{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T05:54:47Z","timestamp":1769320487042,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010849","name":"Health and Family Planning Commission of Wuhan Municipality","doi-asserted-by":"publisher","award":["WX16D28"],"award-info":[{"award-number":["WX16D28"]}],"id":[{"id":"10.13039\/501100010849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010849","name":"Health and Family Planning Commission of Wuhan Municipality","doi-asserted-by":"publisher","award":["WX17A08"],"award-info":[{"award-number":["WX17A08"]}],"id":[{"id":"10.13039\/501100010849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003820","name":"Hubei Provincial Population and Family Planning Commission","doi-asserted-by":"publisher","award":["WJ2018H0129"],"award-info":[{"award-number":["WJ2018H0129"]}],"id":[{"id":"10.13039\/501100003820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2017CFB570"],"award-info":[{"award-number":["2017CFB570"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.actatropica.2019.105239","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:12:00Z","timestamp":1572001920000},"page":"105239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Effects of regulatory T cells on glyceraldehyde-3-phosphate dehydrogenase vaccine efficacy against Schistosoma japonicum"],"prefix":"10.1016","volume":"202","author":[{"given":"Chun-lian","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-ping","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-hui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao-lan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-rong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.actatropica.2019.105239_bib0001","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2005850","article-title":"The Foxp3+ regulatory T-cell population requires IL-4R\u03b1 signaling to control inflammation during helminth infections","volume":"16","author":"Abdel Aziz","year":"2018","journal-title":"PLoS Biol."},{"issue":"6","key":"10.1016\/j.actatropica.2019.105239_bib0002","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/sji.12175","article-title":"On the mechanism determining the TH1\/TH2 phenotype of an immune response, and its pertinence to strategies for the prevention, and treatment, of certain infectious diseases","volume":"79","author":"Bretscher","year":"2014","journal-title":"Scand. J. Immunol."},{"issue":"2","key":"10.1016\/j.actatropica.2019.105239_bib0004","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/0255-0857.180279","article-title":"A recombinant plasmid of composite cysteine proteinase inhibitor\/glyceraldehyde-3-phosphate dehydrogenase gene of periodic Brugia malayi functions on DNA immunity in the host","volume":"34","author":"Fang","year":"2016","journal-title":"Indian J. Med. Microbiol."},{"key":"10.1016\/j.actatropica.2019.105239_bib0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jaut.2017.07.009","article-title":"Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity","volume":"84","author":"Ferreira","year":"2017","journal-title":"J. Autoimmun."},{"issue":"3-4","key":"10.1016\/j.actatropica.2019.105239_bib0006","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.vaccine.2003.07.010","article-title":"IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-gamma and TNF-alpha dependent pathway","volume":"22","author":"Fonseca","year":"2004","journal-title":"Vaccine"},{"issue":"5","key":"10.1016\/j.actatropica.2019.105239_bib0007","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1007\/s10753-018-0821-8","article-title":"Partial depletion of regulatory T cells enhances host inflammatory response against acute pseudomonas aeruginosa infection after sepsis","volume":"41","author":"Hu","year":"2018","journal-title":"Inflammation"},{"key":"10.1016\/j.actatropica.2019.105239_bib0008","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jaut.2017.07.002","article-title":"Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications","volume":"83","author":"Iizuka-Koga","year":"2017","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.actatropica.2019.105239_bib0009","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.exppara.2011.05.012","article-title":"Cimetidine enhances the protective effect of GST DNA vaccine against Schistosoma japonicum","volume":"128","author":"Li","year":"2011","journal-title":"Exp. Parasitol."},{"issue":"4","key":"10.1016\/j.actatropica.2019.105239_bib0010","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/s41385-018-0004-9","article-title":"Vaccine-induced antigen-specific regulatory T cells attenuate the antiviral immunity against acute influenza virus infection","volume":"11","author":"Lin","year":"2018","journal-title":"Mucosal Immunol."},{"issue":"5","key":"10.1016\/j.actatropica.2019.105239_bib0011","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s00436-008-1114-1","article-title":"Schistosoma japonicum infection modulates the development of allergen-induced airway inflammation in mice","volume":"103","author":"Mo","year":"2008","journal-title":"Parasitol. Res."},{"issue":"13","key":"10.1016\/j.actatropica.2019.105239_bib0012","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/S0020-7519(01)00244-2","article-title":"Immunisation with Salmonella typhimurium-delivered glyceraldehyde-3-phosphate dehydrogenase protects mice against challenge infection with Echinococcus multilocularis eggs","volume":"31","author":"M\u00fcller-Schollenberger","year":"2001","journal-title":"Int. J. Parasitol."