{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:45:59Z","timestamp":1778687159509,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,2,1]],"date-time":"2017-02-01T00:00:00Z","timestamp":1485907200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2017,2]]},"DOI":"10.1016\/j.actatropica.2016.10.020","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T23:03:38Z","timestamp":1477609418000},"page":"7-15","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Immune-protective effect of echinococcosis on colitis experimental model is dependent of down regulation of TNF-\u03b1 and NO production"],"prefix":"10.1016","volume":"166","author":[{"given":"Lila","family":"Khelifi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imene","family":"Soufli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moussa","family":"Labsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chafia","family":"Touil-Boukoffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2016.10.020_bib0005","article-title":"Mucosal intestinal alteration in experimental colitis correlates with nitric oxide production by peritoneal macrophages: effect of probiotics and prebiotics","author":"Abdelouhab","year":"2011","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0010","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1089\/jir.2007.0003","article-title":"In vitro antihydatic action of IFN-\u03b3 is dependent on the nitric oxide pathway","volume":"27","author":"Amri","year":"2007","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0015","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/ibd.21151","article-title":"Interleukin-19 protects mice from innate-mediated colonic inflammation","volume":"16","author":"Azuma","year":"2010","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0020","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.intimp.2010.07.007","article-title":"PPAR\u03b1 contributes to colonic protection in mice with DSS-induced colitis","volume":"10","author":"Azuma","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0025","doi-asserted-by":"crossref","DOI":"10.1007\/s10620-007-9802-8","article-title":"The ICE Inhibitor pralnacasan prevents DSS-induced colitis in C57BL\/6 mice and suppresses IP-10 mRNA but not TNF-\u03b1 mRNA expression","author":"Bauer","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0030","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1136\/gut.44.5.643","article-title":"Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinaltissue","volume":"44","author":"Bischoff","year":"1999","journal-title":"Gut"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor-\u03baB in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0040","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/nri1132","article-title":"The immunological and genetic basis of inflammatory bowel disease","volume":"3","author":"Bouma","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0045","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.crohns.2013.01.010","article-title":"The burden of inflammatory bowel disease in Europe","volume":"7","author":"Burisch","year":"2013","journal-title":"J. Crohn\u2019s Colitis"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0050","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.crohns.2011.09.003","article-title":"Risk factors for inflammatory bowel diseases according to the hygiene hypothesis: a case-control, multi-centre, prospective study in Southern Italy","volume":"6","author":"Castiglione","year":"2012","journal-title":"J. Crohn's Colitis"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0055","first-page":"238","article-title":"Clinicopathologic study of dextran sulfate sodium experimental murine colitis","volume":"69","author":"Cooper","year":"1993","journal-title":"LabInvest"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0060","first-page":"681","article-title":"Inflammatory bowel disease: genetic or environmental diseases?","author":"Cortota","year":"2009","journal-title":"Gastroent\u00e9rol. Clin. Biol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0065","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/gut.2005.079129","article-title":"A proof of concept study establishing Necator americanus in Crohn\u2019s patients and reservoir donors","volume":"55","author":"Croese","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.vetpar.2010.08.009","article-title":"Echinococcosis\/hydatidosis: a severe threat in Mediterranean countries","volume":"174","author":"Dakkak","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0075","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.trstmh.2008.03.016","article-title":"Emergence of inflammatory bowel disease \u2018beyond the West\u2019: do prosperity and improved hygiene have a role?","volume":"102","author":"de Silva","year":"2008","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/j.1749-6632.2011.06292.x","article-title":"Helminth-host immunological interactions: prevention and control of immune-mediated diseases","volume":"1247","author":"Elliott","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0085","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1002\/eji.200324833","article-title":"Heligmosomoidespolygyrus inhibits established colitis in IL-10-deficient mice","volume":"34","author":"Elliott","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0090","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0016-5085(98)70381-6","article-title":"Inflammatory bowel disease: etiology and pathogenesis","volume":"115","author":"Fiocchi","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0095","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.2174\/138945011796818225","article-title":"Biological therapy for ulcerative colitis: what is after anti-TNF","volume":"12","author":"Fiorino","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijfoodmicro.2006.10.006","article-title":"Inflammatory bowel disease: current insights into pathogenesis and new therapeutic options; probiotics, prebiotics and synbiotics","volume":"115","author":"Geier","year":"2007","journal-title":"Int. J. Food Microbiol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0105","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1056\/NEJM199603283341307","article-title":"Inflammatory bowel disease","volume":"334","author":"Hanauer","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.pharmthera.2014.02.011","article-title":"Of worms, mice and man: an overview of experimental and clinical helminth based therapy for inflammatory bowel disease","volume":"143","author":"Heylen","year":"2014","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0115","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/S0022-3565(24)29482-9","article-title":"Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl) benzyl] acetamidine","volume":"298","author":"Kankuri","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0120","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.cgh.2007.07.012","article-title":"The prevalence and geographic distribution of Crohn\u2019s disease and ulcerative colitis in the United States","volume":"5","author":"Kappelman","year":"2007","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0125","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3748\/wjg.14.165","article-title":"Hygiene hypothesis in inflammatory bowel disease: a critical review of the literature","volume":"14","author":"Kiloski","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1023\/A:1018849405922","article-title":"Increased nitric oxide production and inducible nitric oxide synthase activity in colonic mucosa of patients with active ulcerative colitis and Crohn\u2019s disease","volume":"42","author":"Kimura","year":"1997","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0135","first-page":"353","article-title":"Neutralization of tumour necrosis factor (TNF) but not of IL-1 reduces inflammation in chronic dextran sulphate sodium-induced colitis in mice","volume":"107","author":"Kojouharoff","year":"1997","journal-title":"Clin. ExpImmunol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0140","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.intimp.2011.01.022","article-title":"Embelin