{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:36:42Z","timestamp":1792640202402,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007070","name":"Universidad Nacional de Mar del Plata","doi-asserted-by":"crossref","award":["EXA 572\/12"],"award-info":[{"award-number":["EXA 572\/12"]}],"id":[{"id":"10.13039\/501100007070","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2015,6]]},"DOI":"10.1016\/j.actatropica.2015.03.016","type":"journal-article","created":{"date-parts":[[2015,4,5]],"date-time":"2015-04-05T18:41:07Z","timestamp":1428259267000},"page":"141-151","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Biochemical and molecular characterization of the calcineurin in Echinococcus granulosus larval stages"],"prefix":"10.1016","volume":"146","author":[{"given":"Mar\u00eda Celeste","family":"Nicolao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Cumino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2015.03.016_bib0005","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/sj.embor.7400133","article-title":"Calcineurin: a central controller of signalling in eukaryotes","volume":"5","author":"Aramburu","year":"2004","journal-title":"EMBO Rep."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0010","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S1016-8478(23)13075-5","article-title":"Regulation of calcineurin, a calcium\/calmodulin-dependent protein phosphatase, in C. elegans","volume":"18","author":"Bandyopadhyay","year":"2004","journal-title":"Mol. Cells"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0015","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1017\/S0031182099004308","article-title":"Ca2+ and calmodulin-dependent protein phosphatase from Leishmania donovani","volume":"118","author":"Banerjee","year":"1999","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0020","doi-asserted-by":"crossref","first-page":"26269","DOI":"10.1074\/jbc.M109.095752","article-title":"Calcineurin-mediated dephosphorylation of synaptotagmin VI is necessary for acrosomal exocytosis","volume":"285","author":"Bennett","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0025","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1124\/mol.112.078253","article-title":"Calcium channel blockers act through nuclear factor Y to control transcription of key cardiac genes","volume":"82","author":"Cha-Molstad","year":"2012","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0030","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1146\/annurev.biochem.77.062005.101135","article-title":"How does synaptotagmin trigger neurotransmitter release?","volume":"77","author":"Chapman","year":"2008","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0035","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/s12281-010-0027-5","article-title":"On the roles of calcineurin in fungal growth and pathogenesis","volume":"4","author":"Chen","year":"2010","journal-title":"Curr. Fungal Infect. Rep."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0040","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1017\/S0031182002002330","article-title":"Anti-parasitic effect of cyclosporin A on Echinococcus granulosus and characterization of the associated cyclophilin protein","volume":"125","author":"Colebrook","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0045","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1017\/S0031182004005773","article-title":"Effect of cyclosporin A on the survival and ultrastructure of Echinococcus granulosus protoscoleces in vitro","volume":"129","author":"Colebrook","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0050","doi-asserted-by":"crossref","first-page":"22366","DOI":"10.1074\/jbc.274.32.22366","article-title":"Importance of the b12\u2013b13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors","volume":"274","author":"Connor","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.vetpar.2012.11.027","article-title":"Echinococcus granulosus pig strain (G7 genotype) protoscoleces did not develop secondary hydatid cysts in mice","volume":"193","author":"Cucher","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0060","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.ijpara.2009.11.011","article-title":"Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasis","volume":"40","author":"Cumino","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0065","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.parint.2012.05.007","article-title":"Echinococcus granulosus tegumental enzymes as in vitro markers of pharmacological damage: a biochemical and molecular approach","volume":"61","author":"Cumino","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0070","doi-asserted-by":"crossref","first-page":"F165","DOI":"10.1152\/ajprenal.00628.2011","article-title":"Calcineurin homologous protein: a multifunctional Ca2+-binding protein family","volume":"303","author":"Di Sole","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0080","doi-asserted-by":"crossref","first-page":"e5245","DOI":"10.1371\/journal.pone.0005245","article-title":"The transcription factor NFAT5 is required for cyclin expression and cell cycle progression in cells exposed to hypertonic stress","volume":"4","author":"Drews-Elger","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0085","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1128\/EC.00322-09","article-title":"Protein phosphatase 2B (PP2B, calcineurin) in Paramecium: partial characterization reveals that two members of the unusually large catalytic subunit family have distinct roles in calcium-dependent processes","volume":"9","author":"Fraga","year":"2010","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0090","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1073\/pnas.0337662100","article-title":"Requirement