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2013.04.003_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/S0066-782X2011001600001","article-title":"I Latin American guidelines for the diagnosis and treatment of Chagas cardiomyopathy","volume":"97","author":"Andrade","year":"2011","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0010","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1001\/jama.298.18.2171","article-title":"Evaluation and treatment of Chagas disease in the United States: a systematic review","volume":"298","author":"Bern","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.actatropica.2013.04.003_bib0015","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1191\/0960327106het653oa","article-title":"Toxic side effects of drugs used to treat Chagas\u2019 disease (American trypanosomiasis)","volume":"25","author":"Castro","year":"2006","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0020","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1590\/S0074-02762011000600001","article-title":"Chronic phase of Chagas disease: why should it be treated? A comprehensive review","volume":"106","author":"Coura","year":"2011","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2013.04.003_bib0025","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE), 2006. National Cancer Institute, US National Institutes of Health."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0030","first-page":"99","article-title":"Diagnosis, management and treatment of chronic Chagas\u2019 heart disease in areas where Trypanosoma cruzi infection is not endemic","volume":"26","author":"Gascon","year":"2008","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0035","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/jac\/dks027","article-title":"Safety of benznidazole use in the treatment of chronic Chagas\u2019 disease","volume":"67","author":"Hasslocher-Moreno","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0040","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1086\/656917","article-title":"Tolerance and safety of nifurtimox in patients with chronic chagas disease","volume":"51","author":"Jackson","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0045","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1111\/j.1469-0691.2010.03423.x","article-title":"Chagas disease in Latin American migrants: a Spanish challenge","volume":"17","author":"Perez-Ayala","year":"2011","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0050","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11908-012-0259-3","article-title":"Chagas disease in non-endemic countries: epidemiology, clinical presentation and treatment","volume":"14","author":"Perez-Molina","year":"2012","journal-title":"Curr. Infect. Dis. Rep."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0055","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.1128\/AAC.00537-10","article-title":"Tolerance of benznidazole in treatment of Chagas\u2019 disease in adults","volume":"54","author":"Pinazo","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0060","first-page":"1611","article-title":"Single-dose pharmacokinetics of the trypanosomicide benznidazole in man","volume":"29","author":"Raaflaub","year":"1979","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/j.actatropica.2013.04.003_bib0065","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1590\/S0037-86822002000600001","article-title":"Treatment of chronic Chagas\u2019 disease with an association of nifurtimox and corticoid","volume":"35","author":"Rassi","year":"2002","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0070","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.actatropica.2009.11.003","article-title":"Chagas disease: a Latin American health problem becoming a world health problem","volume":"115","author":"Schmunis","year":"2010","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1586\/14787210.7.2.157","article-title":"Side effects of benznidazole as treatment in chronic Chagas disease: fears and realities","volume":"7","author":"Viotti","year":"2009","journal-title":"Expert Rev. Anti. Infect. Ther."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0080","doi-asserted-by":"crossref","first-page":"e31","DOI":"10.1017\/S1462399409001252","article-title":"Trypanocidal drugs: mechanisms, resistance and new targets","volume":"11","author":"Wilkinson","year":"2009","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.actatropica.2013.04.003_bib0085","doi-asserted-by":"crossref","first-page":"e488","DOI":"10.1371\/journal.pntd.0000488","article-title":"Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Medecins Sans Frontieres","volume":"3","author":"Yun","year":"2009","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X13001010?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X13001010?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T20:29:25Z","timestamp":1539721765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X13001010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0001706X13001010"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2013.04.003","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2013,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nifurtimox therapy for Chagas disease does not cause hypersensitivity reactions in patients with such previous adverse reactions during benznidazole treatment","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2013.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}