{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:57:04Z","timestamp":1790629024019,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.actatropica.2016.03.038","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T06:18:22Z","timestamp":1459577902000},"page":"142-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Miltefosine lipid nanocapsules: Intersection of drug repurposing and nanotechnology for single dose oral treatment of pre-patent schistosomiasis mansoni"],"prefix":"10.1016","volume":"159","author":[{"given":"Riham M.","family":"El-Moslemany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha M.","family":"Eissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyaa A.","family":"Ramadan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Labiba K.","family":"El-Khordagui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervat Z.","family":"El-Azzouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2016.03.038_bib0005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijpharm.2007.01.009","article-title":"Improvement of in vitro efficacy of a novel schistosomicidal drug by incorporation into nanoemulsions","volume":"337","author":"Ar\u00e1ujo","year":"2007","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0010","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1007\/s00436-011-2786-5","article-title":"Ultrastructural analysis of miltefosine-induced surface membrane damage in adult Schistosoma mansoni BH strain worms","volume":"110","author":"Bert\u00e3o","year":"2012","journal-title":"Parasitol. Res."},{"issue":"12","key":"10.1016\/j.actatropica.2016.03.038_bib0015","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1128\/AAC.47.12.3853-3858.2003","article-title":"Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl] adenine against schistosomiasis mansoni in mice","volume":"47","author":"Botros","year":"2003","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0020","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/BF02535556","article-title":"Distribution and metabolism of hexadecylphosphocholine in mice","volume":"22","author":"Bresiser","year":"1987","journal-title":"Lipids"},{"issue":"2","key":"10.1016\/j.actatropica.2016.03.038_bib0025","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2174\/138920010791110836","article-title":"Nanocarriers: a general strategy for enhancement of oral bioavailability of poorly absorbed or pre-systemically metabolized drugs","volume":"11","author":"Cai","year":"2010","journal-title":"Curr. Drug Metab."},{"issue":"1","key":"10.1016\/j.actatropica.2016.03.038_bib0030","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijpara.2014.08.011","article-title":"The affinity of magnetic microspheres for Schistosoma eggs","volume":"45","author":"Candido","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0035","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/232653a0","article-title":"Acquisition of human antigens by Schistosoma mansoni during cultivation in vitro","volume":"232","author":"Clegg","year":"1971","journal-title":"Nature"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0040","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pt.2009.04.001","article-title":"Treatment of clinical schistosomiasis at the prepatent phase: an option?","volume":"25","author":"Coelho","year":"2009","journal-title":"Trends Parasitol."},{"issue":"417","key":"10.1016\/j.actatropica.2016.03.038_bib0045","article-title":"Repurposing of anticancer drugs: in vitro and in vivo activities against Schistosoma mansoni","volume":"8","author":"Cowan","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0050","first-page":"2","article-title":"Drugs for treating Schistosoma mansoni infection","volume":"28","author":"Danso-Appiah","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"10.1016\/j.actatropica.2016.03.038_bib0055","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.addr.2007.04.009","article-title":"Parasitic diseases: liposomes and polymeric nanoparticles versus lipid nanoparticles","volume":"59","author":"Date","year":"2007","journal-title":"Adv. Drug. Deliv. Rev."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0060","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1128\/AAC.00014-08","article-title":"Pharmacokinetics of miltefosine in Old World cutaneous leishmaniasis patients","volume":"52","author":"Dorlo","year":"2008","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0065","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1093\/jac\/dks164","article-title":"Translational pharmacokinetic modeling and simulation for the assessment of duration of contraceptive use after treatment with miltefosine","volume":"67","author":"Dorlo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0070","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1093\/jac\/dks275","article-title":"Miltefosine: a review of its pharmacology and therapeutic efficacy in the treatment of leishmaniasis","volume":"67","author":"Dorlo","year":"2012","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0075","series-title":"Carleton Histological Technique","author":"Drury","year":"1980"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0080","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1756-3305-4-73","article-title":"Bioactivity of miltefosine against aquatic stages of Schistosoma mansoni, Schistosoma haematobium and their snail hosts supported by scanning electron microscopy","volume":"4","author":"Eissa","year":"2011","journal-title":"Parasites Vectors"},{"issue":"2","key":"10.1016\/j.actatropica.2016.03.038_bib0085","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ijpara.2010.09.010","article-title":"Miltefosine, a promising novel agent for Schistosomiasis mansoni","volume":"41","author":"Eissa","year":"2011","journal-title":"Int. J. Parasitol."