{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:34:29Z","timestamp":1762079669233,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["471009\/2013-0","302159\/2016-9"],"award-info":[{"award-number":["471009\/2013-0","302159\/2016-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.actatropica.2018.12.017","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T17:19:16Z","timestamp":1544721556000},"page":"361-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Oral nitazoxanide treatment of experimental neurocysticercosis induces gluconeogenesis in Taenia crassiceps cysticerci"],"prefix":"10.1016","volume":"190","author":[{"given":"Nayana F.","family":"Lima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4681-0813","authenticated-orcid":false,"given":"Guaraciara A.","family":"Pican\u00e7o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniella de S.M.M.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana D.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eliana","family":"Isac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane L.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruy de S.","family":"Lino Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina C.","family":"Vinaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.actatropica.2018.12.017_bib0005","first-page":"1117","article-title":"In vitro effects of nitazoxanide on morphology of nascent and immature adult stages of Taenia solium","volume":"5","author":"Ambrosio","year":"2017","journal-title":"Ann. Clin. Cytol. Pathol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0010","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1017\/S0031182000054445","article-title":"The anaerobic end-products of helminths","volume":"88","author":"Barret","year":"1984","journal-title":"Parasitology"},{"issue":"5","key":"10.1016\/j.actatropica.2018.12.017_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001500","article-title":"Neurocysticercosis: neglected but not forgotten","volume":"6","author":"Coyle","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0020","doi-asserted-by":"crossref","first-page":"3781","DOI":"10.1007\/s00436-018-6080-7","article-title":"A gel-free proteomic analysis of Taenia solium and Taenia crassiceps cysticerci vesicular extracts","volume":"117","author":"da Costa","year":"2018","journal-title":"Parasitol Res."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0025","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.parint.2016.12.009","article-title":"Antigenic fractions from Taenia crassiceps metacestodes obtained by hydrophobicity for the immunodiagnosis of active and inactive forms of neurocysticercosis in human cerebrospinal fluid samples","volume":"66","author":"da Silva","year":"2017","journal-title":"Parasitol Int."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0030","doi-asserted-by":"crossref","first-page":"198","DOI":"10.2741\/4305","article-title":"Mitochondrial bioenergetics and disease in Caenorhabditis elegans","volume":"20","author":"Dancy","year":"2015","journal-title":"Front. Biosci."},{"issue":"2","key":"10.1016\/j.actatropica.2018.12.017_bib0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.4103\/2229-5070.122103","article-title":"Human cysticercosis (Taenia solium)","volume":"3","author":"Del Brutto","year":"2013","journal-title":"Trop. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0040","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.exppara.2011.11.001","article-title":"Taenia crassiceps: host treatment alters glycolisis and tricarboxilic acid cycle in cysticerci","volume":"130","author":"Fraga","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0045","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1017\/S0031182015001729","article-title":"Alternative energy production pathways in Taenia crassiceps cysticerci in vitro exposed to a benzimidazole derivative (RCB20)","volume":"143","author":"Fraga","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2018.12.017_bib0050","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/jac\/45.4.453","article-title":"Activity of nitazoxanide alone and in combination with azithromycin and rifabutin against Cryptosporidium parvum in cell culture","volume":"45","author":"Giacometti","year":"2000","journal-title":"J Antimicrob Chemother."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0055","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S1471-4922(01)02205-X","article-title":"Treatment of intestinal parasitic infections: a review of nitazoxanide","volume":"18","author":"Gilles","year":"2002","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0060","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.molbiopara.2014.02.005","article-title":"Extracellular functions of glycolytic enzymes of parasites: unpredicted use of ancient proteins","volume":"193","author":"G\u00f3mez-Arreaza","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0065","doi-asserted-by":"crossref","first-page":"292","DOI":"10.4269\/ajtmh.2012.11-0371","article-title":"Efficacy of diverse antiparasitic treatments for cysticercosis in the pig model","volume":"87","author":"Gonzalez","year":"2012","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0070","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/AAC.01159-06","article-title":"Antiparasitic drug nitazoxanide inhibits the pyruvate oxidoreductases of Helicobacter pylori and selected anaerobic bacteria and parasites, and Campylobacter jejuni","volume":"51","author":"Hoffman","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exppara.2016.10.012","article-title":"Nitazoxanide induces in vitro metabolic acidosis in Taenia crassiceps cysticerci","volume":"171","author":"Isac","year":"2016","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0080","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00436-014-3770-7","article-title":"Partial reverse of the TCA cycle is enhanced in Taenia crassiceps experimental neurocysticercosis after in vivo treatment with anthelminthic drugs","volume":"113","author":"Leandro","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0085","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1590\/S0004-282X2012005000010","article-title":"Experimental encephalitis caused by Taenia crassiceps cysticerci in mice","volume":"70","author":"Matos-Silva","year":"2012","journal-title":"Arq. Neuropsiquiatr"},{"key":"10.1016\/j.actatropica.2018.12.017_bib0090","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1590\/0004-282x20160194","article-title":"Experimental neurocysticercosis: absence of IL-4 induces lower encephalitis","volume":"75","author":"Matos-Silva","year":"2017","journal-title":"Arq Neuropsiquiatr."