{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:08:40Z","timestamp":1790050120362,"version":"4.0.1"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.actatropica.2017.06.004","type":"journal-article","created":{"date-parts":[[2017,6,10]],"date-time":"2017-06-10T02:45:11Z","timestamp":1497062711000},"page":"102-108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana"],"prefix":"10.1016","volume":"173","author":[{"given":"Sanjay","family":"Varikuti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Oghumu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noushin","family":"Saljoughian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa S.","family":"Pioso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bren E","family":"Sedmak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Khamesipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhay R.","family":"Satoskar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2017.06.004_bib0005","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1517\/14728214.2012.748036","article-title":"Liposomal amphotericin B as a treatment for human leishmaniasis","volume":"17","author":"Balasegaram","year":"2012","journal-title":"Expert Opin. Emerg. Drugs"},{"key":"10.1016\/j.actatropica.2017.06.004_bib0010","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.4049\/jimmunol.181.2.1386","article-title":"Complete cure of experimental visceral leishmaniasis with amphotericin B in stearylamine-bearing cationic liposomes involves down-regulation of IL-10 and favorable T-cell responses","volume":"181","author":"Banerjee","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0015","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4103\/0974-777X.62887","article-title":"Drug resistance in leishmaniasis","volume":"2","author":"Chakravarty","year":"2010","journal-title":"J. Global Infect. Dis."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0020","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1128\/AAC.36.5.977","article-title":"Pharmacologic Modulation of interleukin-1 expression by amphotericin B-stimulated human mononuclear cells","volume":"36","author":"Cleary","year":"1992","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/1381612023396258","article-title":"Chemotherapy of leishmaniasis","volume":"8","author":"Croft","year":"2002","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0030","first-page":"399","article-title":"Current scenario of drug development for leishmaniasis","volume":"123","author":"Croft","year":"2006","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0035","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1073\/pnas.1110339109","article-title":"Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis","volume":"109","author":"Cummings","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2007\/96410","article-title":"Enhancement of a TH1 immune response in amphotericin B-treated mucocutaneous leishmaniasis","volume":"00","author":"Cuna","year":"2007","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/656523","article-title":"Efficacy of topical liposomal amphotericin B versus intralesional meglumine antimoniate (Glucantime) in the treatment of cutaneous leishmaniasis","volume":"00","author":"Layegh","year":"2011","journal-title":"J. Parasitol. Res."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0050","first-page":"1","article-title":"Clinical response with intralesional Amphotericin B in the treatment of old world cutaneous leishmaniasis: a preliminary report","volume":"00","author":"Mushtag","year":"2016","journal-title":"Dermatol. Ther."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0055","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s002329900086","article-title":"Amphotericin B kills unicellular leishmanias by forming aqueous pores permeable to small cations and anions","volume":"152","author":"Ramos","year":"1996","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0060","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0100-879X1999000300008","article-title":"Electrocardiographic changes during low-dose: short-term therapy of cutaneous leishmaniasis with the pentavalent antimonial meglumine","volume":"32","author":"Ribeiro","year":"1999","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0065","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/intimm\/dxh313","article-title":"Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice","volume":"17","author":"Rosas","year":"2005","journal-title":"Int. Immunol."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0070","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1468-3083.2010.03908.x","article-title":"Liposomal amphotericin B treatment of cutaneous leishmaniasis due to Leishmania tropica","volume":"25","author":"Solomon","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0075","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1590\/S0036-46651985000600002","article-title":"Renal function in patients with mucocutaneous leishmaniasis treated with pentavalent antimony compounds","volume":"27","author":"Veiga","year":"1985","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.actatropica.2017.06.004_bib0080","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1128\/AAC.35.5.796","article-title":"Enhancement of macrophage superoxide anion production by amphotericin B","volume":"35","author":"Wilson","year":"1991","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0085","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3109\/08923979109019702","article-title":"Amphotericin B selectively stimulates macrophages from high responder mouse strains","volume":"13","author":"Wolf","year":"1991","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0090","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.4269\/ajtmh.2010.10-0171","article-title":"Lipsosomal amphotericin B for treatment of cutaneous leishmaniasis","volume":"83","author":"Wortmann","year":"2010","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2017.06.004_bib0095","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1128\/AAC.41.4.752","article-title":"Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis","volume":"41","author":"Yardley","year":"1997","journal-title":"Antimicrob. Agents Chemother."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X17304643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X17304643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T10:38:41Z","timestamp":1574937521000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X17304643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":19,"alternative-id":["S0001706X17304643"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2017.06.004","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical treatment with nanoliposomal Amphotericin B reduces early lesion growth but fails to induce cure in an experimental model of cutaneous leishmaniasis caused by Leishmania mexicana","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2017.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}