{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T03:14:49Z","timestamp":1768619689662,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CNPQ"},{"DOI":"10.13039\/501100007378","name":"UFJF","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007378","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.actatropica.2015.04.018","type":"journal-article","created":{"date-parts":[[2015,4,25]],"date-time":"2015-04-25T22:51:30Z","timestamp":1430002290000},"page":"120-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"special_numbering":"C","title":["High selective antileishmanial activity of vanadium complex with stilbene derivative"],"prefix":"10.1016","volume":"148","author":[{"given":"Patr\u00edcia de Almeida","family":"Machado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Zamprogno","family":"Mota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Clara de Lima","family":"Cavalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Senra Gon\u00e7alves","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adilson David","family":"Da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacy","family":"Gameiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Cuin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elaine Soares","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2015.04.018_bib0005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jinorgbio.2013.09.017","article-title":"Macrophage activation and leishmanicidal activity by galactomannan and its oxovanadium (IV\/V) complex in vitro","volume":"132","author":"Adriazola","year":"2014","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1089\/acm.1999.5.273","article-title":"Vanadium: a review of its potential role in the fight against diabetes","volume":"5","author":"Badmaev","year":"1999","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0015","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jinorgbio.2010.11.001","article-title":"Vanadium polypyridyl compounds as potential antiparasitic and antitumoral agents: new achievements","volume":"105","author":"Ben\u00edtez","year":"2011","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0020","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejmech.2012.12.036","article-title":"New oxidovanadium(IV) N-acylhydrazone complexes: promising antileishmanial and antitrypanosomal agents","volume":"62","author":"Ben\u00edtez","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0025","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0020-7519(97)00169-0","article-title":"The immune response to Leishmania: mechanisms of parasite control and evasion","volume":"28","author":"Bogdan","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0030","doi-asserted-by":"crossref","first-page":"e41440","DOI":"10.1371\/journal.pone.0041440","article-title":"Benzaldehyde thiosemicarbazone derived from limonene complexed with copper induced mitochondrial dysfunction in Leishmania amazonensis","volume":"7","author":"Britta","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0035","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopha.2011.01.003","article-title":"Synthesis of 4-aminoquinoline analogues and their platinum(II) complexes as new antileishmanial and antitubercular agents","volume":"65","author":"Carmo","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0040","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.poly.2012.01.002","article-title":"Silver(I) and gold(I) complexes with penicillamine: synthesis, spectroscopic characterization and biological studies","volume":"34","author":"Costa","year":"2012","journal-title":"Polyhedron"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0045","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.biopha.2011.04.012","article-title":"6-Mercaptopurine complexes with silver and gold ions: anti-tuberculosis and anti-cancer activities","volume":"65","author":"Cuin","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.biopha.2011.03.003","article-title":"4-Aminoquinoline analogues and its platinum (II) complexes as antimalarial agents","volume":"65","author":"de Souza","year":"2011","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0055","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.ejmech.2014.12.003","article-title":"Leishmanicidal activity of polysaccharides and their oxovanadium(IV\/V) complexes","volume":"90","author":"do Amaral","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0060","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jinorgbio.2013.02.010","article-title":"Oxidovanadium(IV) and dioxidovanadium(V) complexes of tridentate salicylaldehyde semicarbazones: searching for prospective antitrypanosomal agents","volume":"127","author":"Fern\u00e1ndez","year":"2013","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0065","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1021\/np400193m","article-title":"Reactive oxygen species production by quercetin causes the death of Leishmania amazonensis intracellular amastigotes","volume":"76","author":"Fonseca-Silva","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0070","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.jinorgbio.2008.05.010","article-title":"Metal compounds for the treatment of parasitic diseases","volume":"102","author":"Fricker","year":"2008","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0075","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.2174\/092986710793213814","article-title":"Advances and current perspectives in medicinal inorganic chemistry","volume":"17","author":"Gambino","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0080","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/j.ccr.2010.12.028","article-title":"Potentiality of vanadium compounds as anti-parasitic agents","volume":"255","author":"Gambino","year":"2011","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0090","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1080\/00958970802663555","article-title":"Synthesis, characterization, crystal structure, and biological studies of vanadium complexes with glycolic acid","volume":"62","author":"Guilherme","year":"2009","journal-title":"J. Coord. Chem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0095","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1111\/cbdd.12017","article-title":"Effect of 3-alkylpyridine marine alkaloid analogues in Leishmania species related to American cutaneous leishmaniasis","volume":"80","author":"Machado","year":"2012","journal-title":"Chem. Biol. Drug. Des."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0100","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1002\/1521-4141(200009)30:9<2555::AID-IMMU2555>3.0.CO;2-X","article-title":"Peroxovanadium-mediated protection against murine leishmaniasis: role of the modulation of nitric oxide","volume":"30","author":"Matte","year":"2000","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0105","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1146\/annurev-micro-090110-102913","article-title":"Metabolic pathways required for the intracellular survival of Leishmania","volume":"65","author":"McConville","year":"2011","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0110","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1093\/qjmed\/hct116","article-title":"Leishmaniasis: clinical syndromes and treatment","volume":"107","author":"McGwire","year":"2014","journal-title":"Q. J. Med."