{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:24:58Z","timestamp":1769639098956,"version":"3.49.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100010292","name":"Miguel Alem\u00e1n Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010292","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda Mexico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"Victorian State Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"Australian Government National Health and Medical Research Council Independent Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.actatropica.2017.09.004","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T17:46:24Z","timestamp":1504719984000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Recent advances in the genomic and molecular biology of Giardia"],"prefix":"10.1016","volume":"184","author":[{"given":"M.Guadalupe","family":"Ortega-Pierres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron R.","family":"Jex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan R.E","family":"Ansell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan G.","family":"Sv\u00e4rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2017.09.004_bib0005","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1093\/gbe\/evt197","article-title":"Genome sequencing of Giardia lamblia genotypes A2 and B isolates (DH and GS) and comparative analysis with the genomes of genotypes A1 and E (WB and Pig)","volume":"5","author":"Adam","year":"2013","journal-title":"Genome Biol. Evol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrmicro2317","article-title":"Behind the smile: cell biology and disease mechanisms of Giardia species","volume":"8","author":"Ankarklev","year":"2010","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0015","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.biotechadv.2015.04.009","article-title":"Drug resistance in Giardia duodenalis","volume":"33","author":"Ansell","year":"2015","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0020","doi-asserted-by":"crossref","first-page":"6034","DOI":"10.1128\/AAC.00977-16","article-title":"Divergent transcriptional responses to physiological and xenobiotic stress in giardia duodenalis","volume":"60","author":"Ansell","year":"2016","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0025","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ncb1599","article-title":"Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair","volume":"9","author":"Berkovich","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0030","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molbiopara.2010.05.010","article-title":"Transcriptome analyses of the Giardia lamblia life cycle","volume":"174","author":"Birkeland","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0035","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S1534-5807(03)00399-X","article-title":"Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice","volume":"6","author":"Branda","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0040","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.biocel.2016.10.010","article-title":"Specific histone modifications play critical roles in the control of encystation and antigenic variation in the early-branching eukaryote Giardia lamblia","volume":"81","author":"Carranza","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0045","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/nrmicro3450","article-title":"Advances in molecular genetic systems in malaria. New Technologies: methods and applications","volume":"13","author":"De Koning Ward","year":"2015","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0050","doi-asserted-by":"crossref","first-page":"13859","DOI":"10.1038\/ncomms13859","article-title":"Cyst-Wall-Protein-1 is fundamental for Golgi-like organelle neogenesis and cyst-wall biosynthesis in Giardia lamblia","volume":"7","author":"Ebneter","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.exppara.2015.03.024","article-title":"UV irradiation responses in Giardia intestinalis","volume":"154","author":"Einarsson","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0060","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.mib.2016.07.019","article-title":"An up-date on Giardia and giardiasis","volume":"34","author":"Einarsson","year":"2016","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0065","doi-asserted-by":"crossref","first-page":"e0004571","DOI":"10.1371\/journal.pntd.0004571","article-title":"Coordinated changes in gene expression throughout encystation of giardia intestinalis","volume":"10","author":"Einarsson","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molbiopara.2015.05.007","article-title":"The generation gap: proteome changes and strain variation during encystation in Giardia duodenalis","volume":"201","author":"Emery","year":"2015","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0075","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1517\/14656566.8.12.1885","article-title":"Giardiasis: a pharmacotherapy review","volume":"8","author":"Escobedo","year":"2007","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0080","doi-asserted-by":"crossref","first-page":"e83207","DOI":"10.1371\/journal.pone.0083207","article-title":"The proteome landscape of Giardia lamblia encystation","volume":"8","author":"Faso","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0085","doi-asserted-by":"crossref","first-page":"e1000560","DOI":"10.1371\/journal.ppat.1000560","article-title":"Draft genome sequencing of giardia intestinalis assemblage B isolate GS: is human giardiasis caused by two different species?","volume":"5","author":"Franzen","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0090","doi-asserted-by":"crossref","first-page":"e1003000","DOI":"10.1371\/journal.pcbi.1003000","article-title":"Transcriptome profiling of Giardia intestinalis using strand-specific RNA-seq","volume":"9","author":"Franzen","year":"2013","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/1471-2180-12-284","article-title":"Putative SF2 helicases of the early-branching eukaryote Giardia lamblia are involved in antigenic variation and parasite differentiation into cysts","volume":"12","author":"Gargantini","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0100","first-page":"103","article-title":"Oxidative