},{"issue":"8","key":"10.1016\/j.actatropica.2019.105239_bib0013","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.vaccine.2015.11.072","article-title":"Glyceradehyde-3-phosphate dehydrogenase as a suitable vaccine candidate for protection against bacterial and parasitic diseases","volume":"34","author":"Perez-Casal","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.actatropica.2019.105239_bib0014","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1017\/S0031182000079701","article-title":"Schistosoma mansoni and S. japonicum: comparison of levels of ultraviolet irradiation for vaccination of mice with cercariae","volume":"1","author":"Ruppel","year":"1990","journal-title":"Parasitology"},{"issue":"3","key":"10.1016\/j.actatropica.2019.105239_bib0015","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1139\/o11-058","article-title":"The multifunctional glycolytic protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a novel macrophage lactoferrin receptor","volume":"90","author":"Rawat","year":"2012","journal-title":"Biochem. Cell Biol."},{"issue":"3","key":"10.1016\/j.actatropica.2019.105239_bib0016","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J. Immunol."},{"issue":"43","key":"10.1016\/j.actatropica.2019.105239_bib0017","doi-asserted-by":"crossref","first-page":"5861","DOI":"10.1016\/j.vaccine.2015.07.110","article-title":"DNA vaccine encoding the moonlighting protein Onchocerca volvulus glyceraldehyde-3-phosphate dehydrogenase (Ov-GAPDH) leads to partial protection in a mouse model of human filariasis","volume":"33","author":"Steisslinger","year":"2015","journal-title":"Vaccine"},{"issue":"3","key":"10.1016\/j.actatropica.2019.105239_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005443","article-title":"Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase","volume":"11","author":"Tallima","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.actatropica.2019.105239_bib0019","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.exppara.2013.11.001","article-title":"Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+)CD25(+) regulatory T cells in murine schistosomiasis japonica","volume":"136","author":"Tang","year":"2014","journal-title":"Exp. Parasitol."},{"issue":"7","key":"10.1016\/j.actatropica.2019.105239_bib0020","first-page":"638","article-title":"The function of glyceraldehyde phosphate dehydrogenase in mice infected with Schistosoma japonicum","volume":"11","author":"Tang","year":"2016","journal-title":"J. Pathog. Biol."},{"issue":"10","key":"10.1016\/j.actatropica.2019.105239_bib0021","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1007\/s00436-017-5581-0","article-title":"Anti-CD25 monoclonal antibody enhances the protective efficacy of Schistosoma japonicum GST vaccine via inhibition of CD4+CD25+Foxp3+ regulatory T cells","volume":"116","author":"Tang","year":"2017","journal-title":"Parasitol. Res."},{"issue":"2","key":"10.1016\/j.actatropica.2019.105239_bib0022","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s00436-018-6186-y","article-title":"Effect of regulatory T cells on the efficacy of the fatty acid-binding protein vaccine against Schistosoma japonicum","volume":"118","author":"Tang","year":"2019","journal-title":"Parasitol. Res."},{"issue":"11","key":"10.1016\/j.actatropica.2019.105239_bib0023","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1128\/iai.61.11.4716-4723.1993","article-title":"Cloning, molecular characterization, and functional activity of Schistosoma japonicum glyceraldehyde-3-phosphate dehydrogenase, a putative vaccine candidate against schistosomiasis japonica","volume":"61","author":"Waine","year":"1993","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.actatropica.2019.105239_bib0024","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1111\/j.1365-2796.2010.02311.x","article-title":"Evidence for a role of regulatory T cells in mediating the atheroprotective effect of apolipoprotein B peptide vaccine","volume":"269","author":"Wigren","year":"2011","journal-title":"J. Intern. Med."},{"issue":"11","key":"10.1016\/j.actatropica.2019.105239_bib0025","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.imbio.2015.07.001","article-title":"Treg depletion attenuates irradiation-induced pulmonary fibrosis by reducing fibrocyte accumulation, inducing Th17 response, and shifting IFN-\u03b3, IL-12\/IL-4, IL-5 balance","volume":"220","author":"Xiong","year":"2015","journal-title":"Immunobiology"},{"issue":"8","key":"10.1016\/j.actatropica.2019.105239_bib0026","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1172\/JCI200317165","article-title":"Activation of natural killer T cells in NZB\/W mice induces Th1-type immune responses exacerbating lupus","volume":"112","author":"Zeng","year":"2003","journal-title":"J. Clin. Invest."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X18316310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X18316310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:16:56Z","timestamp":1757549816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X18316310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":25,"alternative-id":["S0001706X18316310"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2019.105239","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of regulatory T cells on glyceraldehyde-3-phosphate dehydrogenase vaccine efficacy against Schistosoma japonicum","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2019.105239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105239"}}