{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T14:56:10Z","timestamp":1788533770815,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Tropica"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.actatropica.2023.106975","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T11:38:17Z","timestamp":1687261097000},"page":"106975","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Polymorphism analysis of drug resistance markers in Plasmodium falciparum isolates from Benin"],"prefix":"10.1016","volume":"245","author":[{"given":"Mariangela","family":"L'Episcopia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Doderer-Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edvige","family":"Perrotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Priuli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Cavallari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Guidetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bernieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Menard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Severini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.actatropica.2023.106975_bib0001","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1128\/AAC.48.3.879-889.2004","article-title":"Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance","volume":"48","author":"Ahmed","year":"2004","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.actatropica.2023.106975_bib0002","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1475-2875-9-129","article-title":"Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests","volume":"9","author":"Baker","year":"2010","journal-title":"Malar. J."},{"key":"10.1016\/j.actatropica.2023.106975_bib0003","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jgar.2021.03.003","article-title":"High prevalence of genotypes associated with sulfadoxine\/pyrimethamine resistance in the rural area of Fougamou, Gabon","volume":"25","author":"Boukoumba","year":"2021","journal-title":"J. Glob. Antimicrob. Resist."},{"issue":"8","key":"10.1016\/j.actatropica.2023.106975_bib0004","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271489","article-title":"The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana","volume":"17","author":"Dosoo","year":"2022","journal-title":"PLoS ONE"},{"key":"10.1016\/j.actatropica.2023.106975_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.meegid.2020.104503","article-title":"Analysis of sulphadoxine-pyrimethamine resistance-associated mutations in Plasmodium falciparum isolates obtained from asymptomatic pregnant women in Ogun State, Southwest Nigeria","volume":"85","author":"Fagbemi","year":"2020","journal-title":"Infect. Genet. Evol."},{"issue":"8","key":"10.1016\/j.actatropica.2023.106975_bib0006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010317","article-title":"Spatiotemporal spread of Plasmodium falciparum mutations for resistance to sulfadoxine-pyrimethamine across Africa, 1990-2020","volume":"18","author":"Flegg","year":"2022","journal-title":"PLoS Comput. Biol."},{"issue":"1","key":"10.1016\/j.actatropica.2023.106975_bib0007","doi-asserted-by":"crossref","first-page":"e8091","DOI":"10.1371\/journal.pone.0008091","article-title":"A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests","volume":"5","author":"Gamboa","year":"2010","journal-title":"PLoS ONE"},{"issue":"2","key":"10.1016\/j.actatropica.2023.106975_bib0008","doi-asserted-by":"crossref","first-page":"472","DOI":"10.4269\/ajtmh.20-1296","article-title":"Intermittent preventive treatment of malaria in pregnancy coverage estimates from population-based surveys: reliability of women's recall among women with ANC cards","volume":"105","author":"Hansen","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.actatropica.2023.106975_bib30","doi-asserted-by":"crossref","unstructured":"Koko V.S., Warsame M., Vonhm B., Jeuronlon M.K., Menard D., Ma L., Taweh F., Tehmeh L., Nyansaiye P., Pratt O.J., Parwon S., Kamara P., Asinya M., Kollie A., Ringwald P. Artesunate-amodiaquine and artemether-lumefantrine for the treatment of uncomplicated falciparum malaria in Liberia: in vivo efficacy and frequency of molecular markers. Malar J. 2022 Apr 27;21(1):134. doi: 10.1186\/s12936-022-04140-7. PMID: 35477399; PMCID: PMC9044686.","DOI":"10.1186\/s12936-022-04140-7"},{"issue":"3","key":"10.1016\/j.actatropica.2023.106975_bib0009","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4269\/ajtmh.21-0086","article-title":"Efficacy of artemether-lumefantrine for the treatment of plasmodium falciparum malaria in Bohicon and Kandi, Republic of Benin, 2018-2019","volume":"105","author":"Kpemasse","year":"2021","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"3","key":"10.1016\/j.actatropica.2023.106975_bib0010","doi-asserted-by":"crossref","first-page":"455","DOI":"10.3390\/pathogens12030455","article-title":"Low prevalence of plasmodium falciparum histidine-rich protein 2 and 3 gene deletions-a multiregional study in central and West Africa","volume":"12","author":"Krueger","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/j.actatropica.2023.106975_bib0011","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijid.2021.04.081","article-title":"Targeted deep amplicon sequencing of antimalarial resistance markers in Plasmodium falciparum isolates from Cameroon","volume":"107","author":"L'Episcopia","year":"2021","journal-title":"Int. J. Infect. Dis."