stress-induced cell cycle blockage and a protease-independent programmed cell death in microaerophilic Giardia lamblia","volume":"3","author":"Ghosh","year":"2009","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0105","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.1150021","article-title":"The chemical genomic portrait of yeast: uncovering a phenotype for all genes","volume":"320","author":"Hillenmeyer","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0110","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1073\/pnas.79.11.3398","article-title":"P1 site-specific recombination: nucleotide sequence of the recombining sites","volume":"79","author":"Hoess","year":"1982","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0115","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1186\/1471-2164-11-543","article-title":"Genome analysis and comparative genomics of a Giardia intestinalis assemblage E isolate","volume":"11","author":"Jerlstrom-Hultqvist","year":"2010","journal-title":"BMC Genomics"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0120","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1038\/ncomms3493","article-title":"Hydrogenosomes in the diplomonad Spironucleus salmonicida","volume":"4","author":"Jerlstrom-Hultqvist","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0125","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ijpara.2013.06.005","article-title":"Getting to the guts of the matter: the status and potential of \u2018omics' research of parasitic protists of the human gastrointestinal system","volume":"43","author":"Jex","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0130","first-page":"175","article-title":"Cre\/loxP recombination system and gene targeting","volume":"180","author":"Kuhn","year":"2002","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0135","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1111\/j.1365-2958.2006.05345.x","article-title":"Epigenetic mechanisms are involved in the control of Giardia lamblia antigenic variation","volume":"61","author":"Kulakova","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0140","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/WNF.0b013e3182334b35","article-title":"Metronidazole-induced central nervous system toxicity: a systematic review","volume":"34","author":"Kuriyama","year":"2011","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0145","doi-asserted-by":"crossref","first-page":"7741","DOI":"10.1038\/sj.onc.1210872","article-title":"Activation and regulation of ATM kinase activity in response to DNA double-strand breaks","volume":"26","author":"Lee","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0150","doi-asserted-by":"crossref","first-page":"e1338","DOI":"10.1371\/journal.pntd.0001338","article-title":"Gene regulation in Giardia lambia involves a putative microRNA derived from a small nucleolar RNA","volume":"5","author":"Li","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0155","doi-asserted-by":"crossref","first-page":"14159","DOI":"10.1073\/pnas.1414394111","article-title":"Both endo-siRNAs and tRNA-derived small RNAs are involved in the differentiation of primitive eukaryote Giardia lamblia","volume":"111","author":"Liao","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0166-6851(88)90061-8","article-title":"Heat shock and stress response in Giardia lamblia","volume":"28","author":"Lindley","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0165","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2004.08.015","article-title":"Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins","volume":"118","author":"Lisby","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0170","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.ijpara.2015.07.005","article-title":"Transcriptional profiling of Giardia intestinalis in response to oxidative stress","volume":"45","author":"Ma'ayeh","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0175","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3389\/fmicb.2015.00800","article-title":"Albendazole induces oxidative stress and DNA damage in the parasitic protozoan Giardia duodenalis","volume":"6","author":"Martinez-Espinosa","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0180","doi-asserted-by":"crossref","DOI":"10.1093\/jb\/mvx009","article-title":"Giardia duodenalis Rad52 protein: biochemical characterization and response upon DNA damage","author":"Martinez-Miguel","year":"2017","journal-title":"J. Biochem."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0185","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1128\/MCB.21.1.281-288.2001","article-title":"DNA damage-dependent nuclear dynamics of the Mre11 complex","volume":"21","author":"Mirzoeva","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0190","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1128\/EC.00100-10","article-title":"The transcriptional response to encystation stimuli in Giardia lamblia is restricted to a small set of genes","volume":"9","author":"Morf","year":"2010","journal-title":"Eukaryot. Cell"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0195","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1126\/science.1143837","article-title":"Genomic minimalism in the early diverging intestinal parasite Giardia lamblia","volume":"317","author":"Morrison","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0200","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature07585","article-title":"Antigenic variation in Giardia lamblia is regulated by RNA interference","volume":"456","author":"Prucca","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0205","first-page":"185","article-title":"A phylogenomic inventory of meiotic genes; evidence for sex in Giardia and an early eukaryotic origin of meiosis","volume":"15","author":"Ramesh","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0210","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.biochi.2015.01.008","article-title":"MR (Mre11-Rad50) complex in Giardia duodenalis: in vitro characterization and its response upon DNA damage","volume":"111","author":"Sandoval-Cabrera","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0215","doi-asserted-by":"crossref","first-page":"e1000224","DOI":"10.1371\/journal.ppat.1000224","article-title":"snoRNA, a