{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:39:11Z","timestamp":1789864751012,"version":"4.0.1"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009383","name":"Tzu Chi University","doi-asserted-by":"crossref","award":["TCMRC-P-102011"],"award-info":[{"award-number":["TCMRC-P-102011"]}],"id":[{"id":"10.13039\/100009383","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.actatropica.2015.04.004","type":"journal-article","created":{"date-parts":[[2015,4,21]],"date-time":"2015-04-21T18:24:04Z","timestamp":1429640644000},"page":"13-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni"],"prefix":"10.1016","volume":"148","author":[{"given":"Tina Tu-Wen","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence Shih Hsin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Wei-Che","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Yoong","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin-Mu","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Ching","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Yi","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2015.04.004_bib0005","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-3024.2009.01157.x","article-title":"Schistosomiasis and liver fibrosis","volume":"31","author":"Andrade","year":"2009","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0010","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.4161\/auto.7.11.17653","article-title":"Autophagy as a rescue mechanism in efavirenz-induced mitochondrial dysfunction: a lesson from hepatic cells","volume":"7","author":"Apostolova","year":"2011","journal-title":"Autophagy"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0015","first-page":"109","article-title":"Metabolic stress and disorders related to alterations in mitochondrial fission or fusion","volume":"5","author":"Babbar","year":"2013","journal-title":"Mol. Cell. Pharmacol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0020","first-page":"891","article-title":"Inhibition of NF-kappa B activity induces apoptosis in murine hepatocytes","volume":"151","author":"Bellas","year":"1997","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0030","first-page":"505","article-title":"Experimental Schistosomiasis mansoni: characterization of connective tissue cells in hepatic periovular granulomas","volume":"25","author":"Boloukhere","year":"1993","journal-title":"J. Submicrosc. Cytol. Pathol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jlb.62.3.389","article-title":"Liver granulomas in schistosomiasis: mast cell-dependent induction of SCF expression in hepatic stellate cells is mediated by TNF-b","volume":"62","author":"Brito","year":"1997","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0045","doi-asserted-by":"crossref","first-page":"e598","DOI":"10.1371\/journal.pntd.0000598","article-title":"Temporal expression of chemokines dictates the hepatic inflammatory infiltrate in a murine model of schistosomiasis","volume":"4","author":"Burke","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0050","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/MOL.0b013e328328d0a4","article-title":"PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure","volume":"20","author":"Cant\u00f3","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0055","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1749-6632.2010.05629.x","article-title":"Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1","volume":"1201","author":"Chang","year":"2010","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0060","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/978-1-62703-290-2_7","article-title":"Detection of necrosis by release of lactate dehydrogenase activity","volume":"979","author":"Chan","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0065","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.actatropica.2005.12.006","article-title":"Hepatic stellate cells in human Schistosomiasis mansoni: a comparative immunohistochemical study with liver cirrhosis","volume":"97","author":"Chang","year":"2006","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0070","first-page":"14","article-title":"Emerging functions of mammalian mitochondrial fusion and fission","volume":"15","author":"Chen","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0075","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","article-title":"Cell death: critical control points","volume":"116","author":"Danial","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0080","series-title":"The Biology of Schistosomes: Ch 7 Consequencs of Infections with Schistosomes","author":"Rollinson","year":"1987"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0085","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1146\/annurev.biochem.76.071905.090048","article-title":"The machines that divide and fuse mitochondria","volume":"76","author":"Hoppins","year":"2007","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0090","doi-asserted-by":"crossref","first-page":"330","DOI":"10.18632\/aging.100459","article-title":"Role of apoptosis in disease","volume":"4","author":"Favaloro","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0095","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1534-5807(01)00055-7","article-title":"The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis","volume":"1","author":"Frank","year":"2001","journal-title":"Dev. Cell."