{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T19:17:15Z","timestamp":1778181435702,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y T\u00e9cnica (ANPCyT)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.actatropica.2015.04.019","type":"journal-article","created":{"date-parts":[[2015,4,26]],"date-time":"2015-04-26T03:26:40Z","timestamp":1430018800000},"page":"89-96","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Combined flubendazole-nitazoxanide treatment of cystic echinococcosis: Pharmacokinetic and efficacy assessment in mice"],"prefix":"10.1016","volume":"148","author":[{"given":"Ceballos","family":"Laura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elissondo","family":"Celina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e1nchez Bruni","family":"Sergio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denegri","family":"Guillermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lanusse","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvarez","family":"Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2015.04.019_bib0005","doi-asserted-by":"crossref","first-page":"e319","DOI":"10.1371\/journal.pntd.0000319","article-title":"Zoonotic larval cestode infections: neglected, neglected tropical diseases?","volume":"3","author":"Budke","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0015","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.parint.2009.07.006","article-title":"Flubendazole in cystic echinococcosis therapy: pharmaco-parasitologicalevaluation in mice","volume":"58","author":"Ceballos","year":"2009","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002838","article-title":"Exploring the potential of flubendazole in filariasis control: evaluation of the systemic exposure for different pharmaceutical preparations","author":"Ceballos","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0025","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1128\/CMR.17.1.107-135.2004","article-title":"Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern","volume":"17","author":"Eckert","year":"2004","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0030","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0001-706X(02)00217-6","article-title":"Benzimidazole treatment of cystic echinococcosis","volume":"85","author":"El-On","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00436-005-0026-6","article-title":"In vitro effects of flubendazole on Echinococcus granulosus protoscoleces","volume":"98","author":"Elissondo","year":"2006","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0040","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1007\/s00436-006-0381-y","article-title":"In vitro and in vivo effects of flubendazole on Echinococcus granulosus metacestodes","volume":"100","author":"Elissondo","year":"2007","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0045","doi-asserted-by":"crossref","first-page":"447","DOI":"10.2460\/ajvr.1986.47.02.447","article-title":"In vitro sulfoxidation of albendazole by ovine liver microsomes: assay and frequency of various xenobiotics","volume":"47","author":"Galtier","year":"1986","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0050","doi-asserted-by":"crossref","first-page":"367","DOI":"10.4269\/ajtmh.2009.80.367","article-title":"Evaluation of nita-zoxanide and oxfendazole efficacy against cystic echinococcosis in naturally infected sheep","volume":"80","author":"Gavidia","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0055","series-title":"Revised and Expanded","first-page":"45","article-title":"Pharmacokinetics","author":"Gibaldi","year":"1982"},{"key":"10.1016\/j.actatropica.2015.04.019_bib0060","unstructured":"Guide for the Care and Use of Laboratory Animals. Editors. National Research Council (US) Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Source 8th edition. Washington (DC): National Academies Press (US); 2011. The National Academies Collection: Reports funded by National Institutes of Health."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0065","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1517\/14656566.7.7.953","article-title":"Nitazoxanide, a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections","volume":"7","author":"Hemphill","year":"2006","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0070","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1017\/S0031182007003198","article-title":"Innovative chemotherapeutical treatment options for alveolar and cystic echinococcosis","volume":"134","author":"Hemphill","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2015.04.019_bib0075","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/03602539308993977","article-title":"Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants","volume":"25","author":"Lanusse","year":"1993","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0080","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.bcp.2008.07.002","article-title":"Hepatic and extrahepatic metabolic pathways involved in flubendazole biotransformation in sheep","volume":"76","author":"Mat\u00e9","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0085","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1365-2885.2004.00616.x","article-title":"Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability","volume":"27","author":"Moreno","year":"2004","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0090","first-page":"115","article-title":"Hydatidose pleurale disseminee et hydatidoses hepatiques, Traitment post-operatoire par flubendazole a proposde 3 cas","volume":"3","author":"Recco","year":"1984","journal-title":"Bull. Soc. Fr. Parasitol."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0095","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/AAC.47.2.467-474.2003","article-title":"In vitro parasiticidal effect of nitazoxanide against Echinococcus multilocularis metacestodes","volume":"47","author":"Stettler","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0100","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.ijpara.2004.01.006","article-title":"Secondary and primary murine alveolar echinococcosis: combined albendazole\/nitazoxanide chemotherapy exhibits profound anti-parasitic activity","volume":"34","author":"Stettler","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0105","first-page":"3","article-title":"Treatment response of cystic echinococcosis to benzimidazoles: a systematic review","volume":"29","author":"Stojkovic","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0110","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1124\/dmd.32.5.536","article-title":"Comparative hepatic and extrahepatic enantioselective sulphoxidation of albendazole and fenbendazole in sheep and cattle","volume":"32","author":"Virkel","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0115","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/jac\/dkh386","article-title":"In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes","volume":"54","author":"Walker","year":"2004","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2015.04.019_bib0120","series-title":"Puncture, Aspiration, Injection, Re-aspiration. An Option for the Treatment of Cystic Echinococcosis, Geneva, Switzerland","first-page":"1","author":"WHO Informal Working Group of Echinococcosis","year":"2001"}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X15001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X15001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T15:04:37Z","timestamp":1748358277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X15001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":23,"alternative-id":["S0001706X15001151"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.04.019","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined flubendazole-nitazoxanide treatment of cystic echinococcosis: Pharmacokinetic and efficacy assessment in mice","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2015.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}