{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:51:39Z","timestamp":1780480299158,"version":"3.54.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T00:00:00Z","timestamp":1569974400000},"content-version":"vor","delay-in-days":274,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.actatropica.2018.09.015","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T12:10:24Z","timestamp":1538482224000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs"],"prefix":"10.1016","volume":"189","author":[{"given":"Ivo Santana","family":"Caldas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9818-5178","authenticated-orcid":false,"given":"Ana Paula de Jesus","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edvia de Figueiredo","family":"Diniz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro Fernando da Silva do","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00f4mulo Dias","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Terezinha","family":"Bahia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2018.09.015_bib0005","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1590\/S0074-02761984000500016","article-title":"The canine model of Chagas\u2019 disease","volume":"79","author":"Andrade","year":"1984","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0010","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1590\/S0074-02761999000700007","article-title":"Immunopathology of Chagas Disease","volume":"94","author":"Andrade","year":"1999","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0015","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/S0140-6736(96)04128-1","article-title":"Randomised trial of benznidazole in treatment of early Trypanosoma cruzi infection","volume":"348","author":"Andrade","year":"1996","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.actatropica.2018.09.015_bib0020","doi-asserted-by":"crossref","first-page":"594","DOI":"10.4269\/ajtmh.2004.71.594","article-title":"Short report: benznidazole efficacy among Trypanosoma cruzi-infected adolescents after a six-year follow-up","volume":"71","author":"Andrade","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0025","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0166-6851(91)90116-N","article-title":"Polymerase chain reaction amplification of Trypanosoma cruzi kinetoplast minicircle DNA isolated from whole blood lysates: diagnosis of chronic Chagas\u2019 disease","volume":"48","author":"Avila","year":"1991","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0030","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/S0036-46651986000200005","article-title":"Estudo comparativo entre o m\u00e9todo convencional e o m\u00e9todo peroxidase antiperoxidase na pesquisa do parasitismo tissular na cardiopatia chag\u00e1sica cr\u00f4nica","volume":"28","author":"Barbosa","year":"1986","journal-title":"Rev. Inst. Med. Trop. S\u00e3o Paulo"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0035","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.2460\/ajvr.1991.52.12.2033","article-title":"Pathologic features of dogs inoculated with North American Trypanosoma cruzi isolates","volume":"52","author":"Barr","year":"1991","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0040","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.healun.2014.01.920","article-title":"Trypanosoma cruzi persistence in the native heart is associated with high-grade myocarditis, but not with Chagas\u2019 disease reactivation after heart transplantation","volume":"33","author":"Benvenuti","year":"2014","journal-title":"J. Heart Lung Transpl."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0045","first-page":"389","article-title":"Therapeutic activity and criterion of cure on mice experimentally infected with Trypanosoma cruzi","volume":"4","author":"Brener","year":"1962","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0050","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.actatropica.2012.05.002","article-title":"Real-time PCR strategy for parasite quantification in blood and tissue samples of experimental Trypanosoma cruzi infection","volume":"123","author":"Caldas","year":"2012","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0055","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/tmi.12002","article-title":"Myocardial scars correlate with eletrocardiographic changes in chronic Trypanosoma cruzi infection for dogs treated with benznidazole","volume":"18","author":"Caldas","year":"2013","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0060","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.actatropica.2016.12.015","article-title":"Myocarditis in different experimental models infected by Trypanosoma cruzi is correlated with the production of IgG1 isotype","volume":"167","author":"Caldas","year":"2017","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0065","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00428-001-0542-4","article-title":"Immunohistochemical studies in acute and chronic canine chagasic cardiomyopathy","volume":"441","author":"Caliari","year":"2002","journal-title":"Virchows Arch."