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0095","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1128\/AAC.42.11.2836","article-title":"Nitazoxanide, a potential drug for eradication ofHelicobacter pylori with no cross-resistance to metronidazole","volume":"42","author":"M\u00e9graud","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.actatropica.2013.06.010","article-title":"Efficacy of ivermectin and oxfendazole against Taenia solium cisticercosis and other parasitoses in naturally infected pigs","volume":"128","author":"Mkupasi","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0105","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1017\/S0031182015001572","article-title":"Cellular immune response in intraventricular experimental neurocysticercosis","volume":"143","author":"Moura","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.actatropica.2018.12.017_bib0110","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1007\/s00436-017-5614-8","article-title":"In vivo treatment with nitazoxanide induces anaerobic metabolism in experimental intraperitoneal cysticercosis","volume":"116","author":"Nasareth","year":"2017","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0115","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/jac\/dkl463","article-title":"Efficacy of nitazoxanide. Tizoxanide and \/albendazole sulphoxide combination against Taenia crassiceps cysts","volume":"59","author":"Palomares-Alonso","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"issue":"Suppl. 1","key":"10.1016\/j.actatropica.2018.12.017_bib0120","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1007\/s00436-002-0754-9","article-title":"Nitroheterocyclic drugs with broad spectrum activity","volume":"90","author":"Raether","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0125","doi-asserted-by":"crossref","first-page":"511","DOI":"10.4269\/ajtmh.1984.33.511","article-title":"Nitazoxanide in the treatment of Taenia saginata and Hymenolepis nana infections","volume":"33","author":"Rossignol","year":"1984","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jsps.2016.09.005","article-title":"Effect of nitazoxanide on albendazole pharmacokinetics in cerebrospinal fluid and plasma in rats","volume":"25","author":"Ruiz-Olmedo","year":"2017","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0135","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1645\/GE-3102.1","article-title":"Development of the S3Pvac vaccine against porcine Taenia solium cysticercosis: a historical review","volume":"99","author":"Sciutto","year":"2013","journal-title":"J. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/1570163814666170727130003","article-title":"Update on nitazoxanide: a multifunctional chemotherapeutic agent","volume":"15","author":"Shakya","year":"2017","journal-title":"Curr. Drug. Discov. Technol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0145","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s13346-018-0576-7","article-title":"In vivo treatment of experimental neurocysticercosis with praziquantel nanosuspensions\u2014a metabolic approach","volume":"8","author":"Silva","year":"2018","journal-title":"Drug Deliv Transl Res."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0150","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1111\/epi.12159","article-title":"From seizures to epilepsy and its substrates: neurocysticercosis","volume":"54","author":"Singh","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.actatropica.2018.12.017_bib0155","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/AAC.47.2.467-474.2003","article-title":"In vitro parasiticidal effect of nitazoxanide against Echinococcus multilocularis metacestodes","volume":"47","author":"Stettler","year":"2003","journal-title":"Antimicrob Agents Chemother."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0160","doi-asserted-by":"crossref","first-page":"40814","DOI":"10.1038\/srep40814","article-title":"Helminth-induced Ly6Chi monocyte-derived alternatively activated macrophages suppress experimental autoimmune encephalomyelitis","volume":"7","author":"Terrazas","year":"2017","journal-title":"Sci Rep."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0165","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijpara.2009.12.006","article-title":"Acetate formation in the energy metabolism of parasitic helminthes and protists","volume":"40","author":"Tielens","year":"2010","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0170","doi-asserted-by":"crossref","first-page":"354","DOI":"10.4269\/ajtmh.1997.57.354","article-title":"Immunoblot with cerebroespinal fluid from patients with neurocysticercosis using antigen from cysticerci of Taenia solium and Taenia crassiceps","volume":"57","author":"Vaz","year":"1997","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0175","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.exppara.2007.01.013","article-title":"Taenia crassiceps organic acids detected in cysticerci","volume":"116","author":"Vinaud","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0180","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1093\/jac\/dkh386","article-title":"In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes","volume":"54","author":"Walker","year":"2004","journal-title":"J Antimicrob Chemother."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0185","doi-asserted-by":"crossref","first-page":"382","DOI":"10.4269\/ajtmh.2003.68.382","article-title":"Nitazoxanide: an important advance in anti-parasitic therapy","volume":"68","author":"White","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0190","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1586\/14787210.2.1.43","article-title":"Nitazoxanide: a new broad spectrum antiparasitic agent","volume":"2","author":"White","year":"2004","journal-title":"Expert Rev. Anti Infect. Ther."},{"key":"10.1016\/j.actatropica.2018.12.017_bib0195","series-title":"Working to Overcome the Global Impact of Neglected Tropical Diseases: First WHO Report on Neglected Tropical Diseases","isbn-type":"print","author":"WHO","year":"2010","ISBN":"https:\/\/id.crossref.org\/isbn\/9789241564090"},{"key":"10.1016\/j.actatropica.2018.12.017_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0022149X18000755","article-title":"Hippocampal sclerosis induced in mice by a Taenia crassiceps metacestode factor","author":"Zepeda","year":"2018","journal-title":"J. Helminthol."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X18305680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X18305680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T14:58:32Z","timestamp":1605625112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X18305680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":40,"alternative-id":["S0001706X18305680"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2018.12.017","relation":{},"ISSN":["0001-706X"],"issn-type":[{"type":"print","value":"0001-706X"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral nitazoxanide treatment of experimental neurocysticercosis induces gluconeogenesis in Taenia crassiceps cysticerci","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2018.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}