},{"issue":"11","key":"10.1016\/j.actatropica.2016.03.038_bib0090","doi-asserted-by":"crossref","first-page":"e0141788","DOI":"10.1371\/journal.pone.0141788","article-title":"Miltefosine lipid nanocapsules for single dose oral treatment of schistosomiasis mansoni: a preclinical study","volume":"10","author":"Eissa","year":"2015","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.actatropica.2016.03.038_bib0095","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1128\/AAC.00173-10","article-title":"In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium","volume":"54","author":"El Ridi","year":"2010","journal-title":"Antimicrob. Agents. Chemother."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0100","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1645\/GE-3122RN","article-title":"Incubation of Schistosoma mansoni lung-stage schistosomula in corn oil exposes their surface membrane antigenic specificities","volume":"89","author":"El-Ridi","year":"2003","journal-title":"J. Parasitol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0105","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jobaz.2014.09.002","article-title":"The potential role of mefloquine against Schistosoma mansoni infection by prohibition of hepatic oxidative stress in mice","volume":"67","author":"Fahmy","year":"2014","journal-title":"J. Basic Appl. Zool."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0110","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.actatropica.2013.06.011","article-title":"Liposomal-praziquantel: efficacy against Schistosoma mansoni in a preclinical assay","volume":"128","author":"Frezzaa","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0115","doi-asserted-by":"crossref","first-page":"d2651","DOI":"10.1136\/bmj.d2651","article-title":"Diagnosis and management of schistosomiasis","volume":"342","author":"Gray","year":"2011","journal-title":"Brit. Med. J."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0120","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1017\/S0031182013000231","article-title":"New approaches for understanding mechanisms of drug resistance in schistosomes","volume":"140","author":"Greenberg","year":"2013","journal-title":"Parasitology"},{"issue":"4","key":"10.1016\/j.actatropica.2016.03.038_bib0125","doi-asserted-by":"crossref","first-page":"589","DOI":"10.2217\/nnm.14.124","article-title":"In vivo evaluation of paclitaxel-loaded lipid nanocapsules after intravenous and oral administration on resistant tumor","volume":"10","author":"Groo","year":"2015","journal-title":"Nanomedicine (Lond.)"},{"issue":"6","key":"10.1016\/j.actatropica.2016.03.038_bib0130","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1023\/A:1016121319668","article-title":"A novel phase inversion-based process for the preparation of lipid nanocarriers","volume":"19","author":"Heurtault","year":"2002","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0135","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0020-7519(73)90004-0","article-title":"Schistosoma mansoni: changes in the outer membrane of the tegument during development from cercaria to adult worm","volume":"3","author":"Hockley","year":"1973","journal-title":"Int. J. Parasitol."},{"issue":"7","key":"10.1016\/j.actatropica.2016.03.038_bib0140","doi-asserted-by":"crossref","first-page":"e2865","DOI":"10.1371\/journal.pntd.0002865","article-title":"The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases","volume":"8","author":"Hotez","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0145","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s11095-009-0024-y","article-title":"Toxicological study and efficacy of blank and paclitaxel-loaded lipid nanocapsules after i.v. administration in mice","volume":"27","author":"Hureaux","year":"2010","journal-title":"Pharm. Res."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0150","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpharm.2009.04.026","article-title":"Lipid nanocapsules: a new platform for nanomedicine","volume":"379","author":"Huynh","year":"2009","journal-title":"Int. J. Pharma."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0155","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.4049\/jimmunol.119.5.1849","article-title":"Evidence for adsorption of heterospecific host immunoglobulin on the tegument of Schistosoma mansoni","volume":"119","author":"Kemp","year":"1977","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0160","series-title":"The Nano-Micro Interface: Bridging the Micro and Nano Worlds","article-title":"Nanotechnology advances in diagnostics, drug delivery, and regenerative medicine","author":"Kiparissides","year":"2015"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0165","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF01114912","article-title":"Evidence for a change in the organization of the lipid phase of the surface membrane of Schistosoma mansoni during development","volume":"1","author":"Kusel","year":"1981","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0170","first-page":"711","article-title":"Host response to eggs of Schistosoma manosni I: Granuloma formation in the unsensitized laboratory mouse","volume":"41","author":"Lichtenberg","year":"1962","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.actatropica.2016.03.038_bib0175","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/jps.2600680138","article-title":"Direct spectrophotometric assay of quaternary ammonium compounds using bromothymol blue","volume":"68","author":"Lowry","year":"1979","journal-title":"J. Pharm. Sci."