novel precursor of microRNA in Giardia lamblia","volume":"4","author":"Saraiya","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0220","doi-asserted-by":"crossref","first-page":"e1003791","DOI":"10.1371\/journal.ppat.1003791","article-title":"The microRNAs in an ancient protist repress the variant-specific surface protein expression by targeting the entire coding sequence","volume":"10","author":"Saraiya","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0225","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pt.2006.02.015","article-title":"Giardia and cryptosporidium join the \u2018Neglected diseases initiative'","volume":"22","author":"Savioli","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0230","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/j.cub.2004.09.047","article-title":"Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break","volume":"14","author":"Shroff","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0235","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1111\/j.1365-2958.2010.07062.x","article-title":"Epigenetic mechanisms regulate stage differentiation in the minimized protozoan Giardia lamblia","volume":"76","author":"Sonda","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0240","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/mmi.12218","article-title":"An ER-directed transcriptional response to unfolded protein stress in the absence of conserved sensor-transducer proteins in Giardia lamblia","volume":"88","author":"Spycher","year":"2013","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0245","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/0022-2836(81)90376-4","article-title":"Bacteriophage P1 site-specific recombination. II. Recombination between loxP and the bacterial chromosome","volume":"150","author":"Sternberg","year":"1981","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0250","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1046\/j.1365-2958.2002.03233.x","article-title":"A novel Myb-related protein involved in transcriptional activation of encystation genes in Giardia lamblia","volume":"46","author":"Sun","year":"2002","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0255","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.molbiopara.2005.10.017","article-title":"Novel plant-GARP-like transcription factors in Giardia lamblia","volume":"146","author":"Sun","year":"2006","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0260","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1046\/j.1365-2958.1998.01125.x","article-title":"Differentiation-associated surface antigen variation in the ancient eukaryote Giardia lamblia","volume":"30","author":"Svard","year":"1998","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0265","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1093\/nar\/gkm105","article-title":"Bidirectional transcription is an inherent feature of Giardia lamblia promoters and contributes to an abundance of sterile antisense transcripts throughout the genome","volume":"35","author":"Teodorovic","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0270","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.biochi.2016.05.014","article-title":"Characterization of recombinase DMC1B and its functional role as Rad51 in DNA damage repair in Giardia duodenalis trophozoites","volume":"127","author":"Torres-Huerta","year":"2016","journal-title":"Biochimie"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0275","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.dib.2016.08.031","article-title":"In silico data analyses of recombinases GdDMC1A and GdDMC1B from Giardia duodenalis","volume":"9","author":"Torres-Huerta","year":"2016","journal-title":"Data Brief"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0280","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molbiopara.2015.01.005","article-title":"The effect of metronidazole on the cell cycle and DNA in metronidazole-susceptible and \u2013resistant Giardia cell lines","volume":"198","author":"Uzlikova","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0285","doi-asserted-by":"crossref","first-page":"4763","DOI":"10.1128\/IAI.72.8.4763-4771.2004","article-title":"Experimental infections of neonatal mice with cysts of Giardia lamblia clone GS\/M-83-H7 are associated with an antigenic reset of the parasite","volume":"72","author":"Von Allmen","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0290","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ijpara.2014.03.008","article-title":"The Cre\/loxP system in Giardia lamblia: genetic manipulations in a binucleate tetraploid protozoan","volume":"44","author":"Wampfler","year":"2014","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0295","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.molcel.2005.07.006","article-title":"A nanomachine for making ends meet: MRN is a flexing scaffold for the repair of DNA double-strand breaks","volume":"19","author":"Williams","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.actatropica.2017.09.004_bib0300","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1146\/annurev.genet.40.110405.090451","article-title":"DNA double-strand break repair: all's well that ends well","volume":"40","author":"Wyman","year":"2006","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.actatropica.2017.09.004_bib0305","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1074\/jbc.275.15.11432","article-title":"Transcriptional analysis of the glutamate dehydrogenase gene in the primitive eukaryote, Giardia lamblia. Identification of a primordial gene promoter","volume":"275","author":"Yee","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X17308574?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X17308574?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T04:09:43Z","timestamp":1576814983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X17308574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":61,"alternative-id":["S0001706X17308574"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2017.09.004","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Recent advances in the genomic and molecular biology of Giardia","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2017.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}