{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:27:53Z","timestamp":1786984073431,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.actatropica.2018.02.008","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T11:33:15Z","timestamp":1518521595000},"page":"127-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole"],"prefix":"10.1016","volume":"185","author":[{"given":"Leslie Raphael de Moura","family":"Ferraz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alinne \u00c9lida Gon\u00e7alves","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Dolores Souza da Silva","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Ara\u00fajo e","family":"Amariz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Silva","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvana Priscylla Manso","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa Ara\u00fajo","family":"Rolim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1dley Antonini Neves de","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Jos\u00e9","family":"Rolim Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2018.02.008_bib0005","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1542\/peds.2010-1172","article-title":"Adverse events after the use of benznidazole in infants and children with Chagas disease","volume":"127","author":"Altcheh","year":"2011","journal-title":"Pediatrics"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0010","first-page":"123","article-title":"Side effects of benznidazole treatment in a cohort of patients with Chagas disease in non-endemic country","volume":"24","author":"Carrilero","year":"2011","journal-title":"Revista espa\u00edola de quimioterapia: publicaci\u00f1n oficial de La Sociedad Espa\u00edola de Quimioterapia"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1590\/0037-8682-0071-2016","article-title":"Adverse systemic reaction to benznidazole","volume":"50","author":"Coronel","year":"2017","journal-title":"Rev. Soc. Bras. Med. Trop."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0020","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1590\/S0037-86822012000300002","article-title":"Chagas disease: what is known and what should be improved: a systemic review","volume":"45","author":"Coura","year":"2012","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1590\/0074-0276140362","article-title":"The main sceneries of Chagas disease transmission. The vectors: blood and oral transmissions \u2013 a comprehensive review","volume":"110","author":"Coura","year":"2015","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0030","first-page":"105","article-title":"A pr\u00f3polis no combate a tripanossomat\u00eddeos de import\u00e2ncia m\u00e9dica: uma perspectiva terap\u00eautica para doen\u00e7a de Chagas e Leishmaniose","volume":"40","author":"Cunha","year":"2011","journal-title":"Revista de Patologia Tropical"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0035","first-page":"1","article-title":"Recentes avan\u00e7os no tratamento da doen\u00e7a de Chagas","volume":"49","author":"Cunha-Filho","year":"2013","journal-title":"BSB M\u00e9dica"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0040","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1590\/0037-8682-0248-2013","article-title":"The present situation challenges, and perspectives regarding the production and utilization of effective drugs against human Chagas disease","volume":"47","author":"Dias","year":"2014","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0045","first-page":"7","article-title":"Brazilian consensus on chagas disease","volume":"25","author":"Dias","year":"2016","journal-title":"Epidemiol. Serv. Sa\u00fade."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0050","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.exppara.2015.01.002","article-title":"Novel solid dispersions of benznidazole: preparation: dissolution profile and biological evaluation as alternative antichagasic drug delivery system","volume":"149","author":"Fonseca-Berzal","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0055","series-title":"Avalia\u00e7\u00e3o in vitro de derivados 2-tioxo-imidazolidinicos para quimioterapia da doen\u00e7a de chagas. 117f","author":"Gomes","year":"2010"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0060","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijbiomac.2013.10.007","article-title":"Effects of benznidazole: cyclodextrin complexes on the drug bioavailability upon oral administration to rats","volume":"62","author":"Leonardi","year":"2013","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0065","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/jps.22436","article-title":"The use of solid dispersion systems in hydrophilic carriers to increase benznidazole solubility","volume":"100","author":"Lima","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0070","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.parint.2012.09.001","article-title":"Efficacy of novel benznidazole solutions during the experimental infection with Trypanosoma cruzi","volume":"62","author":"Manarin","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0075","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.ejpb.2011.03.003","article-title":"Benznidazole microcrystal preparation by solvent change precipitation and in vivo evaluation in the treatment of Chagas disease","volume":"78","author":"Maximiano","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0080","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.molliq.2013.07.004","article-title":"Host\u2013guest interactions between benznidazole and beta-cyclodextrin in multicomponent complex systems involving hydrophilic polymers andtriethanolamine