},{"issue":"2","key":"10.1016\/j.actatropica.2016.03.038_bib0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/s00436-011-2527-9","article-title":"Curcumin-loaded into PLGA nanoparticles","volume":"110","author":"Luz","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0185","doi-asserted-by":"crossref","first-page":"12086","DOI":"10.1021\/jp404135g","article-title":"Partitioning of oleic acid into phosphatidylcholine membranes is amplified by strain","volume":"117","author":"Mally","year":"2013","journal-title":"J. Phys. Chem. B"},{"issue":"9","key":"10.1016\/j.actatropica.2016.03.038_bib0190","doi-asserted-by":"crossref","first-page":"e1003645","DOI":"10.1371\/journal.ppat.1003645","article-title":"Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni","volume":"9","author":"Marek","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0195","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13071-014-0617-0","article-title":"Predicting the effects of climate change on Schistosoma mansoni transmission in eastern Africa","volume":"8","author":"McCreesh","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0200","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-3024.1985.tb00079.x","article-title":"Ultrastructural studies of the killing of schistosomula of Schistosoma mansoni by activated macrophages in vitro","volume":"7","author":"McLaren","year":"1985","journal-title":"Parasite. Immunol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0205","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S0031182000048204","article-title":"A freeze fracture study of the developing tegumental outer membrane of Schistosoma mansoni","volume":"76","author":"McLaren","year":"1978","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1017\/S0031182000054755","article-title":"Schistosoma mansoni: further studies of the interaction between schistosomula and granulocyte-derived cationic proteins in vitro","volume":"88","author":"McLaren","year":"1984","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0215","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/351693","article-title":"Intestinal lymphatic delivery of praziquantel by solid lipid nanoparticles: formulation design in vitro and in vivo studies","author":"Mishra","year":"2014","journal-title":"J. Nanotech."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0220","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/0022-3859.911","article-title":"Miltefosine, great expectations against visceral leishmaniasis","volume":"49","author":"More","year":"2003","journal-title":"J. Postgrad. Med."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0225","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.ijpharm.2005.02.009","article-title":"Improvement of antischistosomal activity of praziquantel by incorporation into phosphatidylcholine-containing liposomes","volume":"295","author":"Mourao","year":"2005","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.actatropica.2016.03.038_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/0037-8682-0013-2014","article-title":"Cancer and parasitic infections: similarities and opportunities for the development of new control tools","volume":"47","author":"Oliveira","year":"2014","journal-title":"Rev. Soc. Bras. Med. Trop."},{"issue":"5","key":"10.1016\/j.actatropica.2016.03.038_bib0235","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ejps.2010.05.002","article-title":"Intestinal permeability enhancement of levothyroxine sodium by straight chain fatty acids studied in MDCK epithelial cell line","volume":"40","author":"Pabla","year":"2010","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0240","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ijpddr.2014.07.002","article-title":"Repurposing drugs for the treatment and control of helminth infections","volume":"4","author":"Panic","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"issue":"7","key":"10.1016\/j.actatropica.2016.03.038_bib0245","doi-asserted-by":"crossref","first-page":"e0003962","DOI":"10.1371\/journal.pntd.0003962","article-title":"Activity profile of an FDA-approved compound library against Schistosoma mansoni","volume":"9","author":"Panic","year":"2015","journal-title":"PLoS. Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0250","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1017\/S0031182000056535","article-title":"Changes in the surface antigen profile of Schistosoma mansoni during maturation from cercaria to adult worm","volume":"91","author":"Payares","year":"1985","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0255","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nri843","article-title":"The immunobiology of schistosomiasis","volume":"2","author":"Pearce","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0260","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0065-308X(08)60475-3","article-title":"Experimental chemotherapy of schistosomiasis mansoni","volume":"6","author":"Pellegrino","year":"1968","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0265","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ijpara.2003.12.003","article-title":"Sex- and stage-related sensitivity of Schistosoma mansoni to in vivo and in vitro praziquantel treatment","volume":"34","author":"Pica-Mattoccia","year":"2004","journal-title":"Int. J. Parasitol."