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0100","doi-asserted-by":"crossref","first-page":"10792","DOI":"10.1074\/jbc.M610361200","article-title":"Functional and therapeutic analysis of hepatitis C virus NS3.4A protease control of antiviral immune defense","volume":"282","author":"Johnson","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0105","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1128\/MCB.05603-11","article-title":"Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle","volume":"32","author":"Jheng","year":"2012","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0110","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cell.2004.12.041","article-title":"Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases","volume":"120","author":"Kamata","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0115","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mito.2006.11.017","article-title":"Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions","volume":"7","author":"Kang","year":"2007","journal-title":"Mitochondrion"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0125","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/ng0398-231","article-title":"Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice","volume":"18","author":"Larsson","year":"1998","journal-title":"Nat. Genet."},{"issue":"Suppl 1","key":"10.1016\/j.actatropica.2015.04.004_bib0130","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/S0074-02762006000900034","article-title":"Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure","volume":"101","author":"Lenzi","year":"2006","journal-title":"Mem. Inst. Oswaldo. Cruz."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0135","doi-asserted-by":"crossref","first-page":"394","DOI":"10.7150\/ijbs.3882","article-title":"Swainsonine activates mitochondria-mediated apoptotic pathway in human lung cancer A549 cells and retards the growth of lung cancer xenografts","volume":"8","author":"Li","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0378-8741(01)00310-5","article-title":"The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in mice","volume":"79","author":"Mahmoud","year":"2002","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0150","doi-asserted-by":"crossref","first-page":"E585","DOI":"10.1152\/ajpendo.00093.2013","article-title":"Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita(+\/Ins2)-derived \u03b2-cells","volume":"305","author":"Mitchell","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0155","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/CDLI.11.2.411-416.2004","article-title":"Molecular expression of a cysteine proteinase of Clonorchis sinensis and its application to an enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis","volume":"11","author":"Nagano","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0160","doi-asserted-by":"crossref","first-page":"16456","DOI":"10.1074\/jbc.M501485200","article-title":"SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}","volume":"280","author":"Nemoto","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0170","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1146\/annurev.genet.38.072902.093019","article-title":"Mitochondrial morphology and dynamics in yeast and multicellular eukaryotes","volume":"39","author":"Okamoto","year":"2005","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0175","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1074\/jbc.M608009200","article-title":"Signaling of mitochondrial biogenesis following oxidant injury","volume":"282","author":"Rasbach","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00125-007-0852-4","article-title":"R-alpha-lipoic acid and acetyl-l-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1adipocytes","volume":"51","author":"Shen","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S1096-4959(01)00332-3","article-title":"Effect of carnosine administration on metabolic parameters in bilharzia-infected hamsters","volume":"129","author":"Soliman","year":"2001","journal-title":"Comp. Biochem. Physiol. B: Biochem. Mol. Biol."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0190","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1097\/QAD.0b013e32835804f9","article-title":"Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation","volume":"26","author":"Stankov","year":"2012","journal-title":"AIDS"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0195","first-page":"219","article-title":"Effect of long term schistosomes infection on liver of the host","volume":"3","author":"Soomro","year":"2006","journal-title":"JASS"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0200","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1242\/jcs.01058","article-title":"Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphology","volume":"117","author":"Stojanovski","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0210","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1159\/000224644","article-title":"Lactate dehydrogenase leakage as a marker for apoptotic cell degradation induced by influenza virus infection in human fetal membrane cells","volume":"52","author":"Uchide","year":"2009","journal-title":"Intervirology"},{"key":"10.1016\/j.actatropica.2015.04.004_bib0215","doi-asserted-by":"crossref","first-page":"E59","DOI":"10.1210\/jc.2011-1760","article-title":"Mitochondrial fusion, fission, and biogenesis in prolonged critically ill patients","volume":"97","author":"Vanhorebeek","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0220","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1097\/00001432-200410000-00009","article-title":"Morbidity in schistosomiasis: an update","volume":"17","author":"Vennervald","year":"2004","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0225","doi-asserted-by":"crossref","first-page":"12676","DOI":"10.1073\/pnas.0404878101","article-title":"Metabonomic investigations in mice infected with Schistosoma mansoni: an approach for biomarker identification","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.actatropica.2015.04.004_bib0235","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1500100X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1500100X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T04:29:24Z","timestamp":1598934564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X1500100X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":40,"alternative-id":["S0001706X1500100X"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.04.004","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mitochondrial dynamics in the mouse liver infected by Schistosoma mansoni","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}