in aqueoussolution","volume":"186","author":"Melo","year":"2013","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0085","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0213-005X(13)70111-3","article-title":"Diagn\u00f3stico y tratamiento de la enfermedad de Chagas","volume":"31","author":"Murcia","year":"2013","journal-title":"Enfermedades Infecciosas y Microbiolog\u00eda Cl\u00ednica"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0090","series-title":"Composi\u00e7\u00e3o e processo de produ\u00e7\u00e3o da forma l\u00edquida de administra\u00e7\u00e3o a base de sistemas lip\u00eddicos emulsionados, do tipo emuls\u00e3o, microemuls\u00e3o e\/ou nanoemuls\u00e3o contendo benznidazol para o tratamento da doen\u00e7a de chagas","author":"Oliveira","year":"2013"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0095","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jpba.2015.08.019","article-title":"Comparative evaluation of the effect of cyclodextrins and pH on aqueous solubility of apigenin","volume":"117","author":"P\u00e1pay","year":"2016","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0100","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2014.06.015","article-title":"Development of novel benznidazole formulations: physicochemical characterization and in vivo evaluation on parasitemia reduction in Chagas disease","volume":"472","author":"Palmeiro-Rold\u00e1n","year":"2014","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0105","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1128\/AAC.01401-12","article-title":"Benznidazole-related adverse drug reactions and their relationship to serum drug concentrations in patients with chronic chagas disease","volume":"57","author":"Pinazo","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0110","series-title":"24\u00b0 Encontro Anual de Inicia\u00e7\u00e3o Cient\u00edfica, Paran\u00e1","article-title":"Desenvolvimento e caracteriza\u00e7\u00e3o de nano\/micropart\u00edculas contendo benzonidazol associado a compostos sin\u00e9rgicos naturais ou sint\u00e9ticos para o tratamento da doen\u00e7a de Chagas","author":"Rambo","year":"2015"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0115","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhazmat.2014.02.026","article-title":"Toxic effect of zinc nanoscale metal-organic frameworks on rat pheochromocytoma (PC12) cells in vitro","volume":"271","author":"Ren","year":"2014","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0120","article-title":"Formula\u00fa\u00e7es farmac\u00f5uticas contendo associa\u00fa\u00eao de benznidazol e MOF\u00e3s para obten\u00fa\u00eao tecnol\u2019gica de sistemas","author":"Rolim-Neto","year":"2016","journal-title":"Drug Deliv."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0125","series-title":"Mal de chagas, una enfermedadpresente pero olvidada. Estudios in vitro\/in vivo de nuevas formulaciones s\u00f3lidas y liquidas de benznidazol. 208f","author":"Salomon","year":"2012"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0130","first-page":"37","article-title":"Pesquisa: desenvolvimento e inova\u00e7\u00e3o para o controle das doen\u00e7as negligenciadas","volume":"33","author":"Santos","year":"2012","journal-title":"Revista de Ci\u00eancias Farmac\u00eauticas B\u00e1sica e Aplicada"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0135","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.carbpol.2012.02.042","article-title":"Benznidazole drug delivery by binary and multicomponent inclusion complexes using cyclodextrins and polymers","volume":"89","author":"Soares-Sobrinho","year":"2012","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0140","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1111\/tmi.12980","article-title":"Development and in vitro\/in vivo evaluation of a novel benznidazole liquid dosage form using a quality-by-design approach","volume":"22","author":"Souza","year":"2017","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0145","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1590\/S0100-40422011000800028","article-title":"Valida\u00e7\u00e3o de m\u00e9todo anal\u00edtico por espectrofotometria UV para sistema emulsionado lip\u00eddico contendo benznidazol","volume":"34","author":"Streck","year":"2011","journal-title":"Qu\u00edmica Nova"},{"key":"10.1016\/j.actatropica.2018.02.008_bib0150","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.molliq.2014.03.033","article-title":"Surfactant\u2013cosurfactant interactions and process parameters involved in the formulation of stable and small droplet-sized benznidazole-loaded soybean O\/W emulsions","volume":"196","author":"Streck","year":"2014","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.actatropica.2018.02.008_bib0155","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.exppara.2014.03.013","article-title":"Trypanosomacruzi chemical proteomics using immobilized benznidazole","volume":"140","author":"Trochine","year":"2014","journal-title":"Exp. Parasitol."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X17312755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X17312755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:13:00Z","timestamp":1757549580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X17312755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":31,"alternative-id":["S0001706X17312755"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2018.02.008","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Technological innovation strategies for the specific treatment of Chagas disease based on Benznidazole","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2018.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}