ameliorates dextran sodium sulfate-induced colitis in mice","volume":"11","author":"Kumar","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0145","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/563425","article-title":"Extraintestinal helminth infection limits pathology and proinflammatory cytokine expression during DSS-induced ulcerative colitis: a role for alternatively activated macrophages and prostaglandins","author":"Ledesma-Soto","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0150","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1002\/ibd.22858","article-title":"Heligmosomoides polygyrus abrogates antigenspecific gut injury in a murine model of inflammatory bowel disease","volume":"18","author":"Leung","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0155","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0140-6736(03)14573-4","article-title":"Echinococcosis","volume":"362","author":"Mc Manus","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0160","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.jep.2012.07.008","article-title":"Orally administered aqueous extract of Inonotusobliquus ameliorates acute inflammation in dextran sulfate sodium (DSS)-induced colitis in mice","volume":"143","author":"Mishra","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0165","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/0016-5085(90)90290-H","article-title":"Novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice","volume":"98","author":"Okayasu","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0170","doi-asserted-by":"crossref","first-page":"84","DOI":"10.20452\/pamw.614","article-title":"Biological therapy of inflammatory bowel disease","volume":"119","author":"Owczarek","year":"2009","journal-title":"Pol. Arch. Med. Wewn."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0175","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jnutbio.2015.10.006","article-title":"Preventive and therapeutic effects of blueberry (Vaccinium corymbosum) extract against DSS-induced ulcerative colitis by regulation of antioxidant and inflammatory mediators","volume":"28","author":"Pervin","year":"2016","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0180","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJMra020831","article-title":"Inflammatory bowel disease","volume":"347","author":"Podolsky","year":"2002","journal-title":"N. Engl. J. Med"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0185","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gut.2004.044917","article-title":"Will worms really cure Crohn\u2019s disease?","volume":"54","author":"Radford-Smith","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0190","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1089\/jir.2010.0012","article-title":"Involvement of interferon-\u03b3 in bowel disease pathogenesis by nitric oxide pathway: a study in algerian patients","volume":"30","author":"Rafa","year":"2010","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0195","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/ncpgasthep0528","article-title":"Mechanisms of disease: pathogenesis of Crohn\u2019s disease and ulcerative colitis","volume":"3","author":"Sartor","year":"2006","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0200","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.4049\/jimmunol.179.5.2681","article-title":"Cutting edge: the Ikappa B kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis","volume":"179","author":"Shibata","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0205","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.fct.2012.12.013","article-title":"Monotropein isolated from the roots of Morinda officinalis ameliorates proinflammatory mediators in RAW 264.7 macrophages and dextran sulfate sodium (DSS)-induced colitis via NF-kB inactivation","volume":"53","author":"Shin","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0210","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.4049\/jimmunol.178.7.4557","article-title":"Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism1","volume":"178","author":"Smith","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0215","doi-asserted-by":"crossref","DOI":"10.1186\/s12950-015-0063-6","article-title":"Crude extract of hydatid laminated layer from Echinococcus granulosus cyst attenuates mucosal intestinal damage and inflammatory responses in dextran sulfate sodium induced colitis in mice","author":"Soufli","year":"2015","journal-title":"J. Inflamm."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0220","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.20.100301.064816","article-title":"The immunology of mucosal models of inflammation","volume":"20","author":"Strober","year":"2009","journal-title":"Annu. Rev. Immuno."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0225","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/gut.2004.041749","article-title":"Trichuris suis therapy in Crohn\u2019s disease","volume":"54","author":"Summers","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0230","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/IAI.00744-07","article-title":"Anti-inflammatory mechanisms of enteric heligmosomoidespolygyrus infection against tri nitro benzene sulfonic acid-induced colitis in a murine model","volume":"76","author":"Sutton","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0235","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0300-9084(99)80027-3","article-title":"Production of nitric oxide (NO) in human hydatidosis: relationship between nitrite production and interferon-g levels","volume":"80","author":"Touil-Boukoffa","year":"1998","journal-title":"Biochimie"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0240","doi-asserted-by":"crossref","DOI":"10.3109\/08923973.2013.790413","article-title":"Beneficial role of the probiotic mixture ultrabiotique on maintaining the integrity of intestinal mucosal barrier in DSS-induced experimental colitis","author":"Toumi","year":"2013","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0245","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s004360100468","article-title":"Relationship between the efficacy of praziquantel treatment and the cystic differentiation in vivo of Echinococcus granulosus metacestode","volume":"88","author":"Urrea-Paris","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0250","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1186\/s13071-014-0522-6","article-title":"Echinococcus granulosus infection reduces airway inflammation of mice likely through enhancing IL-10 and down-regulation of IL-5 and IL-17A","volume":"7","author":"Wang","year":"2014","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.actatropica.2016.10.020_bib0255","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1172\/JCI11914","article-title":"Therapeutic potential of inhibition of the NFkappa B pathway in the treatment of inflammation and cancer","volume":"107","author":"Yamamoto","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.actatropica.2016.10.020_bib0260","article-title":"Epidemiology and control of echinococcosis in central Asia, with particular reference to the People\u2019s Republic of China","author":"Zhang","year":"2014","journal-title":"Acta Trop."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X16305174?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X16305174?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T22:03:51Z","timestamp":1749679431000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X16305174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2]]},"references-count":52,"alternative-id":["S0001706X16305174"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2016.10.020","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immune-protective effect of echinococcosis on colitis experimental model is dependent of down regulation of TNF-\u03b1 and NO production","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2016.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}