of the calcineurin subunit gene canB2 for indirect flight muscle formation in Drosophila","volume":"100","author":"Gajewski","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0095","doi-asserted-by":"crossref","first-page":"5740","DOI":"10.1073\/pnas.101602398","article-title":"Evolutionary relationships among Rel domains indicate functional diversification by recombination","volume":"98","author":"Graef","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0100","doi-asserted-by":"crossref","first-page":"18009","DOI":"10.1074\/jbc.M702222200","article-title":"Calcineurin activation is only one calcium-dependent step in cytotoxic T lymphocyte granule exocytosis","volume":"282","author":"Grybko","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0105","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1074\/jbc.M007562200","article-title":"Phentolamine inhibits exocytosis of glucagon by Gi2 protein-dependent activation of calcineurin in rat pancreatic \u03b1-cells","volume":"276","author":"H\u00f8y","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(95)90405-0","article-title":"Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling","volume":"80","author":"Hunter","year":"1995","journal-title":"Cell"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0020-7519(93)90005-J","article-title":"Anthelmintic effects of cyclosporin A on protoscoleces and secondary hydatid cysts of Echinococcus granulosus in the mouse","volume":"23","author":"Hurd","year":"1993","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0120","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1021\/bi8019355","article-title":"The proline-rich N-terminal sequence of calcineurin A determines substrate binding","volume":"48","author":"Kilka","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0125","doi-asserted-by":"crossref","first-page":"9870","DOI":"10.1073\/pnas.152336999","article-title":"Calpain-dependent cleavage of cain\/cabin1 activates calcineurin to mediate calcium-triggered cell death","volume":"99","author":"Kim","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0130","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1016\/S0021-9258(17)47231-0","article-title":"The calmodulin-dependent activation and deactivation of the phosphoprotein phosphatase, calcineurin, and the effect of nucleotides, pyrophosphate, and divalent metal ions","volume":"259","author":"King","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0135","doi-asserted-by":"crossref","first-page":"13367","DOI":"10.1074\/jbc.273.22.13367","article-title":"Regulation of the calmodulin-stimulated protein phosphatase, calcineurin","volume":"273","author":"Klee","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0140","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.devcel.2014.01.019","article-title":"Calcineurin regulates coordinated outgrowth of zebrafish regenerating fins","volume":"28","author":"Kujawski","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0145","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tcb.2010.09.011","article-title":"Interaction of calcineurin with substrates and targeting proteins","volume":"21","author":"Li","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0150","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1152\/ajpcell.00588.2005","article-title":"Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress","volume":"292","author":"Li","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0155","doi-asserted-by":"crossref","first-page":"36125","DOI":"10.1074\/jbc.274.51.36125","article-title":"Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein","volume":"274","author":"Lin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0160","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin\u2013cyclosporin A and FKBP\u2013FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0165","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","article-title":"Echinococcosis","volume":"362","author":"McManus","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0170","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0166-6851(00)00287-5","article-title":"Molecular cloning of Schistosoma mansoni calcineurin subunits and immunolocalization to the excretory system","volume":"110","author":"Mecozzi","year":"2000","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0175","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1152\/physrev.00041.2005","article-title":"Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models","volume":"88","author":"Mellstr\u00f6m","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.parint.2013.09.017","article-title":"P-glycoprotein expression and pharmacological modulation in larval stages of Echinococcus granulosus","volume":"63","author":"Nicolao","year":"2014","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0185","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1128\/AAC.02113-13","article-title":"In vitro and in vivo effects of tamoxifen against larval stage Echinococcus granulosus","volume":"58","author":"Nicolao","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0190","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1128\/MCB.25.15.6649-6659.2005","article-title":"Regulation of calcineurin through transcriptional induction of the calcineurin A promoter in vitro and in vivo","volume":"25","author":"Oka","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0195","doi-asserted-by":"crossref","first-page":"e2676","DOI":"10.1371\/journal.pntd.0002676","article-title":"A cytoplasmic new catalytic subunit of calcineurin in Trypanosoma cruzi and its molecular and functional characterization","volume":"8","author":"Orrego","year":"2014","journal-title":"PLoS Neglect. Trop. Dis."