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0115","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.freeradbiomed.2009.06.004","article-title":"The effects on Trypanosoma cruzi of novel synthetic naphthoquinones are mediated by mitochondrial dysfunction","volume":"47","author":"Menna-Barreto","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0120","doi-asserted-by":"crossref","first-page":"e2481","DOI":"10.1371\/journal.pntd.0002481","article-title":"Cellular growth and mitochondrial ultrastructure of Leishmania (Viannia) braziliensis promastigotes are affected by the iron chelator 2,2-dipyridyl","volume":"7","author":"Mesquita-Rodrigues","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0130","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.saa.2012.09.002","article-title":"Crystal structure and theoretical studies of the keto-enol isomerism of N,N\u2032-bis(salicylidene)-o-phenylenediamine (salophen)","volume":"99","author":"Mota","year":"2012","journal-title":"Spectrochim. Acta Mol. Biomol."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0135","doi-asserted-by":"crossref","first-page":"8841","DOI":"10.1073\/pnas.97.16.8841","article-title":"Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens","volume":"97","author":"Nathan","year":"2000","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0140","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.drudis.2010.10.005","article-title":"Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives","volume":"15","author":"Navarro","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0145","doi-asserted-by":"crossref","first-page":"13908","DOI":"10.1039\/c2dt31433a","article-title":"Oxovanadium(IV)-catalysed oxidation of dibenzothiophene and 4,6 dimethyldibenzothiophene","volume":"41","author":"Ogunlaja","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.poly.2013.06.031","article-title":"Silver(I) complexes with symmetrical Schiff bases: synthesis, structural characterization, DFT studies and antimycobacterial assays","volume":"62","author":"Paiva","year":"2013","journal-title":"Polyhedron"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0155","doi-asserted-by":"crossref","first-page":"500","DOI":"10.4103\/0253-7613.99326","article-title":"Efficacy of oral miltefosine in visceral leishmaniasis in rural West Bengal, India","volume":"44","author":"Patra","year":"2012","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0160","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.poly.2012.03.016","article-title":"A broad study of two new promising antimycobacterial drugs: Ag(I) and Au(I) complexes with 2-(2-thienyl)benzothiazole","volume":"38","author":"Pereira","year":"2012","journal-title":"Polyhedron"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0165","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/jac\/dks498","article-title":"LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis","volume":"68","author":"Ribeiro","year":"2013","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-007-7305-9_1","article-title":"Biology of human pathogenic trypanosomatids: epidemiology, lifecycle and ultrastructure","volume":"74","author":"Rodrigues","year":"2014","journal-title":"Subcell. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0175","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.exppara.2013.10.011","article-title":"Spinigerin induces apoptotic like cell death in a caspase independent manner in Leishmania donovani","volume":"135","author":"Sardar","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0180","doi-asserted-by":"crossref","first-page":"3834","DOI":"10.1016\/j.vaccine.2012.03.068","article-title":"Leishmaniasis: vaccine candidates and perspectives","volume":"30","author":"Singh","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/j.actatropica.2015.04.018_bib0185","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1056\/NEJMoa021556","article-title":"Oral miltefosine for Indian visceral Leishmaniasis","volume":"347","author":"Sundar","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0190","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.actatropica.2007.05.017","article-title":"Characterization of the anti-Leishmania effect induced by cisplatin, an anticancer drug","volume":"103","author":"Tavares","year":"2007","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0195","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1055\/s-0030-1250663","article-title":"Current approaches to discover marine antileishmanial natural products","volume":"77","author":"Tempone","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0200","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jinorgbio.2011.09.009","article-title":"Inhibitory effects of decavanadate on several enzymes and Leishmania tarentolae in vitro","volume":"108","author":"Turner","year":"2012","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0205","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1016\/j.jinorgbio.2009.02.011","article-title":"Synthesis and characterization of a pyridine-2-thiol N-oxide gold(I) complex with potent antiproliferative effect against Trypanosoma cruzi and Leishmania sp. insight into its mechanism of action","volume":"103","author":"Vieites","year":"2009","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/874367","article-title":"The effects of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-b-carboline-3-carboxamide against Leishmania amazonensis are mediated by mitochondrial dysfunction","volume":"2013","author":"Volpato","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0215","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bbrc.2010.10.108","article-title":"Hemolysis of human erythrocytes induced by melamine\u2013cyanurate complex","volume":"402","author":"Wang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.actatropica.2015.04.018_bib0225","series-title":"Leishmaniasis","author":"World Health Organization (WHO)","year":"2014"}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1500114X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1500114X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T01:54:35Z","timestamp":1537667675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X1500114X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":44,"alternative-id":["S0001706X1500114X"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.04.018","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High selective antileishmanial activity of vanadium complex with stilbene derivative","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.04.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}