{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:31:58Z","timestamp":1792225918283,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007070","name":"UNMdP","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"ANPCyT","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.actatropica.2014.08.007","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:32:18Z","timestamp":1408408338000},"page":"61-67","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Efficacy of albendazole in combination with thymol against Echinococcus multilocularis protoscoleces and metacestodes"],"prefix":"10.1016","volume":"140","author":[{"given":"Albani Clara","family":"Mar\u00eda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissondo Mar\u00eda","family":"Celina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2014.08.007_bib0005","first-page":"69","article-title":"Echinococcus granulosus: in vitro efficacy of Rosmarinus officinalis essential oil on protoscoleces","volume":"3","author":"Albanese","year":"2009","journal-title":"Int. J. Essent. Oil Ther."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0010","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vetpar.2013.05.016","article-title":"Thymus capitatus from Tunisian arid zone: chemical composition and in vitro anthelmintic effects on Haemonchus contortus","volume":"18","author":"Boubaker Elandalousi","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2009.11.001","article-title":"Writing panel for the WHO International Working Group on Echinococcosis. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans","volume":"114","author":"Brunetti","year":"2010","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0020","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.parint.2012.05.007","article-title":"Echinococcus granulosus tegumental enzymes as in vitro markers of pharmacological damage: a biochemical and molecular approach","volume":"61","author":"Cumino","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0025","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00436-005-0026-6","article-title":"In vitro effects of flubendazole on Echinococcus granulosus protoscoleces","volume":"98","author":"Elissondo","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0030","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00436-006-0381-y","article-title":"In vitro and in vivo effects of flubendazole on Echinococcus granulosus metacestodes","volume":"100","author":"Elissondo","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.parint.2007.12.005","article-title":"Efficacy of thymol against Echinococcus granulosus protoscoleces","volume":"57","author":"Elissondo","year":"2008","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0040","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.actatropica.2012.12.007","article-title":"Could thymol have effectiveness on scolices and germinal layer of hydatid cysts?","volume":"125","author":"Elissondo","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0045","first-page":"1","article-title":"Pharmaceutical and therapeutic potentials of essentials oils and their individual volatile constituents: a review","volume":"20","author":"Edris","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0050","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0944-7113(97)80035-9","article-title":"A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis","volume":"4","author":"Ernst","year":"1997","journal-title":"Phytomedicine"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0055","first-page":"35","article-title":"Anthelmintic activity of some medicinal plants","volume":"40","author":"Garg","year":"1997","journal-title":"Hamdard Med."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0060","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1023\/A:1005884429253","article-title":"Prospects for plant anthelmintics in tropical veterinary medicine","volume":"21","author":"Hammond","year":"1997","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0065","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.ijantimicag.2012.07.007","article-title":"In vitro efficacy of the anticancer drug imatinib on Echinococcus multilocularis larvae","volume":"40","author":"Hemer","year":"2012","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0070","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1017\/S003118200999117X","article-title":"Echinococcus metacestodes as laboratory models for the screening of drugs against cestodes and trematodes","volume":"137","author":"Hemphill","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0075","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0304-4017(97)00106-4","article-title":"Modifying the formulation or delivery mechanism to increase the activity of anthelmintic compounds","volume":"72","author":"Hennessy","year":"1997","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0080","first-page":"175","article-title":"Action of different monoterpenic compounds against Anisakis simplex s.l. L3 larvae","volume":"4","author":"Hierro","year":"2004","journal-title":"Rev. Fitoterapia"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0085","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00436-010-1892-0","article-title":"Effects of in vitro exposure of Echinococcus multilocularis metacestodes to cytostatic drugs on in vivo growth and proliferation of the parasite","volume":"107","author":"H\u00fcbner","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0090","first-page":"563","article-title":"Les propri\u00e9t\u00e9s anti microbiennes des huiles essentielles et compos\u00e9s d\u2019ar\u00f4mes","volume":"18","author":"Hulin","year":"1998","journal-title":"Sci. Aliments"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0095","doi-asserted-by":"crossref","first-page":"S273","DOI":"10.1016\/j.parint.2005.11.040","article-title":"Medical treatment of echinococcosis under the guidance of good clinical practice (GCP\/ICH)","volume":"55","author":"Kern","year":"2006","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0100","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/009127002401102678","article-title":"Systemic