},{"issue":"10","key":"10.1016\/j.actatropica.2016.03.038_bib0270","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4269\/ajtmh.1962.11.201","article-title":"Target repurposing for neglected diseases","volume":"3","author":"Pollastri","year":"2011","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0275","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0166-6851(81)90055-4","article-title":"Schistosoma mansoni: modulation of schistosomular lipid composition by serum","volume":"3","author":"Rumjanek","year":"1981","journal-title":"Mol. Biochem. Parasit."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0280","doi-asserted-by":"crossref","first-page":"626","DOI":"10.4049\/jimmunol.124.2.626","article-title":"Tumour cell lipid composition and sensitivity to hormonal immune killing","volume":"124","author":"Schlager","year":"1980","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.actatropica.2016.03.038_bib0285","doi-asserted-by":"crossref","first-page":"973","DOI":"10.4269\/ajtmh.14-0328","article-title":"Efficacy and safety of arachidonic acid for treatment of Schistosoma mansoni-infected children in Menoufiya, Egypt","volume":"91","author":"Selim","year":"2014","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"2","key":"10.1016\/j.actatropica.2016.03.038_bib0290","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1021\/mp500527x","article-title":"Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles","volume":"12","author":"Serrano","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0295","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1084\/jem.148.1.46","article-title":"Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni","volume":"148","author":"Sher","year":"1978","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0300","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1017\/S0031182000086248","article-title":"Infection of laboratory hosts with cercaria of Schistosoma mansoni and the recovery of adult worms","volume":"55","author":"Smithers","year":"1965","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0305","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/0014-4894(73)90118-5","article-title":"Schistosoma mansoni Topochemical features of cercariae, schistosomula, and adults","volume":"33","author":"Stein","year":"1973","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0310","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1645\/GE-439R","article-title":"Methyl-beta-cyclodextrin treatment and filipin staining reveal the role of cholesterol in surface membrane antigen sequestration of Schistosoma mansoni and S. haematobium lung-stage larvae","volume":"91","author":"Tallima","year":"2005","journal-title":"J. Parasitol."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0315","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1773-2247(13)50084-0","article-title":"Lipid nanocapsules: a nanocarrier suitable for scale-up process","volume":"23","author":"Thomas","year":"2013","journal-title":"J. Drug Del. Sci. Tech."},{"issue":"7","key":"10.1016\/j.actatropica.2016.03.038_bib0320","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1590\/0074-0276130135","article-title":"Schistogram changes after administration of antischistosomal drugs in mice at the early phase of Schistosoma mansoni infection","volume":"108","author":"Vimieiro","year":"2013","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0325","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00436-012-3151-z","article-title":"Susceptibility or resistance of praziquantel in human schistosomiasis: a review","volume":"111","author":"Wang","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2016.03.038_bib0330","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1017\/S0031182000047533","article-title":"The formation and turnover of the membranocalyx on the tegument of Schistosoma mansoni","volume":"74","author":"Wilson","year":"1977","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2016.03.038_bib0335","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijpharm.2013.12.022","article-title":"In vitro evaluation of permeation, toxicity and effect of praziquantel-loaded solid lipid nanoparticles against Schistosoma mansoni as a strategy to improve efficacy of the schistosomiasis treatment","volume":"463","author":"de Souza","year":"2014","journal-title":"Int. J. Pharm."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1630153X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X1630153X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T12:51:08Z","timestamp":1692276668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X1630153X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":67,"alternative-id":["S0001706X1630153X"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2016.03.038","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Miltefosine lipid nanocapsules: Intersection of drug repurposing and nanotechnology for single dose oral treatment of pre-patent schistosomiasis mansoni","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2016.03.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}