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0036-46652002000100006","article-title":"Long term evaluation of etiological treatment of Chagas disease with benznidazole","volume":"44","author":"Can\u00e7ado","year":"2002","journal-title":"Rev. Inst. Med. Trop. Sao Paulo"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004651","article-title":"Electrocardiographic abnormalities and treatment with benznidazole among children with chronic infection by Trypanosoma cruzi: a retrospective cohort study","volume":"10","author":"Colantonio","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0080","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1086\/596061","article-title":"Functional IL-10 gene polymorphism is associated with chagas disease cardiomyopathy","volume":"199","author":"Costa","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1590\/S0074-02761992000100011","article-title":"Experimental Chagas\u2019 disease in dogs","volume":"87","author":"de Lana","year":"1992","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(03)00054-9","article-title":"Organization of satellite DNA in the genome of Trypanosoma cruzi","volume":"129","author":"Elias","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0095","doi-asserted-by":"crossref","first-page":"526","DOI":"10.4269\/ajtmh.1998.59.526","article-title":"Efficacy of chemotherapy with benznidazole in children in the indeterminate phase of Chagas\u2019 disease","volume":"59","author":"Estani","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0100","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0035-9203(87)90020-4","article-title":"Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease","volume":"81","author":"Filardi","year":"1987","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0105","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1471-4922(02)00006-5","article-title":"Etiology of Chagas disease myocarditis: autoimmunity, parasite persistence, or both?","volume":"19","author":"Giron\u00e8s","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0110","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1006\/expr.1998.4191","article-title":"Trypanosoma cruzi: optimization of polymerase chain reaction for detection in human blood","volume":"33","author":"Gomes","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0115","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1073\/pnas.81.11.3356","article-title":"Minichromosomal repetitive DNA in Trypanosoma cruzi: its use in a high-sensitivity parasite detection assay","volume":"81","author":"Gonzalez","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0001-706X(02)00139-0","article-title":"The dog as model for chemotherapy of the Chagas\u2019 disease","volume":"84","author":"Guedes","year":"2002","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0125","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.vetimm.2010.06.010","article-title":"Increased type 1 chemokine expression in experimental Chagas disease correlates with cardiac pathology in Beagle dogs","volume":"138","author":"Guedes","year":"2010","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0130","first-page":"107","article-title":"Rapid negativization of serology after treatment with benznidazole for Chagas disease in a group of colombian schoolchildren","volume":"vol. 1","author":"Guhl","year":"2004","journal-title":"Medimond International Proceedings"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0135","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/1054-8807(93)90021-S","article-title":"Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: light microscopy and immunohistochemical findings","volume":"2","author":"de L. Higuchi","year":"1993","journal-title":"Cardiovasc. Pathol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0140","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0008-6363(03)00361-4","article-title":"Pathophysiology of the heart in Chagas\u2019 disease: current status and new developments","volume":"60","author":"Higuchi","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.parint.2012.09.003","article-title":"Identification by Q-PCR of Trypanosoma cruzi lineage and determination of blood meal sources in triatomine gut samples in M\u00e9xico","volume":"62","author":"Ib\u00e1\u00f1ez-Cervantes","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0150","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1590\/S0074-02761986000300001","article-title":"Caracteriza\u00e7\u00e3o biol\u00f3gica comparativa das cepas Berenice e Berenice-78 de Trypanosoma cruzi isoladas da mesma paciente em diferentes per\u00edodos","volume":"81","author":"Lana","year":"1986","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0155","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1590\/S0074-02762003000300013","article-title":"Detection of Trypanosoma cruzi DNA within murine cardiac tissue sections by in situ polymerase chain reaction","volume":"98","author":"Lane","year":"2003","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0160","first-page":"913","article-title":"Apoptosis as a cause of T-cell unresponsiveness in experimental Chagas\u2019 disease","volume":"28","author":"Lopes","year":"1995","journal-title":"Brazilian J. Med. Biol. Res. Rev. Bras. Pesqui. m\u00e9dicas e biol\u00f3gicas\/Soc. Bras. Biof\u00edsica."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0165","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1590\/S0074-02762000000600021","article-title":"A simplified method for sample collection and DNA isolation for polymerase chain reaction detection of trypanosoma rangeli and Trypanosoma cruzi in triatomine vectors","volume":"95","author":"Machado","year":"2000","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0170","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic Chagas heart disease","volume":"115","author":"Marin-Neto","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0175","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actatropica.2012.08.020","article-title":"Towards the establishment of a consensus real-time qPCR to monitor Trypanosoma cruzi parasitemia in patients with chronic Chagas disease cardiomyopathy: a substudy from the BENEFIT trial","volume":"125","author":"Moreira","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0180","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1590\/S0074-02762010000700014","article-title":"Trypanosoma cruzi benznidazole susceptibility in vitro does not predict the therapeutic outcome of human Chagas