availability and pharmacokinetics of thymol in humans","volume":"42","author":"Kohlert","year":"2002","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0105","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1128\/AAC.01392-10","article-title":"In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis","volume":"55","author":"K\u00fcster","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0110","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1046\/j.1365-2672.2001.01428.x","article-title":"A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol","volume":"91","author":"Lambert","year":"2001","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0115","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.bcp.2009.11.002","article-title":"Nematicidal activity of two monoterpenoids and SER-2 tyramine receptor of Caenorhabditis elegans","volume":"1","author":"Lei","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0120","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00436-011-2595-x","article-title":"Anthelmintic effect of Mentha spp. essential oils on Echinococcus granulosus protoscoleces and metacestodes","volume":"110","author":"Maggiore","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0125","first-page":"700","article-title":"Efficacy and tolerability of myrtol standardized in acute bronchitis: a multi-centre, randomised, double-blind, placebo-controlled parallel group clinical trial vs. cefuroxime andambroxol","volume":"50","author":"Matthys","year":"2000","journal-title":"Arzneim. Forsch."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0130","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.1002\/jsfa.3358","article-title":"In vitro degradation and in vivo passage kinetics of carvacrol, thymol, eugenol and trans-cinnamaldehyde along the gastrointestinal tract of piglets","volume":"13","author":"Michiels","year":"2008","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.vetpar.2011.12.025","article-title":"In vitro lethal effect of ajowan (Trachyspermum ammi L.) essential oil on hydatid cyst protoscoleces","volume":"187","author":"Moazeni","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0140","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/AAC.00578-06","article-title":"In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus","volume":"50","author":"Naguleswaran","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0145","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/jac\/46.3.451","article-title":"Benzimidazoles in the treatment of alveolar echinococcosis: a comparative study and review of the literature","volume":"46","author":"Reuter","year":"2000","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0150","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/hep.20078","article-title":"Structured treatment interuption in patients with alveolar echinococcosis","volume":"39","author":"Reuter","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0155","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.actatropica.2010.04.009","article-title":"Combined albendazole and amphotericin B against Echinococcus multilocularis in vitro","volume":"115","author":"Reuter","year":"2010","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0160","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1007\/s00436-013-3321-7","article-title":"In vitro efficacy of triclabendazole and clorsulon against the larval stage of Echinococcus multilocularis","volume":"112","author":"Richter","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0165","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1128\/AAC.49.4.1652-1655.2005","article-title":"In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivatives","volume":"49","author":"Robledo","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0170","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.colsurfb.2003.11.007","article-title":"Surface activity of thymol: implications for an eventual pharmacological activity","volume":"34","author":"S\u00e1nchez","year":"2004","journal-title":"Colloids Surf., B: Biointerfaces"},{"key":"10.1016\/j.actatropica.2014.08.007_bib0175","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.exppara.2008.02.012","article-title":"In vitro and in vivo effects of 2-methoxyestradiol, either alone or combined with albendazole, against Echinococcus metacestodes","volume":"119","author":"Spicher","year":"2008","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0180","doi-asserted-by":"crossref","first-page":"4866","DOI":"10.1128\/AAC.00478-11","article-title":"In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes","volume":"55","author":"Stadelmann","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0185","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/AAC.47.2.467-474.2003","article-title":"In vitro parasiticidal effect of nitazoxanide against Echinococcus multilocularis metacestodes","volume":"47","author":"Stettler","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.08.007_bib0190","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jhep.2008.03.023","article-title":"Alveolar echinococcosis: from a deadly disease to a well-controlled infection. Relative survival and economic analysis in Switzerland over the last 35 years","volume":"49","author":"Torgerson","year":"2008","journal-title":"J. Hepatol."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1400268X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1400268X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:45:15Z","timestamp":1589244315000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X1400268X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":38,"alternative-id":["S0001706X1400268X"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2014.08.007","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of albendazole in combination with thymol against Echinococcus multilocularis protoscoleces and metacestodes","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2014.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}