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0200","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.ceb.2010.05.001","article-title":"Cell biology of Ca2+-triggered exocytosis","volume":"22","author":"Pang","year":"2010","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0205","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1046\/j.1432-1033.2002.03040.x","article-title":"Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the R or catalytic subunit","volume":"269","author":"Perrino","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0210","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/bj3340659","article-title":"Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin","volume":"334","author":"Rascher","year":"1998","journal-title":"Biochem. J."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0215","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-4889(97)00023-2","article-title":"Regulation of calcium-induced exocytosis from gastric chief cells by protein phosphatase-2B (calcineurin)","volume":"1357","author":"Raufman","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0220","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1017\/S0031182096008190","article-title":"Characterization of calcineurin from Hymenolepis microstoma and H. diminuta and its interaction with cyclosporin A","volume":"114","author":"Roberts","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0225","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.molcel.2009.01.030","article-title":"A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants","author":"Rodr\u00edguez","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0230","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S0031182000051519","article-title":"Echinococcus granulosus: in vitro effect of monensin on the tegument of the protoscolex","volume":"93","author":"Rogan","year":"1986","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0235","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1152\/physrev.2000.80.4.1483","article-title":"Calcineurin: form and function","volume":"80","author":"Rusnak","year":"2000","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2003.10.008","article-title":"Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development","volume":"266","author":"Schulz","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0245","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/23054","article-title":"Skeletal muscle hypertrophy is mediated by a Ca2+-dependent calcineurin signalling pathway","volume":"400","author":"Semsarian","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0250","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1471-4159.2006.03874.x","article-title":"Generation of constitutively active calcineurin by calpain contributes to delayed neuronal death following mouse brain ischemia","volume":"98","author":"Shioda","year":"2006","journal-title":"J. Neurochem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0255","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1042\/bj20030484","article-title":"The role of serine\/threonine protein phosphatases in exocytosis","volume":"373","author":"Sim","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0260","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/cmi.12177","article-title":"Role of calcineurin and actin dynamics in regulated secretion of microneme proteins in Plasmodium falciparum merozoites during erythrocyte invasion","volume":"16","author":"Singh","year":"2014","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0265","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1749-6632.2009.05377.x","article-title":"Role of mitochondrial reactive oxygen species in osteoclast differentiation","volume":"1192","author":"Srinivasan","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0270","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.4049\/jimmunol.165.9.4884","article-title":"The NFAT-related protein NFATL1 (TonEBP\/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner","volume":"165","author":"Trama","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0275","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature12031","article-title":"The genomes of four tapeworm species reveal adaptations to parasitism","volume":"496","author":"Tsai","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.actatropica.2015.03.016_bib0280","doi-asserted-by":"crossref","first-page":"6722","DOI":"10.1016\/S0021-9258(18)68702-2","article-title":"Purification of the major protein tyrosine-phosphatases of human placenta","volume":"263","author":"Tonks","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0285","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.tcb.2007.04.006","article-title":"NFAT signaling and the invention of vertebrates","volume":"17","author":"Wu","year":"2007","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.actatropica.2015.03.016_bib0290","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1038\/ng.2757","article-title":"The genome of the hydatid tapeworm Echinococcus granulosus","volume":"45","author":"Zheng","year":"2013","journal-title":"Nat. Genet."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X15000649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X15000649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T06:21:24Z","timestamp":1717827684000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X15000649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":57,"alternative-id":["S0001706X15000649"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.03.016","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biochemical and molecular characterization of the calcineurin in Echinococcus granulosus larval stages","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.03.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}