disease","volume":"105","author":"Moreno","year":"2010","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0185","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1507574","article-title":"Randomized trial of benznidazole for chronic Chagas\u2019 cardiomyopathy","volume":"373","author":"Morillo","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0190","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4269\/ajtmh.1998.59.563","article-title":"Polymerase chain reaction amplification of three different Trypanosoma cruzi DNA sequences from human chagasic cardiac tissue","volume":"59","author":"Olivares-Villag\u00f3mez","year":"1998","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0195","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/QCO.0000000000000023","article-title":"Management of Trypanosoma cruzi coinfection in HIV-positive individuals outside endemic areas","volume":"27","author":"P\u00e9rez-Molina","year":"2014","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.actatropica.2007.05.019","article-title":"Development of a real-time PCR assay for Trypanosoma cruzi detection in blood samples","volume":"103","author":"Piron","year":"2007","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0205","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S1473-3099(01)00065-2","article-title":"Clinical and epidemiological aspects of Chagas disease","volume":"1","author":"Prata","year":"2001","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0210","first-page":"293","article-title":"Myocardial damage in Trypanosoma cruzi myocarditis: a role for macrophages","volume":"6","author":"Rossi","year":"1990","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0215","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1007\/BF00202486","article-title":"Genetic and population study of a Y-linked tetranucleotide repeat DNA polymorphism with a simple non-isotopic technique","volume":"90","author":"Santos","year":"1993","journal-title":"Hum. Genet."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0220","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.actatropica.2016.05.007","article-title":"Chagas cardiomyopathy: the potential effect of benznidazole treatment on diastolic dysfunction and cardiac damage in dogs chronically infected with Trypanosoma cruzi","volume":"161","author":"Santos","year":"2016","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0225","series-title":"Characterization of Strains of Trypanosoma Cruziisolated from Patients with Different Clinical Forms of Chagas Disease","author":"Schlemper","year":"1982"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0230","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023042","article-title":"Genome size, karyotype polymorphism and chromosomal evolution in Trypanosoma cruzi","volume":"6","author":"Souza","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0235","series-title":"Biology of Kinetoplastidae","first-page":"547","article-title":"Pathogenesis of Trypanosoma cruzi infections","author":"Tafuri","year":"1979"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0240","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1590\/S0074-02762006000500001","article-title":"Evolution and pathology in Chagas disease - a review","volume":"101","author":"Teixeira","year":"2006","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0245","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1128\/AAC.47.1.223-230.2003","article-title":"Chemotherapy with benznidazole and itraconazole for mice infected with different Trypanosoma cruzi clonal genotypes","volume":"47","author":"Toledo","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.actatropica.2018.09.015_bib0250","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1590\/S0074-02762008000600003","article-title":"Trypanosoma cruzi: blood parasitism kinetics and their correlation with heart parasitism intensity during long-term infection of Beagle dogs","volume":"103","author":"Veloso","year":"2008","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.actatropica.2018.09.015_bib0255","doi-asserted-by":"crossref","first-page":"724","DOI":"10.7326\/0003-4819-144-10-200605160-00006","article-title":"Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial","volume":"144","author":"Viotti","year":"2006","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0260","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.actatropica.2006.11.005","article-title":"Trypanosoma cruzi: typing of genotype (sub)lineages in megacolon samples from bolivian patients","volume":"100","author":"Virreira","year":"2006","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.09.015_bib0265","first-page":"55","article-title":"Enzyme immunoassays in diagnostic medicine. Theory and practice","volume":"53","author":"Voller","year":"1976","journal-title":"Bull. WHO"},{"issue":"18","key":"10.1016\/j.actatropica.2018.09.015_bib0270","first-page":"75","article-title":"Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-Year experience of M\u00e9decins Sans Fronti\u00e8res","volume":"3","author":"Yun","year":"2009","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X18304637?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X18304637?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:11:15Z","timestamp":1757549475000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X18304637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":54,"alternative-id":["S0001706X18304637"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2018.09.015","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Parasitaemia and parasitic load are limited targets of the aetiological treatment to control the progression of cardiac fibrosis and chronic cardiomyopathy in Trypanosoma cruzi-infected dogs","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2018.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V.","name":"copyright","label":"Copyright"}]}}