{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T08:23:26Z","timestamp":1722500606812},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.actatropica.2014.09.002","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T02:05:54Z","timestamp":1410833154000},"page":"181-183","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine"],"prefix":"10.1016","volume":"140","author":[{"given":"Narumon","family":"Sereekhajornjaru","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanat","family":"Somboon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roonglawan","family":"Rattanajak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William A.","family":"Denny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prapin","family":"Wilairat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saranya","family":"Auparakkitanon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2014.09.002_bib0005","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1006\/bbrc.2000.2305","article-title":"Cleavage of DNA induced by 9-anilinoacridine inhibitors of topoisomerase II in the malaria parasite Plasmodium falciparum","volume":"269","author":"Auparakkitanon","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0010","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1128\/AAC.47.12.3708-3712.2003","article-title":"Antimalarial 9-anilinoacridine compounds directed at hematin","volume":"47","author":"Auparakkitanon","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0015","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1128\/AAC.00119-06","article-title":"Targeting of hematin by the antimalarial pyronaridine","volume":"50","author":"Auparakkitanon","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0020","first-page":"619","article-title":"Antimalarial activity of concanamycin A alone and in combination with pyronaridine","volume":"37","author":"Auparakkitanon","year":"2006","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"10.1016\/j.actatropica.2014.09.002_bib0025","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1172\/JCI109925","article-title":"Hemolysis of mouse erythrocytes by ferroprotoporphyrin IX and chloroquine: chemotherapeutic implications","volume":"66","author":"Chou","year":"1980","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0030","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1021\/cb300454t","article-title":"Insights into the role of heme in the mechanism of action of antimalarials","volume":"8","author":"Combrinck","year":"2013","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0035","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1475-2875-11-270","article-title":"Review of pyronaridine anti-malarial properties and product characteristics","volume":"11","author":"Croft","year":"2012","journal-title":"Malaria J."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0040","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1475-2875-12-70","article-title":"Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials","volume":"12","author":"Duparc","year":"2013","journal-title":"Malaria J."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0045","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0005-2736(83)90219-5","article-title":"The effect of ferriprotoporphyrin IX and chloroquine on phospholipid monolayers and the possible implications to antimalarial activity","volume":"732","author":"Ginsburg","year":"1983","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.actatropica.2014.09.002_bib0050","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1089\/ars.2012.4625","article-title":"Glutathione transport: a new role for PfCRT in chloroquine resistance","volume":"19","author":"Patzewitz","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0055","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1021\/jm00360a005","article-title":"Synthesis and antiarrhythmic and parasympatholytic properties of substituted phenols: 1. Heteroarylamine derivatives","volume":"26","author":"Stout","year":"1983","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.actatropica.2014.09.002_bib0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1874104501105010011","article-title":"Acridine and acridinones: old and new structures with antimalarial activity","volume":"5","author":"Vald\u00e9s","year":"2011","journal-title":"Open Med. Chem. J."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X14002939?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X14002939?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T16:24:03Z","timestamp":1538238243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X14002939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":12,"alternative-id":["S0001706X14002939"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2014.09.002","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of hematin-targeting properties of pynacrine, an acridine analog of the benzonaphthyridine antimalarial pyronaridine","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2014.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}