},{"issue":"29","key":"10.1016\/j.actatropica.2023.106975_bib0012","doi-asserted-by":"crossref","first-page":"12025","DOI":"10.1073\/pnas.0905922106","article-title":"Stepwise acquisition of pyrimethamine resistance in the malaria parasite","volume":"106","author":"Lozovsky","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.actatropica.2023.106975_bib0013","doi-asserted-by":"crossref","first-page":"6057","DOI":"10.3390\/ijms22116057","article-title":"Selection of pfcrt K76 and pfmdr1 N86 coding alleles after uncomplicated malaria treatment by artemether-lumefantrine in mali","volume":"22","author":"Maiga","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.actatropica.2023.106975_bib0014","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1186\/s12936-016-1503-3","article-title":"Selection of Plasmodium falciparum pfcrt and pfmdr1 polymorphisms after treatment with artesunate-amodiaquine fixed dose combination or artemether-lumefantrine in Liberia","volume":"15","author":"Otienoburu","year":"2016","journal-title":"Malar. J."},{"key":"10.1016\/j.actatropica.2023.106975_bib28","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1186\/s12936-016-1490-4","article-title":"Selection of N86F184D1246 haplotype of Pfmrd1 gene by artemether-lumefantrine drug pressure on Plasmodium falciparum populations in Senegal","volume":"15","author":"Sisowath","year":"2016","journal-title":"Malar. J."},{"issue":"5","key":"10.1016\/j.actatropica.2023.106975_bib0015","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1086\/596738","article-title":"In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa","volume":"199","author":"Sisowath","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.actatropica.2023.106975_bib29","first-page":"189","article-title":"Nested PCR analysis of Plasmodium parasites","volume":"72","author":"Snounou","year":"2002","journal-title":"Methods Mol Med"},{"issue":"1","key":"10.1016\/j.actatropica.2023.106975_bib0016","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12936-021-03605-5","article-title":"Low prevalence of highly sulfadoxine-resistant dihydropteroate synthase alleles in Plasmodium falciparum isolates in Benin","volume":"20","author":"Svigel","year":"2021","journal-title":"Malar. J."},{"key":"10.1016\/j.actatropica.2023.106975_bib0017","unstructured":"The DHS Program. 2020. Malaria indicator trends in Benin: outputs from a DHS program workshop on data use. Rockville, Maryland, USA: The DHS Program."},{"issue":"6","key":"10.1016\/j.actatropica.2023.106975_bib0018","doi-asserted-by":"crossref","first-page":"e02029","DOI":"10.1128\/AAC.02029-19","article-title":"Effect of drug pressure on promoting the emergence of antimalarial-resistant parasites among pregnant women in Ghana","volume":"64","author":"Tornyigah","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"1","key":"10.1016\/j.actatropica.2023.106975_bib0019","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1038\/s41467-022-33873-x","article-title":"Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda","volume":"13","author":"Tumwebaze","year":"2022","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.actatropica.2023.106975_bib0020","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1016\/S2666-5247(21)00085-9","article-title":"Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study","volume":"2","author":"Tumwebaze","year":"2021","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.actatropica.2023.106975_bib0021","unstructured":"U.S. President's Malaria Initiative Benin Malaria Operational Plan FY. 2020."},{"key":"10.1016\/j.actatropica.2023.106975_bib0022","series-title":"World Malaria Report 2022","year":"2022"},{"key":"10.1016\/j.actatropica.2023.106975_bib0023","series-title":"Guidelines for Malaria","year":"2022"},{"key":"10.1016\/j.actatropica.2023.106975_bib0024","unstructured":"WHO. Report on antimalarial drug efficacy, resistance and response: 10 years of surveillance (2010\u20132019). 2020. https:\/\/www.who.int\/publications\/i\/item\/9789240012813 (accessed October 16, 2022)."},{"key":"10.1016\/j.actatropica.2023.106975_bib0025","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1475-2875-12-34","article-title":"Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests","volume":"12","author":"Wurtz","year":"2013","journal-title":"Malar. J."},{"issue":"1","key":"10.1016\/j.actatropica.2023.106975_bib0026","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1186\/s12879-017-2634-z","article-title":"Polymorphisms of plasmodium falciparum k13-propeller gene among migrant workers returning to Henan Province, China from Africa","volume":"17","author":"Yang","year":"2017","journal-title":"BMC Infect. Dis."},{"issue":"2","key":"10.1016\/j.actatropica.2023.106975_bib0027","first-page":"6","article-title":"Assessment of the risk posed to Singapore by the emergence of artemisinin-resistant malaria in the Greater Mekong Subregion","volume":"10","author":"Zhang","year":"2019","journal-title":"West. Pac. Surveill. Response J."}],"container-title":["Acta Tropica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X23001626?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001706X23001626?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T00:41:39Z","timestamp":1757551299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001706X23001626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":30,"alternative-id":["S0001706X23001626"],"URL":"https:\/\/doi.org\/10.1016\/j.actatropica.2023.106975","relation":{},"ISSN":["0001-706X"],"issn-type":[{"value":"0001-706X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polymorphism analysis of drug resistance markers in Plasmodium falciparum isolates from Benin","name":"articletitle","label":"Article Title"},{"value":"Acta Tropica","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.actatropica.2023.106975","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"106975"}}